Gastrointestinal Bleeding in Congenital Bleeding Disorders

Gastrointestinal bleeding (GIB) is serious, intractable, and potentially life-threatening condition. There is considerable heterogeneity in GIB phenotypes among congenital bleeding disorders (CBDs), making GIB difficult to manage. Although GIB is rarely encountered in CBDs, its severity in some patients makes the need for a comprehensive and precise assessment of underlying factors and management approaches imperative. Initial evaluation of GIB begins with assessment of hematological status; GIB should be ruled out in patients with chronic anemia, and in presentations that include hematemesis, hematochezia, or melena. High-risk patients with recurrent GIB require urgent interventions such as replacement therapy for treatment of coagulation factor deficiency (CFD). However, the best management strategy for CFD-related bleeding remains controversial. While several investigations have identified CBDs as potential risk factors for GIB, research has focused on assessing the risks for individual factor deficiencies and other CBDs. This review highlights recent findings on the prevalence, management strategies, and alternative therapies of GIB related to CFDs, and platelet disorders.

Examination of aspects of pro-consumer refund system

PurposePro-consumer refund system (PCRS) should be understood as a process in customer service, within which activities are related to the handling of goods that do not meet customer expectations, both in business-to-consumer (B2C) and business-to-business (B2B) relations. The research monitored three groups of variables – the importance of shopping decision factors, customer ID characteristics and PCRS characteristics. The authors explore relationships between these three groups of variables, and the authors tried to understand better the role of the PCRS system in customer perception of service quality.Design/methodology/approachAn electronic survey was used to collect data in the planned structure. Research questions were developed into variables, and these were then the basis for creating questionnaires. Data were collected through electronic questionnaires. The sample consisted of 327 respondents from Poland (confidence level = 95%, confidence interval = 5.42).FindingsThe results of the research show that the PCRS is very important and appreciated from the customer's perspective. Most of the respondents are aware of their consumer rights and correctly understand the meaning of the term “pro-consumer refund system”. Respondents require complex service in terms of returns; their satisfaction does not depend on any individual factor. This also means that the return system must be lenient in each aspect.Originality/valueA detailed analysis of aspects of PCRS has not yet been carried out in the literature. Although previous studies have focused, at least in part, on defining the essential attributes of PCRS, in most cases, it was an organization-driven view of this topic. The research examined the interrelationships between aspects of PCRS based on empirical data and offered a new perspective on this evolving concept.

CONCILIATOR VS BLOC LEADER : PERBANDINGAN KEBIJAKAN BARACK OBAMA & DONALD TRUMP DALAM MERESPON PERTUMBUHAN EKONOMI CHINA

ABSTRACT Since the fall of the Berlin Wall in 1989, the United States has become the world's undisputed economic superpower. However, the economic reforms carried out by China since the 1980s have had a big effect on its economic growth, so that it is able to rank as the second largest economy in the world after the United States. This makes America must respond to China's development by making strategic policies. State leaders have an important role in determining the direction of United States Foreign Policy. From 2009 to 2018, America underwent 2 transitions of leadership, namely from President Barack Obama to being replaced by President Donald Trump. Even though the two leadership eras are close together, the US Foreign Policy towards China is in stark contrast. This research will analyze how the differences in the US Foreign Policy against China in the Barack Obama and Donald Trump Era and the factors that cause differences in their policies by using the idiosyncratic individual factor approach. This article finds that the different backgrounds in the life of a country's leader will influence their perception in determining the direction of their foreign policy. Key words: U.S. Foreign Policy, China, Barack Obama, Donald Trump, Idiosyncratic, Psychobiography

Foreign Policy in Times of Crisis: Venezuela's Blockade Policy towards Brazilian Aids

Venezuela, an economically oil-dependent country in South America, has experienced a turmoil of economic crisis since 2014 under the administration of President Nicolás Maduro. This crisis has been spilling towards social and political issues, with one being the emergence of an opposition group led by Juan Guaidó. This crisis, at first, has invited sympathy from various international actors, both states and non-states, with one being Brazil under the leadership of President Bolsonaro. Brazil at first is actively sending logistical aids towards the Venezuelans. However, in February 2019, President Maduro decided to fully-blockade Venezuela-Brazil borders for any human or goods movement. Beside the individual factor of the state's leader, group factor, specifically its cabinet which still acquires legitimacy from the leader, is also often seen as affecting and advising a policy in the time of a crisis. This paper aims to analyze the presence of President Maduro’s cabinet towards the Brazil border blockade in Venezuelan Crisis in 2019. By using the groupthink paradigm, this paper argues that there is a position of convergence between the members of the cabinet with the background of: (1) the dominance of nationalist military groups loyal to President Maduro; (2) the same ideology of left-wing political spectrum. It also argues that beside the two internal factors above, the external factors of regional and global tension towards Venezuela also create an isolation as an element of stress towards this government. This paper concludes that the combination of the three factors above become the main factors that formulated the blockade policy. Keywords: economic crisis, foreign policy, groupthink, Venezuela

Households' intentions under financial vulnerability conditions: is it likely for the COVID-19 pandemic to leave a permanent scar?

PurposeThe authors draw on psychological reactance theory, collective mental programming, psychological profiles and financial vulnerability experiences to assess the possibility that the pandemic may induce transformative changes in households' behavioral intentions related to financial decisions after the pandemic is over.Design/methodology/approachUsing a unique survey data drawn from four different countries located in North America, Europe, Africa and Latin America, the authors show that the stressful conditions that accompanied the pandemic have instigated a state of financial vulnerability and stimulated instinctual defensive mechanisms among consumers.FindingsThe study results indicate that households have intentions to make defensive decisions in spending, consumption, planning and investment. Furthermore, the authors report evidence that personal psychological heterogeneity (as an individual factor) and collective mental programming (as a cultural factor) play a significant role in shaping households' postpandemic financial intentions.Research limitations/implicationsThe study findings carry important practical implications. For financial institutions, marketers and financial advisors, the authors’ work implies that individual and collective factors affect people's perception and behavioral intentions in response to financial adversities. For social planners and legislators, the authors’ work shows that they should expect not only short-term but also long-term reactions to the COVID-19 pandemic.Originality/valueMost research on the impact of COVID-19 pandemic on households' financial behavior focuses on transitional adjustments made during the pandemic, and little emphasis has been placed on potential postpandemic adjustments. The authors contend that it would be a mistake to analyze the pandemic-induced crisis as a temporary financial hardship.

Maintaining Effort and Interest despite Challenges during the COVID-19 Pandemic: A Process Tracing Approach to a Teacher’s Grit during an Online L2 Course

Grit—the ability to maintain effort and interest for long-term goals—is argued to be an important individual factor for achievement, especially in the face of obstacles. However, little research has examined the possible fluctuations of effort and interest and how challenges may trigger the changes of effort and interest. In this study, we measured a teacher’s grit at the beginning of an online course during the COVID-19 pandemic, and we focused on the changes in a teacher’s effort and interest throughout the course. In this case study we unpacked the explanations of possible changes in grit via process tracing. Despite the fact that the teacher scored high on the grit scale, we found that the sudden shift from in-person to online teaching had put much pressure and demand on the teacher. The new teaching challenge influenced the teacher’s self-evaluation of their teaching performance and students’ engagement, which led to changes in effort and interest. Therefore, we argue that one’s average grit (e.g., measured by grit scale) cannot be the representation of their ability to maintain interest and effort on different occasions due to the influence of different situational causes or pressure. Specifically, during the course, the teacher’s effort and interest underwent changes on four occasions, characterized by four distinct dynamic patterns in terms of the interaction of high and low interest and effort. The four emerging patterns of L2 teacher effort and interest indicate that the construct of grit could be explained in terms of four dynamic clusters or archetypes. This study provides implications for understanding the complex dynamic nature of grit, which can be further explored through cluster analytic approaches in future studies.

Impact of adiposity on risk of female gout among those genetically predisposed: sex-specific prospective cohort study findings over >32 years

ObjectivesTo evaluate the joint (combined) association of excess adiposity and genetic predisposition with the risk of incident female gout, and compare to their male counterparts; and determine the proportion attributable to body mass index (BMI) only, genetic risk score (GRS) only, and to their interaction.MethodsWe prospectively investigated potential gene-BMI interactions in 18 244 women from the Nurses’ Health Study and compared with 10 888 men from the Health Professionals Follow-Up Study. GRS for hyperuricaemia was derived from 114 common urate-associated single nucleotide polymorphisms.ResultsMultivariable relative risk (RR) for female gout was 1.49 (95% CI 1.42 to 1.56) per 5 kg/m2 increment of BMI and 1.43 (1.35 to 1.52) per SD increment in the GRS. For their joint association of BMI and GRS, RR was 2.18 (2.03 to 2.36), more than the sum of each individual factor, indicating significant interaction on an additive scale (p for interaction <0.001). The attributable proportions of joint effect for female gout were 42% (37% to 46%) to adiposity, 37% (32% to 42%) to genetic predisposition and 22% (16% to 28%) to their interaction. Additive interaction among men was smaller although still significant (p interaction 0.002, p for heterogeneity 0.04 between women and men), and attributable proportion of joint effect was 14% (6% to 22%).ConclusionsWhile excess adiposity and genetic predisposition both are strongly associated with a higher risk of gout, the excess risk of both combined was higher than the sum of each, particularly among women.

JOB SATISFACTION OF THE EMPLOYEESAT RED STARUNIVERSITY IN VIETNAM

The current paper aims to analyze the effect of thesix factors on the employeessatisfaction with their jobs atSao Do(Red Star) University in the North of Vietnam, which include: job characteristics, income and welfair, training for promotion, colleague, superior, working condition. The individual factor is also investigated in this study. The results of the research show that all the six factors have positive relation to the employees satisfaction with jobs while the individual factor (age, gender, educational/skill level) has no different effect to the employees satisfaction with job. Quantitative research methodology was applied for the research and some suggestions for Sao Do(Red Star)University was also proposed to increase their employees satisfaction with their jobs.

Definition of conceptual basics of nanoeconomics as inclusive society environment

The definition of nanoeconomics can relate to different levels and areas of economic life. First of all, this is the nanolevel of the economic system. As a human economy, nanoeconomics provides for the allocation of an individual factor within the framework of a socio-economic phenomenon. The nanoeconomic aspect is central to the definition of inclusion. So, the inclusion of a person, as the main subject of nanoeconomics, to the formation and stabilization of economic systems is the initial one in the integration of an individual in relation to production processes and economic development. A person is involved in academic and social life by making decisions about their own business and integrating it into the sectoral and national economic space. It is proved that its indicators are the conditions for clustering the economic system. The study carried out a cluster analysis of the innovation system in a country with an economy in transition. In addition, the study outlined that inclusive phenomena in the economy are close to integration and are the opposite of segregation and isolation. It is noted that different institutions of integration can be used to form objective conditions for the development of babyeconomics. Public decisions of inclusion involve the use of Arrow's impossibility theorem. The research results can be used: – the individualistic functions of inclusion should be used in the formation of the babyeconomics, the human economy and the economy of nanotechnology; – states of inclusion must be created at all levels of the economic system; – a person and wealth are an individualistic aspect of an inclusive economy, because national wealth consists of individual wealth. Nanoeconomics is just beginning to be included in the systemic processes of inclusive economic phenomena, especially in countries with economies in transition

Association between Age Group and Perception towards ‘Women's Career Success and Barriers’

The age factor plays a vital role in the perception of human beings on different issues. Regarding this, the main objective of this study is to examine the association between age group and perception of Nepali universities female teachers in the issues of women's career success and barriers such as individual factor, family factor, organizational factor, and socio-cultural factor. With judgmental sampling technique, only 202 responses were selected and usable out of 275 questionnaires distributed to female University teachers. This study has tested the reliability by using Cronbach alpha. Using likelihood ratio, it was found that there is only a significant association of agegroup and perception of female teachers in the issue of women’s career success but there is no significant association in the issues of individual factor, family factor, organizational factor, and socio-cultural factor. From this output, it concluded that perceptions of women university teachers are different with different age-group in the issue of women’s career success. This study could be useful for University/college management, trainers, and human resource developers to assist the career success of female university teachers.