UV-assisted synthesis of hydroxyapatite from eggshells at ambient temperature: cytotoxicity, drug delivery and bioactivity

Hap has been developed from eggshell by UV-irradiation for the first time. The negligible cytotoxicity and the efficient delivery of a therapeutic level of ciprofloxacin as well as bioactivity of this UV- Hap supports its use in biomedical fields.

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Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots

Microsystems & Nanoengineering ◽

10.1038/s41378-020-00228-9 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Leela Goel ◽

Huaiyu Wu ◽

Bohua Zhang ◽

Jinwook Kim ◽

Paul A. Dayton ◽

...

Keyword(s):

Drug Delivery ◽

Negative Pressure ◽

Boiling Point ◽

Clot Lysis ◽

Control Group ◽

Peak Negative Pressure ◽

Blood Clots ◽

Tissue Plasminogen ◽

First Time

AbstractOne major challenge in current microbubble (MB) and tissue plasminogen activator (tPA)-mediated sonothrombolysis techniques is effectively treating retracted blood clots, owing to the high density and low porosity of retracted clots. Nanodroplets (NDs) have the potential to enhance retracted clot lysis owing to their small size and ability to penetrate into retracted clots to enhance drug delivery. For the first time, we demonstrate that a sub-megahertz, forward-viewing intravascular (FVI) transducer can be used for ND-mediated sonothrombolysis, in vitro. In this study, we determined the minimum peak negative pressure to induce cavitation with low-boiling point phase change nanodroplets and clot lysis. We then compared nanodroplet mediated sonothrombolysis to MB and tPA mediate techniques. The clot lysis as a percent mass decrease in retracted clots was 9 ± 8%, 9 ± 5%, 16 ± 5%, 14 ± 9%, 17 ± 9%, 30 ± 8%, and 40 ± 9% for the control group, tPA alone, tPA + US, MB + US, MB + tPA + US, ND + US, and ND + tPA + US groups, respectively. In retracted blood clots, combined ND- and tPA-mediated sonothrombolysis was able to significantly enhance retracted clot lysis compared with traditional MB and tPA-mediated sonothrombolysis techniques. Combined nanodroplet with tPA-mediated sonothrombolysis may provide a feasible strategy for safely treating retracted clots.

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Nanoparticles as Drug Delivery Systems of RNAi in Cancer Therapy

Molecules ◽

10.3390/molecules26082380 ◽

2021 ◽

Vol 26 (8) ◽

pp. 2380

Author(s):

Diedie Li ◽

Chengzhi Gao ◽

Meiyan Kuang ◽

Minhao Xu ◽

Ben Wang ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Therapeutic Strategy ◽

Target Gene ◽

Treatment Approach ◽

Systemic Delivery ◽

Efficient Delivery ◽

Rnai Therapeutics ◽

Cellular Machinery ◽

Tumor Delivery

RNA interference (RNAi) can mediate gene-silencing by knocking down the expression of a target gene via cellular machinery with much higher efficiency in contrast to other antisense-based approaches which represents an emerging therapeutic strategy for combating cancer. Distinct characters of nanoparticles, such as distinctive size, are fundamental for the efficient delivery of RNAi therapeutics, allowing for higher targeting and safety. In this review, we present the mechanism of RNAi and briefly describe the hurdles and concerns of RNAi as a cancer treatment approach in systemic delivery. Furthermore, the current nanovectors for effective tumor delivery of RNAi therapeutics are classified, and the characteristics of different nanocarriers are summarized.

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Recent trends in nano-based drug delivery systems for efficient delivery of phytochemicals in chemotherapy

RSC Advances ◽

10.1039/c6ra07802h ◽

2016 ◽

Vol 6 (54) ◽

pp. 48294-48314 ◽

Cited By ~ 50

Author(s):

A. P. Subramanian ◽

S. K. Jaganathan ◽

A. Manikandan ◽

K. N. Pandiaraj ◽

Gomathi N ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Cells ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Free Form ◽

Remarkable Effect ◽

Efficient Delivery ◽

Recent Trends

The phytochemicals were found to become more soluble when delivered by the nanocarriers and exhibited a remarkable effect on the cancer cells compared to its free form.

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Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽

10.1039/c6ra03718f ◽

2016 ◽

Vol 6 (29) ◽

pp. 24142-24153

Author(s):

Andreea S. Voda ◽

Kevin Magniez ◽

Nisa V. Salim ◽

Cynthia Wong ◽

Qipeng Guo

Keyword(s):

Drug Delivery ◽

Ethylene Glycol ◽

Self Assembly ◽

Triblock Copolymers ◽

Potential Drug ◽

Poly Ethylene Glycol ◽

Drug Delivery Applications ◽

Poly Ethylene ◽

First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

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Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

Soft Matter ◽

10.1039/d1sm00780g ◽

2021 ◽

Author(s):

Michael Meleties ◽

Priya Katyal ◽

Bonnie Lin ◽

Dustin Britton ◽

Jin Kim Montclare

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Self Assembly ◽

Coiled Coil ◽

Stimuli Responsive ◽

Tunable Properties ◽

Stimuli Sensitive ◽

Biomedical Fields

Owing to their tunable properties, hydrogels comprised of stimuli sensitive polymers are one of the most appealing scaffolds with applications in tissue engineering, drug delivery and other biomedical fields. We...

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Advanced and Innovative Nano-Systems for Anticancer Targeted Drug Delivery

Pharmaceutics ◽

10.3390/pharmaceutics13081151 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1151

Author(s):

Lu Tang ◽

Jing Li ◽

Qingqing Zhao ◽

Ting Pan ◽

Hui Zhong ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Treatment ◽

Small Molecule ◽

Anticancer Agents ◽

Targeted Drug Delivery ◽

Treatment Modalities ◽

Biological Macromolecules ◽

Passive Targeting ◽

Efficient Delivery ◽

Targeted Drug

The encapsulation of therapeutic agents into nano-based drug delivery system for cancer treatment has received considerable attention in recent years. Advancements in nanotechnology provide an opportunity for efficient delivery of anticancer drugs. The unique properties of nanoparticles not only allow cancer-specific drug delivery by inherent passive targeting phenomena and adopting active targeting strategies, but also improve the pharmacokinetics and bioavailability of the loaded drugs, leading to enhanced therapeutic efficacy and safety compared to conventional treatment modalities. Small molecule drugs are the most widely used anticancer agents at present, while biological macromolecules, such as therapeutic antibodies, peptides and genes, have gained increasing attention. Therefore, this review focuses on the recent achievements of novel nano-encapsulation in targeted drug delivery. A comprehensive introduction of intelligent delivery strategies based on various nanocarriers to encapsulate small molecule chemotherapeutic drugs and biological macromolecule drugs in cancer treatment will also be highlighted.

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Ambient Temperature as a Strong Zeitgeber of Circadian Rhythms in Response to Temperature Sensitivity and Poor Heat Dissipation Abilities in Subterranean African Mole-Rats

Journal of Biological Rhythms ◽

10.1177/07487304211034287 ◽

2021 ◽

pp. 074873042110342

Author(s):

Daniel W. Hart ◽

Barry van Jaarsveld ◽

Kiara G. Lasch ◽

Kerryn L. Grenfell ◽

Maria K. Oosthuizen ◽

...

Keyword(s):

Circadian Rhythms ◽

Ambient Temperature ◽

Heat Dissipation ◽

Direct Consequence ◽

Ecological Constraints ◽

Photic Entrainment ◽

Mole Rat ◽

Intimate Link ◽

Response To Temperature ◽

First Time

Mammals have evolved circadian rhythms in internal biological processes and behaviors, such as locomotor activity (LA), to synchronize to the environmental conditions they experience. Photic entrainment of LA has been well established; however, non-photic entrainment, such as ambient temperature ( Ta), has received much less attention. To address this dearth of knowledge, we exposed two subterranean endothermic-homeothermic African mole-rat species, the solitary Cape mole-rat ( Georychus capensis [GC]) and social Mahali mole-rat ( Cryptomys hottentotus mahali [CHM]), to varying Ta cycles in the absence of light. We showed that the LA rhythms of these two species entrain to Ta cycles and that the majority of LA occurred during the coolest 12-h period. LA confined to the coolest Ta periods may be the direct consequence of the poor heat dissipation abilities of African mole-rats brought about by physiological and ecological constraints. Recently, it has been hypothesized that Ta is only a strong zeitgeber for circadian rhythms in species whose thermoregulatory abilities are sensitive to changes in Ta (i.e., heterotherms and ectotherms), which previously has excluded endothermic-homeothermic mammals. However, this study demonstrates that Ta is a strong zeitgeber or entrainer for circadian rhythms of LA in subterranean endothermic-homeothermic mammals as a consequence of their sensitivity to changes in Ta brought about by their poor heat dissipation abilities. This study reinforces the intimate link between circadian rhythms and thermoregulation and conclusively, for the first time, provides evidence that Ta is a strong zeitgeber for endothermic-homeothermic mammals.

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Rhamnolipid-coated W/O/W double emulsion nanoparticles for efficient delivery of doxorubicin/erlotinib and combination chemotherapy

Journal of Nanobiotechnology ◽

10.1186/s12951-021-01160-4 ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Yeeun Lee ◽

Donghyun Lee ◽

Eunyoung Park ◽

Seok-young Jang ◽

Seo Young Cheon ◽

...

Keyword(s):

Drug Delivery ◽

Combination Therapy ◽

Combination Chemotherapy ◽

Tumor Tissue ◽

Tumor Therapy ◽

Synergetic Effect ◽

Double Emulsion ◽

High Accumulation ◽

Efficient Delivery ◽

Multiple Drugs

Abstract Background Combination therapy using more than one drug can result in a synergetic effect in clinical treatment of cancer. For this, it is important to develop an efficient drug delivery system that can contain multiple drugs and provide high accumulation in tumor tissue. In particular, simultaneous and stable loading of drugs with different chemical properties into a single nanoparticle carrier is a difficult problem. Results We developed rhamnolipid-coated double emulsion nanoparticles containing doxorubicin and erlotinib (RL-NP-DOX-ERL) for efficient drug delivery to tumor tissue and combination chemotherapy. The double emulsion method enabled simultaneous loading of hydrophilic DOX and hydrophobic ERL in the NPs, and biosurfactant RL provided stable surface coating. The resulting NPs showed fast cellular uptake and synergetic tumor cell killing in SCC7 cells. In real-time imaging, they showed high accumulation in SCC7 tumor tissue in mice after intravenous injection. Furthermore, enhanced tumor suppression was observed by RL-NP-DOX-ERL in the same mouse model compared to control groups using free drugs and NPs containing a single drug. Conclusions The developed RL-NP-DOX-ERL provided efficient delivery of DOX and ERL to tumor tissue and successful tumor therapy with a synergetic effect. Importantly, this study demonstrated the promising potential of double-emulsion NPs and RL coating for combination therapy. Graphical Abstract

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PHOTOCHEMICAL DEGRADATION OF PHENOL WITH THE PARTICIPATION OF TiO2 NANOPARTICLES AND ETHYL-3,3,5,5-TETRACIANO-2-HYDROXIDE-2-METIL-4,6-DIPHENYL CYCLOHEXANE CARBOXYLATE

Azerbaijan Chemical Journal ◽

10.32737/0005-2531-2021-2-101-105 ◽

2021 ◽

pp. 101-105

Author(s):

E.M. Gadirova ◽

Keyword(s):

Tio2 Nanoparticles ◽

Uv Irradiation ◽

Uv Spectroscopy ◽

Nano Particles ◽

Photochemical Degradation ◽

Cyclohexane Carboxylate ◽

Photochemical Decomposition ◽

First Time

The photochemical decomposition of phenol with the participation of TiO2 nano-particles and ethyl-3,3,5,5-tetraciano-2-hydroxide-2-metil-4,6-diphenyl cyclohexane carboxylate by UV spectroscopy was studied for the first time. It has been shown, that UV irradiation of this mixture during 1 hour brings to 52% decomposition of phenol

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MOF Decomposition and Introduction of Repairable Defects Using a Photodegradable Strut

10.26434/chemrxiv.7081151.v1 ◽

2018 ◽

Author(s):

Jingjing Yan ◽

John MacDonald ◽

Shawn Burdette

Keyword(s):

Drug Delivery ◽

Porous Materials ◽

New Method ◽

Innovative Approach ◽

Partial Decomposition ◽

Multiple Defects ◽

Potential Applications ◽

Defect Repair ◽

First Time ◽

Interesting Area

Utilizing a photolabile ligand as MOF strut can make a framework undergo full or partial decomposition upon irradiation. For the first time, a nitrophenylacetate derivative has been incorporated into MOF as a backbone linker via PLSE method. The photo-induced decarboxylation of the NPDAC-MOF represents a novel way of degrading a MOF, which provides an innovative approach to formulating photoresponsive porous materials with potential applications in molecular release and drug delivery. When photoactive linker is mixed with non-photolabile linker via partial PLSE, the MOF structure can be retained after irradiation, but with the introduction of multiple defects, offering a new method to create vacancies in MOFs. Defect repair can be achieved by treatment with replacement ligands, the scope of which is an interesting area for developing customizable MOF contents.<br>

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