scholarly journals The Study on the basic research for Integrated social community development crime and safety indicators - Analysis of the correlation between delinquency risk factors of juvenile of Multicultural -

2016 ◽  
Vol 11 (2) ◽  
pp. 53-78
Author(s):  
윤경희
Keyword(s):  
Risk Factors ◽  
Community Development ◽  
Basic Research ◽  
Social Community

scholarly journals Obesity-related hypertension: possible pathophysiological mechanisms

2014 ◽  
Vol 223 (3) ◽  
pp. R63-R78 ◽  
Author(s):  
Ivana Vaněčková ◽  
Lenka Maletínská ◽  
Michal Behuliak ◽  
Veronika Nagelová ◽  
Josef Zicha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Basic Research ◽  
Epidemiological Studies ◽  
Early Ontogeny ◽  
Detailed Knowledge ◽  
Critical Periods ◽  
Pathophysiological Mechanisms ◽  
Global Epidemic ◽  
The Metabolic Syndrome ◽  
Different Populations

Hypertension is one of the major risk factors of cardiovascular diseases, but despite a century of clinical and basic research, the discrete etiology of this disease is still not fully understood. The same is true for obesity, which is recognized as a major global epidemic health problem nowadays. Obesity is associated with an increasing prevalence of the metabolic syndrome, a cluster of risk factors including hypertension, abdominal obesity, dyslipidemia, and hyperglycemia. Epidemiological studies have shown that excess weight gain predicts future development of hypertension, and the relationship between BMI and blood pressure (BP) appears to be almost linear in different populations. There is no doubt that obesity-related hypertension is a multifactorial and polygenic trait, and multiple potential pathogenetic mechanisms probably contribute to the development of higher BP in obese humans. These include hyperinsulinemia, activation of the renin–angiotensin–aldosterone system, sympathetic nervous system stimulation, abnormal levels of certain adipokines such as leptin, or cytokines acting at the vascular endothelial level. Moreover, some genetic and epigenetic mechanisms are also in play. Although the full manifestation of both hypertension and obesity occurs predominantly in adulthood, their roots can be traced back to early ontogeny. The detailed knowledge of alterations occurring in the organism of experimental animals during particular critical periods (developmental windows) could help to solve this phenomenon in humans and might facilitate the age-specific prevention of human obesity-related hypertension. In addition, better understanding of particular pathophysiological mechanisms might be useful in so-called personalized medicine.

scholarly journals WADAH INTERAKSI SOSIAL

2020 ◽  
Vol 2 (1) ◽  
pp. 37
Author(s):  
Yonathan Yoel Mulyadi ◽  
Franky Liauw
Keyword(s):  
Community Development ◽  
Limited Time ◽  
Human Beings ◽  
Network Development ◽  
Social Community ◽  
Community Activities ◽  
Interview Method ◽  
The Social ◽  
Mutual Relations ◽  
Observation Method

People always engage in mutual relations and influence with other human beings in order to fulfill their needs and sustain their lives. The reaction action is a form of interaction created by humans, because humans are social beings who cannot live without the help of others. The purpose of this research is to know the pattern of communication built by the community and to know the process of social integration. The process of collecting data using the observation method conducted within 5 days in the study site area, and the interview method is conducted to obtain more accurate data in reviewing community development. Based on the results of the research, the pattern of interaction built by the community in Kramat is less good, because the whole community activities are done in the Office, school or other workplace. There is a social community that is engaged in the art of craft, but there are less people in the field because of limited time and location is less strategic, but also because it is commercial there are some people who lack It. Intersocial learning and network development in Kramat is a social facility that can be accessed by the whole community without seeing the social status. The facilities provided are the result of the interview data with the surrounding community as the basis for creating this project. Social containers are a facility provided to the community without charging a fee in certain provisions for the Community can be recreation and brainstorm and also knowledge in certain areas.AbstrakManusia senantiasa melakukan hubungan dan pengaruh timbal balik dengan manusia yang lain dalam rangka memenuhi kebutuhan dan mempertahankan kehidupannya. Adanya aksi reaksi merupakn sebuah bentuk interaksi yang diciptakan oleh manusia, karena manusia merupakan mahkluk sosial yang tidak dapat hidup tanpa bantuan orang lain. Tujuan penelitian ini untuk mengetahui pola komunikasi yang dibangun oleh para masyarakat dan untuk mengetahui proses integrasi sosial yang dilakukan. Proses pengumpulan data menggunakan metode observasi yang dilakukan dalam jangka waktu 5 hari di area tapak studi, selain itu juga metode wawancara dilakukan untuk memperoleh data yang lebih akurat dalam meninjau perkembangan masyarakat. Berdasarkan hasil penelitian, pola interaksi yang dibangun oleh masyarakat di Kramat tergolong kurang baik, karena hampir seluruh aktivitas masyarakat dilakukan di kantor, sekolah maupun tempat bekerja lainnya. Terdapat komunitas sosial yang bergerak dalam bidang seni kriya akan tetapi maksyarakat sekitar kurang meminatinya karena keterbatasan waktu dan juga lokasi yang kurang strategis, selain itu juga karena bersifat komersial ada beberapa masyarakat yang kurang meminatinya. Wadah belajar dan interaksi sosial sebagai pengembangan jaringan di kramat merupakan fasilitas sosial yang dapat diakses oleh seluruh kalangan masyarakat tanpa melihat status sosialnya. Fasilitas yang disediakan merupakan hasil dari data wawancara dengan masyarakat sekitar sebagai dasar dalam menciptakan proyek ini. Wadah sosial merupakan sebuah fasilitas yang diberikan kepada masyarakat tanpa memungut biaya dalam ketentuan tertentu untuk masyarakat dapat berekreasi serta bertukar pikiran dan juga ilmu dalam bidang – bidang tertentu.

scholarly journals Ghrelin in Diabetes and Metabolic Syndrome

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
Leena Pulkkinen ◽  
Olavi Ukkola ◽  
Marjukka Kolehmainen ◽  
Matti Uusitupa
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Complex Disease ◽  
Association Studies ◽  
Genetic Association Studies ◽  
Public Health Problem ◽  
Basic Research ◽  
Global Public Health

Metabolic syndrome is a cluster of related risk factors for cardiovascular disease, type 2 diabetes and liver disease. Obesity, which has become a global public health problem, is one of the major risk factors for development of metabolic syndrome and type 2 diabetes. Obesity is a complex disease, caused by the interplay between environmental and genetic factors. Ghrelin is one of the circulating peptides, which stimulates appetite and regulates energy balance, and thus is one of the candidate genes for obesity and T2DM. During the last years both basic research and genetic association studies have revealed association between the ghrelin gene and obesity, metabolic syndrome or type 2 diabetes

scholarly journals Herb-Induced Liver Injury Related to Reynoutria multiflora (Thunb.) Moldenke: Risk Factors, Molecular and Mechanistic Specifics

2021 ◽  
Vol 12 ◽  
Author(s):  
Xing-Ran Zhai ◽  
Zheng-Sheng Zou ◽  
Jia-Bo Wang ◽  
Xiao-He Xiao
Keyword(s):  
Risk Factors ◽  
Herbal Medicine ◽  
Liver Injury ◽  
Clinical Characteristics ◽  
Molecular Mechanisms ◽  
Basic Research ◽  
Polygonum Multiflorum ◽  
The West ◽  
The World ◽  
Molecular Aspects

Herbal medicine is widely used in Asia as well as the west. Hepatotoxicity is one of the most severe side effects of herbal medicine which is an increasing concern around the world. Reynoutria multiflora (Thunb.) Moldenke (Polygonum multiflorum Thunb., PM) is the most common herb that can cause herb-induced liver injury (HILI). The recent scientific and technological advancements in clinical and basic research are paving the way for a better understanding of the molecular aspects of PM-related HILI (PM-HILI). This review provides an updated overview of the clinical characteristics, predisposing factors, hepatotoxic components, and molecular mechanisms of PM-HILI. It can also aid in a better understanding of HILI and help in further research on the same.

scholarly journals Empoderamento para o desenvolvimento social comunitário mediante tecnologias intelectuais digitais / Empowerment for the Social Community Development through Digital Intellectual Technology

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Maria Giovanna Guedes Farias ◽  
Aida Varela Varela ◽  
Isa Maria Freire
Keyword(s):  
Community Development ◽  
Social Development ◽  
Information Society ◽  
Information Science ◽  
Digital Technologies ◽  
Collective Consciousness ◽  
Social Community ◽  
Community Needs ◽  
The Social ◽  
The City

ABSTRACTIn the context of the information society and knowledge, the social development of a urban community needs the empowerment of intellectual technologies by its members, in a process that goes beyond the access and use of this technologies. Empowerment means appropriating with a view to developing a collective consciousness. From this perspective, it is presented a Ph.D research in Information Science, whose field of study is the Community of Santa Clara, located in the city of João Pessoa, Brazil, where since 2011 are being implemented various actions support of information social development of their subjects, in order that they can become the protagonists of their own lives. The methodological assumptions are based on a qualitative approach, with the use of participatory research. The technique of the content analysis will be used to process the data collected during the events organized in the community. The research will be supported by means of intellectual digital technologies and an information operator will make the mediation in this process. Finally, it is expected that the actions of information and empowerment for community development, become actions of socialization for the subjects, so that they can move toward themselves as responsible not only for their own attitudes, but also by existence and living conditions of the community.RESUMONo contexto da sociedade da informação e do conhecimento, para que o desenvolvimento social de uma comunida-de urbana ocorra, entende-se como necessário o empoderamento das tecnologias intelectuais por parte dos seus integrantes, em um processo que vai além do acesso e uso dessas tecnologias. Empoderar-se significa apropriar-se visando o desenvol-vimento de uma consciência coletiva. Nessa perspectiva, apresenta-se pesquisa de doutorado em Ciência da Informação, que tem como campo de estudo a Comunidade Santa Clara, localizada na cidade de João Pessoa, Brasil, onde desde 2011 estão sendo implantadas diversas ações de informação em prol dos moradores, objetivando que os mesmos se tornem protagonis-tas de suas próprias vidas. Os pressupostos metodológicos têm como base a abordagem qualitativa, com uso da pesquisa participante e da técnica de análise de conteúdo para tratamento dos dados coletados durante os eventos promovidos na comunidade, tendo como suporte as tecnologias intelectuais digitais mediadas por um profissional da informação. Ao final, espera-se que as ações de informação e de empoderamento para o desenvolvimento comunitário se transformem em ações de socialização para esses sujeitos, de modo que possam caminhar em direção a se reconhecem como responsáveis por suas próprias atitudes e, também, pela existência e condições de vida da comunidade.

scholarly journals Assessment of risk factors and clinical characteristics of elderly patients with hypertensive encephalopathy against the background of hypertension

2015 ◽  
pp. 35-39
Author(s):  
V. V. Jaworski
Keyword(s):  
Risk Factors ◽  
Elderly Patients ◽  
Cerebrovascular Disease ◽  
Detailed Analysis ◽  
Neurological Examination ◽  
Cognitive Functions ◽  
Clinical Characteristics ◽  
Basic Research ◽  
Hypertensive Encephalopathy ◽  
Middle Aged

The article presents the results of clinical and neurological examination of 105 elderly and middle- aged hipertenzivnoyu encephalopathy of II degree on a background of hypertension. The urgency of a detailed analysis of the patients to determine risk factors for cerebrovascular disease and basic research cognitive functions of patients.

scholarly journals Intervensi Sosial Komunitas Birmingham Owner’s Motorcycle Siantar

PERSPEKTIF ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 111-118
Author(s):  
Fajar Utama Ritonga ◽  
Adil Arifin ◽  
Tuti Atika
Keyword(s):  
Community Development ◽  
Social Action ◽  
Research Method ◽  
Community Intervention ◽  
Qualitative Approach ◽  
Social Intervention ◽  
Social Community ◽  
Key Informants ◽  
Cultural Arts ◽  
The Social

This research purpose to describe the social intervention of the Birmingham Small Arm Owner Motorcycle Siantar (BOM'S) community in fighting for pedicabs with the Birmingham Small Arm (BSA) motorbike brand as a means of transportation for tourists. The research method was carried out with a qualitative approach, the informants in the study were the key informants and 4 main informants. The location of the study was carried out in Pematangsiantar City. The results of this study describe social intervention by the Birmingham Small Arm Owner Motorcycle Siantar (BOM'S) with 4 demands called the " Empat Tuntutan Rakyat Bikers Becak Siantar ", with demonstration activities, besides the community also conducts social activities such as touring, tourism promotion in Pematangsiantar City. antique motorbike exhibitions, cultural arts performances, and the next action was the construction of the Becak Siantar monument in the Siantar City Square in 2018, which featured the Siantar pedicab with the Birmingham Small Arm/BSA brand motorbike as an icon of the Pematangsiantar City. The conclusion of this study is a model of social community intervention that is carried out using a model of social action and community development.

scholarly journals Adaptasi Berbasis Budaya dan Sosial Masyarakat (Studi Kasus Etnis Tionghoa di Kota Palembang)

2020 ◽  
Vol 12 (1) ◽  
pp. 220
Author(s):  
Nursapia Harahap
Keyword(s):  
Community Development ◽  
Social Role ◽  
Economic Life ◽  
Theory And Practice ◽  
Social Adaptation ◽  
Social Community ◽  
Ethnic Chinese ◽  
Starting Point ◽  
The City

Adaptation depends on the structure or physical behavior of an individual that increases his ability to survive in his habitat. Whatever helps him survive in the environment he occupies includes the cultural and social community. Remembering adaptation refers to the ability to adapt to various conditions in their environment. This study aims to analyze the cultural adaptation and social adaptation of ethnic Chinese communities in theory and practice. Then clarify the important role that culture plays in enabling adaptation, and show how community-based cultural and social adaptation is well placed. Besides that it also measures the typical starting point of good community development by emphasizing community participation, kinship systems, individual welfare, culture, community and adaptation. For this reason, in particular this research relies on thoughts that have emerged from observations about the cultural and social role of society in individual lives. The results of this study indicate that the Chinese ethnic has been able to adapt to the cultural and social adaptation of the community well in the city of Palembang. This ability can be seen from the socio-economic life, society and culture of ethnic Chinese who are able to survive with the capital of developing business ventures and working in the political field. In addition, the Chinese are also able to adapt structurally and culturally by following the cultural and community development of Palembang City.kkan

scholarly journals Understanding the Connection Between Common Stroke Comorbidities, Their Associated Inflammation, and the Course of the Cerebral Ischemia/Reperfusion Cascade

2021 ◽  
Vol 12 ◽  
Author(s):  
Łukasz Przykaza
Keyword(s):  
Risk Factors ◽  
Cerebral Ischemia ◽  
Stroke Risk ◽  
Ischemia Reperfusion ◽  
Basic Research ◽  
Substantial Contribution ◽  
Low Grade ◽  
Stroke Risk Factors ◽  
Cerebral Ischemia Reperfusion ◽  
Inflammatory Processes

Despite the enormous progress in the understanding of the course of the ischemic stroke over the last few decades, a therapy that effectively protects neurovascular units (NVUs) and significantly improves neurological functions in stroke patients has still not been achieved. The reasons for this state are unclear, but it is obvious that the cerebral ischemia and reperfusion cascade is a highly complex phenomenon, which includes the intense neuroinflammatory processes, and comorbid stroke risk factors strongly worsen stroke outcomes and likely make a substantial contribution to the pathophysiology of the ischemia/reperfusion, enhancing difficulties in searching of successful treatment. Common concomitant stroke risk factors (arterial hypertension, diabetes mellitus and hyperlipidemia) strongly drive inflammatory processes during cerebral ischemia/reperfusion; because these factors are often present for a long time before a stroke, causing low-grade background inflammation in the brain, and already initially disrupting the proper functions of NVUs. Broad consideration of this situation in basic research may prove to be crucial for the success of future clinical trials of neuroprotection, vasculoprotection and immunomodulation in stroke. This review focuses on the mechanism by which coexisting common risk factors for stroke intertwine in cerebral ischemic/reperfusion cascade and the dysfunction and disintegration of NVUs through inflammatory processes, principally activation of pattern recognition receptors, alterations in the expression of adhesion molecules and the subsequent pathophysiological consequences.

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