scholarly journals Pengaruh Pemberian Kombinasi Ekstrak Etanol Daun Sidaguri (Sida rhombifolia L.) dan Rimpang Jahe Merah (Zingiber officinale Rosc.) pada Mencit Jantan Hiperurisemia

2018 ◽  
Vol 6 (2) ◽  
pp. 205
Author(s):  
Kinanthi Putri Rizki ◽  
Siti Muslichah ◽  
Indah Yulia Ningsih
Keyword(s):  
Uric Acid ◽  
Zingiber Officinale ◽  
Positive Control ◽  
Negative Control ◽  
Male Mice ◽  
Treatment Groups ◽  
Ginger Rhizome ◽  
Red Ginger ◽  
Sida Rhombifolia ◽  
Potassium Oxonate

  This study aimed to determine the effect of the combination of sidaguri leaves and red ginger rhizome extracts in uric acid levels of hyperuricemic male mice. Thirty-six mice were divided into nine groups including normal group, the positive control (+), negative control (-), extracts of four treatment groups with a variety of combinations and two groups of single extract. Hyperuricemia induction was performed by administering mixture melinjo 10% of the standard feed mice for 7 days dan potassium oxonate 250 mg/kg BB intraperitoneally at 2 hours before blood sampling. The results showed that the combination dose of sidaguri leaves of 50 mg/kg BB and red ginger rhizome 400 mg/kg BB had higher antihyperuricemia activity than other combinations in lowering uric acid levels of mice. Compounds may have antihyperuricemic activity were flavonoids, alkaloids, saponins, tannins, and terpenoids.   Keywords: sidaguri leaves, red ginger rhizome, antihyperuricemic activity, uric acid  

Effectiveness of Gout Therapy with Polyherbal Extract of Shallot (Allium ascalonicum L.) and Red Ginger (Zingiber officinale var rubrum) in Hyperuricemia Mice

2020 ◽  
Vol 38 (2) ◽  
pp. 135
Author(s):  
Fathur Rohman Haryadi
Keyword(s):  
Uric Acid ◽  
Zingiber Officinale ◽  
Positive Control ◽  
Negative Control ◽  
Male Rats ◽  
Acute Gout ◽  
Ginger Extract ◽  
Oxidase Enzyme ◽  
Red Ginger ◽  
Potassium Oxonate

Gout can cause inflammation of acute gout arthtritis, as well as other complications. Provision of chemical drugs in the long term have side effects. Shallots (Allium ascalonicum L.) contain flavonoids which can inhibit the xanthine oxidase enzyme, so as to reduce uric acid levels. Red ginger extract (Zingiber officinale var rubrum) is rich in gingerol to reduce uric acid with anti-inflammatory effect. Polyberbal combination is expected to increase the effectiveness of therapy. The research aims to determine the effectiveness of polyherbal combinations. 25 male rats (2-3 months) were divided into five groups, namely negative control, positive control, (P1) 25% red ginger extract: 75% shallot, (P2) 50% red ginger extract: 50% shallot, ( P3) 75% red ginger extract: 25% shallot. Induction of potassium oxonate 250 mg / kg BW intraperitoneally on the 7th day. The first measurement of uric acid on the 14th day with Urid Acid Toos, the 15th to 28th days was administered herbal / chemical drugs according to the group. Measurement of second and third uric acid on days 21 and 28. Data were analyzed by one-way Anova (RAL), further significance tests using Least Significant Different (LSD). The results showed that administration of potassium oxonate and combination of herbal extracts had a significant effect (p <0.05) on uric acid levels in all groups. The most effective herbal combination doses are (P3) 75% red ginger (450 mg / 200 gr) and 25% shallot (150 mg / 200 gr BW). The conclusion of this study is the combination of red ginger extract and shallot can be recommended as a uric acid-lowering agent.

scholarly journals Aggressiveness and Libido of Male Mus musculus L. in Ethanol Extract of Red Ginger (Zingiber officinale Roxb. var. Rubrum)

2019 ◽  
Vol 6 (1) ◽  
pp. 8-14
Author(s):  
Nida Nurhanifah ◽  
Sutyarso Sutyarso ◽  
M. Kanedi ◽  
Hendri Busman
Keyword(s):  
Free Radicals ◽  
Ethanol Extract ◽  
Serum Testosterone ◽  
Zingiber Officinale ◽  
The Body ◽  
Male Mice ◽  
Ginger Extract ◽  
Treatment Groups ◽  
Randomized Design ◽  
Red Ginger

The residue of paraquat herbicides may cause human health problems. Paraquat causes the testosterone hormone to decline. Testosterone hormone affects aggressive and sexual behavior. It is caused by free radicals in the body. Free radicals can be non-reactive if in the body there are antioxidants. Red ginger could be used as an antioxidant because it has active phenolic compounds, such as arginine, gingerol, shogaol, zingerone, gingerdiol, and zingiber. Ginger could increase serum testosterone levels. The purpose of this research is to know the effect of red ginger ethanol extract on aggressiveness and libido of male mice induced by paraquat herbicide. This study used a Completely Randomized Design (RAL) consisting of six treatment groups with four replications each. Group P1 as control (aqua dest), P2 (paraquat at dose 20 mg/kg BM), P3, P4, P5 (paraquat with dose 20 mg/kg BM and red ginger extract at 200 mg/kg BM, 400 mg/kg BM, 600 mg/kg BM) and P6 (red ginger extract at 600mg/kg BM). Paraquat is given 2 times a week for 21 days and the red ginger extract is given daily for 35 days. The result of analysis with One-way ANOVA and continued BNT at 5% showed that giving of red ginger ethanol extract can increase aggressive behavior and libido of male mice induced paraquat herbicide.

scholarly journals Effect of Apium Graveolens (Celery) Seed Extract on Serum Uric Acid Level of Hyperuricemic Rats and its Comparison with Allopurinol

2021 ◽  
Vol 2 (2) ◽  
pp. 85-91
Author(s):  
Abdul Karim ◽  
Shabbir Ali bhatti ◽  
Mahreen Akhtar ◽  
Zartasha Safdar ◽  
Noman Johnson ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Positive Control ◽  
Negative Control ◽  
Seed Extract ◽  
Control Group ◽  
Lowering Effect ◽  
Celery Seed ◽  
Group B ◽  
Potassium Oxonate

Background: Plant derived medicines are widely used in traditional culture all over the world. Objectives: To determine the effect of Celery Seed Extract (CSE) on uric acid levels in hyperuricemic rats and to compare the effect of allopurinol and CSE. Methods: It was an animal experimental research study. Group A served as negative control whereas Group B served as positive control. CSE was given orally to three groups of rats (C, D, and E). One hour prior to administration of CSE; potassium oxonate was injected intraperitoneally in all groups except negative control to induce hyperuricemia. Similarly, group F was given allopurinol one hour after injection of potassium oxonate. Blood samples were collected for uric acid estimation. Results: It was found that administration of both CSE (group C, D, E) and allopurinol (group F) significantly lowered serum uric acid levels (p<0.001) as compared to positive control (group B). Serum uric acid lowering effect of both drugs CSE and allopurinol was found to be statistically significant on day 3rd and day 7th and was almost comparable. Conclusions: Celery seed extract significantly reduces serum uric acid levels in potassium oxonate-induced hyperuricemic rats and its uric acid lowering effect was comparable with that of allopurinol.

scholarly journals UJI EFEK ANALGETIK EKSTRAK ETANOL RIMPANG JAHE PUTIH (Zingiber officinale Rosc.var. Amarum) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus)

PHARMACON ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 927
Author(s):  
Beatriks Lahamendu ◽  
Widdhi Bodhi ◽  
Jainer P. Siampa
Keyword(s):  
Treatment Group ◽  
White Male ◽  
Zingiber Officinale ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Analgesic Effects ◽  
Wistar Strain ◽  
Ginger Rhizome ◽  
Ethanol Extracts

ABSTRACTWhite Ginger Rhizome (Zingiber officinale Rosc.var. Amarum) contains secondary metabolites such as flavonoids, there are also several compounds such as gingerol, shogaol, and zhigeron which provide anti-inflamatory, antioxidant, analgesic, anticarsinogenic and cardiotonic effects. This study aims to determine the analgesic effect of ethanol extracts of white ginger rhizome with different doses, namely the treatment group 1, dose 0.006 g, the Treatment  Group 2, dose 0.012 g and the Treatment Group 3, dose 0.024 g tested on white male wistar strain rats. This study uses a laboratory experimental research design using male white rats as experimental animals. The result of the study using LSD showed a difference between the group of negative control and the group of positive control, and also the treatment group with extracts with significance value (0.014, 0.008, 0.012 and 0.005 ) the value <0.05, which indicates that according to the hypothesis namely rejecting H0 and accepting H1, which means significantly different between the negative control group with  positive control group and the treatment group with extracts, but there is no difference between the positive control group and the treatment group with extract which means there is no difference because they both have analgesic effects. From the results of the study it can be concluded that the ethanol extracts of white ginger rhizome at a dose 0.006 g, 0.012 g, and 0.024 g has analgesic effects in male white wistar strain rats can be seen from the decreasing number of rat responses (licks and jumps).Keywords: Analgesic, anova, White Ginger Rhizome, White male wistar strain ABSTRAKRimpang Jahe putih (Zingiber officinale Rosc.var amarum ) mengandung metabolit sekunder seperti flavonoid juga terdapat beberapa senyawa seperti gingerol, shogaol, dan zingeron yang memberikan efek antiinflamasi, antioksidan, analgetik, antikarsinogenik dan kardiotonik. Penelitian ini bertujuan untuk mengetahui adanya efek analgetik dari ekstrak etanol rimpang jahe putih dengan dosis yang berbeda-beda yaitu Kelompok Perlakuan 1 dosis 0,006 g, kelompok Perlakuan 2 dosis 0,012 g dan Kelompok Perlakuan 3 dosis 0,024 g yang diuji pada tikus putih jantan galur wistar. Penelitian ini menggunakan rancangan penelitian eksperimental laboratorium dengan menggunakan tikus putih jantan sebagai hewan percobaan. Hasil penelitian menggunakan LSD menunjukkan adanya perbedaan antara kelompok kontrol negatif dengan kelompok kontrol positif, dan juga kelompok perlakuan dengan ekstrak dengan nilai signifikansi (0,014, 0,008, 0,012 dan 0,005) nilai tersebut <0,05 yang menandakan bahwa sesuai hipotesis yaitu menolak H0 dan menerima H1 yang berarti berbeda secara signifikan antara kelompok kontrol negatif dengan kontrol positif dan kelompok perlakuan dengan ekstrak,tapi tidak terdapat perbedaan antara kelompok kontrol positif dengan kelompok perlakuan dengan ekstrak yang berarti tidak memiliki perbedaan karena sama-sama memiliki efek analgetik. Dari hasil penelitian dapat disimpulkan bahwa ekstrak etanol rimpang jahe putih dengan dosis 0,006 g, 0,012 g dan 0,024 g memiliki efek analgetik pada tikus putih jantan galur wistar dapat dilihat dari menurunnya jumlah respon tikus (jilatan dan lompatan).Kata kunci : Analgetik, anova, rimpang Jahe putih, tikus Putih jantan galur wistar

scholarly journals UJI AKTIVITAS ANTIHIPERURISEMIA EKSTRAK ETANOL DAUN KUMIS KUCING (Orthosiphon aristatus (Blume) Miq.) PADA TIKUS PUTIH JANTAN (Rattus Norvegicus)

PHARMACON ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 730
Author(s):  
Frinsia Rutly Mokalu ◽  
Widdhi Bodhi ◽  
Julianri S. Lebang
Keyword(s):  
Uric Acid ◽  
Xanthine Oxidase ◽  
Rattus Norvegicus ◽  
Ethanol Extract ◽  
Acid Value ◽  
Positive Control ◽  
Negative Control ◽  
Anova Test ◽  
Antioxidants Activity ◽  
Treatment Groups

ABSTRACT Kumis Kucing Leaves (Orthosiphon aristatus (Blume) Miq.) contains flavonoid compounds that has antioxidants activity that inhibits the action of the enzyme xanthine oxidase with reduced uric acid as result. This research is done to find out the effects antihyperuricemia ethanol extract of Kumis Kucing leaves on male white rat (Rattus norvegicus). 15 rats were used in this research and there were 5 treatment groups that is negative control (NACMC 1%), positive control (Allopurinol) 1,8 mg, and Kumis Kucing leaves extract group with dosage of 4,5 mg, 9 mg, 18 mg. The result of this research showed a decrease on uric acid value after ethanol extract of Kumis Kucing leave were given. The next result of this research used ANOVA test and LSD test, that showed the ethanol extract of Kumis Kucing leave had Antihyperuricemia activity on male white rat.Keywords:  Orthosiphon aristatus (Blume.) Miq., Antihyperuricemia, Rattus norvegicus.   ABSTRAK Daun kumis kucing (Orthosiphon aristatus (Blume) Miq.) mengandung senyawa flavonoid yang mempunyai aktivitas antioksidan yang dapat menghambat kerja enzim xantin oksidase sehingga pembentukan asam urat berkurang. Penelitian ini dilakukan untuk mengetahui efek antihiperurisemia ekstrak etanol daun kumis kucing, terhadap tikus putih jantan (Rattus norvegicus). Penelitian ini menggunakan 15 ekor tikus dan terdapat 5 kelompok perlakuan yaitu kontrol negatif (NaCMC 1%), kontrol positif (Allopurinol) 1,8 mg, dan kelompok ekstrak daun kumis kucing dengan dosis 4,5 mg, 9 mg, 18 mg. Hasil penelitian menunjukkan nilai asam urat mengalami penurunan setelah diberikan ekstrak etanol daun kumis kucing. Hasil penelitian selanjutnya dianalisis menggunakan uji ANOVA dan uji LSD, menunjukkan bahwa ekstrak etanol daun kumis kucing memiliki aktivitas antihiperurisemia terhadap tikus putih jantan. Kata kunci: Orthosiphon aristatus (Blume.) Miq., Antihiperurisemia, Rattus norvegicus

scholarly journals PENGHAMBATAN KSANTIN OKSIDASE OLEH KOMBINASI EKSTRAK TEMPUYUNG (Sonchus Arvensis) DAN SALAM (Syzygium Polyanthum) PADA MENCIT HIPERURISEMIA

Biomedika ◽  
2012 ◽  
Vol 5 (1) ◽  
Author(s):  
Dr. Muhtadi . ◽  
Idi Retnani ◽  
Nurcahyanti Wahyuningtyas
Keyword(s):  
Uric Acid ◽  
Xanthine Oxidase ◽  
Oxidase Activity ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Xanthine Oxidase Activity ◽  
Group I ◽  
Sonchus Arvensis ◽  
Potassium Oxonate

Tempuyung (Sonchus arvensis) and salam (Syzygium polyanthum) leaves can lower uric acid levels were studied. The purpose of this research was to determine mechanism of combined o f tempuyung and salam extracts to reduce uric acid levels by inhibiting xanthine oxidase in hyperuricemic mice. This research used completely randomized design using mice. Fifteen mice were made hiperuricemic by 250 mg/kgBW potassium oxonate p.o then the mice were divided into 3 groups. Group I induced 10 mg/kgBW allopurinol p.o as positive control, group II induced tempuyung-salam p.o each 100 mg/kgBW as the treatment group, group th III induced 0.5 mL/20 gBW distilled water p.o as negative control. Liver was taken 4 day after 2 hours induced potassium oxonate. Data inhibition xanthine oxidase activity was tested with Mann-Whitney. The result showed that the combination of tempuyung-salam extract each 100 mg/kgBW could inhibit xanthine oxidase activity of 51,16%±2,76%, while allopurinol 90,20%±0,16% (p = 0.000).Keyword: Hyperuricemia, Xanthine Oxidase, Sonchus arvensis, Syzygium polyanthum

scholarly journals Kadar Asam Urat Mencit Hiperurisemia Setelah Pemberian Perasan Daun Kersen (Muntingia calabura L.) dan Daun Kelor (Moringa oleifera L.)

2020 ◽  
Vol 7 (1) ◽  
pp. 1090
Author(s):  
Wa Ode Harlis ◽  
Sitti Wirdhana Ahmad ◽  
Jusrianti Jusrianti
Keyword(s):  
Uric Acid ◽  
Moringa Oleifera ◽  
Calculated Data ◽  
Competitive Inhibitor ◽  
Positive Control ◽  
Negative Control ◽  
Chicken Liver ◽  
Treatment Groups ◽  
Blood Uric Acid ◽  
Leaf Juice

The quercetin flavonoid content in cherry leaves and Moringa serves as a competitive inhibitor of hypoxanthine and xanthine which causes uric acid not to form. The purpose of this study was to determine the effect of grains of cherry leaves and Moringa leaves on the uric acid levels of mice. 25 male mice weighing 20-30 grams 2-3 months old were divided into 5 treatment groups, namely: K1 as a negative control (without treatment), K2 as the positive control (chicken liver juice 0.5 mL), K3 (cherry leaf juice and liver juice chicken), K4 (Moringa leaf juice and chicken liver juice) and K5 (a mixture of cherry leaf juice, Moringa, and chicken liver juice). Mice are first measured initial uric acid levels. The administration of chicken liver juice at a dose of 0.5 mL is done three times a day for 7 days so as to achieve a hyperuricemia condition. Furthermore, the juice was given according to the treatment group at a dose of 0.2 mL for 14 days and finally, uric acid levels were calculated. Data were analyzed by ANOVA and LSD test (α = 0.05). The results showed that the administration of cherry leaves and moringa juice significantly reduced blood uric acid levels in mice in all treatment groups. The highest mean decrease in uric acid levels was in the K5 (0.91 mg / dL) group, compared with K1 (0.93 mg / dL), K2 (2.03 mg / dL), K3 (0.994 mg / dL) and K4 (0.98 mg / dL) .Keywords:  Uric Acid Levels, Hyperuricemia, Munitingia calabura L, Moringa oleifera L. AbstrakKandungan flavonoid golongan kuercetin pada daun kersen dan kelor berfungsi sebagai inhibitor kompetitif hipoxantin dan xantin yang menyebabkan asam urat tidak terbentuk. Tujuan penelitian ini untuk mengetahui pengaruh pemberian perasan daun kersen dan daun kelor terhadap kadar asam urat mencit. 25 ekor mencit jantan berat 20-30 gr berumur 2-3 bulan dibagi kedalam 5 kelompok perlakuan yaitu: K1 sebagai kontrol negatif (tanpa perlakuan), K2 sebagai kontrol positif (jus hati ayam 0.5 mL), K3 (perasan daun kersen dan jus hati ayam), K4 (perasan daun kelor dan jus hati ayam) dan K5 (campuran perasan daun kersen, kelor dan jus hati ayam). Mencit terlebih dahulu diukur kadar asam urat awal. Pemberian jus hati ayam dengan dosis 0.5 mL  dilakukan tiga kali sehari selama 7 hari sehingga mencapai kondisi hiperurisemia. Selanjutnya diberi perasan sesuai kelompok perlakuan dengan dosis 0.2 mL selama 14 hari dan dihitung kadar asam urat akhir. Data dianalisis dengan ANOVA dan uji BNT (α=0,05). Hasil penelitian menunjukkan bahwa pemberian perasan daun kersen dan kelor secara signifikan menurunkan kadar asam urat darah mencit pada semua kelompok perlakuan. Rerata penurunan kadar asam urat tertinggi terdapat pada kelompok K5 (0.91 mg/dL), dibandingkan dengan K1 (0.93 mg/dL),  K2 (2.03 mg/dL), K3 (0.994 mg/dL) dan K4 (0.98 mg/dL).Kata kunci : Kadar Asam Urat, Hiperurisemia.,Munitingia calabura L, Moringa oleifera L.

scholarly journals NEPHROPROTECTIVE ACTIVITY OF ETHANOL EXTRACT OF CURCUMA MANGGA VAL. IN PARACETAMOL-INDUCED MALE MICE

2018 ◽  
Vol 11 (13) ◽  
pp. 126
Author(s):  
Rosita Rosita ◽  
Yuandani Yuandani ◽  
Marianne Marianne
Keyword(s):  
Creatinine Level ◽  
Cell Damage ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Dependent Manner ◽  
Male Mice ◽  
Treatment Groups ◽  
Level Measurement ◽  
Nephroprotective Activity

Objective: This study aimed to evaluate nephroprotective activity of Curcuma mangga in paracetamol-induced male mice.Methods: Male mice were divided into several groups including normal control, negative, positive, and treatment groups. Treatment groups were orally administered with C. mangga extract at doses of 100, 200, and 400 mg/kg bw for 7 days. On day 7after 1 h of treatment, the mice were induced with paracetamol 1.05 g/kg bw. Serum creatinine level measurement and histopathotlogy study were performed at the end of experiment.Results: C. mangga extract was able to inhibit the increase of creatinine level and showed a significantly different from negative control (p<0.05) and did not different significantly from positive control (p>0.05). The result was supported by histopathology examination which did not show any cell damage. The nephroprotective effect of C. mangga was in a dose-dependent manner. C. mangga extract at dose of 400 mg/kg bw depicted the strongest nephroprotective effect.Conclusion: C. mangga extract was able to protect mice kidney induced by paracetamol.

scholarly journals UJI AKTIVITAS PENURUNAN KADAR ASAM URAT EKSTRAK ETANOL BUAH PINANG YAKI (Areca vestiaria) PADA TIKUS PUTIH GALUR WISTAR (Rattus norvegicus) YANG DIINDUKSI KALIUM OKSONAT

PHARMACON ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 465
Author(s):  
Christani Rambi ◽  
Edwin De Queljoe ◽  
Herny E. I. Simbala
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Positive Control ◽  
Statistical Test ◽  
Negative Control ◽  
Randomized Design ◽  
Unhealthy Diet ◽  
Group 2 ◽  
Ethanol Extracts ◽  
Potassium Oxonate

ABSTRACTAn unhealthy diet in a high society protein, especially animal protein that contains a lot of purine, causes hyperuricemia (excess uric acid) to increase. The use of allopurinol that is too frequent or excessive  can cause dangerous side effects. Based on these things, it is necessary to do research on antihyperuricemia substances that have high effectiveness and guaranted safety. This study aims to determine the potential for decreasing uric acid levels of areca nut fruit. This type of research as laboratory experiments using a Completely Randomized Design (CRD), with 5 types of treatment each treatment with 3 replications. Group 1 as a negative control was given induction of potassium oxonate, Group 2 as a positive control was given induction of potassium oxonate and allopurinol. Group 3-5 was trated with betel nut extract with different doses of 3,6 mg; 7,2 mg and 14,4 mg. Based on the results of the ANOVA statistical test, serum uric acid levels were significantly different from p = 0,002 (< 0,05). The results of the ethanol extracts of pinangyaki fruit at doses of 3,6 mg / 200gr BW, 7.2mg / 200gr BW and 14,4mg / 200gr BW can reduce serum uric acid levels by anova statistical test with a confidence level of 95%. Keywords: Yaki Areca Fruit, Anthihiperurisemia, Anova ABSTRAKPola makan yang tidak sehat dalam masyarakat yang berprotein tinggi,terutama protein hewani yang banyak mengandung purin, menyebabkan penyakit hiperurisemia (kelebihan asam urat) semakin meningkat. Penggunaan allopurinol yang terlalu sering atau berlebihan dapat menimbulkan efek samping yang berbahaya. Berdasarkan hal-hal tersebut, perlu dilakukan penelitian mengenai zat antihiperurisemia yang memiliki efektivitas tinggi dan terjamin keamanannya . Penelitian ini bertujuan untuk mengetahui potensi aktivitas penurunan kadar asam urat dari Buah Pinang Yaki. Jenis penelitian ini ialah eksperimen laboratorium menggunakan Rancangan Acak Lengkap (RAL), dengan 5 macam perlakuan masing-masing perlakuan dengan 3 ulangan. Kelompok 1 sebagai kontrol negatif diberi induksi kalium oksonat), Kelompok 2 sebagai kontrol positif diberi induksi kalium oksonat dan Allopurinol. Kelompok3-5 diberi perlakuan ekstrak buah pinang yaki dengan dosis yang berbeda-beda yaitu 3,6 mg; 7,2 mg dan 14,4 mg. Berdasarkan hasil uji statistik  Anova didapatkan kadar asam urat serum berbeda secara bermakna dengan p = 0,002 (<0,05). Hasil dari ekstrak etanol buah pinang yaki di dosis 3,6mg/200grBB, 7,2mg/200grBB dan 14,4mg/200grBB dapat menurunkan kadar asam urat serum dengan uji statistik Anova dengan tingkat kepercayaan 95% Kata kunci : Buah Pinang Yaki, Antihiperurisemia, Anova

scholarly journals Antihyperuricemia Activity of the Ethyl Acetate Fraction of Bilimbi Leaves (Averrhoa bilimbi L.)

2021 ◽  
pp. 168
Author(s):  
Fitra Fauziah ◽  
Ifora Ifora ◽  
Silvi Karlila Sari
Keyword(s):  
Uric Acid ◽  
Ethyl Acetate ◽  
Biological Marker ◽  
Ethyl Acetate Fraction ◽  
Positive Control ◽  
Negative Control ◽  
The Body ◽  
Flavonoid Compounds ◽  
Traditional Medicinal Plants ◽  
Potassium Oxonate

Hyperuricemia is a condition where there is an increase in uric acid levels above normal. An increase in the number of leukocytes is also a biological marker of hyperuricemia. The leaves of bilimbi (Averrhoa bilimbi L.) are one of the traditional medicinal plants which contain alkaloids, tannins, steroids, and flavonoid compounds. Flavonoid compounds are thought to inhibit the formation of uric acid in the body. This study investigates the antihyperuricemia activity of the ethyl acetate fraction of bilimbi leaves. The animals were male white mice grouped into six groups: the normal group, negative control, positive control (allopurinol), and the group was given the ethyl acetate fraction of bilimbi leaves at doses of 100, 200, and 400 mg/kg BW. Hyperuricemia induction is by giving high-purine diets and potassium oxonate. The results showed that the variation of the ethyl acetate fraction of bilimbi leaves significantly reduce uric acid levels and the number of leukocyte cells (sig <0.05). Giving ethyl acetate fraction at a dose of 400 mg/kg BW showed the best reduction in uric acid and leukocyte levels.

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