Closing an Eye for the Reliability of Orbital Tightening in Pain Detection: A Model-Specific Simplification of the Mouse Grimace Scale

Abstract Despite its long establishment and its applicability in pain detection in mice, the Mouse Grimace Scale still seems to be underused in terms of acute pain detection during chronic experiments. However, a broadening of its applicability can identify possible refinement approaches such as cumulative severity and habituation to painful stimuli. Therefore, this study focuses on two main aspects: First, five composite MGS criteria were evaluated with two independent methods (the MoBPs algorithm and a penalized least squares regression) and ranked for their relative importance. The most important variable was used in a second analysis to specifically evaluate the context of pain after an i.p. injection (intervention) in two treatment groups (CCl4 and oil (control)) at fixed times throughout four weeks in 24 male C57BL/6N mice. One hour before and after each intervention, video recordings were taken and the MGS assessment was performed. In this study, the results indicate orbital tightening as the most important criterion. In this experimental setup, a highly significant difference after treatment between week 0 and 1 was found in the CCl4 group, resulting in a medium-sized effect (W = 62.5, p-value <0.0001, rCCl4= 0.64). The oil group showed no significant difference (week 0 vs 1, W = 291.5, p-value = 0.7875, rcontrol= 0.04). Therefore, the study showed that the pain caused by i.p. injections was only dependent on the applied substance and no significant cumulation or habituation occurred due to the intervention. Further, the results indicated that the MGS system can be simplified.

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Comparative Analysis of Beet Juice and Red Guava Juice against Erythrocyte and Hematocrit Levels in Post-partum Women

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.6259 ◽

2021 ◽

Vol 9 (B) ◽

pp. 821-825

Author(s):

Cut Nurhasanah ◽

Andri Idiana ◽

Putri Santi ◽

Yushida Yushida

Keyword(s):

Treatment Group ◽

Health Center ◽

Post Partum ◽

Control Group ◽

P Value ◽

Treatment Groups ◽

Significant Difference ◽

Before And After ◽

The Difference ◽

And Control

BACKGROUND: Post-partum physiological bleeding can cause post-partum mothers to experience anemia; often, post-partum mothers are limited by nutrient and fluid intake to keep the body strong and have ideal body weight. AIM: The aim of the study is to knowing the difference between beet juice and Guava juice on erythrocyte and hematocrit (HTC) levels in post-partum mothers at Darul Imarah Health Center, Darul Imarah District, Aceh Besar District. METHODS: This was a quasi-experimental study with a pre-post test design using a randomized controlled trial. The population of post-partum mothers in the Darul Imarah Health Center, Darul Imarah District, Aceh Besar District. The sample selection is purposive sampling with inclusion and exclusion criteria; the sample is 45 people. RESULTS: The results showed differences in erythrocyte and HTC levels between before and after giving guava and iron (Fe) juices with a p-value of 0.00 <0.05. Beet juice increases the average erythrocytes and HTC levels higher than guava juice. There were significant differences in erythrocyte levels in the guava + Fe, beet + Fe, and control (Fe) treatment groups with a p-value of 0.001 <0.05. the difference in the average difference in erythrocyte levels between the guava and beet treatment groups was 0.03. The treatment group Bit + Fe had a higher mean erythrocyte level different than the guava + the treatment group and the control group (Fe). There was a significant difference in HTC levels in the guava + Fe, beet + Fe, and control (Fe) treatment groups with a p-value of 0.001 <0.05. the difference in the average difference in erythrocyte levels between the guava and beet treatment groups was 0.03. The treatment group Bit + Fe had a higher mean difference in HTC levels than the guava + the treatment group and the control group (Fe). CONCLUSION: There is a significant difference in erythrocytes and HTC levels between before and after giving guava juice and beet juice to post-partum mothers with a p-value of 0.00 <0.05. Beet juice increases the average level of erythrocytes and HTC, which is higher than guava juice in post-partum mothers at the Darul Imarah Health Center.

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Real-Time High-Level Acute Pain Detection Using a Smartphone and a Wrist-Worn Electrodermal Activity Sensor

Sensors ◽

10.3390/s21123956 ◽

2021 ◽

Vol 21 (12) ◽

pp. 3956

Author(s):

Youngsun Kong ◽

Hugo F. Posada-Quintero ◽

Ki H. Chon

Keyword(s):

Real Time ◽

Electrodermal Activity ◽

Smartphone Application ◽

Real Time Processing ◽

Pain Stimulation ◽

Significant Difference ◽

Before And After ◽

Electrical Pulses ◽

Pain Detection ◽

High Level

The subjectiveness of pain can lead to inaccurate prescribing of pain medication, which can exacerbate drug addiction and overdose. Given that pain is often experienced in patients’ homes, there is an urgent need for ambulatory devices that can quantify pain in real-time. We implemented three time- and frequency-domain electrodermal activity (EDA) indices in our smartphone application that collects EDA signals using a wrist-worn device. We then evaluated our computational algorithms using thermal grill data from ten subjects. The thermal grill delivered a level of pain that was calibrated for each subject to be 8 out of 10 on a visual analog scale (VAS). Furthermore, we simulated the real-time processing of the smartphone application using a dataset pre-collected from another group of fifteen subjects who underwent pain stimulation using electrical pulses, which elicited a VAS pain score level 7 out of 10. All EDA features showed significant difference between painless and pain segments, termed for the 5-s segments before and after each pain stimulus. Random forest showed the highest accuracy in detecting pain, 81.5%, with 78.9% sensitivity and 84.2% specificity with leave-one-subject-out cross-validation approach. Our results show the potential of a smartphone application to provide near real-time objective pain detection.

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PENGARUH TERAPI AKUPRESUR TERHADAP PENINGKATAN PRODUKSI ASI PADA IBU POST PARTUM DI PKU MUHAMADIYAH BANTUL

Coping: Community of Publishing in Nursing ◽

10.24843/coping.2020.v08.i04.p10 ◽

2020 ◽

Vol 8 (4) ◽

pp. 416

Author(s):

Anita Liliana ◽

Melania Wahyuningsih

Keyword(s):

Breast Milk ◽

Milk Production ◽

Post Partum ◽

Control Group ◽

P Value ◽

Breast Milk Production ◽

Significant Difference ◽

Before And After ◽

Increase Milk Production ◽

Postpartum Mothers

Abstract Adequacy of milk production in the newborns will affect the success of exclusive breastfeeding. Not all postpartum mothers are able to increase milk production in the postpartum period. Acupressure at the meridian points is one way to increase milk production in postpartum mothers. This study aims to determine the effect of acupressure therapy on increasing breast milk production in postpartum mothers at PKU Muhamadiyah Bantul. This study was a quantitative study a quasi-experimental research design with pre-test and post-test nonequivalent control group. The number of respondents in each group was 17 people. The treatment given was acupressure at the meridian points for 5 minutes on days 2 and 3of poatpartum. Breastfeeding adequacy was assessed before treatment and on day 4 postpartum. Data were analyzed by Mc Nemar analysis. The results showed that there was a significant difference in breast milk production before and after acupressure with p value of 0.000 (p value <0.05). There was a significant difference in breast milk production in the control group before and after being given the breastfeeding technique leaflet p value 0.001 (p value <0.05). Conclusion: There is no significant difference in breast milk production after being given acupressure and after being given leaflets about breastfeeding techniques at PKU Muhamadiyah Bantul p value 0.100 (p value> 0.05). Keywords: acupressure, breast milk production, postpartum

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The Effect of Extract Supplements of Moringa Oleifera Leaves Plus Royal Jelly on Hemoglobin (Hb) Levels of Anemia Pregnant Mother in Takalar Regency

International Journal Papier Advance and Scientific Review ◽

10.47667/ijpasr.v1i2.31 ◽

2020 ◽

Vol 1 (2) ◽

pp. 22-29

Author(s):

Yulni Yulni ◽

Veni Hadju ◽

Burhanuddin Bahar ◽

Citrakesumasari Citrakesumasari ◽

Rahayu Indriasari ◽

...

Keyword(s):

Pregnant Women ◽

Leaf Extract ◽

Moringa Oleifera ◽

Royal Jelly ◽

P Value ◽

Double Blind ◽

Significant Difference ◽

Before And After ◽

The Difference ◽

Double Blind Design

The aim of this study was to determine the effect of Moringa oleifera leaf extract supplements, Moringa oleifera leaf extract plus royal jelly and placebo on hemoglobin levels in anemic pregnant women. This research is a randomized controlled double blind design study which was conducted in Polombangkeng Utara District, Takalar Regency for 2 months. The subjects of this study were pregnant women with anemia, the majority of which were 20-35 years old, primigravida parity, income less than UMR, unemployment, higher education, pregnancy distance of more than 2 years with p value> 0.05. Then divided into three groups, namely Moringa capsules plus royal jelly (KRJ) (n = 24), Moringa capsules (KTR) (n = 24) and placeco (PLC) (n = 21). Before and after the intervention, measurements of hemoglobin levels were carried out using the Hemocue tool and interviewing the characteristics of the respondents. The results showed that the average Hb level increased from each group (mean SD): KRJ 10.06 ± 0.75 to 11.42 ± 1.23, P = 0.001, KTR 10.40 ± 0.46 to 11.15 ± 0 , 90 P = 0.001 and PLC 10.43 ± 0.42 becomes 11.14 ± 0.88 P = 0.002. but there was no significant difference from the difference in the average increase in Hb levels in the three groups, but there was a tendency that KRJ was superior to the KTR and PLC groups with an increase of 1.36 gr / dl, KTR 0.75 gr / dl and PLC 0.71 gr / dl. So it can be concluded that KRJ is better than KTR and PLC in increasing Hb levels in anemic pregnant women in Takalar Regency.

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Improving The Knowledge Of Primary School Children On Fourth Grade Stundents About Vegetables And Fruits And Attraction Of Puzzle Media In SDN Mekarjaya I

SANITAS : Jurnal Teknologi dan Seni Kesehatan ◽

10.36525/sanitas.2017.19 ◽

2017 ◽

Vol 8 (2) ◽

pp. 134-145

Author(s):

Wiena Arynda ◽

Rosmida M Marbun

Keyword(s):

School Children ◽

Fruits And Vegetables ◽

Fourth Grade ◽

Primary School Children ◽

P Value ◽

Significant Difference ◽

Fourth Grade Students ◽

Before And After ◽

The Media ◽

Vegetables And Fruits

In Indonesia, 93.5% of the population aged ≥10 years still consume less fruits and vegetables 5 servings per day for 7 days a week (RISKESDAS, 2013). The preliminary study conducted at SDN Mekarjaya I shows that the level of knowledge of school children about vegetables and fruits by 60% is still low and 93.3% of vegetable and fruit consumption is still lacking. In addition, SDN Mekarjaya I has never been used as a place of prior research. Therefore, it is necessary to conduct research on the knowledge of fruit vegetables in the fourth grade students of SDN Mekarjaya I. One of them is by doing counseling with the media of puzzle game. This research was conducted to know the increase of knowledge about vegetables and fruits before and after given counseling with puzzle game media in fourth grade students of SDN Mekarjaya I. This research was conducted by Pre-exsperiment method using "One group pretest and posttest" research design. Sampling by purposive sampling is 66 people. The statistical test used is paired sample t-test. Based on the results of the analysis shows that there is a significant difference of knowledge where p-value 0.000 or p <0,05 means there is a meaningful difference between before and after given counseling with puzzle game media.This puzzle game media can be developed by the teachers as a medium of learning in the classroom so that students are more motivated in following the learning process and make students do not feel bored

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The Effect of the Covid-19 Free Operation Path Protocol on the Incidence of Lung Complications in Postoperative Elective Patients at dr. Moewardi Hospital Surakarta

BioScientia Medicina ◽

10.32539/bsm.v5i11.369 ◽

2021 ◽

Vol 5 (11) ◽

pp. 1030-1036

Author(s):

Galih Aktama ◽

Henky Agung Nugroho ◽

Muhammad David Perdana Putra

Keyword(s):

Cancer Patients ◽

Elective Surgery ◽

Pulmonary Complications ◽

P Value ◽

Chi Square ◽

Elective Surgical Procedures ◽

Significant Difference ◽

Before And After ◽

Chi Square Test ◽

Elective Patients

The pandemic that began in late 2019, COVID-19, affects all patients, including cancer patients. Patients with cancer that continues to spread and there is no other effective alternative treatment must undergo surgery so that cancer does not get worse. Given this problem, many health care centers have developed a protocol system in the form of a COVID-19-free surgical route. This study is a retrospective cohort study comparing the incidence of pulmonary complications in patients undergoing elective cancer surgery at dr. Moewardi Surakarta before and during the COVID-19 pandemic. The study sample was adult patients aged ≥ 18 years which underwent elective surgical procedures with the aim of curative cancer starting before COVID-19 (March 2019-February 2020) until the time the COVID-19 pandemic emerged (March 2020 - February 2021). The data obtained were 768 patients. Of these patients, 384 were classified as having a COVID19-free operation route during the pandemic, and 384 others underwent elective surgery in the pre-pandemic period. Based on the Chi-Square test, a p-value of 0.850 was obtained (P>0.05) which shows that there is significant difference between cases of pulmonary complications in surgical patients before and after the pandemic who were carried out through the COVID-19-free protocol route. In conclusion, there is no significant change in effect of the covid-19 free operation path protocol on the incidence of lung complications in postoperative elective patients at dr. Moewardi Hospital Surakarta, although this patented and mandatory protocol can reduce cancer patients’ morbidity and mortality who undergoing elective surgery during a pandemic.

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Short-term impact of introducing a soft opt-out organ donation system in Wales: before and after study

BMJ Open ◽

10.1136/bmjopen-2018-025159 ◽

2019 ◽

Vol 9 (4) ◽

pp. e025159 ◽

Cited By ~ 10

Author(s):

Jane Noyes ◽

Leah McLaughlin ◽

Karen Morgan ◽

Philip Walton ◽

Rebecca Curtis ◽

...

Keyword(s):

Organ Donation ◽

Organ Donor ◽

P Value ◽

Short Term ◽

Consent Rate ◽

Potential Organ Donor ◽

Opt Out ◽

Significant Difference ◽

Before And After ◽

Donor Numbers

ObjectivesTo determine the short-term impact of a soft opt-out organ donation system on consent rates and donor numbers.DesignBefore and after observational study using bespoke routinely collected data.SettingNational Health Service Blood and Transplant.Participants205 potential organ donor cases in Wales.InterventionsThe Act and implementation strategy.Primary and secondary outcomesConsent rates at 18 months post implementation compared with 3 previous years, and organ donor numbers 21 months before and after implementation. Changes in organ donor register activity post implementation for 18 months.ResultsThe consent rate for all modes of consent was 61.0% (125/205), showing a recovery from the dip to 45.8% in 2014/2015. 22.4% (46/205) were deemed consented donors: consent rate 60.8% (28/46). Compared with the 3 years before the switch there was a significant difference in Welsh consent rates (χ2 p value=0.009). Over the same time period, rest of the UK consent rates also significantly increased from 58.6% (5256/8969) to 63.1% (2913/4614) (χ2 p value<0.0001), therefore the Wales increase cannot be attributed to the Welsh legislation change. Deceased donors did not increase: 101 compared with 104. Organ donation registration increased from 34% to 38% with 6% registering to opt-out.ConclusionThis is the first rigorous initial evaluation with bespoke data collected on all cases. The longer-term impact on consent rates and donor numbers is unclear. Concerns about a potential backlash and mass opting out were not realised. The move to a soft opt-out system has not resulted in a step change in organ donation behaviour, but can be seen as the first step of a longer journey. Policymakers should not assume that soft opt-out systems by themselves simply need more time to have a meaningful effect. Ongoing interventions to further enhance implementation and the public’s understanding of organ donation are needed to reach the 2020 target of 80% consent rates. Further longitudinal monitoring is required.

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Administering DVT Prophylaxis Sooner Than 48 Hours Does Not Increase Failure of Nonoperative Management of High-Grade (Grades III-V) Splenic Injuries

The American Surgeon ◽

10.1177/0003134820950303 ◽

2020 ◽

pp. 000313482095030

Author(s):

Jared Griffard ◽

Bethany Sappington ◽

Megan Griffard ◽

Reagan Bollig ◽

James McMillen ◽

...

Keyword(s):

Failure Rate ◽

Nonoperative Management ◽

Linear Regression Analysis ◽

P Value ◽

High Grade ◽

Dvt Prophylaxis ◽

Significant Difference ◽

Before And After ◽

Injury Grade ◽

Grade 3

Splenic injuries are mostly treated with nonoperative management (NOM) with observation to monitor for continued hemorrhage and holding early chemical DVT prophylaxis to reduce the risk of NOM failure. Eberle et al demonstrated chemoprophylaxis prior to 72 hours didn’t increase failure rate of NOM. We chose to extrapolate this finding and compare outcomes in high-grade splenic injuries (HGSI) with chemoprophylaxis before and after 48 hours. From January 2013 to December 2017, 104 patients with HGSI received chemoprophylaxis with unfractionated heparin (UH) or low molecular weight heparin (LMWH) within 72 hours of diagnosis. Of these, 8 patients received chemoprophylaxis within 24 hours, 46 between 24 and 48 hours, and 50 patients between 48 and 72 hours. This population consisted of 70 males and 34 females, with an average age of 40.1 years. The average ISS was 23 and the majority (77%) were grade 3 injuries. We observed 6 failures of NOM: 1 in the <24 hour group, 3 in the 24-48 hour group, and 2 in the 48-72 hour group. There was no statistically significant difference between the <24 hour and >24 groups or between the <48 hour and 48-72 hour groups. A linear regression analysis created a model describing the time to initiation of DVT prophylaxis using age, sex, splenic injury grade, and ISS; the failure rate decreased by 0.00002% for each hour prior to giving DVT prophylaxis, with a P value of .111. We conclude a noninferiority statement that DVT prophylaxis prior to 48 hours does not increase the risk of NOM failure.

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Learning Model Based on Multiple Representation to Increase Memorize Ability of Short Letter of Al Qur'an

International Journal of Multidisciplinary and Current Research ◽

10.14741/ijmcr/v.6.4.25 ◽

2018 ◽

Vol 6 (04) ◽

Author(s):

T.Nurbani Chalid ◽

Myrnawati Crie Handini ◽

Elindra Yetti

Keyword(s):

Learning Model ◽

T Test ◽

Assessment Instrument ◽

Expert Assessment ◽

P Value ◽

Applied Model ◽

Stage Of Development ◽

Field Note ◽

Significant Difference ◽

Before And After

The purpose of this study is to produc a learning model to memorize the Qur'an which corresponds to the stage of development and learning styles of children. The ability to memorize the Qur'an is marked marked by ability to recognize namely ability to verify and to match and the ability to remember namely the ability to corespond dan ability to retrieving orally. The method used in this research is research and development, modification of research model by Borg and Gall and Dick and Carrey. The data were collected by observation technique, questionnaire, interview, expert assessment instrument and field note. Quantitative data from the questionnaire results were analyzed using descriptive analysis technique with percentage, while the test result data (pretest and posttest) the ability to memorize Al-Qur'an was analyzed by t test (t-test) using SPSS program. The result of paired sample t test in the experimental class shows 0.000 less than 0,05 so there is difference before and after applied model. While the result of t test in control class showed value 0,423 and gt; 0,05 so there is no significant difference before and after applied model. The result of independent sample t test shows 0.000 so p value less than 0,05 and it can be concluded that there is a significant difference between the control class and the experimental class.

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PENURUNAN NYERI KEPALA PADA LANSIA DENGAN HIPERTENSI MENGGUNAKAN RELAKSASI AUTOGENIK DI KELURAHAN MERSI PURWOKERTO

Media Ilmu Kesehatan ◽

10.30989/mik.v7i2.229 ◽

2019 ◽

Vol 7 (2) ◽

pp. 104-113

Author(s):

Dwi Novitasari ◽

Ikit Netra Wirakhmi

Keyword(s):

The Elderly ◽

Wilcoxon Test ◽

Relaxation Technique ◽

P Value ◽

Common Symptom ◽

Parasympathetic System ◽

Significant Difference ◽

Before And After ◽

Autogenic Relaxation ◽

The Mean

Background: Headache in the occipital region is the most common symptom of hypertension, caused by enhanchement intra-cranial pressure and vasoconstriction resulting in decreased perfusion of cerebral tissue. This causes insomnia, decreased concentration and decreased ability of daily living activity. Autogenic relaxation causes vasodilation and a calm emotional response that increases the response of the parasympathetic system. This modulation stimulus can decrease perception of headache. Objective: The aims of this study was to find out how the reduction of headache on hypertension before and after autogenic relaxation. Methods: The design of this research was pre experimental with one group pretest-postest design approach. The sample are 38 patients with hypertension who complained of headache in Mersi Purwokerto. Selection has been using purposive sampling. Measurement of head pain using visual analog scale. Data analysis using Wilcoxon test. Results: The mean headache before the autogenic relaxation technique was 5.24, and the mean headache after autogenic relaxation technique was 3.47, including the range of moderate pain. There was a significant difference between headache before and after the autogenic relaxation technique with p value: 0,000. Conclusion: Autogenic relaxation can be used by the elderly with hypertension to reduce headache. Keywords: Autogenic relaxation, headache, hypertension.

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