scholarly journals DIFFERENCE IN BLOOD FUNCTION TOXICITY BETWEEN STADIUM IIB-IIIB SQUAMOUS CELL CERVICAL CANCER PATIENTS WITH PACLITAXEL CISPLATIN AND PACLITAXEL CARBOPLATIN CHEMOTHERAPY AT SANGLAH HOSPITAL, DENPASAR.

2018 ◽  
Vol 11 (1) ◽  
pp. 224
Author(s):  
Indrayathi Pa ◽  
Noviyani R ◽  
Niruri R ◽  
Budiana Ing ◽  
Tunas K
Keyword(s):  
Cervical Cancer ◽  
Observational Research ◽  
Hematologic Toxicity ◽  
Inclusion Criteria ◽  
Cancer Treatments ◽  
Exclusion Criteria ◽  
Consecutive Sampling ◽  
Normality Test ◽  
Before And After ◽  
The Difference

 Objective: Paclitaxel cisplatin and paclitaxel carboplatin were chemotherapy regimens used for cervical cancer treatments at Sanglah Hospital, Denpasar. They came with hematologic toxicity side effects. This could be monitored from hemoglobin, thrombocyte, and leukocyte parameter. Data that compared the toxicity of these two regimens were still limited at Sanglah Hospital, Denpasar. Therefore, it was necessary to conduct a research about the difference in blood function toxicity between patients who underwent paclitaxel cisplatin chemotherapy and those who underwent paclitaxel carboplatin chemotherapy based on those three parameters.Methods: This was a prospective observational research with consecutive sampling, inclusion, and exclusion criteria. It was carried out from January to August 2016 at Sanglah Hospital, Denpasar. Patients were categorized into two groups based on their chemotherapy regimens. Next, blood samples from both groups were tested for its hemoglobin, thrombocyte, and leukocyte level before and after chemotherapy. The data underwent normality test using either Shapiro–Wilk or Mann–Whitney test with SPSS.Results: There were 17 patients who fulfilled the inclusion criteria. The result showed a decrease in hemoglobin, thrombocyte, as well as leukocyte values in patients who underwent paclitaxel cisplatin and paclitaxel carboplatin chemotherapy.Conclusion: The decrease of both hemoglobin and leukocyte level was not meaningful in both groups (p>0.05). Meanwhile, the decrease of thrombocyte level was meaningful in both groups (*p<0.05) in which patients who belong to paclitaxel carboplatin chemotherapy group showed a higher decrease of thrombocyte values.

scholarly journals DIFFERENCE IN BLOOD FUNCTION TOXICITY BETWEEN STADIUM IIB-IIIB SQUAMOUS CELL CERVICAL CANCER PATIENTS WITH PACLITAXEL CISPLATIN AND PACLITAXEL CARBOPLATIN CHEMOTHERAPY AT SANGLAH HOSPITAL, DENPASAR.

2018 ◽  
Vol 11 (1) ◽  
pp. 224
Author(s):  
Indrayathi Pa ◽  
Noviyani R ◽  
Niruri R ◽  
Budiana Ing ◽  
Tunas K
Keyword(s):  
Cervical Cancer ◽  
Observational Research ◽  
Hematologic Toxicity ◽  
Inclusion Criteria ◽  
Cancer Treatments ◽  
Exclusion Criteria ◽  
Consecutive Sampling ◽  
Normality Test ◽  
Before And After ◽  
The Difference

 Objective: Paclitaxel cisplatin and paclitaxel carboplatin were chemotherapy regimens used for cervical cancer treatments at Sanglah Hospital, Denpasar. They came with hematologic toxicity side effects. This could be monitored from hemoglobin, thrombocyte, and leukocyte parameter. Data that compared the toxicity of these two regimens were still limited at Sanglah Hospital, Denpasar. Therefore, it was necessary to conduct a research about the difference in blood function toxicity between patients who underwent paclitaxel cisplatin chemotherapy and those who underwent paclitaxel carboplatin chemotherapy based on those three parameters.Methods: This was a prospective observational research with consecutive sampling, inclusion, and exclusion criteria. It was carried out from January to August 2016 at Sanglah Hospital, Denpasar. Patients were categorized into two groups based on their chemotherapy regimens. Next, blood samples from both groups were tested for its hemoglobin, thrombocyte, and leukocyte level before and after chemotherapy. The data underwent normality test using either Shapiro–Wilk or Mann–Whitney test with SPSS.Results: There were 17 patients who fulfilled the inclusion criteria. The result showed a decrease in hemoglobin, thrombocyte, as well as leukocyte values in patients who underwent paclitaxel cisplatin and paclitaxel carboplatin chemotherapy.Conclusion: The decrease of both hemoglobin and leukocyte level was not meaningful in both groups (p>0.05). Meanwhile, the decrease of thrombocyte level was meaningful in both groups (*p<0.05) in which patients who belong to paclitaxel carboplatin chemotherapy group showed a higher decrease of thrombocyte values.

scholarly journals THE AMOUNT OF LYMPHOCYTES BEFORE AND AFTER CEMOTHERAPY IN BREAST CANCER AT ULIN GENERAL HOSPITAL BANJARMASIN

2017 ◽  
Vol 13 (2) ◽  
pp. 125
Author(s):  
Firdinia Gafuri Dohamid ◽  
M. Darwin Prenggono ◽  
Dona Marisa
Keyword(s):  
Breast Cancer ◽  
General Hospital ◽  
Sampling Technique ◽  
Breast Cancer Treatment ◽  
Breast Cancer Patients ◽  
Inclusion Criteria ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Before And After ◽  
The Difference

Abstract: Breast cancer is the most common malignancies among woman in Indonesian. One of breast cancer treatment is chemotherapy which resist cancer’s cells to grow. But chemotherapy also cause DNA damage that interfere lymphocyte proliferation. Depletion on lymphocyte counts will increased patient’s susceptibility to opportunistic infection. The aim of this research was to knowing the difference of lymphocyte counts because of chemotherapy on breast cancer patients in general hospital Ulin Banjarmasin. This research was an observational analytic with cross sectional approach. The sampling technique was non-probability sampling followed by consecutive sampling. Total samples were 61 patients that match with inclusion criteria. Paired T-test was used to analyze the hypothesis with the result of pvalue=0.000 (ρ<0.05), that means there’s a significant decrease in the number of lymphocyte counts after receiving chemotherapy in general hospital Ulin Banjarmasin, January 2014 to December 2015 period. Keywords: chemotherapy, lymphocyte, breast cancer

scholarly journals Efektivitas Akupresur dan Minuman Jahe terhadap Pengurangan Intensitas Nyeri Haid/Dismenore Pada Remaja Putri

2021 ◽  
Vol 21 (1) ◽  
pp. 215
Author(s):  
Indah Dewi Sari ◽  
Utary Dwi Listiarini
Keyword(s):  
Young Women ◽  
Learning Activities ◽  
Wilcoxon Test ◽  
P Value ◽  
Menstrual Pain ◽  
Normality Test ◽  
Before And After ◽  
Post Test ◽  
Quasi Experimental ◽  
The Difference

Half of the women in Indonesia experience menstrual pain / dysmenorrhoea, 54.89%, experience various disorders including abdominal pain, cramps and back pain. The purpose of this study was to determine the effectiveness of acupressure, ginger drink and the difference in giving acupressure and ginger drink to reducing the intensity of menstrual pain / dysmenorrhea in young women at SMK Swasta PAB 5 Klambir Lima 2020. The design of this study used a quasi-experimental pre and post test with a sample of 30 students who were divided into two groups. Each group was given acupressure and ginger drink in the morning and evening during menstruation from day one to day two. Respondents were assessed for pain before and after the intervention was given. The results of the Shapiro-Wilk normality test contained Sig data (p <0.05). The Wilcoxon test has a p-value of 0.002 (p <0.05), which means that acupressure is effective in reducing the intensity of menstrual pain / dysmenorrhea, there is a p-value of 0.001 (p <0.05) which means that ginger is effective against reducing pain intensity. menstruation / dysmenorrhea, there is a p-value of 0.034 (p <0.05), which means that there is a difference in the effectiveness of acupressure and ginger drink in reducing the intensity of menstrual pain / dysmenorrhea. There is an effectiveness of giving acupressure, ginger drink, and there is a difference in giving acupressure and ginger drink on the intensity of menstrual pain / dysmenorrhea on young women. It is hoped that the school will provide ginger drinks and acupressure measures to young women who experience menstrual pain / dysmenorrhea so that they can participate in learning activities at school.

scholarly journals Critical Appraisal on the Selection Criteria for Evidence-based Healthcare

2021 ◽  
Author(s):  
Paulo Cesar Morales Mayer ◽  
Caroline Amélia Gonçalves ◽  
Franz Porzsolt
Keyword(s):  
Cervical Cancer ◽  
Clinical Trials ◽  
Selection Criteria ◽  
Human Subjects ◽  
Evidence Based ◽  
Inclusion Criteria ◽  
Pragmatic Trials ◽  
Exclusion Criteria ◽  
Policy Makers ◽  
Evidence Based Healthcare

Abstract Background: Evidence-Based healthcare deals basically with published clinical trials to guide the decision making on what treatment to use for any specific conditions.Aims: The present paper assessed the inclusion and exclusion criteria used in clinical trials of cervical cancer aiming at establishing a clear distinction between each criterion.Methods: We performed a bibliographical search in pubmed with the terms cervical cancer and treatment or therapy filtered for clinical trials with human subjects for the last ten years. A total of 30 papers were used extracting and classifying the inclusion and exclusion category according to the characteristic they described. Results: We found no clear parameter to establish which criteria could exclusively serve as inclusion or exclusion across the papers, about 56% of the categories identified were found either listed as inclusion or exclusion criteria or even as both in some cases.Conclusions: The key issue of selection criteria is not in its form but in its function, the first point to consider is if the trial is experimental (focused on efficacy and proof of principle) or observational (pragmatic trials, focused on effectiveness and real world conditions). We suggest, inclusion criteria should be broad, focused on the investigated condition; exclusion criteria should apply only to the subset of this “included” population, and do not take part in observational studies. These conclusions do not serve only for researchers but should affect practitioners and policy makers to correctly compare the results of investigated treatment.

scholarly journals Telephone interventions for adherence to colpocytological examination

2017 ◽  
Vol 25 (0) ◽  
Author(s):  
Thais Marques Lima ◽  
◽  
Ana Izabel Oliveira Nicolau ◽  
Francisco Herlânio Costa Carvalho ◽  
Camila Teixeira Moreira Vasconcelos ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Experimental Study ◽  
Educational Intervention ◽  
Educational Interventions ◽  
Inclusion Criteria ◽  
Examination Method ◽  
Before And After ◽  
Quasi Experimental ◽  
Behavioral Group ◽  
Health Education And Promotion

ABSTRACT Objective: to test the effects of behavioral and educational intervention by telephone on adherence of women with inappropriate periodicity to colpocytological examination. Method: quasi-experimental study with a sample of 524 women, selected with the following inclusion criteria: be aged between 25 and 64 years, have initiated sexual activity, have inappropriate periodicity of examination and have mobile or landline phone. The women were divided into two groups for application of behavioral and educational intervention by telephone. It was used an intervention script according to the principles of Motivational Interviewing. Results: on comparing the results before and after the behavioral and educational interventions, it was found that there was a statistically significant change (p = 0.0283) with increase of knowledge of women who participated in the educational intervention. There was no change in the attitude of women of any of the groups and there was an increase of adherence to colpocytological examination in both groups (p < 0.0001), with greater adherence of women participating in the behavioral group (66.8%). Conclusion: the behavioral and educational interventions by phone were effective in the adherence of women to colpocytological examination, representing important strategies for permanent health education and promotion of care for the prevention of cervical cancer.

scholarly journals REAKSI PASAR MODAL DARI DAMPAK PERISTIWA KERUSUHAN MAKO BRIMOB MEI 2018 TERHADAP ABNORMAL RETURN INDEKS LQ45 YANG TERDAFTAR DI BEI

PERFORMA ◽  
2021 ◽  
Vol 4 (2) ◽  
pp. 30-36
Author(s):  
Dewo Adhi Guminto ◽  
Maria Assumpta Evi Marlina
Keyword(s):  
Abnormal Return ◽  
T Test ◽  
P Value ◽  
Normality Test ◽  
Average Abnormal Return ◽  
Before And After ◽  
The Subject ◽  
The Difference ◽  
Corporate Actions ◽  
Observation Period

This research is an event study that aims to determine the difference in the average Abnormal return (AR) before, during and after the Mako Brimob riots. The subject of this study is the LQ45 index company that has fulfilled the criteria, namely the company does not conduct corporate actions such as the announcement of stock split, right issue, merger & acquisition and devidend in the observation period, which is five days before the riot, one day during the riot (May 9, 2018) and five days after the riots. The results of the data normality test found that the data in this study were normally distributed. p-value shows the number 0.412. The results of the different tests using independent Sample T-Test (H1) showed no difference in the average abnormal return before and during the Mako Brimob riots (ρ = 0.050). The results of different tests using independent Sample T-Test (H2) showed no difference in the average abnormal return during and after the incident of the Mako Brimob riots (ρ = 0.117). The results of different tests using Paired Sample T-Test (H3) showed no difference in the average abnormal return before and after the incident of the Mako Brimob riots (ρ = 0.77).

scholarly journals Perbedaan Motivasi Wanita PUS Usia 35-49 Tahun untuk Menggunakan Implant Sebelum dan Setelah Diberi Penyuluhan di Dusun Mojolegi Desa Bendo Kec. Pare.

2017 ◽  
Vol 3 (2) ◽  
pp. 68
Author(s):  
Triatmi Andri Yanuarini ◽  
Susanti Pratamaningtyas ◽  
Rika Aprilia Susanti
Keyword(s):  
Random Sampling ◽  
Simple Random Sampling ◽  
Test Design ◽  
Childbearing Age ◽  
Exclusion Criteria ◽  
Before And After ◽  
Post Test ◽  
The Difference ◽  
Removal Technique

Women who have age 35 these group will get increased morbidity and mortality experience if they pregnant. Implant is one method of effective an safety long-term contraception. Bendo Health Center have the lowest acceptor implants in Kediri that is 0%. The purpose of this research to know the difference motivation of childbearing age couples women in age  35-49 years to use implant before and after giving information. The design used a pre-experiment design with one group pre-test post-test design, the population was all childbearing age couples women in age  35-49 years at Mojolegi Hamlet Bendo Village Pare District who have children, not use contraception or still use non-Long Term contraception Method which total 72 people. The samplehave a lot 61 people according to inclusion and exclusion criteria. The sample removal technique used simple random sampling. The result of this research, from 61 respondents get average of respondent motivation before give information is 65 and after give information is 69, show that respondent’s motivation get increase after got information. And after going through the data analysis it was found z calculate ; z table, so in this case have difference motivation of childbearing age couples women in age  35-49 years to use implants before and after giving information.; Keywords: Counseling, Motivation, Implants

scholarly journals Analysis of ANC Levels after Filgrastim Therapy in Acute Leukemia Children with Neutropenia

2019 ◽  
Vol 55 (1) ◽  
pp. 10
Author(s):  
Reta Anggraeni Widya ◽  
Susanto Nugroho ◽  
Sri Winarsih ◽  
Yulistiani Yulistiani
Keyword(s):  
Acute Leukemia ◽  
Prospective Observational Study ◽  
Longitudinal Design ◽  
Dose Intensity ◽  
Hematologic Toxicity ◽  
Risk Of Infection ◽  
Inclusion Criteria ◽  
Before And After ◽  
Post Therapy ◽  
Ethical Clearance

Cytotoxic chemotherapy suppresses the hematopoietic system, and the most serious hematologic toxicity is neutropenia. This can decrease a risk of infection that causes delays in treatment and reduction of dose intensity, which reduces therapeutic outcome. Filgrastim is used to increase neutrophils level whose therapeutic effect is unknown. The effectiveness of filgrastim is based on the ANC level pre- and post-therapy. This study aimed to analyze the use of filgrastim on ANC level changes in acute leukemia children with neutropenia, and to analyze the patient that achieve ANC level’s targeted therapy = 1000 cell/mm3. A prospective observational study with a longitudinal design was conducted from June to October 2016. The inclusion criteria of the study were patients who diagnosed acute leukemia with neutropenia and received filgrastim 10 µg/kgBW for 3, 4, 5 days. Patients’ ANC levels were measured before and after filgrastim therapy. This study has been approved its ethical clearance by Dr. Saiful Anwar Hospital, Malang. Data were obtained on the basis of neutropenic episodes, followed by 7 episodes of obtaining filgrastim for 3 days, 1 episode of obtaining filgrastim for 4 days, and 7 episodes of obtaining filgrastim for 5 days. Thus, it consists of 15 episodes. In 3 days, ANC levels increased by 9.5 fold from 381.3 ± 91.8 cell/mm3 to 3984.9 ± 426.8 cell/mm3, but in 5 days, ANC levels decreased by 0.9 fold from 200.9 cell/mm3 ± 98.2 to 189.7 ± 14.2 cell/mm3. Filgrastim was able to increased the ANC levels around nine fold for 3 days of theraphy. There were 53% neutropenia patients who achieved the goal of therapy. Filgrastim therapy with dose 10 µg/kgBW for 3 to 5 days has been able to reach the therapeutic target of 53% in acute leukemia children with neutropenia. The increased levels of ANC maximum was reached on the third day with increased levels of 9.5 fold.

scholarly journals Pengaruh Edukasi Virtual Menyikat Lidah Terhadap Kondisi COATED TONGUE Pada Siswa SMP Negeri 1 Pematang Tanah Jawa di Masa Pandemik Tahun 2020

2021 ◽  
Vol 16 (1) ◽  
pp. 130-133
Author(s):  
Junita Elvrida Doloksaribu
Keyword(s):  
Virtual Education ◽  
P Value ◽  
Exclusion Criteria ◽  
Analytical Test ◽  
Before And After ◽  
Tongue Cleaning ◽  
The Difference ◽  
Oral Health Practices ◽  
Quasi Experiment

                                                                                                     ABSTRAK Lidah merupakan salah satu organ vital yang terdapat dalam rongga mulut. Lidah mempunyai selaput alami ketika sehat. Tetapi jika kegagalan sel terjadi, maka menimbulkan infeksi pada permukaan lidah berwarna putih disebut lidah berlapis. Pembersihan lidah untuk mencegah terjadinya infeksi tersebut. Oleh karena itu, masyarakat perlu mendapatkan edukasi mengenai istilah lidah dengan edukasi virtual. Praktek kesehatan gigi dan mulut tetap harus ditingkatkan. Salah satunya dengan memberukan edukasi virtual. Edukasi virtual mengacu pada proses pembelajaran melalui jaringan internet yang menanganinya untuk mengatasi masalah keterpisahan ruang dan waktu antara siswa dan pengajar melalui smartphone. Tujuan penelitian ini adalah untuk melihat pengaruh edukasi virtual menyikat lidah terhadap kondisi lidah yang dilapisi pada siswa SMP Negeri I Pematang Tanah Jawa di masa pandemi tahun 2020. Jenis penelitian adalah eksperimen semu (eksperimen semu) dengan desain pretest dan posttest. Jumlah sampel 20 orang. Penentuan sampel dalam penelitian ini menggunakan kriteria inklusi dan eksklusi. Uji analisis yang digunakan adalah wilcoxon. Pada penelitian ditemukan kondisi kondisi lidah terlapis sebelum dan sesudah edukasi virtual adalah p value = 0,000 <0,05). Kesimpulan penelitian ini yaitu ada pengaruh edukasi virtual terhadap kondisi lidah terlapisi pada SMP Negeri I Pematang Tanah Jawa dengan nilai p = 0,000. Jenis penelitian adalah semu eksperimen (quasi experiment) dengan desain pretest dan posttest. Jumlah sampel 20 orang. Penentuan sampel dalam penelitian ini menggunakan kriteria inklusi dan eksklusi. Uji analisis yang digunakan adalah wilcoxon. Pada penelitian ditemukan kondisi kondisi lidah terlapis sebelum dan sesudah edukasi virtual adalah p value = 0,000 <0,05). Kesimpulan penelitian ini yaitu ada pengaruh edukasi virtual terhadap kondisi lidah terlapisi pada SMP Negeri I Pematang Tanah Jawa dengan nilai p = 0,000. Jenis penelitian adalah semu eksperimen (quasi experiment) dengan desain pretest dan posttest. Jumlah sampel 20 orang. Penentuan sampel dalam penelitian ini menggunakan kriteria inklusi dan eksklusi. Uji analisis yang digunakan adalah wilcoxon. Pada penelitian ditemukan kondisi kondisi lidah terlapis sebelum dan sesudah edukasi virtual adalah p value = 0,000 <0,05). Kesimpulan penelitian ini yaitu ada pengaruh edukasi virtual terhadap kondisi lidah terlapisi pada SMP Negeri I Pematang Tanah Jawa dengan nilai p = 0,000.                                                                                          ABSTRACT The tongue is one of the vital organs found in the oral cavity. The tongue has a natural membrane when it is healthy. But if cell failure occurs, it causes infection on the white surface layer of the tongue called coated tongue. Tongue cleaning is recommended to prevent these infections. Therefore, people need to get education about tongue cleaning with virtual education. Dental and oral health practices still need to be improved. One of them is by providing virtual education. Virtual education refers to the learning process through the internet network whose application is intended to overcome the problem of separation of space and time between students and teachers via smartphones. The purpose of this study was to determine the effect of virtual tongue brushing education on coated tongue conditions in students of SMP Negeri I Pematang Tanah Jawa during the pandemic in 2020. This type of research is a quasi experiment with pretest and posttest designs. The number of samples is 20 people. The determination of the sample in this study used inclusion and exclusion criteria. The analytical test used was Wilcoxon. In the study, it was found that the difference in the conditions of coated tongue before and after virtual education was p value = 0.000 <0.05). The conclusion of this study is that there is an effect of virtual education on the condition of coated tongue in SMP Negeri I Pematang Tanah Jawa with p value =0.000. Kata Kunci: Edukasi virtual, lidah, lidah berlapis  

scholarly journals The Effect of Recreative Purpose Modern and Traditional Archery Education on Attention Parameters in Adolescents

2020 ◽  
Vol 9 (1) ◽  
pp. 244
Author(s):  
Ferhat Ustun ◽  
Erdal Tasgin
Keyword(s):  
Data Collection ◽  
Normal Distribution ◽  
Age Group ◽  
Data Collection Tool ◽  
Paired Samples ◽  
Normality Test ◽  
Before And After ◽  
The Difference ◽  
Sports And Exercise ◽  
Positive Effect

This study aims to investigate the effect of recreational archery exercise on attention levels of children aged 9&ndash;13 years. 20 girls and 20 boys who participated in archery training for 4 weeks held in archery areas of special sports centers in Konya Province. The participants were given archery training 60 minutes a day, 3 days a week for 4 weeks. They participated in the attention test before and after the training. In this study, Bourdon attention test was applied as a data collection tool. The normality test was performed to determine whether the data fit the normal distribution and the data were found to be suitable for parametric tests. In order to determine the difference between the before and after of the test, paired samples t-test was applied. As a result of the study, it was revealed that the attention levels of the participants increased in respect of both total scores and comparisons according to variables (p &lt; 0.001). In this respect, it can be suggested that archery activities will have a positive effect on the attention development of 9&ndash;13 age group children. When the general literature is examined, it can be stated that attention levels of children participating in sports and exercise-based recreational activities are positively affected.

Sign in / Sign up

Export Citation Format

Share Document