scholarly journals Temperature distribution of SiC bed surface in a large-scale microwave-assisted pyrolysis reactor

2021 ◽  
Author(s):  
Ying Duan ◽  
Xiaogen Yi ◽  
Qinglong Xie ◽  
Zhengai Weng ◽  
Peng Yuan ◽  
...  
Keyword(s):  
Temperature Distribution ◽  
Low Power ◽  
Large Scale ◽  
Scale Up ◽  
Microwave Pyrolysis ◽  
Microwave Assisted ◽  
Stable Temperature ◽  
Microwave Reactors ◽  
Pyrolysis Reactor ◽  
Scale Reactor

Microwave reactors equipped with microwave absorbent as high-temperature bed are effective for the pyrolysis reactions. The uniformity and stability of temperature distribution on the microwave absorbent bed surface is important to the microwave pyrolysis reactor especially in the large-scale reactor. Herein, the temperature distribution on the SiC microwave absorbent bed in a large-scale microwave pyrolysis reactor without feeding was examined by both infrared thermography and simulation. Considering the economics of using multiple low-power magnetrons in large-scale reactor, the effect of the working magnetrons location on the heating rate of bed surface and the COV of temperature distribution was investigated. The results showed that more uniform and stable temperature distribution of bed surface in the large-scale reactor was obtained when the magnetrons located at the bottom of the reactor were in use. This study provides guidance for the scale-up of microwave-assisted pyrolysis reactor with multiple low-power magnetrons.

Solid Lipid Nanoparticles: A Promising Drug Delivery Technology

2009 ◽  
Vol 2 (2) ◽  
pp. 509-516
Author(s):  
S. Pragati ◽  
S. Kuldeep ◽  
S. Ashok ◽  
M. Satheesh
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Large Scale ◽  
Colloidal Particles ◽  
Scale Up ◽  
Lipid Nanoparticles ◽  
Scale Production ◽  
Research Activity ◽  
New Approach ◽  
Solid Lipid

One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticle represents an important particulate carrier system, developed accordingly. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. Solid lipid nanoparticle technology represents a promising new approach to lipophile drug delivery. Solid lipid nanoparticles (SLNs) are important advancement in this area. The bioacceptable and biodegradable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. Supplemented with small size which prolongs the circulation time in blood, feasible scale up for large scale production and absence of burst effect makes them interesting candidates for study. In this present review this new approach is discussed in terms of their preparation, advantages, characterization and special features.

Recombinant Protein Production in Microalgae: Emerging Trends

2020 ◽  
Vol 27 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Niaz Ahmad ◽  
Muhammad Aamer Mehmood ◽  
Sana Malik
Keyword(s):  
Chloroplast Genome ◽  
Recombinant Proteins ◽  
Large Scale ◽  
Higher Plants ◽  
Scale Up ◽  
Chloroplast Transformation ◽  
Point Of View ◽  
Nuclear Transformation ◽  
Scale Production ◽  
Algal Chloroplast

: In recent years, microalgae have emerged as an alternative platform for large-scale production of recombinant proteins for different commercial applications. As a production platform, it has several advantages, including rapid growth, easily scale up and ability to grow with or without the external carbon source. Genetic transformation of several species has been established. Of these, Chlamydomonas reinhardtii has become significantly attractive for its potential to express foreign proteins inexpensively. All its three genomes – nuclear, mitochondrial and chloroplastic – have been sequenced. As a result, a wealth of information about its genetic machinery, protein expression mechanism (transcription, translation and post-translational modifications) is available. Over the years, various molecular tools have been developed for the manipulation of all these genomes. Various studies show that the transformation of the chloroplast genome has several advantages over nuclear transformation from the biopharming point of view. According to a recent survey, over 100 recombinant proteins have been expressed in algal chloroplasts. However, the expression levels achieved in the algal chloroplast genome are generally lower compared to the chloroplasts of higher plants. Work is therefore needed to make the algal chloroplast transformation commercially competitive. In this review, we discuss some examples from the algal research, which could play their role in making algal chloroplast commercially successful.

Expanding the boundaries of learning

2021 ◽  
Vol 102 (8) ◽  
pp. 8-13
Author(s):  
Thomas Hatch
Keyword(s):  
Instructional Practices ◽  
New Hampshire ◽  
Large Scale ◽  
Educational Experiences ◽  
Scale Up ◽  
Project Based Learning

Taking advantage of the possibilities for learning outside of school requires us to build on what we know about why it is so hard to sustain and scale up unconventional educational experiences within conventional schools. To illustrate the opportunities and challenges, Thomas Hatch describes a large-scale approach to project-based learning developed in a camp in New Hampshire and incorporated in a Brooklyn school, a trip-based program in Detroit, and Singapore’s systemic embrace of learning outside school. By understanding the conditions that can sustain alternative instructional practices, educators can find places to challenge the boundaries of schooling and create visions of the possible that exceed current constraints.

scholarly journals Stator Non-Uniform Radial Ventilation Design Methodology for a 15 MW Turbo-Synchronous Generator Based on Single Ventilation Duct Subsystem

Energies ◽  
2021 ◽  
Vol 14 (10) ◽  
pp. 2760
Author(s):  
Ruiye Li ◽  
Peng Cheng ◽  
Hai Lan ◽  
Weili Li ◽  
David Gerada ◽  
...  
Keyword(s):  
Finite Element ◽  
Temperature Distribution ◽  
Design Methodology ◽  
Large Scale ◽  
Synchronous Generator ◽  
Axial Direction ◽  
Scale Model ◽  
Element Analysis ◽  
Axial Temperature ◽  
Ventilation Duct

Within large turboalternators, the excessive local temperatures and spatially distributed temperature differences can accelerate the deterioration of electrical insulation as well as lead to deformation of components, which may cause major machine malfunctions. In order to homogenise the stator axial temperature distribution whilst reducing the maximum stator temperature, this paper presents a novel non-uniform radial ventilation ducts design methodology. To reduce the huge computational costs resulting from the large-scale model, the stator is decomposed into several single ventilation duct subsystems (SVDSs) along the axial direction, with each SVDS connected in series with the medium of the air gap flow rate. The calculation of electromagnetic and thermal performances within SVDS are completed by finite element method (FEM) and computational fluid dynamics (CFD), respectively. To improve the optimization efficiency, the radial basis function neural network (RBFNN) model is employed to approximate the finite element analysis, while the novel isometric sampling method (ISM) is designed to trade off the cost and accuracy of the process. It is found that the proposed methodology can provide optimal design schemes of SVDS with uniform axial temperature distribution, and the needed computation cost is markedly reduced. Finally, results based on a 15 MW turboalternator show that the peak temperature can be reduced by 7.3 ∘C (6.4%). The proposed methodology can be applied for the design and optimisation of electromagnetic-thermal coupling of other electrical machines with long axial dimensions.

COMPOSITE TRANSISTOR CELL USING DYNAMIC BODY BIAS FOR HIGH GAIN AND LOW-VOLTAGE APPLICATIONS

2014 ◽  
Vol 23 (08) ◽  
pp. 1450108 ◽  
Author(s):  
VANDANA NIRANJAN ◽  
ASHWANI KUMAR ◽  
SHAIL BALA JAIN
Keyword(s):  
Low Power ◽  
Large Scale ◽  
Low Voltage ◽  
Supply Voltage ◽  
High Gain ◽  
Signal Frequency ◽  
Output Impedance ◽  
Self Cascode ◽  
Intrinsic Gain ◽  
Body Bias

In this work, a new composite transistor cell using dynamic body bias technique is proposed. This cell is based on self cascode topology. The key attractive feature of the proposed cell is that body effect is utilized to realize asymmetric threshold voltage self cascode structure. The proposed cell has nearly four times higher output impedance than its conventional version. Dynamic body bias technique increases the intrinsic gain of the proposed cell by 11.17 dB. Analytical formulation for output impedance and intrinsic gain parameters of the proposed cell has been derived using small signal analysis. The proposed cell can operate at low power supply voltage of 1 V and consumes merely 43.1 nW. PSpice simulation results using 180 nm CMOS technology from Taiwan Semiconductor Manufacturing Company (TSMC) are included to prove the unique results. The proposed cell could constitute an efficient analog Very Large Scale Integration (VLSI) cell library in the design of high gain analog integrated circuits and is particularly interesting for biomedical and instrumentation applications requiring low-voltage low-power operation capability where the processing signal frequency is very low.

scholarly journals Scaling Up Delivery of Biofortified Staple Food Crops Globally: Paths to Nourishing Millions

2021 ◽  
pp. 037957212098250
Author(s):  
Jennifer K. Foley ◽  
Kristina D. Michaux ◽  
Bho Mudyahoto ◽  
Laira Kyazike ◽  
Binu Cherian ◽  
...  
Keyword(s):  
Pearl Millet ◽  
Large Scale ◽  
Scale Up ◽  
Lessons Learned ◽  
Raw Material ◽  
Micronutrient Deficiencies ◽  
Seed Systems ◽  
Public And Private ◽  
Context Specific ◽  
Public And Private Sector

Background: Micronutrient deficiencies affect over one quarter of the world’s population. Biofortification is an evidence-based nutrition strategy that addresses some of the most common and preventable global micronutrient gaps and can help improve the health of millions of people. Since 2013, HarvestPlus and a consortium of collaborators have made impressive progress in the enrichment of staple crops with essential micronutrients through conventional plant breeding. Objective: To review and highlight lessons learned from multiple large-scale delivery strategies used by HarvestPlus to scale up biofortification across different country and crop contexts. Results: India has strong public and private sector pearl millet breeding programs and a robust commercial seed sector. To scale-up pearl millet, HarvestPlus established partnerships with public and private seed companies, which facilitated the rapid commercialization of products and engagement of farmers in delivery activities. In Nigeria, HarvestPlus stimulated the initial acceptance and popularization of vitamin A cassava using a host of creative approaches, including “crowding in” delivery partners, innovative promotional programs, and development of intermediate raw material for industry and novel food products. In Uganda, orange sweet potato (OSP) is a traditional subsistence crop. Due to this, and the lack of formal seed systems and markets, HarvestPlus established a network of partnerships with community-based nongovernmental organizations and vine multipliers to popularize and scale-up delivery of OSP. Conclusions: Impact of biofortification ultimately depends on the development of sustainable markets for biofortified seeds and products. Results illustrate the need for context-specific, innovative solutions to promote widespread adoption.

scholarly journals Chemical looping reforming in packed-bed reactors: Modelling, experimental validation and large-scale reactor design

2017 ◽  
Vol 156 ◽  
pp. 156-170 ◽  
Author(s):  
V. Spallina ◽  
B. Marinello ◽  
F. Gallucci ◽  
M.C. Romano ◽  
M. Van Sint Annaland
Keyword(s):  
Large Scale ◽  
Experimental Validation ◽  
Packed Bed ◽  
Reactor Design ◽  
Chemical Looping ◽  
Packed Bed Reactors ◽  
Scale Reactor

scholarly journals Direct detection of SARS-CoV-2 using non-commercial RT-LAMP reagents on heat-inactivated samples

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alisa Alekseenko ◽  
Donal Barrett ◽  
Yerma Pareja-Sanchez ◽  
Rebecca J. Howard ◽  
Emilia Strandback ◽  
...  
Keyword(s):  
Large Scale ◽  
Direct Detection ◽  
Dna Polymerases ◽  
Scale Up ◽  
Lamp Assay ◽  
Cost Effective ◽  
Reaction Conditions ◽  
Clinical Patient ◽  
Reverse Transcriptases ◽  
Large Scale Testing

AbstractRT-LAMP detection of SARS-CoV-2 has been shown to be a valuable approach to scale up COVID-19 diagnostics and thus contribute to limiting the spread of the disease. Here we present the optimization of highly cost-effective in-house produced enzymes, and we benchmark their performance against commercial alternatives. We explore the compatibility between multiple DNA polymerases with high strand-displacement activity and thermostable reverse transcriptases required for RT-LAMP. We optimize reaction conditions and demonstrate their applicability using both synthetic RNA and clinical patient samples. Finally, we validate the optimized RT-LAMP assay for the detection of SARS-CoV-2 in unextracted heat-inactivated nasopharyngeal samples from 184 patients. We anticipate that optimized and affordable reagents for RT-LAMP will facilitate the expansion of SARS-CoV-2 testing globally, especially in sites and settings where the need for large scale testing cannot be met by commercial alternatives.

scholarly journals Mechanical Properties of Protective Coatings against Marine Fouling: A Review

Polymers ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 173
Author(s):  
Alessandro Pistone ◽  
Cristina Scolaro ◽  
Annamaria Visco
Keyword(s):  
Mechanical Properties ◽  
Large Scale ◽  
Protective Coatings ◽  
Scale Up ◽  
Product Distribution ◽  
Properties Of Coatings ◽  
Fouling Organism ◽  
Ship Hulls ◽  
Marine Industry ◽  
Application Fields

The accumulation of marine organisms on ship hulls, such as microorganisms, barnacles, and seaweeds, represents a global problem for maritime industries, with both economic and environmental costs. The use of biocide-containing paints poses a serious threat to marine ecosystems, affecting both target and non-target organisms driving science and technology towards non-biocidal solutions based on physico-chemical and materials properties of coatings. The review reports recent development of hydrophobic protective coatings in terms of mechanical properties, correlated with the wet ability features. The attention is focused mainly on coatings based on siloxane and epoxy resin due to the wide application fields of such systems in the marine industry. Polyurethane and other systems have been considered as well. These coatings for anti-fouling applications needs to be both long-term mechanically stable, perfectly adherent with the metallic/composite substrate, and capable to detach/destroy the fouling organism. Prospects should focus on developing even “greener” antifouling coatings solutions. These coatings should also be readily addressable to industrial scale-up for large-scale product distribution, possibly at a reasonable cost.

Sign in / Sign up

Export Citation Format

Share Document