scholarly journals Effect of salicylidene salicylhydrazide on testes of albino mice: A histomorphological study.

2021 ◽  
Vol 29 (01) ◽  
pp. 101-109
Author(s):  
Shagufta Sultana ◽  
Muhammad Haris ◽  
Falak Naz ◽  
Shazia Iftikhar ◽  
Zainab Rehman
Keyword(s):  
Morphometric Analysis ◽  
Dose Group ◽  
The Body ◽  
Germinal Epithelium ◽  
Seminiferous Tubules ◽  
Testicular Toxicity ◽  
Medical College ◽  
Toxicological Effects ◽  
Processing Techniques ◽  
Study Setting

Objectives: To evaluate salicylidene salicylhydrazide (SCS) for any possible toxicological effects on male reproductive system in Albino male BALB/c mice. Study Design: Experimental study. Study Setting: Department of Histopathology, Khyber Medical College Peshawar and Department of Pharmacy, University of Peshawar, Peshawar were utilized for conducting this study. Period: July, 2020 to December, 2020. Material & Methods: Male BALB/c mice were daily administered with SCS at 5, 25, and 50 mg/kg for 7 and 14 days. The body and testes weights were measured and the testes were subjected to histological tissue processing techniques. Results: The extent of testicular toxicity was evaluated by using modified Johnsen scoring system for assessing the level of spermatogenesis, and morphometric analysis by measuring the diameter of the seminiferous tubules, thickness of germinal epithelium, and area of interstitial cells of Leydig. The body and testes weights showed that the various doses of SCS have no substantial effects after 7 and 14 days. The tested doses of SCS did not produce any distinguishable change in the normal histological features of seminiferous tubules and interstitium after 7 days. However, after 14 days, the 50 mg/kg dose of SCS was associated with vacuolization and loosening of germinal epithelium. These mild-to-moderate histopathological aberrations was confirmed from morphometric analysis in this dose group in which a decrease in the seminiferous tubules’ diameter and reduction in the thickness of germinal epithelium along with an increase in the interstitial area were observed. Conclusion: These findings concluded that SCS is considered to be relatively safe.

scholarly journals Siddha Diagnostic Methodology of Envagai thervu for Gunmam Patients at Government Siddha Medical College & Hospital, Palayamkottai

2020 ◽  
pp. 1-13
Author(s):  
Rakulini Raveendran
Keyword(s):  
Tamil Nadu ◽  
South India ◽  
The Body ◽  
Age Group ◽  
Microsoft Excel ◽  
College Hospital ◽  
Medical College ◽  
Diagnostic Methodology ◽  
The Voice ◽  
Study Setting

Introduction: Siddha Medicine is a system of traditional medicine originating in ancient Tamil Nadu in South India and Sri Lanka. Traditionally, it is taught that the siddhars laid the foundation for this system of medicine. Siddha system has a unique diagnostic method to identify the diseases and their causes. According to the Saint Theraiyar, there are eight tools of diagnosis: symptoms of the body, the colour, the voice, the eyes, the tongue, stools, urine and the pulse. Aim: The aim of this study was to study the siddha diagnostic methodology of envagaithervu for gunmam patient sat government siddha medical college & hospital, palayamkottai. Study Setting: Government Siddha Medical College, Palayamkottai from April to August 2019. Methodology: It is an observational study. After identifying the eligible subjects, Data will be collected by using the interview administrated questionnaire & relevant data will be collected by measurement. Collected data were processed and statistically analysed by a simple statistical method using Microsoft Excel. Results and Discussion: Majority of the gunmam subjects were females (60%) and age group within 41-60 & 51-60 years. The maximum number of subjects were observed in Pitha Kaalam. Majority of the gunmam subjects had Abdominal pain, eructation, generalized body weakness. Vali azhalnaadi (38%) and azhalvalinaadi (32%) were observed in majority of the gunmam subjects. Neikuri was observed as valiazhal & azhalvali in gunmam subjects. Conclusion: This study has given quite evidence for literatures. These collected information are helpful for further studies in gunmam.

scholarly journals Effect of Nickel Administration in vivo on the Testicular Structure in Male Mice

2007 ◽  
Vol 76 (2) ◽  
pp. 223-229 ◽  
Author(s):  
P. Massányi ◽  
N. Lukáč ◽  
J. Zemanová ◽  
A. V. Makarevich ◽  
P. Chrenek ◽  
...  
Keyword(s):  
Body Mass ◽  
Seminiferous Tubule ◽  
Basal Membrane ◽  
Relative Volume ◽  
The Body ◽  
Germinal Epithelium ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Group B

The aim of this study was to describe the effects of nickel (NiCl2) on murine testicular structure. Experimental animals were injected intraperitoneally with a single dose of 20 mg NiCl2 per kg of body mass (group A, n = 5) and 40 mg NiCl2 per kg b. m. (group B, n = 5). The group without injection (n = 5) was the control (C). Animals were killed 48 hours after administration of nickel. The body mass of animals, the mass of testes and the testes : body mass ratio were not significantly affected. In both experimental groups a significant (p < 0.001) decrease of germinal epithelium in comparison with control group was observed. The relative volume of the interstitium was increased but not significantly in both experimental groups. An increase in the relative volume of the lumen was registered in both experimental groups in comparison with the control group. The qualitative analysis detected a dilatation of blood vessels in the interstitium, undulation of the basal membrane and several empty spaces in the germinal epithelium. The diameter (n = 150) of the seminiferous tubule was markedly (p < 0.05) decreased in both experimental groups (A, B) compared to control group. The height of the germinal epithelium showed a significant decrease (p < 0.05 - 0.001) after nickel administration. Evaluation of the lumen diameter in the seminiferous tubule showed a significant increase in both experimental groups. The data of the perimeter of seminiferous tubules corresponded with those of the seminiferous tubule diameter. TUNEL assay detected a higher frequency of localized apoptosis in the interstitium of nickel-administered animals compared to control group. Our findings clearly suggest a negative effect of nickel on the structure as well as on the function of the seminferous epithelium at the site of spermatozoa production.

scholarly journals Study of autopsy based suicidal hanging

2015 ◽  
Vol 30 (2) ◽  
pp. 14-17
Author(s):  
Nirupama Talukder ◽  
Kh A Karim ◽  
Tarana Chowdhury ◽  
Ashan Habib ◽  
Azreen Momen Chowdhury ◽  
...  
Keyword(s):  
Study Design ◽  
Forensic Medicine ◽  
Descriptive Study ◽  
The Body ◽  
Social Health ◽  
Age Group ◽  
Cross Sectional ◽  
Medical College ◽  
The People ◽  
Study Setting

Introduction: Hanging is one of the most commonly used methods for suicide in most countries. Commission of suicide by hanging is increasing in the people of Bangladesh. Suicidal hanging is detrimental to social health. Appropriate measures to prevent it are essential. Objectives: To find out the demography, cause and nature of suicidal hanging. Study design: It is a cross sectional type of descriptive study. Setting: Data was collected on predesigned proformas from postmortem reports recorded by the students of DFM and MD in Forensic Medicine at Dhaka medical college during their course. Subject: Autopsy performed on the cases of suicidal hanging at Dhaka Medical College Morgue from September, 2011 to June, 2013. Result: Out of 100 cases, eighty two (82%) were female and the most commonest (50%) age group were from 11-20 years. In 18(18%) cases Dopatta were the commonest material used for hanging. Quarrel with husband 12(12%) were the predominant cause to destroy life. In ninety (90%) cases had complete suspension where the most commonest situation of gap was on the back (38.89%). During autopsy of suicidal hanging there were injuries on the body of deceased in few cases. But these injuries did not result in death of the victim. DOI: http://dx.doi.org/10.3329/bjpp.v30i2.22677 Bangladesh J Physiol Pharmacol 2014; 30(2): 14-17

EPIDEMIOLOGY AND OUTCOMES OF ELECTRIC BURN INJURY AT TERTIARY CARE CENTER IN JODHPUR, RAJASTHAN

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Bharti Saraswat ◽  
Ashok Yadav ◽  
Krishna Kumar Maheshwari
Keyword(s):  
Burn Injury ◽  
Low Voltage ◽  
Care Center ◽  
Tertiary Care ◽  
The Body ◽  
Electrical Injury ◽  
Age Group ◽  
Electric Circuits ◽  
Medical College ◽  
Social Burden

Background- Electric burns and injuries are the result of electric current passing through the body. Temporary or permanent damage can occur to the skin, tissues, and major organs. Methods- This prospective study was carried out on patients admitted in burn unit of department of surgery M.G. Hospital associated with Dr. S.N. Medical College Jodhpur. Records of the patients admitted from January 2018 to December 2018 were studied. Bed head tickets of the patients evaluated in detail. Results- In our study out of 113 patients maximum no. of patients were in age group of 21-30 years 44 (38.94%) followed by age group <11 years in 21 (18.58%) patients and age group of > 60 years in only 3 (2.65%).39 (34.51%) patients were farmer and 15 (13.27%) were electrician in out of 113 total patients, while 37 (32.74%) were without any occupation. 65 (57.52%) cases of high voltage (HV) electrical injury and 48 (42.48%) cases were of low voltage (LV) electrical injury. Conclusion- Morbidity leading to permanent disabilities make the person physically dependent on others. It can be prevented by educating the people about the proper handling to electric circuits & devices. Proper communication among the electricians may help in lowering such accidents. Proper rehabilitation of the handicapped person & employment to the member of the affected family may reduce the social burden caused by such electricity concerned accidents.

scholarly journals A Mapping Literature Review of Medical Cannabis Clinical Outcomes and Quality of Evidence in Approved Conditions in the USA from 2016 to 2019

2021 ◽  
pp. 1-22
Author(s):  
Sebastian Jugl ◽  
Aimalohi Okpeku ◽  
Brianna Costales ◽  
Earl J. Morris ◽  
Golnoosh Alipour-Haris ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
The Body ◽  
Medical Cannabis ◽  
High Quality ◽  
Chronic Noncancer Pain ◽  
High Quality Evidence ◽  
Improved Outcomes ◽  
Noncancer Pain ◽  
Study Setting

In 2017, a National Academies of Sciences, Engineering, and Medicine (NASEM) report comprehensively evaluated the body of evidence regarding cannabis health effects through the year 2016. The objectives of this study are to identify and map the most recently (2016–2019) published literature across approved conditions for medical cannabis and to evaluate the quality of identified recent systematic reviews, published following the NASEM report. Following the literature search from 5 databases and consultation with experts, 11 conditions were identified for evidence compilation and evaluation: amyotrophic lateral sclerosis, autism, cancer, chronic noncancer pain, Crohn’s disease, epilepsy, glaucoma, human immunodeficiency virus/AIDS, multiple sclerosis (MS), Parkinson’s disease, and posttraumatic stress disorder. A total of 198 studies were included after screening for condition-specific relevance and after imposing the following exclusion criteria: preclinical focus, non-English language, abstracts only, editorials/commentary, case studies/series, and non-U.S. study setting. Data extracted from studies included: study design type, outcome definition, intervention definition, sample size, study setting, and reported effect size. Few completed randomized controlled trials (RCTs) were identified. Studies classified as systematic reviews were graded using the Assessing the Methodological Quality of Systematic Reviews-2 tool to evaluate the quality of evidence. Few high-quality systematic reviews were available for most conditions, with the exceptions of MS (9 of 9 graded moderate/high quality; evidence for 2/9 indicating cannabis improved outcomes; evidence for 7/9 indicating cannabis inconclusive), epilepsy (3 of 4 graded moderate/high quality; 3 indicating cannabis improved outcomes; 1 indicating cannabis inconclusive), and chronic noncancer pain (12 of 13 graded moderate/high quality; evidence for 7/13 indicating cannabis improved outcomes; evidence from 6/7 indicating cannabis inconclusive). Among RCTs, we identified few studies of substantial rigor and quality to contribute to the evidence base. However, there are some conditions for which significant evidence suggests that select dosage forms and routes of administration likely have favorable risk-benefit ratios (i.e., epilepsy and chronic noncancer pain). The body of evidence for medical cannabis requires more rigorous evaluation before consideration as a treatment option for many conditions, and evidence necessary to inform policy and treatment guidelines is currently insufficient for many conditions.

scholarly journals An Intelligent Baby Monitor with Automatic Sleeping Posture Detection and Notification

AI ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 290-306
Author(s):  
Tareq Khan
Keyword(s):  
Language Translation ◽  
Video Data ◽  
The Body ◽  
Night Vision ◽  
Monitoring Device ◽  
Peace Of Mind ◽  
Image Processing Techniques ◽  
Pose Detection ◽  
Processing Techniques ◽  
Monitoring Devices

Artificial intelligence (AI) has brought lots of excitement to our day-to-day lives. Some examples are spam email detection, language translation, etc. Baby monitoring devices are being used to send video data of the baby to the caregiver’s smartphone. However, the automatic understanding of the data was not implemented in most of these devices. In this research, AI and image processing techniques were developed to automatically recognize unwanted situations that the baby was in. The monitoring device automatically detected: (a) whether the baby’s face was covered due to sleeping on the stomach; (b) whether the baby threw off the blanket from the body; (c) whether the baby was moving frequently; (d) whether the baby’s eyes were opened due to awakening. The device sent notifications and generated alerts to the caregiver’s smartphone whenever one or more of these situations occurred. Thus, the caregivers were not required to monitor the baby at regular intervals. They were notified when their attention was required. The device was developed using NVIDIA’s Jetson Nano microcontroller. A night vision camera and Wi-Fi connectivity were interfaced. Deep learning models for pose detection, face and landmark detection were implemented in the microcontroller. A prototype of the monitoring device and the smartphone app were developed and tested successfully for different scenarios. Compared with general baby monitors, the proposed device gives more peace of mind to the caregivers by automatically detecting un-wanted situations.

Implications of body condition and seasonality on morphological and functional parameters of testes of Myotis nigricans (Chiroptera: Vespertilionidae)

2018 ◽  
Vol 30 (7) ◽  
pp. 1029
Author(s):  
Marcelo Ferreira ◽  
Aline Soldati ◽  
Sirlene S. S. Rodrigues ◽  
Laércio dos Anjos Benjamin
Keyword(s):  
Light Microscopy ◽  
Body Condition ◽  
Environmental Variables ◽  
Reproductive Strategies ◽  
Leydig Cells ◽  
Dry Season ◽  
The Body ◽  
Reproductive Capacity ◽  
Seminiferous Tubules ◽  
The Mean

The insectivorous bat Myotis nigricans is widely distributed throughout the Neotropics, including Brazil, and has a reproductive biology that is affected by climate and food availability. To evaluate the reproductive capacity of this species, morphofunctional parameters of the testes were correlated with environmental variables and the body condition of individuals captured. After bats had been killed, their testes were removed, fixed in Karnovsky’s fluid for 24 h and embedded in resin for evaluation by light microscopy. The mean annual tubulosomatic index (0.58%) and the percentage of seminiferous tubules in the testes (88.96%) were the highest ever recorded for the Order Chiroptera. The percentage of Leydig cells and volume of the cytoplasm of Leydig cells were higher in the rainy than dry season (80.62 ± 3.19% and 573.57 ± 166.95 μm, respectively; mean ± s.d.). Conversely, the percentage of nuclei of the Leydig cells in the dry season (26.17 ± 3.70%; mean ± s.d.) and the total number of Leydig cells (6.38 ± 1.84 × 109; mean ± s.d.) were higher in the dry season. The results of the present study could help in future conservation of these bats because they provide a better understanding of the bats’ reproductive strategies and how the species can adapt to changes.

OBSERVATIONS ON CADMIUM DAMAGE AND REPAIR IN RAT TESTES AND THE EFFECTS ON THE PITUITARY GONADOTROPHS

1962 ◽  
Vol 24 (4) ◽  
pp. 453-NP ◽  
Author(s):  
M. ALLANSON ◽  
R. DEANESLY
Keyword(s):  
Subcutaneous Injection ◽  
Cadmium Chloride ◽  
Cytological Study ◽  
Interstitial Cells ◽  
Germinal Epithelium ◽  
Seminiferous Tubules ◽  
Interstitial Tissue ◽  
Long Term Effects ◽  
Single Subcutaneous Injection

SUMMARY Cadmium chloride, in a single subcutaneous injection, can destroy spermatogenic and interstitial cells in the rat testis (Pařízek, 1957) and produce changes in the pituitary. The interstitial tissue is restored by ingrowths from the tunica and full androgen secretion returns before there is any regeneration of germinal epithelium. A cytological study has been made of the peripheral and central pituitary gonadotrophs; the latter revert almost to normal as the interstitial tissue regenerates, whereas the former retain characteristic castration features, unless there is also regeneration of the germinal epithelium. This seems to indicate that in the normal testis there is a hormone contribution from the seminiferous tubules as well as from the interstitial cells. The long-term effects of cadmium on the testis depend on the dose. Early stages of tubule restoration have been studied, but after administration of 0·9 mg., actual proliferation of the germinal epithelium was rarely found—only in four out of twenty rats, 113 or 142 days after injection.

Incidence of writing double NSAIDs in a single prescription for osteoarthritis.

2021 ◽  
Vol 28 (05) ◽  
pp. 702-706
Author(s):  
Niaz Hussain Keerio ◽  
Nasrullah Aamir ◽  
Nuresh Kumar ◽  
Masood Ahmad Qureshi ◽  
Hassan Amir us Saqlain ◽  
...  
Keyword(s):  
Elderly Population ◽  
Cross Sectional Study ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Medical College ◽  
Bleeding Ulcers ◽  
Study Setting

 Objective: To determine how frequent NSAIDs are used for osteoarthritic patients because OA is common old age patients and NSAIDs can cause divesting complications on their health. In our study we tried to identify the main reasons and suggest a best possible solution. Study Design: Community Based Cross-sectional study. Setting: Mohammad Medical College and Hospital Mirpurkhas Pakistan. Period:  June 2018 to August 2018. Material & Methods: In this study, we included more than 300 prescriptions written for Osteoarthritis, a degenerative joint disease. Prescriptions collected from hospital pharmacy (80%) and from other pharmacies (20%). Data was collected on preformed proforma and was analyzed in SPSS version 25. Results: Osteoarthritis mainly affects elderly population. NSAIDs are used for pain relief but can cause acute renal failure and GIT bleeding ulcers. In our study 69% patients were prescribed double NSAIDs. Traditional NSAIDs were used 95% of the time and only 5% percent of the time selective cox 2 were used. Along with these NSAIDS only 20% patient were given prophylactically gastroprotective agents like PPI and other medications. Conclusion: Prescription osteoarthritis include multiple NSAID without any protocol and over dosage was observed commonly.

Lung Cancer Detection using Image Processing Techniques and its Classification

2021 ◽  
Vol 9 (9) ◽  
pp. 1578-1583
Author(s):  
Aishwarya .R
Keyword(s):  
Lung Cancer ◽  
Image Processing ◽  
Support Vector Machine ◽  
Cell Carcinoma ◽  
Mortality Rates ◽  
The Body ◽  
Support Vector ◽  
Lung Tumour ◽  
Image Processing Techniques ◽  
Processing Techniques

Abstract: Lung cancer has been a major contribution to mortality rates world-wide for many years now. There is a need for early diagnosis of lung cancer which if implemented, will help in reducing mortality rates. Recently, image processing techniques have been widely applied in various medical facilities for accurate detection and diagnosis of abnormality in the body images like in various cancers such as brain tumour, breast tumour and lung tumour. This paper is a development of an algorithm based on medical image processing to segment the lung tumour in CT images due to the lack of such algorithms and approaches used to detect tumours. The work involves the application of different image processing tools in order to arrive at the desired result when combined and successively applied. The segmentation system comprises different steps along the process. First, Image preprocessing is done where some enhancement is done to enhance and reduce noise in images. In the next step, the different parts in the images are separated to be able to segment the tumour. In this phase threshold value was selected automatically. Then morphological operation (Area opening) is implemented on the thresholded image. Finally, the lung tumour is accurately segmented by subtracting the opened image from the thresholded image. Support Vector Machine (SVM) classifier is used to classify the lung tumour into 4 different types: Adenocarcinoma(AC), Large Cell Carcinoma(LCC) Squamous Cell Carcinoma(SCC), and No tumour (NT). Keywords: Lung tumour; image processing techniques; segmentation; thresholding; image enhancement; Support Vector Machine; Machine learning;

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