STABILITAS DAN AKTIVITAS GEL EKSTRAK BULBUS BAWANG TIWAI (Eleutherine americana (Mill.) Urb.) SEBAGAI ANTI ACNE

2017 ◽  
Vol 1 (1) ◽  
pp. 94
Author(s):  
Husnul Warnida ◽  
Yullia Sukawaty ◽  
Mega Mega
Keyword(s):  
Antibacterial Activity ◽  
Staphylococcus Epidermidis ◽  
Oil Content ◽  
Physical Stability ◽  
Gelling Agent ◽  
Test Results ◽  
Propionibacterium Acne ◽  
Spreading Test ◽  
Carbomer 940 ◽  
Eleutherine Americana

awang Tiwai has an antibacterial activity toward some microorganisms e.g. Staphylococcus epidermidis dan Propionibacterium acne, two acne related bacteria. Bawang Tiwai extract 1% and 2% were formulated into gel (no oil content, because oil could make the acne worse) with carbomer 940 as gelling agent. Physical stability of bawang tiwai gel was evaluated included stability, organoleptic, pH, homogeneity, viscosity, consistency, spreading test, and activity toward Staphylococcus epidermidis.  The result showed that all formulas are stable after 7 days. The test results of antibacterial activity gel are 17,24 mm dan gel 19,75 mm to gel 1% dan 2% respectively.

scholarly journals Carrageenan Biopolymer for Medical Ultrasonography using Phantom CIRS

2020 ◽  
Vol 202 ◽  
pp. 12001
Author(s):  
Anak Agung Aris Diartama ◽  
Suryono Suryono ◽  
Sugiyanto Sugiyanto ◽  
Putu Irma Wulandari ◽  
I Putu Eka Juliantara ◽  
...  
Keyword(s):  
Rapid Development ◽  
Control Group ◽  
Environmental Aspects ◽  
Control Group Design ◽  
Safe Alternative ◽  
Test Analysis ◽  
Acoustic Coupling ◽  
Group Design ◽  
Significant Difference ◽  
Carbomer 940

The use of polymer as conductor in medical ultrasonography is very crucial to establish patient diagnosis and to prevent administration of improper treatment. Rapid development in science and technology encourages people to create more innovations that are readily usable. However, these innovations sometimes put health and environmental aspects aside that in turn become disadvantageous to health and may lead to environmental pollution. This research proposes the use of carrageenan biopolymer as a safe alternative for people’s health and the environment. It aims to prove differences in resulting phantom CIRS images taken with the help of carrageenan gel and standard gel based on Carbomer 940 as acoustic coupling agents (ACA) for ultrasonography (USG). It is an experimental research that uses true experiment technique with posttest only control group design. Results from T-test analysis show significance value of p>0.05, meaning there is no significant difference between the use of carrageenan gel and ACA gel (Carbomer 940). This result proves that carrageenan gel can be used as an acoustic coupling agent for ultrasonography. Results from imaging tests also reveal that there is no difference between the use of carrageenan gel and that of a manufacturer gel based on Carbomer 940 available in Indonesia, in terms of visualization of phantom CIRS images.

scholarly journals Optimasi Formula Gel Antioksidan Ekstrak Etanol Buah Bligo (Benincasa hispida) dengan Metode Simplex Lattice Design (SLD)

2017 ◽  
Vol 3 (2) ◽  
pp. 150-156
Author(s):  
Suryani Suryani ◽  
Andi Nafisah ◽  
Syahrir Mana'an
Keyword(s):  
Antioxidant Activity ◽  
Laboratory Experiments ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Benincasa Hispida ◽  
Dpph Method ◽  
Simplex Lattice ◽  
Dispersive Power ◽  
Carbomer 940 ◽  
Optimal Formula

Benincasa hispida has many benefits including as antioxidant. This study aims to evaluate the effect of Carbomer 940, HPMC and NaOH concentrations in antioxidant gel formula and to determine Carbomer 940, HPMC and NaOH concentrations that could produce the optimal antioxidant gel formula. Benincasa hispida was extracted by maceration method and antioxidant activity was tested by DPPH method. The antioxidant gels were formulated with variety combinations of Carbomer 940, HPMC and NaOH. The optimal gel formula was obtained by Design Expert 7.1.5 with Simplex Lattice Design method. The physical characteristic of optimal gel formula was retested and compared with the results of Simplex Lattice Design .The results showed that antioxidant activity of Benincasa hispida ethanolic extract has potent activity with the IC50 40,28 μg/mL. The increasing concentration of Carbomer 940, HPMC and NaOH possessed the high coefficients viscosity (cPs) with the value of 4366, 4133 and 3750 respectively. The increasing concentration of NaOH possessed pH and dispersive power of the gel with coefficients of 11,0 and 5,21 respectively. The desirability values suggested by Simplex Lattice Design were 1,000 with component variation of the optimal formula were Carbomer 940 1,5%, HPMC 0,5% and NaOH 0,4%. The significance test of the optimal formula  compared to the results of laboratory experiments showed the significance of viscosity of 0,130, the dispersive power of 0,348 and pH of 0,184 that means there was no significant difference between the prediction values by using Simplex Lattice Design and results of laboratory experiments. It was indicated that significance values of each responses were over 0,05 (p>0.05).

scholarly journals Formulation of Toothpaste Toothpaste Gel Essential Oil of Lime Leaves (Citrus Aurantifolia) With Variations Concentration of Carbomer 940 As Gelling Agent Base

2021 ◽  
Vol 4 (2) ◽  
pp. 98-103
Author(s):  
Nurista Dida Ayuningtyas ◽  
Agustina Putri Pitarisa Sudarsono ◽  
Anastasiya Sisca Yuswanti
Keyword(s):  
Leaf Extract ◽  
Statistical Tests ◽  
Gelling Agent ◽  
Spreading Area ◽  
Significant Difference ◽  
Independent Variable ◽  
Spss Software ◽  
Ph Range ◽  
Carbomer 940 ◽  
One Way Anova

Background : Lime leaves contain flavonoids, tannins, and saponins. This content is known to have activity as an antibacterial and protective of gums and teeth. Based on these activities, lime leaves can be developed as an active ingredient in gel toothpaste preparations. In the manufacture of gel toothpaste, the component that plays an important role is the gelling agent. Purpose: In this study, a variation of the gelling agent Carbomer 940 will be used to make a gel toothpaste with lime leaf extract. Methods: The independent variable used is Carbomer 940 with a variation of 3 formulas, namely 0.6%; 1.2%; and 1.8%. The evaluations carried out on gel toothpaste were organoleptic, homogeneity, pH, adhesion, spreadability and pH. Data analysis was carried out with SPSS software to see the differences between each formula. Results: The results showed that the formula 1-3 was homogeneous with a clear, homogeneous color, and a characteristic smell of menthol with a pH range of 5.85-7.49; spreading area 20.60-29.91 cm2, adhesion 6.01-35.1 seconds. The results of statistical tests with one-way ANOVA obtained a significant difference between each formula.  

scholarly journals Synerisis and Cycling Test the Sendok Leaf Extract Gel (Plantago Mayor L.) with Optimization of Variations of Gelling Agent Carbomer 940 Concentration

2021 ◽  
Vol 6 (12) ◽  
pp. 908-910
Author(s):  
A L Yusuf ◽  
D Nugraha
Keyword(s):  
Experimental Method ◽  
Extraction Method ◽  
Leaf Extract ◽  
Storage Temperature ◽  
Gelling Agent ◽  
Plantago Major ◽  
Test Results ◽  
Cycling Test ◽  
Carbomer 940

The purpose of this study was to determine the effect of the concentration of the gelling agent Carbomer 940 on the gel of daun Leaf Extract (Plantago major L.). The method used is the experimental method. The extraction method used is maceration with 96% alcohol. The design in this study is the manufacture of a gel formulation of sendok Leaf extract (Plantago major L.) with the concentration of the gelling agent Carbomer 940 and the syneresis test. Syneresis test results show that all formulas do not occur syneresis. The results of the cycling test showed that the sendok Leaf (Plantago major L.) extract gel was not affected by storage temperature. The conclusion of this study shows the effect of variations in the concentration of the gelling agent Carbomer 940 on the quality of gel.

EVALUATION OF ANTI-AGING AND ANTI-ACNE EFFECT OF ANDALIMAN (ZANTHOXYLUM ACANTHOPODIUM DC.) ETHANOLIC EXTRACT PEEL OFF GEL MASK

2018 ◽  
Vol 11 (13) ◽  
pp. 90
Author(s):  
Ismanelly Hanum T ◽  
Lia Laila
Keyword(s):  
Polyvinyl Alcohol ◽  
Pore Size ◽  
Dosage Form ◽  
Black Spot ◽  
Ethanolic Extract ◽  
Distilled Water ◽  
Small Pore Size ◽  
Small Pore ◽  
Carbomer 940 ◽  
Skin Moisture

Objective: The study was conducted to evaluate the anti-aging and anti-acne effect of and aliman ethanolic extract (AEE) in the form of peel off gel mask (PGM) on human skin. Methods: The formulation of PGM base was consisted of polyvinyl alcohol, glycerine, methylparaben, propylparaben, Carbomer 940, and distilled water (blank). The AEE (30%) was formulated in the PGM base and labeled as F1. The anti-aging and anti-acne tests were conducted by comparing the blank and the F1. The evaluation of anti-aging activity was conducted using skin analyzer apparatus. The aging parameters were moisture, evenness, pore size, black spot, and wrinkle of the skin. The anti-acne evaluation was conducted on color, shape, volume, and number of acne. The data were collected for 4 weeks. Results: The anti-aging evaluation of andaliman PGM showed that the and AEE PGM could pretend the skin moisture, skin evenness, small pore size, and declined in number of black spot and wrinkle. The anti-acne evaluation showed the healing of acne after 4 weeks treatment. Conclusion: It is concluded that and AEE PGM can be used as an effective anti-aging and anti-acne dosage form.

Biopharmaceutical assessment of a polycomplex matrix system based on carbomer 940 and Eudragit® EPO for colon-specific drug delivery

2011 ◽  
Vol 45 (8) ◽  
pp. 491-494 ◽  
Author(s):  
R. I. Mustafin ◽  
T. V. Kabanova ◽  
I. I. Semina ◽  
A. V. Bukhovets ◽  
V. R. Garipova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Specific Drug ◽  
Matrix System ◽  
Colon Specific Drug Delivery ◽  
Carbomer 940

Decontamination of mobile phones and electronic devices for health care professionals using a chlorhexidine/carbomer 940® gel

2018 ◽  
Vol 13 (1) ◽  
pp. 192-198
Author(s):  
Rafael Muniz de Oliveira ◽  
Nereida Mello da Rosa Gioppo ◽  
Jancineide Oliveira de Carvalho ◽  
Francilio Carvalho Oliveira ◽  
Thomas Jay Webster ◽  
...  
Keyword(s):  
Health Care ◽  
Mobile Phones ◽  
Health Care Professionals ◽  
Electronic Devices ◽  
Carbomer 940

scholarly journals Impregnated Nanofibrous Mat with Nanogel of Citrus sinensis Essential Oil as a New Type of Dressing in Cutaneous Leishmaniasis

2020 ◽  
Vol 11 (4) ◽  
pp. 11066-11076
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Citrus Sinensis ◽  
Leishmania Major ◽  
Electrospun Nanofibers ◽  
In Vivo Studies ◽  
Excellent Candidate ◽  
New Type ◽  
Carbomer 940 ◽  
Better Than

Leishmaniases are a group of diseases caused by the Leishmania genus. Essential oils (EO)s have recently received more attention for the development of new green drugs. In this study, Citrus sinensis EO was used as an antileishmanial agent; its half-maximal inhibitory concentration (IC50) against promastigotes of Leishmania tropica and Leishmania major was observed at 151.13 and 108.31 µg/mL. After that, the nanoemulsion-based nanogel of C. sinensis was prepared to improve its stability, potency, and facilitated topical usage. By adding carbomer 940 (2% w/v) to the prepared nanoemulsion with a 225 ± 7 nm droplet size, the nanogel was prepared. The nanogel was then impregnated on the electrospun nanofibers of chitosan-polycaprolactone, diameter = ~ 200 nm. The prototype's leishmanicidal effect was substantially better than the non-formulated EO; both species' viabilities were reduced to ~ 0%. The prepared sample could be used as a new type of dressing for cutaneous leishmaniasis; moreover, it could be considered an excellent candidate for in-vivo studies.

scholarly journals Optimasi Formula Basis Sediaan Edible Film dengan Kombinasi Polimer Carbomer 940 dan Kappa Karagenan

2020 ◽  
Vol 5 (3) ◽  
Author(s):  
Patihul Husni ◽  
Wirna Grace Tua Sihombing ◽  
Taofik Rusdiana
Keyword(s):  
Edible Film ◽  
Solvent Casting ◽  
Carbomer 940

Salah satu bentuk sediaan mukoadhesif adalah edible film. Bentuk ini dapat meningkatkan waktu tinggal pada mukosa dibandingkan dengan gel oral. Pada penghantaran lokal untuk penyakit mulut seperti sariawan, edible film membantu melindungi luka permukaan sehingga rasa sakit dapat berkurang serta pengobatan lebih efektif. Tujuan penelitian ini adalah optimasi formula basis sediaan edible film menggunakan kombinasi Carbomer 940 dan kappa karagenan dengan merancang beberapa formula secara bertahap sampai didapatkan komposisi formula yang baik. Metode pembuatan sediaan edible film  yang digunakan dalam penelitian ini adalah solvent casting yang evaluasinya berupa kemampuan formula membentuk lembaran sediaan edible film yang kering, tidak lengket dan tidak mudah sobek. Hasil optimasi menunjukkan bahwa basis sediaan edible film menggunakan kombinasi Carbomer 940 dan kappa karagenan menghasilkan sediaan edible film yang baik yaitu formula dengan konsentrasi karagenan sebesar 1,5% dan Carbomer 940 antara 0,1-0,5%. Berdasarkan hal tersebut dapat disimpulkan bahwa formula dengan kombinasi Carbomer 940 1,5% dan kappa karagenan 0,1-0,5% dapat digunakan sebagai basis sediaan edible film.Kata kunci: Mukoadhesif, Edible Film, Polimer, Carbomer, Kappa karagenan 

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