scholarly journals The potential effect of pandan wangi leaf “pandanus amaryllifolius roxb.’’ extract from Indonesia as time sleep inductor

2019 ◽  
pp. 5-7
Author(s):  
Nita Tri Sulistiyati ◽  
Riandini Aisyah ◽  
EM Sutrisna
Keyword(s):  
Sleep Disturbances ◽  
Leaf Extract ◽  
Traffic Accidents ◽  
Sleep Onset ◽  
Potential Effect ◽  
Control Group ◽  
Control Group Design ◽  
Post Test ◽  
Experimental Laboratory ◽  
Pandanus Amaryllifolius

Sleep plays a role in restoring the body's biochemical and physiological processes which decrease when awake. People is not familiar yet with sleep disturbances, so they rarely seek help. Sleep disturbances can cause family problems and are at risk of fatal traffic accidents. Fragant Pandan leaves (Pandanus amaryllifolius Roxb.) contains alkaloids, saponins and flavonoids which can provide a hypnotic sedative effect. The purpose of this study was to determine the effect of fragant Pandan leaf extract (Pandanus amaryllifolius Roxb.) administration in shortening the sleep induction time of male Swiss Webster strain mice. A post-test only design experimental laboratory study was conducted with control group design. The test animals used were 25 Swiss Webster male mice divided into five groups randomly : G1 group was given distilled water, G2 was given diazepam dose 1 mg / KgBB, the G3, G4 and G5 groups were given fragant Pandan leaf extract with a dose of 4 mg/25g BB, 6 mg/25g BB and 8mg/25g BB, respectively. One Way ANOVA statistical test showed significant differences in mice sleep onset (p=0.000) between groups. The results of the Post Hoc test using LSD analysis showed that there were significant differences between positive controls with groups G3, G4 and G5. Fragrant Pandan leaf extract dose of 8 mg/g BB can shorten the time of mice sleep induction male Swiss Webster strain mice. While the dose of 4 mg/g BB cannot shorten the time of induction of sleeping mice. Keywords: Fragant Pandan leaf extract; Hypnotic-sedative; Sleep disturbances.

scholarly journals Pengaruh Spirulina terhadap Kadar beta hCG Tikus Bunting yang Diinduksi Interleukin-6 (Studi Bahan Biologis Tersimpan)

2021 ◽  
Vol 10 (1) ◽  
pp. 84
Author(s):  
Harry K Gondo ◽  
Elizabeth Haryanti
Keyword(s):  
Interleukin 6 ◽  
Potential Effect ◽  
Control Group ◽  
Antioxidant Vitamin ◽  
Control Group Design ◽  
Pregnant Rats ◽  
Beta Hcg ◽  
Post Test ◽  
Experimental Laboratory ◽  
Β Hcg

Preeclampsia is multisystem specific disorder in pregnancy. Preeclampsia characterized by increased cytokine Interleukin-6 and β hCG (human Chorionic Gonadotropin). Spirulina is green-blue alga contain antioxidant, vitamin, mineral. Spirulina has a potential effect as antiinflammation. The aim of this research was to know effect of spirulina to repair trophoblast at β hCG level of pregnant rats with preeclampsia condition (biology material collecting). The type of this research is an experimental laboratory with post-test only control group design. Preeclampsia models induced by Interleukin-6. Twenty-five rats were grouped to five group: Control, Control Positive, Spirulina dose 10, 20, and 40 mg/day, at the end of treatment, β hCG level were analyzed. Statistical analysis was used by one-way ANOVA. The results of this study showed that β hCG level of group spirulina dose 10 mg/day (85.11 ± 25.70 mIU/ml) did not significantly different (p=0.353), with group Dose 20 mg/day (79.65 ± 10.65 mIU/ml). Level of β hCG in Spirulina group dose 40 mg/day were 93.28 ± 17.12 mIU/ml. The spirulina groups dose 10 mg/day and dose 40 mg/day did not show significantly different level of β hCG (0.730> 0.05). Administration of spirulina at a dose of 10 mg was able to significantly reduce levels of β hCG (P <0.05) than at doses of 20 mg / day and 40 mg/ day.

scholarly journals Antibacterial Activity of Cherry Leaf (Muntingia calabura L.) Extract on Porphyromonas gingivalis Growth

el–Hayah ◽  
2017 ◽  
Vol 6 (2) ◽  
pp. 45
Author(s):  
Dewi Muflikhah ◽  
Amandia Dewi Permana Shita ◽  
Pudji Astuti
Keyword(s):  
Porphyromonas Gingivalis ◽  
Dental Plaque ◽  
Maximum Concentration ◽  
Leaf Extract ◽  
Control Group ◽  
Zone Of Inhibition ◽  
Control Group Design ◽  
Periodontal Tissues ◽  
Post Test ◽  
Digital Caliper

<em>Pathological inflamatory condition that often complained and neglected in Indonesian is periodontal disease . The main ethiology of periodontitis is dental plaque. Porphyromonas gingivalis is one of anaerobic Gram-negative bacteria which contained in dental plaque. Increase in P. gingivalis colony will escalate damage in periodontal tissues. One of the alternative to control microorganism growth is by antibacterial agents in cherry leaf based material which contain flavonoids, saponins and tannins as active subtance. <strong>Objective</strong>: The aim of this study  was to determine the effect of cherry leaf extract to P. gingivalis growth and to determine the maximum concentration in inhibiting the growth of P. gingivalis. <strong>Methods:</strong> This research used experimental laboratories methods with the post test only control group design. This research used well diffusion with 8 samples of each group. BHI-A was filled into petridish and inoculated by P. gingivalis. The holes was made 5 mm diameter and was filled 20μl cherry leaf extract concentration 100%, 50%, 25%, 12,5%, 6,25%, aquadest steril (K-) and Chlorhexidine (K+). Petridish was placed in desicator and incubator at 37<sup>0</sup>C for 24 hours. Zone of inhibition were measured by using digital caliper. <strong>Result and</strong> <strong>Conclusion: </strong>Cherry leaf extract contain antibacterial effect which can inhibit P. gingivalis increase in number with maximum concentration of 100%.</em>

scholarly journals Effectiveness of Averrhoa bilimbi leaf extract on spermatogenic cells of mice (Mus Musculus L.) hyperglycemia

2021 ◽  
Vol 4 (2) ◽  
pp. 273-279
Author(s):  
Ida Ayu Manik Damayanti ◽  
Putu Indrayoni ◽  
Ni Wayan Sukma Antari ◽  
Anak Agung Istri Mas Padmiswari
Keyword(s):  
Leaf Extract ◽  
Sperm Quality ◽  
Quality Parameters ◽  
Control Group ◽  
P Value ◽  
Spermatogenic Cells ◽  
Male Mice ◽  
Control Group Design ◽  
Post Test

The purpose of this study was to determine the effect of giving Averrhoa bilimbi leaf extract on sperm quality of diabetic mice. This research is a pure experimental (true experimental) with a post-test-only control group design approach. This research was conducted by giving Averrhoa bilimbi leaf extract as a treatment for 42 days in male mice. Sperm quality parameters observed included viability, abnormalities, motility in sperm. In all variables, the results of the data showing a normal distribution with a p-value > 0.05 were then carried out with a parametric test using one-way ANOVA. Averrhoa bilimbi leaf extract can increase the number of spermatogenic cells in male mice with hyperglycemia.

scholarly journals Gambaran Histopatologi Pankreas Tikus Putih (Rattus norvegicus) Pasca Perlakuan Iskemia-Reperfusi Ginjal

2019 ◽  
Vol 13 (1) ◽  
pp. 58
Author(s):  
Elva Rosiana ◽  
Wiwit Ade Fidiawati ◽  
Darmawi Darmawi
Keyword(s):  
Tissue Damage ◽  
Control Treatment ◽  
Laboratory Research ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
White Rats ◽  
Post Test ◽  
Experimental Laboratory ◽  
Histopathologic Feature

Ischemic-reperfusion injury is defined by a condition of hypoperfusion in the spesific organ followed by reperfusion(reoxygenation) inducing tissue damage. Tissue damage produces reactive oxygen species (ROS) leading to oxidativestress condition. Oxidative stress mediate the lipid peroxidation reactions, harm the cell and finally facilitate the celldeath. The aim of this study was to evaluate the histopathologic feature of white rat’s pancreas post renal ischemiareperfusion.This study was an experimental laboratory research with post-test-only control group design including 20male white rats. Rats were divided into 5 groups, control, treatment 1 (45 minutes ischemia), treatment 2 (45 minutesischemia followed by 1 hour reperfusion), treatment 3 (45 minutes ischemia followed by 2 hours reperfusion) andtreatment 4 (45 minutes ischemia followed by24 hours reperfusion). We found the change of the histopathologicalcharacteristics of white rat’s pancreas in term of edema, leukocyte infiltration and vacuolization.

scholarly journals JUS SEMANGKA MENURUNKAN NEUTROFIL TIKUS JANTAN GALUR WISTAR YANG TERPAPAR ASAP ROKOK

2018 ◽  
Vol 11 (2) ◽  
pp. 166
Author(s):  
Rizky Prihandari ◽  
Lailatul Muniroh
Keyword(s):  
Cigarette Smoke ◽  
Hazardous Substances ◽  
Male Rats ◽  
Laboratory Research ◽  
Control Group ◽  
Control Group Design ◽  
Treatment Groups ◽  
Wistar Strain ◽  
Post Test ◽  
Experimental Laboratory

Cigarette smoke contains many hazardous substances and free radical which affect respiratory system. Watermelon “Sugar Baby” juice contain lycopene as antiinfl ammation. The aim of this research was to analyze the effect of watermelon as antiinfl ammation toward neutrophils count in wistar strain male rats exposed by  cigarette smoke. This study was an experimental laboratory research with pre and post test control group design. Sample consisted of 24 wistar strain male rats with ±150-230 grams weight and 3 months old which were divided into four groups. Control group was given placebo (aquadest) and treatment groups were given w atermelon juice with terraced quantity (1.5 ml, 2.5 ml, and 3.5 ml). Every group was given two sticks of cigarette smoked per day during two weeks then smoked with treatment during one week. Neutrophil from peripheral smear was observed by manual method and statistically analyzed using Anova Mixed Design and continued with One Way Anova. The result showed signifi cant increased of  neutrophil at second observation on control group (p=0.002) and treatment groups (p=0.000). Signifi cance decreased also found in the treatment groups’s at third observation p=0.000. Signifi cant between each group p= 0.017. There was signifi cant different between control and treatment groups but there was no signifi cant different between each treatment groups. This study concluded that there was decreased of  neutrophil in wistar strain male rats which were given w atermelon juice 1.5 ml, 2.5 ml, and 3.5 ml during infl ammation. 3.5 ml w atermelon juice which were given showed better result as antiinfl ammation..

scholarly journals THE EFFECT OF SEMBUNG LEAF EXTRACT (BLUMEA BALSAMIFERA) ON THE NUMBER AND DIAMETER OF RATS LEYDIG CELLS INDUCED BY HIGH-FAT DIET

2021 ◽  
Vol 21 (no 1) ◽  
Author(s):  
Gede Widhiantara ◽  
Anak Agung Ayu Putri Permatasari ◽  
Putu Angga Wiradana
Keyword(s):  
Treatment Group ◽  
Leydig Cells ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Control Group ◽  
Control Group Design ◽  
Core Diameter ◽  
Post Test ◽  
Male Wistar Rats ◽  
The Mean

This study aims to determine the morphology of Leydig cells in hyperlipidemic wistar rats after having administered with sembung (Blumea balsamifera) extract orally. This study utilised a randomized post-test only control group design. The sample in this study were 16 adult male wistar rats (Rattus novergicus) aged 3-4 months with a body weight of 150-200 grams, which were equally and randomly divided into two groups, namely control group (hyperlipidaemia and sterile aquadest) and treatment group (hyperlipidaemia and sembung leaf extract). Hyperlipidaemia was induced with lard administration for 50 days. Data were analysed statistically using the Independent t-test. The results showed that the number of Leydig cells in the treatment group was higher than the control group with 68.13 ± 1.89 and 55.63 ± 1.92 cells respectively (P <0.05). In addition, the mean Leydig cell core diameter of the control group, 5.00 ± 0.34 µm, was smaller compared to the treatment group which was 5.80 ± 0.20 µm (P <0.05). It can be inferred that sembung leaf extract provides a protective effect against damage to Leydig cells due to hyperlipidaemia.

scholarly journals TINGKAT KEKERASAN PERMUKAAN RESIN KOMPOSIT AKIBAT MASA KEDALUWARSA MATERIAL

2018 ◽  
Vol 5 (1) ◽  
pp. 45
Author(s):  
Yuvika Intan Ristian Putri ◽  
Muhammad Dian Firdausy ◽  
Niluh Ringga Woroprobosari
Keyword(s):  
Surface Hardness ◽  
Composite Resins ◽  
Control Group ◽  
Expiration Date ◽  
Control Group Design ◽  
Expiry Date ◽  
Post Test ◽  
Experimental Laboratory ◽  
Post Hoc ◽  
One Way Anova

Background: Aplication of composites resin in relatively small amount as a restorative material often causing the material reaches its expiry date before all of the material can be used. Composites resin that have passed the expiry date would affect charateristic of the material. The aim of this study was to investigate surface hardness difference of composite resins based on material expiration date.Methods: This research was an experimental laboratory using post test only with control group design. Samples for this research were 27 divided into 3 groups based on its expiration date (2016, 2018 and 2019). The surface hardness was measured by Shore D Hardness. The result of this research were tested with One Way Anova and Post Hoc test LSD.Result: The lowest surface hardness result was measured on group 1 (81.02SHD) and the highest was group 3 (94.72 SHD). The result of One Way Anova test showed that there was signifcant differences in all groups (p<0.05). Post Hoc LSD test showed difference signifcantly between each groups.Conclusion: It can be concluded that there was signifcant difference of composite resins surface hardness based on material’s expiration date

scholarly journals Inhibitory Power of Papaya Leaves to the Adhesion of Streptococcus Mutans Bacteria to Neutrophils

2021 ◽  
Vol 14 (3) ◽  
pp. 1381-1387
Author(s):  
Nining Kurniati
Keyword(s):  
Streptococcus Mutans ◽  
Control Group ◽  
Mean Square ◽  
Control Group Design ◽  
Minimum Concentration ◽  
Post Test ◽  
Experimental Laboratory ◽  
Inhibitory Power ◽  
Adhesion Index

Papaya leaves contain several active substances that are thought to inhibit bacterial adhesion. This study aims to determine the inhibitory power of papaya leaf extraction and papaya leaf infusion to the adhesion of Streptococcus mutans bacteria to neutrophils and differences in inhibition in various concentrations. The method used is an in vitro experimental laboratory with a post-test-only control group design. The sample consisted of several concentrations of papaya leaf extraction and papaya leaf infusion (control, 25%, 50%, 75%, and 100%). The treatment group was added with neutrophil isolates and incubated for 3 hours, then exposed to Streptococcus mutans for 2.5 hours. Knowing the adhesion index can be done by calculating the average number of Streptococcus mutans attached to 100 neutrophils. The results showed successively with rounding in control, 25%, 50%, 75%, 100% papaya leaf infusion, adhesion of 9237, 8929, 7436, 3870, 3162 bacteria to neutrophils occurred. The minimum concentration of 25% papaya leaf extraction and 50% papaya leaf infusion can inhibit the adhesion of Streptococcus mutans to neutrophils. There is a difference in the ability between papaya leaf extraction and papaya leaf infusion in inhibiting the adhesion of Streptococcus mutans to neutrophils as follows: papaya leaf extraction 25% to papaya leaf infusion 25% obtained sig value ≥0.001* with a mean square of -16.38, papaya leaf extraction 50% to Papaya leaf infusion 50% got a sig value of ≥0.001* with a mean square of -42.91, 75% papaya leaf extraction to 75% papaya leaf infusion got a sig value of ≥0.001* with a mean square of -28.85 and 100% papaya leaf extraction to 100% papaya leaf infusion obtained a sig value of ≥0.001* with a mean square of -26.11.

scholarly journals The effect of papaya leaf extract (Carica papaya l.) to the bleeding time on mice with trombositopenia

2018 ◽  
Vol 6 (3) ◽  
pp. 133
Author(s):  
Saktya Yudha Ardhi Utama
Keyword(s):  
Treatment Group ◽  
Leaf Extract ◽  
Carica Papaya ◽  
Bleeding Time ◽  
Control Group ◽  
Control Group Design ◽  
Treatment Groups ◽  
Group Design ◽  
Post Test ◽  
Mean Time

<p align="center"><strong>ABSTRAK</strong></p><p><strong>Latar belakang: </strong>Trombositopenia merupakan suatu keadaan jumlah trombosit di bawah 150.000/mm<sup>3</sup>, hal ini dapat menyebabkan perdarahan yang apabila tidak ditangani dengan baik dapat berujung pada kematian. Beberapa tindakan yang dapat dilakukan untuk mengatasi  trombositopenia, salah satunya adalah dengan tanaman daun pepaya.</p><p><strong>Tujuan:</strong> untuk menganalisis pengaruh pemberian ekstrak daun pepaya terhadap <em>bleeding time</em> (waktu perdarahan).</p><p><strong>Metode : </strong>Desain penelitian ini menggunakan <em>true experimental</em> dengan rancangan <em>post test only control group design</em>. Sampel dalam penelitian ini sejumlah 30 ekor mencit jantan (<em>Mus musculus</em>) yang dibagi menjadi lima kelompok. Kelompok pertama sebagai kelompok kontrol negatif (CMC Na 0,5%), kelompok kedua sebagai kontrol positif (CMC Na 0,5%)<a href="file:///D:/peer/VOLUME%206/VOLUME%206%20NOMOR%203/KIRIM%20LINTANG%20VOLUME%206%20ISSUE%203,%202018%20(AKREDITASI)/6.%20Revisi%20Publish%20JGDI%20(1)_Yudha.rtf#_msocom_1">[a1]</a> <a href="file:///D:/peer/VOLUME%206/VOLUME%206%20NOMOR%203/KIRIM%20LINTANG%20VOLUME%206%20ISSUE%203,%202018%20(AKREDITASI)/6.%20Revisi%20Publish%20JGDI%20(1)_Yudha.rtf#_msocom_2">[A2]</a> , kelompok ketiga diberi esktrak etanol 96% daun pepaya dosis 0,5g/kgBB, kelompok keempat diberi esktrak etanol 96% daun pepaya dosis 1g/kgBB, kelompok kelima diberi esktrak etanol 96% daun pepaya dosis 2g/kgBB. Pengumpulan data menggunakan lembar pengukuran <em>bleeding time</em>, yang dianalisa dengan uji ANOVA.</p><p><strong>Hasil: </strong>Hasil penelitian ini menunjukkan bahwa didapatkan nilai <em>p</em>&lt;0.0001 dengan rerata waktu paling cepat antara kelompok perlakuan yaitu kelompok perlakuan dengan dosis 2g/kgBB (2.74±0.14). Hal ini menunjukkan bahwa terdapat perbedaan signifikan antar semua kelompok. <a href="file:///D:/peer/VOLUME%206/VOLUME%206%20NOMOR%203/KIRIM%20LINTANG%20VOLUME%206%20ISSUE%203,%202018%20(AKREDITASI)/6.%20Revisi%20Publish%20JGDI%20(1)_Yudha.rtf#_msocom_3">[a3]</a> <a href="file:///D:/peer/VOLUME%206/VOLUME%206%20NOMOR%203/KIRIM%20LINTANG%20VOLUME%206%20ISSUE%203,%202018%20(AKREDITASI)/6.%20Revisi%20Publish%20JGDI%20(1)_Yudha.rtf#_msocom_4">[A4]</a> </p><p><strong>Kesimpulan: </strong>Kesimpulan dari penelitian ini adalah pemberian ekstrak daun pepaya (<em>Carica papaya L.</em>) dapat mempercepat <em>bleeding time</em> (waktu perdarahan).</p><p><strong>KATA KUNCI: </strong>daun pepaya; <em>bleeding time, </em>trombositopenia<strong></strong></p><p align="center"> </p><p align="center"><strong>ABSTRACT</strong></p><p><strong><em>Background</em></strong><strong>: </strong>Thrombocytopenia is a condition of platelet counts below 150,000/mm<sup>3</sup>, this may cause bleeding which, if not handled properly, may lead to death. Some actions that can be done to overcome thrombocytopenia, one of which is with papaya leaf.</p><p><strong>Objectives:</strong> This study aims to analyze the effect of giving papaya leaf extract to bleeding time.</p><p><strong><em>Methods:</em></strong><strong> </strong>This research design uses true experimental with design of post-test only control group design. The sample in this study were 30 male mice (<em>Mus musculus</em>) divided into five groups. The first group as the negative control group (CMC Na 0.5%), the second group as the positive control (CMC Na 0.5%), the third group was given ethanol 96% extract papaya leaf dose 0.5g/kgBW, the fourth group was given ethanol 96% extract papaya leaf dose 1g/kgBW, the fifth group was given ethanol 96% extract papaya leaf dose 2g/kgBW. Data collection using measurement sheet of  bleeding time which were analyzed by ANOVA test.</p><p><strong><em>Results:</em></strong><strong> </strong>The results of this study showed that p&lt;0.0001 the fastest mean time occur between treatment groups that is treatment group with dose 2g/kgBW (2.74±0.14). In the bleeding time variables p&lt;0.0001 the fastest mean time occur between treatment groups that is treatment group with dose 2g/kgBW (2.74±0.14). This result shows that there are significant differences between every groups.</p><p><strong><em>Conclusion:</em></strong><strong> </strong>The conclusion of this research is giving papaya leaf extract can increase bleeding time.</p><p> </p><p><strong>KEYWORDS: </strong>leaf of papaya, bleeding time, thrombocytopenia.</p><p> </p>

scholarly journals EFEKTIVITAS KOMBINASI EKSTRAK DAUN SIRIH MERAH (Piper Crocatum) DAN EKSTRAK BIJI ALPUKAT (Persea americana) DALAM MENGHAMBAT PERTUMBUHAN Candida albicans

2017 ◽  
Vol 2 (2) ◽  
pp. 86 ◽  
Author(s):  
Vini Anggraini ◽  
Masfufatun Masfufatun
Keyword(s):  
Candida Albicans ◽  
Leaf Extract ◽  
Seed Extract ◽  
Persea Americana ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Betel Leaf ◽  
Post Test ◽  
Avocado Seed

Abstrak   Candida albicans merupakan salah satu mikrooganisme penyebab infeksi kandidiasis. Daun sirih merah (Piper crocatum) dan biji alpukat (Persea americana) telah diteliti dapat menghambat pertumbuhan Candida albicans. Tujuan penelitian ini adalah untuk mengetahui efektivitas kombinasi daun sirih merah (Piper crocatum) dan ekstrak biji alpukat (Persea americana) dalam menghambat pertumbuhan Candida albicans. Penelitian bersifat eksperimental laboratorium (true experiment) dengan pendekatan post test control group design only. Daun sirih merah dan biji alpukat diekstraksi secara maserasi menggunakan pelarut etanol.    Pada masing-masing ekstrak etanol dilakukan uji pendahuluan untuk mengetahui konsentrasi optimum ektrak dalam memnghambat pertumbuhan C. albicans. Daya Hambat pertumbuhan C. albicans diuji menggunakan metode difusi. Hasil penelitian menunjukkan bahwa ekstraks daun sirih merah dan biji alpukat masing-masing memiliki daya hambat terbesar pada konsentrasi 10%. Kombinasi ekstrak daun sirih merah dan ekstrak biji alpukat memiliki daya hambat yang signifikan terhadap pertumbuhan Candida albicans dibandingakan kontrol negatif, kontrol positif dan ekstrak daun sirih merah. Dengan demikian kombinasi ekstrak daun sirih dan biji aplukat etanol berpotensi sebagai antifungi dalam menghambat pertumbuhan C. albicans sehingga diharapkan bisa mengurangi prevalensi kandidiasis. Kata Kunci :    daun sirih merah,  biji alpukat, Candida albicans,                                                           Abstract Candida albicans is one of the microbialism that causes candidiasis infection. Red betel leaf (Piper crocatum) and avocado seed (Persea americana) have been studied to inhibit the growth of C. albicans. The purpose of this study was to determine the effectiveness of red betel leaf (Piper crocatum) and avocado seed extract (Persea americana) combination in inhibiting the growth of C. albicans. Research is experimental laboratory (true experiment) with post test approach control group design only. Red betel leaf and avocado seeds are extracted by maceration using ethanol solvent. In each ethanol extract, a preliminary test was performed to find out the optimum concentration of extract in inhibiting the growth of C. albicans. C. albicans growth retardant was tested using diffusion method. The results showed that the extract of red betel leaf and avocado seeds each had the greatest inhibitory concentration at 10%. The combination of red betel leaf extract and avocado seed extract have significant inhibitory effect on C. albicans growth compared to negative control, positive control and red betel leaf extract. Thus, the combination of betel leaf extract and ethanol  seed has the potential as an antifungal in inhibiting the growth of C. albicans so it is expected to reduce the prevalence of candidiasis. Keywords: red betel leaf, avocado seed, Candida albicans, 

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