scholarly journals Anti-Fungal Effects 0f Ambon Banana Skin Extract (Musa paradisiaca Linn. Var. Sapientum) on Candida albicans ATCC® 10231 ™ (In Vitro)

2021 ◽  
Vol 5 (3) ◽  
Keyword(s):  
Candida Albicans ◽  
Inhibition Zone ◽  
The Body ◽  
Diffusion Method ◽  
Control Group ◽  
Dilution Method ◽  
Skin Extract ◽  
Fungal Cell ◽  
Potato Dextrose Broth ◽  
Musa Paradisiaca

Introduction: Disease is a global problem for health. One of the most common infectious diseases is a disease caused by fungi (mycosis), a species of Candida (candidiasis) caused by Candida albicans. These bananas are generally often consumed daily by Indonesians. Ambon banana skin extract (Musa Paradisiaca Linn. Var.Sapientum) is a nutritious medicinal plant, because Ambon banana skin waste has active antifungal compounds, namely tannins, flavonoids, quinones, phenols, and steroids. Which can damage fungal cell wall membrane proteins, damage the DNA chain causing brittle cell walls resulting in fungal cell death. Objectives: Research to determine the zone of inhibition, MIC and MBC of Ambon banana skin extract at concentrations of 100%, 90%, 80%, 70%, 60%, and 50% against Candida albicans ATCC® 10231™. Method: Laboratory experimental research with a post test only control group research design, the sample used was 18 samples, tested with the Anova test. In determining the inhibition zone using the well diffusion method, the measurement of the inhibition zone uses the calipers, MIC and MBC using the dilution method. Ambon banana skin was extracted by maceration method using 70% ethanol solvent, carried out 6 treatments with various concentrations. Each treatment was repeated 3 times. Results: The inhibition zone research at concentrations of 100%, 90%, 80%, 70%, 60%, and 50% with an average of 13.2mm 11.6mm 11.3mm, 10.5mm, 9.9mm, 8.3mm. The MIC of each concentration was clear and equalized according to the standard of 0.5 McFarland (1.5 x 108 CFU / ml) with potato dextrose broth medium, and the MBC was emphasized with potato dextrose agar (PDA) medium. Conclusion Inhibition zone concentrations of 100% -70% indicate strong criteria, 60-50% including weak criteria. MIC obtained at a concentration of 50%, MBC at a concentration of 60%. In this study, using a concentration of 70% indicates an average diameter of above 10mm, meaning that it is in accordance with the David and Stout method which states that the criteria are strong at an average of 10-20 mm. a concentration of 70% is used because it is effective in killing Candida albicans ATCC® 10231™, 100% -80% has a high toxicity which can cause toxic effects on all organisms such as the body, fungi, plants, etc.

scholarly journals Potensi Antifungi Tangkai Daun Jarak Pagar Terhadap Pertumbuhan Candida albicans

2017 ◽  
Vol 3 (2) ◽  
pp. 63
Author(s):  
Ni Made Niagita Wiratni ◽  
I Nyoman Jirna ◽  
IGA. Sri Dhyanaputri
Keyword(s):  
Candida Albicans ◽  
Jatropha Curcas ◽  
Vaginal Discharge ◽  
Average Diameter ◽  
Inhibition Zone ◽  
Diffusion Method ◽  
Dilution Method ◽  
Common Symptom ◽  
Antifungal Potential ◽  
Potential Test

<p style="text-align: justify;">Jatropha curcas twigs are part of the Jatropha curcas which can be utilized as herbal treatment by the community to overcome the vaginal discharge problem. Vaginal discharge is a common symptom experienced by most women caused by Candida albicans infection. This research used the true experiment with posttest only control design which aimed to know the content of phytochemistry and antifungal potential of Jatropha curcas twigs extract on Candida albicans growth. Extract of Jatropha curcas in this study was obtained through a solvent extraction process using ethanol 96% by the method of maceration. The method used for the phytochemistry test was a qualitative method, while for the antifungal potential test was done by diffusion method with the concentration of 10%, 25%, 30%, 40% and 50%. The results of Phytochemistry test showed that Jatropha curcas twigs extracts are saponins, tannins, and flavonoids, but no alkaloid compounds were found, however a test result of the antifungal potential test showed that the average diameter of inhibition zone of Candida albicans growth is 0 mm. The conclusion of this study is Jatropha curcas twigs extracts can not inhibit Candida albicans growth, For other researchers which use jatropha curcas twigs, are suggested to do a phytochemical test quantitatively and to test the antifungal potential with dilution method.

scholarly journals AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL BIJI KAPULAGA JAWA (Amomum compactum Soland. ex Maton) TERHADAP Streptococcus pyogenes

EKOLOGIA ◽  
2020 ◽  
Vol 20 (1) ◽  
pp. 31-39
Author(s):  
Oom Komala ◽  
. Ismanto ◽  
Muhammad Alan Maulana
Keyword(s):  
Antibacterial Activity ◽  
Streptococcus Pyogenes ◽  
Pathogenic Bacteria ◽  
Inhibition Zone ◽  
Positive Control ◽  
Negative Control ◽  
Diffusion Method ◽  
Dilution Method ◽  
Natural Treatment ◽  
Amomum Compactum

Streptococcus pyogenes is one of the pathogenic bacteria that causes pharyngitis. Natural treatment to overcome these problems is to use cardamom seeds. The purpose of this study was to test the antibacterial activity, determine the concentration of inhibitory zone and phytochemical compounds from  ethanol 96% extract of Java cardamom seeds (Amomum compactum Soland. Ex Maton) against Streptococcus pyogenes. The method is used   solid dilution and paper disc diffusion method. The solid dilution method is used for the Minimum Inhibitory Concentration (MIC) test with a concentration of 1.25%, 2.5%, 5% and 7.5% while the paper diffusion method is used for the Inhibition zone Diameter (IZD)  using five treatments namely three concentrations of ethanol 96% extract of Java cardamom seeds (7.5%, 10% and 12%), one positive control of amoxicillin 0.01 mg/mL and one negative control of sterile distilled water. IZD data were  analyzed using ANOVA with a confidence level of 95% and α = 0.05 and Duncan's further tests to determine differences between treatments. The results showed that the MIC  was at a concentration of 7.5% while for the IZD test which had the highest activity there was a concentration of 12% with an average inhibition diameter of 12.03 ± 0.14 mm. In addition, ethanol 96% extract of Java cardamom seeds contain alkaloids, flavonoids, terpenoids and tannins which function in antibacterial activity.

scholarly journals JUMLAH KOLONI CANDIDA ALBICANS PADA PLAT RESIN AKRILIK HEAT CURED SETELAH DILAKUKAN PERENDAMAN EKSTRAK DAUN KEMANGI (OCIMUM BASSILICUM LINN) 50%

2020 ◽  
Vol 16 (2) ◽  
pp. 61-63
Author(s):  
Kadek Ayu Wirayuni ◽  
◽  
Sintha Nugrahini
Keyword(s):  
Candida Albicans ◽  
Leaf Extract ◽  
Acrylic Resin ◽  
The Body ◽  
Control Group ◽  
Control Group Design ◽  
Denture Stomatitis ◽  
Parametric Test ◽  
Group Design ◽  
Cleaning Methods

Accumulation of plaque and food scraps on an acrylic resin base will increase bacterial colonies and C. albicans which will cause denture stomatitis. Maintenance of denture hygiene using mechanical, chemical and combination of two methods. Basil leaf extract contain essential oils which are important in fight against resistant C. albicans biofilms. The purpose of this study was to determine the comparison of C. albicans colonies after cleaning various denture cleaning methods. The method of this study is used an experimental method, the study design is posttest only with control group design. Sample size of heat-cured acrylic resin plate is 40x12x3mm. this study use Kruskall-Wallis test and Mann-Whitney test as data analysis for comparison tests between groups (non-parametric test). The results showed that there were significant differences between the various cleansing methods used in reducing C. albicans colonies. The compotition of flavonoids basil leaf extract is anti-microbial which can prevent the entry of fungi that harm the body.

scholarly journals Quantitative Phytochemical Analysis and Antimicrobial Potential of the Ethanol and Aqueous Extracts of the Leaf, Stem and Root of Chromolaena odorata (Asteraceae)

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Ugwoke C E C ◽  
Orji J. ◽  
Anze S P G ◽  
Ilodibia C V
Keyword(s):  
Escherichia Coli ◽  
Candida Albicans ◽  
Aspergillus Niger ◽  
Infectious Diseases ◽  
Antimicrobial Effect ◽  
Inhibition Zone ◽  
Salmonella Typhi ◽  
Diffusion Method ◽  
Phytochemical Analysis ◽  
Chromolaena Odorata

Background: Plants contain secondary metabolites or phytochemicals, which when consumed by humans give therapeutic effect. This study therefore analyzed the phytochemical composition of Chromolaena odorata so as to give an idea of its possible pharmacological potentials. An antimicrobial assay was also carried out to verify claims on its use in the treatment of infectious diseases. Methods: The experimental procedure involved collection of the leaf, stem and root of the plant from the wild, authenticating the samples and drying under shade to facilitate pulverization. Preliminary qualitative and quantitative phytochemical analyses were done using standard methods to reveal the presence and percentage composition of basic phytochemicals. The powder was also macerated in ethanol and water to produce ethanol and aqueous crude extracts that were reconstituted in normal saline to concentrations (mg/ml) of 150, 100, 75 and 50. Clinical isolates of Staphylococcus aureus, Salmonella typhi, Escherichia coli, Aspergillus niger and Candida albicans were screened for sensitivity to the extracts using the agar well diffusion method. Results: The plant parts contain alkaloids, tannins, flavonoids, saponins, terpenoids, phenols, cardiac glycosides, and sterols at varying concentrations. The leaf however had highest concentration of almost all phytochemicals present. The antimicrobial activity of the plant was concentrationdependent in all parts of the plant and both extracts. Aspergillus niger and Candida albicans were most susceptible while Salmonella typhi and Escherichia coli were least susceptible with an average Inhibition Zone Diameter (IZD) of about 8 – 10 mm. Conclusion: The substantial quantity of the basic phytochemicals in Chromolaena odorata could render it a utility plant in therapeutic use. Due to the profound antimicrobial effect as revealed by the IZDs, the plant could be classified as a broad spectrum antimicrobial agent. Thus, the claim on its potency in treatment of infectious diseases by traditional medical practitioners could be said to be justified.

scholarly journals Chemical composition and antimicrobial activity of extracts from thyme and rosemary against Staphylococcus aureus and Candida albicans

BioResources ◽  
2020 ◽  
Vol 15 (4) ◽  
pp. 9656-9671
Author(s):  
Akram Sabzikar ◽  
Seyyed Khalil Hosseinihashemi ◽  
Younes Shirmohammadli ◽  
Abbas Jalaligoldeh
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Chemical Composition ◽  
Inhibition Zone ◽  
Gas Chromatography Mass Spectrometry ◽  
Diffusion Method ◽  
Rosemary Extract ◽  
Gram Positive Bacteria ◽  
Main Components

Different concentrations of ethanolic extracts of thyme (Zataria multiflora) and rosemary (Rosmarinus officinalis) were evaluated to determine their antimicrobial activity using the agar-well diffusion method. The values of inhibition zone diameter (IZD) for Candida albicans fungus and Staphylococcus aureus Gram-positive bacteria were determined. The bioactivities of two various extracts were studied, and the chemical composition of the extracts were identified using gas chromatography-mass spectrometry (GC-MS) technique. The results of the test showed that at concentrations of 10% and 40% thyme extract, the values of IZD were 12.5 mm and 23.3 mm, respectively, against the growth of S. aureus, which were higher than C. albicans (7.0 mm and 22.5 mm, respectively). The rosemary extract at concentrations of 20% and 60% showed lower antibacterial activity against S. aureus (4.7 mm and 8.7 mm IZD, respectively) and lower antifungal activity against C. albicans (12.2 mm and 1.7 mm IZD, respectively). At a concentration of 40% thyme extract, the highest antibacterial (23.3 mm IZD) and antifungal (22.5 mm IZD) activities were observed. The GC/MS analysis showed that carvacrol (52.3%), linalool L (16%), and thymol (9.6%) were the main components of thyme extract, while in the rosemary extract β-amyrone (18.0%), verbenone (8.0%), and 1,8-cineole (7.26%) were the major constituents.

scholarly journals Uji Daya Hambat Ekstrak Kulit Langsat (Lansium parasiticum) Terhadap Pertumbuhan Bakteri Enterococcus faecalis Secara In Vitro

2020 ◽  
Vol 8 (2) ◽  
pp. 70-74
Author(s):  
Andhini Ardi ◽  
Dedi Sumantri ◽  
Surma Adnan
Keyword(s):  
Enterococcus Faecalis ◽  
Inhibition Zone ◽  
Diffusion Method ◽  
Control Group ◽  
Fruit Peel ◽  
Control Group Design ◽  
Inhibition Effect ◽  
Facultative Anaerobic Bacteria ◽  
Peel Extract

Enterococcus faecalis is a bacteria that commonly found in secondary root canal infections. Enterococcus faecalis is a gram-positive, facultative anaerobic bacteria. Langsat (Lansium parasiticum) is a natural ingredient that contains secondary metabolites and has antibacterial ativity. The aim of this study was to examine the inhibition effect of langsat fruit peel extract (Lansium parasiticum) to the growth of Enterococcus faecalis. This was a laboratory experimental study with post-only control group design. Langsat fruit peel extract with 25%, 50%, 75%, and 100% concentration was using disc diffusion method on Mueller-Hinton Agar (MHA) and the inhibition zone was measured with a sliding caliper. The data were analyzed with Kruskal-Wallis test and Mann-Whithney test. The result of this study was langsat fruit peel extract with 25%, 50%, 75% concentration showed a inhibition zone, while at 100% showed no inhibition zone. The Kruskal-Wallis test showed that there are significant differences (p <0.05) between all groups. The conclusion was langsat fruit peel extract (Lansium parasiticum) have weak inhibition effect of the growth of Enterococcus faecalis bacteria. The inhibition zone of concentrations 25% : 2,20 mm;  50%: 0,94 mm; 75%: 0,36 mm and 100% : 0,00 mm.

scholarly journals PERBEDAAN DAYA HAMBAT MADN KONSENTRASI 100% TERHADAP PERTUMBUHAN BAKTERI PORPHYROMONAS GINGIVALIS DAN AGGREGATIBACTER ACTINOMYCETEMCOMITANS

2020 ◽  
Vol 6 (1) ◽  
pp. 1-10
Author(s):  
Indah Wulandari ◽  
Emriadi Emriadi ◽  
Kosno Supriyanto
Keyword(s):  
Essential Oil ◽  
Porphyromonas Gingivalis ◽  
Inhibition Zone ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Diffusion Method ◽  
Control Group ◽  
Control Group Design ◽  
Bacteria Growth ◽  
Pogostemon Cablin ◽  
Leaf Essential Oil

Periodontal disease is the second common oral health disease after dental caries. Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans are the main species of bacteria that cause periodontitis. Improper use of antibiotics can cause bacterial resistence to antibiotics. Essential oil from Pogostemon cablin, Benth leaf is an essential oil from herb contains eugenol and terpenoid compounds which can be used as an alternative antimicrobial agent. The purpose of this research was to know the difference of inhibitory effect of Pogostemon cablin, Benth leaf essential oil to Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.The method of this research was experimental laboratories with posttest only control group design. This Research was done using disc diffusion method on the Mueller Hinton Agar. The inhibition zone around the disc was measured by sliding caliper. The results were analyzed with non parametric test Mann Whitney.The results showed that Pogostemon cablin, Benth leaf essential oil had the inhibition zone. The inhibition zone againts Porphyromonas gingivalis was 13,47 mm and 41,15 mm on Aggregatibacter actinomycetemcomitans. The statistical test showed that Pogostemon cablin, Benth leaf essential oil can inhibit both bacterial growth with the bigger inhibition was on Aggregatibacter actinomycetemcomitans bacteria growth.

scholarly journals Uji Konsentrasi Hambat Minimum (KHM) Ekstrak Daun Mengkudu (Morinda citrifolia L.) terhadap Candida albicans Secara In Vitro

e-GIGI ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Lisa Ramschie ◽  
Pieter L. Suling ◽  
Krista V. Siagian
Keyword(s):  
Candida Albicans ◽  
Minimum Inhibitory Concentration ◽  
Leaf Extract ◽  
Inhibitory Concentration ◽  
Morinda Citrifolia ◽  
Control Group ◽  
Dilution Method ◽  
Control Group Design ◽  
Group Design

Abstract: Noni (Morinda cittrifolia L.) leaves contain antraquinon, atsiri oil, saponin, tannin, alkaloid, flavonoid, polifenol, and sterol that have been proved can inhibit the growth of Candida albicans. This study was aimed to establish the minimum inhibitory concentration (MIC) of noni leaf extract against Candida abicans. This was a true experimental study with a randomized pretest-posttest control group design. We used serial dilution method with turbidimetry and spectrophotometry tests. Noni leaves were extracted by using maceration with 96% ethanol. Candida albicans fungi were obtained from Microbiology Laboratory of Faculty of Mathematics and Natural Sciences, Sam Ratulangi University. The turbidimetry test using three repetitions showed that the MIC of noni leaf extract against Candida albicans was 6.25% meanwhile the spectrophotometry test established 12.5% as the MIC of noni leaf extract. Conclusion: Minimum inhibitory concentration of noni (Morinda cittrifolia L.) leaf extract against the growth of Candida albicans was 12.5%.Keywords: noni (Morinda citrifolia L.), Candida albicans, minimum inhibitory concentration (MIC) Abstrak: Daun mengkudu (Morinda citrifolia L.) mengandung antraquinon, minyak atsiri, saponin, tannin, alkaloid, flavonoid, polifenol dan sterol yang terbukti dapat menghambat pertumbuhan Candida albicans. Penelitian ini bertujuan untuk mendapatkan konsentrasi hambat minimum (KHM) dari ekstrak daun mengkudu terhadap Candida albicans. Jenis penelitian ialah eksperimental murni dengan randomized pretest-posttest control group design. Metode yang digunakan dalam penelitian yaitu serial dilusi dengan pengujian turbidimetri dan spektrofotometri. Daun mengkudu diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Jamur Candida albicans diambil dari stok jamur Laboratorium Mikrobiologi Program Studi Farmasi Fakultas MIPA Universitas Sam Ratulangi. Hasil penelitian menunjukkan bahwa pengujian turbidimetri dengan tiga kali perlakuan mendapatkan KHM pada konsentrasi 6,25% sedangkan pengujian spektrofotometri mendapatkan KHM pada konsentrasi 12,5%. Simpulan: Konsentrasi hambat minimum (KHM) ekstrak daun mengkudu (Morinda citrifolia L.) terhadap pertumbuhan Candida albicans terdapat pada konsentrasi 12,5%.Kata kunci: mengkudu (Morinda citrifolia L.), Candia albicans, konsentrasi hambat minimum (KHM)

scholarly journals Fluconazole Susceptibilities of Bloodstream Candidasp. Isolates as Determined by National Committee for Clinical Laboratory Standards Method M27-A and Two Other Methods

1999 ◽  
Vol 37 (7) ◽  
pp. 2197-2200 ◽  
Author(s):  
Emilia Cantón ◽  
Javier Pemán ◽  
Alfonso Carrillo-Muñoz ◽  
Ana Orero ◽  
Pedro Ubeda ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Geometric Mean ◽  
Inhibition Zone ◽  
Diffusion Method ◽  
National Committee ◽  
Dilution Method ◽  
Inhibition Zone Diameter ◽  
Zone Diameter ◽  
The Mean

The in vitro activity of fluconazole against 143Candida spp. obtained from the bloodstreams of 143 hospitalized patients from 1995 to 1997 was studied. Susceptibility tests were carried out by two macrodilution methods, the M27-A and a modified M27-A method (0.165 M, pH 7/morpholinepropanesulfonic acid-buffered RPMI 1640 medium supplemented with 20 g ofd-dextrose per liter), and by the agar diffusion method (with 15-μg fluconazole [Neo-Sensitab] tablets). With 2 μg of fluconazole per ml, 96.92% of 65 C. albicans isolates, 86.2% of 58 C. parapsilosis isolates 7 of 8 C. tropicalis isolates, and 1 of 6 C. glabrata isolates were inhibited. Only one strain of C. albicans and one strain of C. tropicalis were resistant. The agreement between the two macrodilution methods was greater than 90% within ±2 log2 dilutions for all strains except C. glabrata (83.3%) and C. tropicalis(87.5%). Generally, MICs were 1 log2 dilution lower in glucose-supplemented RPMI 1640 medium. No correlation between zone sizes and MICs was found. All strains susceptible by the diffusion test were susceptible by the dilution method, but the converse was not necessarily true. Interestingly, inhibition zones were smaller forC. albicans, for which the geometric mean MIC was 0.29 μg/ml and the mean inhibition zone diameter was 25.7 mm, while for C. parapsilosis the geometric mean MIC was 0.96 μg/ml and the mean inhibition zone diameter was 31.52 mm. In conclusion, the two macrodilution methods give similar results. The modified M27-A method with 2% dextrose has the advantage of shortening the incubation time and simplifying the endpoint determination.

Pengaruh perendaman plat resin akrilik dalam ekstrak kayu manis (Cinnamomum burmanii) terhadap jumlah blastospora Candida Albicans

e-GIGI ◽  
2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Christian Dama
Keyword(s):  
Candida Albicans ◽  
Acrylic Resin ◽  
T Test ◽  
Control Group ◽  
Dilution Method ◽  
Denture Stomatitis ◽  
Cinnamon Extract ◽  
Acrylic Plate ◽  
Removable Denture ◽  
Significant Difference

Resin akrilik sering digunakan sebagai bahan dari gigi tiruan, khususnya basis gigi tiruan. Adanya rongga-rongga mikro pada akrilik menjadi tempat perlekatan sisa-sisa makanan yang dapat meningkatkan jumlah mikroorganisme dalam rongga mulut, salah satunya ialah jamur Candida albicans. Pertumbuhan yang pesat dari jamur Candida albicans menjadi penyebab utama infeksi pada mukosa rongga mulut pemakai gigi tiruan lepasan akrilik, disebut denture stomatitis. Ekstrak kayu manis yang mengandung minyak atsiri, sinamaldehid, eugenol dan juga senyawa seperti flavonoid, Saponin, serta tanin memiliki efek antifungi. Tujuan penelitian ini untuk mengetahui pengaruh dari ekstrak kayu manis dan konsentrasi ekstrak kayu manis terhadap jumlah blastospora Candida albicans pada plat akrilik sehingga mampu mencegah dan menanggulangi penyakit denture stomatitis. Plat akrilik yang telah terkontaminasi dengan jamur Candida albicans direndam dalam ekstrak kayu manis dengan konsentrasi 20%, 30%, 40%, 50%, dan aquades sebagai kontrol. selanjutnya, plat akrilik di getarkan untuk menjatuhkan Candida albicans dalam tabung reaksi dan dihitung jumlah blastosporanya dengan metode pengenceran menggunakan cairan NaCl dan metode hitung langsung pada mikroskop. Hasil perhitungan statistik dengan uji Independent t-test diketahui terdapat perbedaan yang bermakna antara kelompok ekstrak kayu manis dan kelompok kontrol (p ≤ 0,05). Dari hasil penelitian dapat disimpulkan bahwa ekstrak kayu manis dapat memengaruhi pertumbuhan jumlah blastospora Candida albicans pada plat resin akrilik dan meningkat seiring dengan meningkatnya konsentrasi ekstrak kayu manis (cinnamomum burmanii) yang digunakan.Kata kunci: Resin akrilik, Candida albicans, ekstrak kayu manis.ABSTRACTAcrylic resin is often used as an ingredient of artificial teeth, denture base in particular. The existence of micro cavities in acrylic attachment to place leftover food that can increase the number of microorganisms in the oral cavity, one of which is Candida albicans. The rapid growth of Candida albicans is a main cause of infection in the oral mucosa acrylic removable denture wearers, called denture stomatitis. Cinnamon extract that contains essential oils, sinamaldehid, eugenol and also compounds such as flavonoids, saponins, and tannins have antifungal effects. The purpose of this study to determine the effect of cinnamon extract and cinnamon extract concentrations against Candida albicans blastospora number on acrylic plate so as to prevent and control disease denture stomatitis. Acrylic plate that has been contaminated with Candida albicans soaked in cinnamon extract with a concentration of 20%, 30%, 40%, 50%, and sterile water as a control. furthermore, acrylic plate vibrate to drop Candida albicans in a test tube and counted the number of blastospora by using saline dilution method and direct count method on the microscope. The results of calculations with the statistical test known Independent t-test significant difference between cinnamon extract group and the control group (p ≤ 0,05). From the results of this study concluded that cinnamon extract may affect the growth of Candida albicans blastospora on acrylic resin plate and increases with increasing concentration of the extract of cinnamon (Cinnamomum burmanii) were used.Keywords : Acrylic resin, Candida albicans, cinnamon extract.

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