scholarly journals Para-Phenylenediamine (PPD) in commercially available Henna preparations in Bangladesh

2021 ◽  
Vol 8 (1) ◽  
pp. 1088-1092
Author(s):  
Sultan Abu Saleh Mahmud ◽  
Tasnuva Ferdous ◽  
Md Morshedul Alam ◽  
Md Shohag Hossain ◽  
Habibul Bari Shozib ◽  
...  
Keyword(s):  
High Performance ◽  
Consumer Products ◽  
The Body ◽  
Dhaka City ◽  
Cosmetic Products ◽  
Production And Distribution ◽  
Permissible Levels ◽  
Allergic Contact ◽  
The Average Range ◽  
Skin Sensitizer

In Bangladesh Henna is one of the most popular cosmetic products. The leaves of Henna are dried to make powder on which oil or water is mixed to get a paste to stain the body or hair. Although the occurance of contact allergic dermatitis in natural Henna is not so common, but this risk is increased by adding para-Phenylenediamine (PPD), which is used to make the Henna color dark to deep black. According to Scientific Committee on Consumer Products (SCCP), para-Phenylenediamine (PPD) is treated as an allergen and is considered as a very strong potential skin sensitizer. The presence of PPD in the commercially used tube Henna increases the risk of allergic contact dermatitis and several cases have already been reported worldwide. For this study, about 10 Henna samples were randomly collected from 10 selected areas of Dhaka city. The presence of PPD in Henna samples was determined by using High Performance Liquid Chromatography (HPLC). The result showed the presence of PPD in all of the Henna samples at substantial concentrations, ranging between 79.12-204.77 mg/kg where the average range is 142.36 mg/kg, which is much higher than the permissible levels (<2% or 0.1 mg/m3). The finding suggests that there should be a regulation and monitoring condition for the production and distribution of these adulterated Henna products in Bangladesh. Bioresearch Commu. 8(1): 1088-1092, 2022 (January)

Mechanisms of Nickel-Induced Cell Damage in Allergic Contact Dermatitis and Nutritional Intervention Strategies

2020 ◽  
Vol 20 (7) ◽  
pp. 1010-1014 ◽  
Author(s):  
Dana Filatova ◽  
Christine Cherpak
Keyword(s):  
Lipid Peroxidation ◽  
Contact Dermatitis ◽  
Oxidative Damage ◽  
Allergic Contact Dermatitis ◽  
Cell Damage ◽  
Consumer Products ◽  
The Body ◽  
Cellular Damage ◽  
Nutritional Interventions ◽  
Allergic Contact

Background: Hypersensitivity to nickel is a very common cause of allergic contact dermatitis since this metal is largely present in industrial and consumer products as well as in some commonly consumed foods, air, soil, and water. In nickel-sensitized individuals, a cell-mediated delayed hypersensitivity response results in contact to dermatitis due to mucous membranes coming in long-term contact with nickel-containing objects. This process involves the generation of reactive oxidative species and lipid peroxidation-induced oxidative damage. Immunologically, the involvement of T helper (h)-1 and Th-2 cells, as well as the reduced function of T regulatory cells, are of importance. The toxicity, mutagenicity, and carcinogenicity of nickel are attributed to the generation of reactive oxygen species and induction of oxidative damage via lipid peroxidation, which results in DNA damage. Objective: The aim of this research is to identify nutritionally actionable interventions that can intercept nickel-induced cell damage due to their antioxidant capacities. Conclusion: Nutritional interventions may be used to modulate immune dysregulation, thereby intercepting nickel-induced cellular damage. Among these nutritional interventions are a low-nickel diet and an antioxidant-rich diet that is sufficient in iron needed to minimize nickel absorption. These dietary approaches not only reduce the likelihood of nickel toxicity by minimizing nickel exposure but also help prevent oxidative damage by supplying the body with antioxidants that neutralize free radicals.

scholarly journals Ocular Allergy: A Review on Ocular Effects of Cosmetic Products

2020 ◽  
Vol 10 (5-s) ◽  
pp. 299-301
Author(s):  
Cherakkulath C Neena ◽  
K. Sreejith ◽  
B Athulnadh ◽  
K.V. Musaina Thasneem ◽  
Namitha Maniyan ◽  
...  
Keyword(s):  
Brain Function ◽  
Adverse Reactions ◽  
Tear Film ◽  
The Body ◽  
Ocular Allergy ◽  
Cosmetic Products ◽  
Inflammatory Reactions ◽  
Causative Agents ◽  
Allergic Contact

The eyes are the windows to the body, healthy brain function needs healthy eyesight. Recently so many problems arise due to the unsafe use of ocular cosmetics. Eye cosmetics can cause ocular allergy or toxicity. It produces mild discomfort to serious vision threatening problems. This review focus on the reason as well as problems associated with ocular cosmetics. Based on the data from various reviews and research shows that preservatives, metals & fragrances include in the products are the main causative agents for ocular allergy. The main adverse reactions were found to be allergic blepharo conjunctivitis, disruption of the tear film and other inflammatory reactions. The purpose of this article is to give a general awareness about the safe use of ocular cosmetics to get rid of ocular allergy. Keywords: Ocular cosmetics; Ocular Allergy; Allergic contact blepharo conjunctivitis; inflammatory reactions.

scholarly journals ENHANCING VITAMIN C CONTENT IN SOAP PRODUCTION VIA SUBSEQUENT AMOUNT OF EXTRACT FROM PHYLLANTHUS AMBLICA AND COSNICIUM BLUEMEANUM

2021 ◽  
Vol 3 (7) ◽  
pp. 01-09
Author(s):  
Ruhana Wati Iran ◽  
Surina Nordin ◽  
Dayang Kamariah Tajul Maulok
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Vitamin C ◽  
High Performance ◽  
Descriptive Analysis ◽  
The Body ◽  
Cosmetic Products ◽  
Chemical Substances ◽  
Unpleasant Odor ◽  
Soap Production

The demand for cosmetic products is rapidly growing, despite the majority of them is high in chemical substances and may harm the skin. Nowadays, there are other alternatives that may help to prevent the use of chemical substances in cosmetic products. For example, fruit contains its own nutrient. Furthermore, there are some fruits that contains high in vitamins and also good for the skin. Researchers noticed that Phyllantus amblica (Melaka fruits) has an unpleasant odor but it higher with contains 30 times more vitamin C compared to orange while Cosnicium blumeanem (mengkunyit) helps raise the level of vitamins C in the body. Therefore, looking at potential and benefits, research has been conducted to produce a bar soap (Amblica Soap) from Phyllantus amblica and Cosnicium blumeanem. Analyze has been done to determine the vitamin C, antioxidant level, and perception level of respondents towards Amblica Soap. Likert Scale and High-Performance Liquid Chromatography (HPLC) was used as the quantitative instrument. A number of 30 respondents were selected based on their locality. Descriptive analysis was used to analyses collected using SPSS version 25.0. Resulting confirming that is Amblica Soap not contain in vitamin C and shows the perception level of respondents towards Amblica Soap is highly positive. In conclusion, Amblica Soap accepted optimistically.

scholarly journals Formaldehyde may be found in cosmetic products even when unlabelled

Open Medicine ◽  
2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Laura Malinauskiene ◽  
Audra Blaziene ◽  
Anzelika Chomiciene ◽  
Marléne Isaksson
Keyword(s):  
High Performance ◽  
Contact Allergy ◽  
Normal Skin ◽  
High Performance Liquid Chromatographic ◽  
Chromotropic Acid ◽  
Cosmetic Products ◽  
Liquid Chromatographic Method ◽  
Allergic Contact ◽  
Liquid Chromatographic ◽  
The Eu

AbstractConcomitant contact allergy to formaldehyde and formaldehyde-releasers remains common among patients with allergic contact dermatitis. Concentration of free formaldehyde in cosmetic products within allowed limits have been shown to induce dermatitis from shortterm use on normal skin.The aim of this study was to investigate the formaldehyde content of cosmetic products made in Lithuania. 42 samples were analysed with the chromotropic acid (CA) method for semi-quantitative formaldehyde determination. These included 24 leave-on (e.g., creams, lotions) and 18 rinse-off (e.g., shampoos, soaps) products. Formaldehyde releasers were declared on the labels of 10 products. No formaldehyde releaser was declared on the label of the only face cream investigated, but levels of free formaldehyde with the CA method was >40 mg/ml and when analysed with a high-performance liquid chromatographic method – 532 ppm. According to the EU Cosmetic directive, if the concentration of formaldehyde is above 0.05% a cosmetic product must be labelled “contains formaldehyde“. It could be difficult for patients allergic to formaldehyde to avoid contact with products containing it as its presence cannot be determined from the ingredient labelling with certainty. The CA method is a simple and reliable method for detecting formaldehyde presence in cosmetic products.

Determination of Selected Phthalates in Some Commercial Cosmetic Products by HPLC-UV

2020 ◽  
Vol 23 (10) ◽  
pp. 1010-1022
Author(s):  
Emrah Dural
Keyword(s):  
High Performance ◽  
Phthalate Esters ◽  
High Sensitivity ◽  
Hplc Method ◽  
Cosmetic Products ◽  
Limit Of Quantification ◽  
Nail Polish ◽  
Accuracy And Precision ◽  
Butyl Phthalate

Aim and scope: Due to the serious toxicological risks and their widespread use, quantitative determination of phthalates in cosmetic products have importance for public health. The aim of this study was to develop a validated simple, rapid and reliable high-performance liquid chromatography (HPLC) method for the determination of phthalates which are; dimethyl phthalate (DMP), diethyl phthalate (DEP), benzyl butyl phthalate (BBP), di-n-butyl phthalate (DBP), di(2- ethylhexyl) phthalate (DEHP), in cosmetic products and to investigate these phthalate (PHT) levels in 48 cosmetic products marketing in Sivas, Turkey. Materials and Methods: Separation was achieved by a reverse-phase ACE-5 C18 column (4.6 x 250 mm, 5.0 μm). As the mobile phase, 5 mM KH2PO4 and acetonitrile were used gradiently at 1.5 ml min-1. All PHT esters were detected at 230 nm and the run time was taking 21 minutes. Results: This method showed the high sensitivity value the limit of quantification (LOQ) values for which are below 0.64 μg mL-1 of all phthalates. Method linearity was ≥0.999 (r2). Accuracy and precision values of all phthalates were calculated between (-6.5) and 6.6 (RE%) and ≤6.2 (RSD%), respectively. Average recovery was between 94.8% and 99.6%. Forty-eight samples used for both babies and adults were successfully analyzed by the developed method. Results have shown that, DMP (340.7 μg mL-1 ±323.7), DEP (1852.1 μg mL-1 ± 2192.0), and DBP (691.3 μg mL-1 ± 1378.5) were used highly in nail polish, fragrance and cream products, respectively. Conclusion: Phthalate esters, which are mostly detected in the content of fragrance, cream and nail polish products and our research in general, are DEP (1852.1 μg mL-1 ± 2192.0), DBP (691.3 μg mL-1 ± 1378.5) and DMP (340.7 μg mL-1 ±323.7), respectively. Phthalates were found in the content of all 48 cosmetic products examined, and the most detected phthalates in general average were DEP (581.7 μg mL-1 + 1405.2) with a rate of 79.2%. The unexpectedly high phthalate content in the examined cosmetic products revealed a great risk of these products on human health. The developed method is a simple, sensitive, reliable and economical alternative for the determination of phthalates in the content of cosmetic products, it can be used to identify phthalate esters in different products after some modifications.

Evaluation of New 99mTc(CO)3 + Radiolabeled Glycylglycine In Vivo

2019 ◽  
Vol 19 (11) ◽  
pp. 1382-1387
Author(s):  
Ahmet M. Şenışık ◽  
Çiğdem İçhedef ◽  
Ayfer Y. Kılçar ◽  
Eser Uçar ◽  
Kadir Arı ◽  
...  
Keyword(s):  
High Performance ◽  
The Body ◽  
Biological Behavior ◽  
In Vivo Evaluation ◽  
Radiolabeled Peptides ◽  
Tumor Bearing ◽  
Biodistribution Data ◽  
Good Accordance ◽  
Rapid Clearance

Background: Peptide-based agents are used in molecular imaging due to their unique properties, such as rapid clearance from the circulation, high affinity and target selectivity. Many of the radiolabeled peptides have been clinically experienced with diagnostic accuracy. The aim of this study was to investigate in vivo biological behavior of [99mTc(CO)3(H2O)3]+ radiolabeled glycylglycine (GlyGly). Methods: Glycylglycine was radiolabeled with a high radiolabeling yield of 94.69±2%, and quality control of the radiolabeling process was performed by thin layer radiochromatography (TLRC) and High-Performance Liquid Radiochromatography (HPLRC). Lipophilicity study for radiolabeled complex (99mTc(CO)3-Gly-Gly) was carried out using solvent extraction. The in vivo evaluation was performed by both biodistribution and SPECT imaging. Results: The high radiolabelling yield of 99mTc(CO)3-GlyGly was obtained and verified by TLRC and HPLRC as well. According to the in vivo results, SPECT images and biodistribution data are in good accordance. The excretion route from the body was both hepatobiliary and renal. Conclusion: This study shows that 99mTc(CO)3-GlyGly has the potential to be used as a peptide-based imaging agent. Further studies, 99mTc(CO)3-GlyGly can be performed on tumor-bearing animals.

scholarly journals Calculating the optimal hematocrit under the constraint of constant cardiac power

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Michal Sitina ◽  
Heiko Stark ◽  
Stefan Schuster
Keyword(s):  
Blood Flow ◽  
High Performance ◽  
Animal Species ◽  
Normal Values ◽  
Mechanical Load ◽  
The Body ◽  
Trade Off ◽  
Cardiac Power ◽  
Optimal Value ◽  
Good Agreement

AbstractIn humans and higher animals, a trade-off between sufficiently high erythrocyte concentrations to bind oxygen and sufficiently low blood viscosity to allow rapid blood flow has been achieved during evolution. Optimal hematocrit theory has been successful in predicting hematocrit (HCT) values of about 0.3–0.5, in very good agreement with the normal values observed for humans and many animal species. However, according to those calculations, the optimal value should be independent of the mechanical load of the body. This is in contradiction to the exertional increase in HCT observed in some animals called natural blood dopers and to the illegal practice of blood boosting in high-performance sports. Here, we present a novel calculation to predict the optimal HCT value under the constraint of constant cardiac power and compare it to the optimal value obtained for constant driving pressure. We show that the optimal HCT under constant power ranges from 0.5 to 0.7, in agreement with observed values in natural blood dopers at exertion. We use this result to explain the tendency to better exertional performance at an increased HCT.

scholarly journals Plasma radio-metabolite analysis of PET tracers for dynamic PET imaging: TLC and autoradiography

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Fiona Li ◽  
Justin W. Hicks ◽  
Lihai Yu ◽  
Lise Desjardin ◽  
Laura Morrison ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Blood Plasma ◽  
Kinetic Parameters ◽  
High Performance ◽  
The Body ◽  
Accurate Estimation ◽  
Dynamic Pet ◽  
Arterial Concentration ◽  
In Blood Plasma

Abstract Background In molecular imaging with dynamic PET, the binding and dissociation of a targeted tracer is characterized by kinetics modeling which requires the arterial concentration of the tracer to be measured accurately. Once in the body the radiolabeled parent tracer may be subjected to hydrolysis, demethylation/dealkylation and other biochemical processes, resulting in the production and accumulation of different metabolites in blood which can be labeled with the same PET radionuclide as the parent. Since these radio-metabolites cannot be distinguished by PET scanning from the parent tracer, their contribution to the arterial concentration curve has to be removed for the accurate estimation of kinetic parameters from kinetic analysis of dynamic PET. High-performance liquid chromatography has been used to separate and measure radio-metabolites in blood plasma; however, the method is labor intensive and remains a challenge to implement for each individual patient. The purpose of this study is to develop an alternate technique based on thin layer chromatography (TLC) and a sensitive commercial autoradiography system (Beaver, Ai4R, Nantes, France) to measure radio-metabolites in blood plasma of two targeted tracers—[18F]FAZA and [18F]FEPPA, for imaging hypoxia and inflammation, respectively. Results Radioactivity as low as 17 Bq in 2 µL of pig’s plasma can be detected on the TLC plate using autoradiography. Peaks corresponding to the parent tracer and radio-metabolites could be distinguished in the line profile through each sample (n = 8) in the autoradiographic image. Significant intersubject and intra-subject variability in radio-metabolites production could be observed with both tracers. For [18F]FEPPA, 50% of plasma activity was from radio-metabolites as early as 5-min post injection, while for [18F]FAZA, significant metabolites did not appear until 50-min post. Simulation study investigating the effect of radio-metabolite in the estimation of kinetic parameters indicated that 32–400% parameter error can result without radio-metabolites correction. Conclusion TLC coupled with autoradiography is a good alternative to high-performance liquid chromatography for radio-metabolite correction. The advantages of requiring only small blood samples (~ 100 μL) and of analyzing multiple samples simultaneously, make the method suitable for individual dynamic PET studies.

scholarly journals Influence of Fabric Weave on Thermal Radiation Resistance and Water Vapor Permeability

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 525
Author(s):  
Ana Kiš ◽  
Snježana Brnada ◽  
Stana Kovačević
Keyword(s):  
High Temperatures ◽  
High Performance ◽  
Thermal Protection ◽  
Water Vapor Permeability ◽  
Radiant Heat ◽  
The Body ◽  
Vapor Permeability ◽  
Weave Structure ◽  
Fabric Structures ◽  
The Impact

In this work, aramid fibers were used to develop new, high-performance fabrics for high-temperature protective clothing. The research was based on the impact of the weave structure on fabric resistance to radiant heat. The goals of the research were primarily related to the development of new fabric structures created by the weave structure, which gives better protection of the body against high temperatures in relation to the standard weave structures that are used today. According to the results obtained it can be concluded that the fabric weave significantly affects the fabric structure, which consequently determines the effectiveness of protection against high temperatures. The justification for the use of multi-weft and strucks weave structure, which provides greater thermal protection and satisfactory breathability than commonly used weave structures, was ascertained.

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