scholarly journals Supercritical CO2 Extraction as a Tool to Isolate Anti-Inflammatory Sesquiterpene Lactones from Cichorium intybus L. Roots

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2583
Author(s):  
João P. Baixinho ◽  
José D. Anastácio ◽  
Viktoriya Ivasiv ◽  
Katarina Cankar ◽  
Dirk Bosch ◽  
...  
Keyword(s):  
Flow Rate ◽  
Supercritical Co2 ◽  
Nuclear Translocation ◽  
Sesquiterpene Lactones ◽  
Green Technology ◽  
Operating Conditions ◽  
Cichorium Intybus ◽  
Health Promoting ◽  
Anti Inflammatory ◽  
Chicory Roots

Cichorium intybus L. or chicory plants are a natural source of health-promoting compounds in the form of supplements such as inulin, as well as other bioactive compounds such as sesquiterpene lactones (SLs). After inulin extraction, chicory roots are considered waste, with most SLs not being harnessed. We developed and optimized a new strategy for SL extraction that can contribute to the conversion of chicory root waste into valuable products to be used in human health-promoting applications. In our work, rich fractions of SLs were recovered from chicory roots using supercritical CO2. A response surface methodology was used to optimize the process parameters (pressure, temperature, flow rate, and co-solvent percentage) for the extraction performance. The best operating conditions were achieved at 350 bar, 40 °C, and 10% EtOH as a co-solvent in a 15 g/min flow rate for 120 min. The extraction with supercritical CO2 revealed to be more selective for the SLs than the conventional solid–liquid extraction with ethyl acetate. In our work, 1.68% mass and a 0.09% sesquiterpenes yield extraction were obtained, including the recovery of two sesquiterpene lactones (8-deoxylactucin and 11β,13-dihydro-8-deoxylactucin), which, to the best of our knowledge, are not commercially available. A mixture of the abovementioned compounds were tested at different concentrations for their toxic profile and anti-inflammatory potential towards a human calcineurin/NFAT orthologue pathway in a yeast model, the calcineurin/Crz1 pathway. The SFE extract obtained, rich in SLs, yielded results of inhibition of 61.74 ± 6.87% with 50 µg/mL, and the purified fraction containing 8-deoxylactucin and 11β,13-dihydro-8-deoxylactucin inhibited the activation of the reporter gene up to 53.38 ± 3.9% at 10 µg/mL. The potential activity of the purified fraction was also validated by the ability to inhibit Crz1 nuclear translocation and accumulation. These results reveal a possible exploitable green technology to recover potential anti-inflammatory compounds from chicory roots waste after inulin extraction.

scholarly journals The Common Cichory (Cichorium intybus L.) as a Source of Extracts with Health-Promoting Properties—A Review

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1814
Author(s):  
Katarzyna Janda ◽  
Izabela Gutowska ◽  
Małgorzata Geszke-Moritz ◽  
Karolina Jakubczyk
Keyword(s):  
Recent Literature ◽  
Sesquiterpene Lactones ◽  
Cichorium Intybus ◽  
Human Organism ◽  
Gastrointestinal Disorders ◽  
Cichoric Acid ◽  
Biologically Relevant ◽  
Coffee Substitute ◽  
Health Promoting ◽  
The Common

Natural products are gaining more interest recently, much of which focuses on those derived from medicinal plants. The common chicory (Cichorium intybus L.), of the Astraceae family, is a prime example of this trend. It has been proven to be a feasible source of biologically relevant elements (K, Fe, Ca), vitamins (A, B1, B2, C) as well as bioactive compounds (inulin, sesquiterpene lactones, coumarin derivatives, cichoric acid, phenolic acids), which exert potent pro-health effects on the human organism. It displays choleretic and digestion-promoting, as well as appetite-increasing, anti-inflammatory and antibacterial action, all owing to its varied phytochemical composition. Hence, chicory is used most often to treat gastrointestinal disorders. Chicory was among the plants with potential against SARS-CoV-2, too. To this and other ends, roots, herb, flowers and leaves are used. Apart from its phytochemical applications, chicory is also used in gastronomy as a coffee substitute, food or drink additive. The aim of this paper is to present, in the light of the recent literature, the chemical composition and properties of chicory.

Stabilization of the Speed of the Hydraulic Motor Through Throttle Compensation for Volume Losses

2020 ◽  
Vol 26 (3) ◽  
pp. 126-130
Author(s):  
Krasimir Kalev
Keyword(s):  
Flow Rate ◽  
Hydraulic Drive ◽  
Pressure Change ◽  
Operating Conditions ◽  
Drive System ◽  
Inlet Pressure ◽  
Schematic Diagram ◽  
Hydraulic Characteristics ◽  
Hydraulic Motor ◽  
Flow Through

AbstractA schematic diagram of a hydraulic drive system is provided to stabilize the speed of the working body by compensating for volumetric losses in the hydraulic motor. The diagram shows the inclusion of an originally developed self-adjusting choke whose flow rate in the inlet pressure change range tends to reverse - with increasing pressure the flow through it decreases. Dependent on the hydraulic characteristics of the hydraulic motor and the specific operating conditions.

Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect

2020 ◽  
Vol 17 (9) ◽  
pp. 1102-1116
Author(s):  
Sudip Kumar Mandal ◽  
Utsab Debnath ◽  
Amresh Kumar ◽  
Sabu Thomas ◽  
Subhash Chandra Mandal ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Biological Activities ◽  
Sesquiterpene Lactones ◽  
Structural Diversity ◽  
Cancer Drug ◽  
Cancer Drug Discovery ◽  
Anti Cancer ◽  
Drug Discovery Program ◽  
Anti Inflammatory ◽  
Family Based

Background and Introduction: Sesquiterpene lactones are a class of secondary metabolite that contains sesquiterpenoids and lactone ring as pharmacophore moiety. A large group of bioactive secondary metabolites such as phytopharmaceuticals belong to this category. From the Asteraceae family-based medicinal plants, more than 5,000 sesquiterpene lactones have been reported so far. Sesquiterpene lactone-based pharmacophore moieties hold promise for broad-spectrum biological activities against cancer, inflammation, parasitic, bacterial, fungal, viral infection and other functional disorders. Moreover, these moiety based phytocompounds have been highlighted with a new dimension in the natural drug discovery program worldwide after the 2015 Medicine Nobel Prize achieved by the Artemisinin researchers. Objective: These bitter substances often contain an α, β-unsaturated-γ-lactone as a major structural backbone, which in recent studies has been explored to be associated with anti-tumor, cytotoxic, and anti-inflammatory action. Recently, the use of sesquiterpene lactones as phytomedicine has been increased. This study will review the prospect of sesquiterpene lactones against inflammation and cancer. Methods: Hence, we emphasized on the different features of this moiety by incorporating its structural diversity on biological activities to explore structure-activity relationships (SAR) against inflammation and cancer. Results: How the dual mode of action such as anti-inflammatory and anti-cancer has been exhibitedby these phytopharmaceuticals will be forecasted in this study. Furthermore, the correlation of anti-inflammatory and anti-cancer activity executed by the sesquiterpene lactones for fruitful phytotherapy will also be revealed in the present review in the milieu of pharmacophore activity relation and pharmacodynamics study as well. Conclusion: So, these metabolites are paramount in phytopharmacological aspects. The present discussion on the future prospect of this moiety based on the reported literature could be a guide for anti-inflammatory and anti-cancer drug discovery programs for the upcoming researchers.

Sesquiterpene lactones from Lychnophora species: Antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout

2021 ◽  
Vol 269 ◽  
pp. 113738
Author(s):  
Ana Catharina Fernandes Pereira Ferreira Bernardes ◽  
Rafaela Cunha Matosinhos ◽  
Marcela Carolina de Paula Michel Araújo ◽  
Camila Helena Barros ◽  
Rodrigo Dian de Oliveira Aguiar Soares ◽  
...  
Keyword(s):  
Sesquiterpene Lactones ◽  
Acute Gout ◽  
Anti Inflammatory

scholarly journals Chemical–Electrochemical Process Concept for Lead Recovery from Waste Cathode Ray Tube Glass

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1546
Author(s):  
Árpád Imre-Lucaci ◽  
Melinda Fogarasi ◽  
Florica Imre-Lucaci ◽  
Szabolcs Fogarasi
Keyword(s):  
Flow Rate ◽  
Current Density ◽  
Complete Recovery ◽  
Electrochemical Process ◽  
Operating Conditions ◽  
General Effect ◽  
Optimal Operating ◽  
Recirculation Flow ◽  
Lead Recovery ◽  
Cathode Ray Tube

This paper presents a novel approach for the recovery of lead from waste cathode-ray tube (CRT) glass by applying a combined chemical-electrochemical process which allows the simultaneous recovery of Pb from waste CRT glass and electrochemical regeneration of the leaching agent. The optimal operating conditions were identified based on the influence of leaching agent concentration, recirculation flow rate and current density on the main technical performance indicators. The experimental results demonstrate that the process is the most efficient at 0.6 M acetic acid concentration, flow rate of 45 mL/min and current density of 4 mA/cm2. The mass balance data corresponding to the recycling of 10 kg/h waste CRT glass in the identified optimal operating conditions was used for the environmental assessment of the process. The General Effect Indices (GEIs), obtained through the Biwer Heinzle method for the input and output streams of the process, indicate that the developed recovery process not only achieve a complete recovery of lead but it is eco-friendly as well.

scholarly journals Sesquiterpene Lactones: Promising Natural Compounds to Fight Inflammation

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 991
Author(s):  
Melanie S. Matos ◽  
José D. Anastácio ◽  
Cláudia Nunes dos Santos
Keyword(s):  
Biological Activities ◽  
Sesquiterpene Lactones ◽  
Physiological State ◽  
Plant Secondary Metabolites ◽  
Inflammatory Pathways ◽  
Inflammatory State ◽  
Anti Inflammatory ◽  
Inflammatory Molecules

Inflammation is a crucial and complex process that reestablishes the physiological state after a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to chronic inflammation and causing tissue damage. Sesquiterpene lactones (SLs) are composed of a large and diverse group of highly bioactive plant secondary metabolites, characterized by a 15-carbon backbone structure. In recent years, the interest in SLs has risen due to their vast array of biological activities beneficial for human health. The anti-inflammatory potential of these compounds results from their ability to target and inhibit various key pro-inflammatory molecules enrolled in diverse inflammatory pathways, and prevent or reduce the inflammatory damage on tissues. Research on the anti-inflammatory mechanisms of SLs has thrived over the last years, and numerous compounds from diverse plants have been studied, using in silico, in vitro, and in vivo assays. Besides their anti-inflammatory potential, their cytotoxicity, structure–activity relationships, and pharmacokinetics have been investigated. This review aims to gather the most relevant results and insights concerning the anti-inflammatory potential of SL-rich extracts and pure SLs, focusing on their effects in different inflammatory pathways and on different molecular players.

scholarly journals Isoquinolinequinone Derivatives from a Marine Sponge (Haliclona sp.) Regulate Inflammation in In Vitro System of Intestine

Marine Drugs ◽  
2021 ◽  
Vol 19 (2) ◽  
pp. 90
Author(s):  
Yun Kim ◽  
Yeong Ji ◽  
Na-Hyun Kim ◽  
Nguyen Van Tu ◽  
Jung-Rae Rho ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Marine Sponge ◽  
Nuclear Translocation ◽  
Hydroxyl Group ◽  
Subsequent Increase ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
Key Functional Groups ◽  
Oxide Synthase

Using bio-guided fractionation and based on the inhibitory activities of nitric oxide (NO) and prostaglandin E2 (PGE2), eight isoquinolinequinone derivatives (1–8) were isolated from the marine sponge Haliclona sp. Among these, methyl O-demethylrenierate (1) is a noble ester, whereas compounds 2 and 3 are new O-demethyl derivatives of known isoquinolinequinones. Compound 8 was assigned as a new 21-dehydroxyrenieramycin F. Anti-inflammatory activities of the isolated compounds were tested in a co-culture system of human epithelial Caco-2 and THP-1 macrophages. The isolated derivatives showed variable activities. O-demethyl renierone (5) showed the highest activity, while 3 and 7 showed moderate activities. These bioactive isoquinolinequinones inhibited lipopolysaccharide and interferon gamma-induced production of NO and PGE2. Expression of inducible nitric oxide synthase, cyclooxygenase-2, and the phosphorylation of MAPKs were down-regulated in response to the inhibition of NF-κB nuclear translocation. In addition, nuclear translocation was markedly promoted with a subsequent increase in the expression of HO-1. Structure-activity relationship studies showed that the hydroxyl group in 3 and 5, and the N-formyl group in 7 may be key functional groups responsible for their anti-inflammatory activities. These findings suggest the potential use of Haliclona sp. and its metabolites as pharmaceuticals treating inflammation-related diseases including inflammatory bowel disease.

Photo-degradation of butyl parahydroxybenzoate by using TiO2-supported catalyst

2013 ◽  
Vol 67 (10) ◽  
pp. 2141-2147 ◽  
Author(s):  
Patrick Atheba ◽  
Patrick Drogui ◽  
Brahima Seyhi ◽  
Didier Robert
Keyword(s):  
Flow Rate ◽  
Photocatalytic Oxidation ◽  
Supported Catalyst ◽  
Operating Conditions ◽  
Treatment Efficiency ◽  
Optimal Operating ◽  
Photo Degradation ◽  
Photochemical Process ◽  
Recirculation Flow ◽  
High Treatment

The present work evaluates the potential of the photocatalysis (PC) process for the degradation of butylparaben (BPB). Relatively high treatment efficiency was achieved by comparison to photochemical process. Prior to photocatalytic degradation, adsorption (AD) of BPB occurred on the titanium dioxide (TiO2)-supported catalyst. AD was described by Langmuir isotherm (KL = 0.085 L g−1, qm = 4.77 mg g−1). The influence of angle of inclination of the reactor, pH, recirculation flow rate and initial concentration of BPB were investigated. The PC process applied under optimal operating conditions (recirculation flow rate of 0.15 L min−1, angle of inclination of 15°, pH = 7 and 5 mg L−1 of BPB) is able to oxidize 84.9–96.6% of BPB and to ensure around 38.7% of mineralization. The Langmuir–Hinshelwood kinetic model described well the photocatalytic oxidation of BPB (k = 7.02 mg L−1 h−1, K = 0.364 L mg−1).

Flow Features Analysis of Throttle Notches of Proportional Direct Valve

2011 ◽  
Vol 189-193 ◽  
pp. 2285-2288
Author(s):  
Wen Hua Jia ◽  
Chen Bo Yin ◽  
Guo Jin Jiang
Keyword(s):  
Fluid Flow ◽  
Dynamic Behavior ◽  
Flow Rate ◽  
Discharge Coefficient ◽  
3D Models ◽  
Operating Conditions ◽  
Flow Models ◽  
Flow Features ◽  
Rate Discharge ◽  
Spool Valve

Flow features, specially, flow rate, discharge coefficient and efflux angle under different operating conditions are numerically simulated, and the effects of shapes and the number of notches on them are analyzed. To simulate flow features, 3D models are developed as commercially available fluid flow models. Most construction machineries in different conditions require different actions. Thus, in order to be capable of different actions and exhibit good dynamic behavior, flow features should be achieved in designing an optimized proportional directional spool valve.

scholarly journals Experimental Investigation and Modeling of Inertance Tubes

2005 ◽  
Vol 127 (5) ◽  
pp. 1029-1037 ◽  
Author(s):  
L. O. Schunk ◽  
G. F. Nellis ◽  
J. M. Pfotenhauer
Keyword(s):  
Mass Flow Rate ◽  
Mass Flow ◽  
Flow Rate ◽  
Acoustic Power ◽  
Operating Conditions ◽  
Thermodynamic Efficiency ◽  
Pulse Tube ◽  
Design Charts ◽  
Wide Range ◽  
Pulse Tube Refrigerators

Growing interest in larger scale pulse tubes has focused attention on optimizing their thermodynamic efficiency. For Stirling-type pulse tubes, the performance is governed by the phase difference between the pressure and mass flow, a characteristic that can be conveniently adjusted through the use of inertance tubes. In this paper we present a model in which the inertance tube is divided into a large number of increments; each increment is represented by a resistance, compliance, and inertance. This model can include local variations along the inertance tube and is capable of predicting pressure, mass flow rate, and the phase between these quantities at any location in the inertance tube as well as in the attached reservoir. The model is verified through careful comparison with those quantities that can be easily and reliably measured; these include the pressure variations along the length of the inertance tube and the mass flow rate into the reservoir. These experimental quantities are shown to be in good agreement with the model’s predictions over a wide range of operating conditions. Design charts are subsequently generated using the model and are presented for various operating conditions in order to facilitate the design of inertance tubes for pulse tube refrigerators. These design charts enable the pulse tube designer to select an inertance tube geometry that achieves a desired phase shift for a given level of acoustic power.

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