scholarly journals Morphological rationale of the optimum material searching for the conservative treatment of pulp inflammation (literature review)

2021 ◽  
Vol 19 (2) ◽  
pp. 101-106
Author(s):  
K. A. Myasoedova ◽  
I. V. Firsova ◽  
S. V. Krajnov ◽  
A. N. Popova
Keyword(s):  
Dental Caries ◽  
Conservative Treatment ◽  
Dental Pulp ◽  
The Body ◽  
Pulp Inflammation ◽  
Optimum Material ◽  
Materials Used ◽  
Biological Methods ◽  
New Generation ◽  
The Ideal

Pulpitis is one of the most prevalence complication of dental caries. In the structure of visits for dental care, the diagnosis of pulpitis accounts for 14 – 20%. Preservation of the vitality of the pulp is very important for the tooth and for the body as a whole. Since the death of the neurovascular bundle leads to a abnormalities of the protective, trophic and plastic functions of the tooth, causing the loss of its functional signifcance, the development of complications and, as a consequence, removal of a tooth. So, conservative methods of pulpitis treatment must be used to prevent the spread of inflammation in the dental pulp. The success of both direct and indirect biological methods for treating pulpitis in more than 50% of cases depends on the drugs and materials used for the pulp. In the arsenal of dentists there are appropriate new generation drugs with a suffciently high evidential base, however, the problem of fnding the "ideal" material is still crucial.

SIGNIFICANCE AND NEED OF TREATMENT OF PERIAPICAL LESION

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (07) ◽  
pp. 5-13
Author(s):  
S.R Pattan ◽  
◽  
P.S Bykod ◽  
P.U. Shetkar ◽  
S.V. Pattewar ◽  
...  
Keyword(s):  
Dental Caries ◽  
Infectious Diseases ◽  
Dental Pulp ◽  
Severe Pain ◽  
Tooth Loss ◽  
The Body ◽  
Periapical Lesion ◽  
Endodontic Disease ◽  
Periapical Inflammation ◽  
Effective Treatments

Dental caries, one of the most prevalent infectious diseases worldwide, affects approximately 80% of children and the majority of adults. Dental caries may result in endodontic disease, leading to dental pulp necrosis, periapical inflammation and bone desorption, severe pain, and tooth loss. Periapical inflammation may also increase inflammation in other parts of the body. Although many studies have attempted to develop therapies for this disease, there is still an urgent need for effective treatments.

scholarly journals Dental Pulp Defence and Repair Mechanisms in Dental Caries

2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
Jean-Christophe Farges ◽  
Brigitte Alliot-Licht ◽  
Emmanuelle Renard ◽  
Maxime Ducret ◽  
Alexis Gaudin ◽  
...  
Keyword(s):  
Dental Caries ◽  
Dental Pulp ◽  
Molecular Mechanisms ◽  
Inflammatory Responses ◽  
Oral Bacteria ◽  
Barrier Formation ◽  
Reparative Dentin ◽  
Pulp Inflammation

Dental caries is a chronic infectious disease resulting from the penetration of oral bacteria into the enamel and dentin. Microorganisms subsequently trigger inflammatory responses in the dental pulp. These events can lead to pulp healing if the infection is not too severe following the removal of diseased enamel and dentin tissues and clinical restoration of the tooth. However, chronic inflammation often persists in the pulp despite treatment, inducing permanent loss of normal tissue and reducing innate repair capacities. For complete tooth healing the formation of a reactionary/reparative dentin barrier to distance and protect the pulp from infectious agents and restorative materials is required. Clinical andin vitroexperimental data clearly indicate that dentin barrier formation only occurs when pulp inflammation and infection are minimised, thus enabling reestablishment of tissue homeostasis and health. Therefore, promoting the resolution of pulp inflammation may provide a valuable therapeutic opportunity to ensure the sustainability of dental treatments. This paper focusses on key cellular and molecular mechanisms involved in pulp responses to bacteria and in the pulpal transition between caries-induced inflammation and dentinogenic-based repair. We report, using selected examples, different strategies potentially used by odontoblasts and specialized immune cells to combat dentin-invading bacteriain vivo.

scholarly journals An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Ji-Hyun Jang ◽  
Hee Woong Shin ◽  
Jung Min Lee ◽  
Hyeon-Woo Lee ◽  
Eun-Cheol Kim ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Dental Pulp ◽  
Germ Line ◽  
The Body ◽  
Host Responses ◽  
Pathogen Recognition ◽  
Lectin Receptors ◽  
Pulp Inflammation ◽  
Inflammatory Processes ◽  
Pathogen Recognition Receptors

Pathogen recognition receptors (PRRs) are a class of germ line-encoded receptors that recognize pathogen-associated molecular patterns (PAMPs). The activation of PRRs is crucial for the initiation of innate immunity, which plays a key role in first-line defense until more specific adaptive immunity is developed. PRRs differ in the signaling cascades and host responses activated by their engagement and in their tissue distribution. Currently identified PRR families are the Toll-like receptors (TLRs), the C-type lectin receptors (CLRs), the nucleotide-binding oligomerization domain-like receptors (NLRs), the retinoic acid-inducible gene-I-like receptors (RLRs), and the AIM2-like receptor (ALR). The environment of the dental pulp is substantially different from that of other tissues of the body. Dental pulp resides in a low compliance root canal system that limits the expansion of pulpal tissues during inflammatory processes. An understanding of the PRRs in dental pulp is important for immunomodulation and hence for developing therapeutic targets in the field of endodontics. Here we comprehensively review recent finding on the PRRs and the mechanisms by which innate immunity is activated. We focus on the PRRs expressed on dental pulp and periapical tissues and their role in dental pulp inflammation.

scholarly journals Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Hitomi Kuramoto ◽  
Kouji Hirao ◽  
Hiromichi Yumoto ◽  
Yuki Hosokawa ◽  
Tadashi Nakanishi ◽  
...  
Keyword(s):  
Dental Caries ◽  
Caffeic Acid ◽  
Dental Pulp ◽  
Biological Activities ◽  
Specific Inhibitor ◽  
Caffeic Acid Phenethyl Ester ◽  
Vegf Receptor ◽  
Normal Medium ◽  
Reparative Dentin ◽  
Pulp Inflammation

Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion. Odontoblasts located in the outermost layer of dental pulp play crucial roles such as production of growth factors and formation of hard tissue termed reparative dentin in host defense against dental caries. In this study, we investigated the effects of CAPE on the upregulation of vascular endothelial growth factor (VEGF) and calcification activities of odontoblasts, leading to development of novel therapy for dental pulp inflammation caused by dental caries. CAPE significantly induced mRNA expression and production of VEGF in rat clonal odontoblast-like KN-3 cells cultured in normal medium or osteogenic induction medium. CAPE treatment enhanced nuclear factor-kappa B (NF-κB) transcription factor activation, and furthermore, the specific inhibitor of NF-κB significantly reduced VEGF production. The expression of VEGF receptor- (VEGFR-) 2, not VEGFR-1, was up regulated in KN-3 cells treated with CAPE. In addition, VEGF significantly increased mineralization activity in KN-3 cells. These findings suggest that CAPE might be useful as a novel biological material for the dental pulp conservative therapy.

Mutual Influence Study of Food Acids and Polysaccharides of Different Nature on the Sensory Perception of Low-Calorie Sweet Dishes

Food Industry ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 71-78
Author(s):  
Ekaterina Minnikhanova ◽  
Nataliya Zavorokhina ◽  
Anna Gilina
Keyword(s):  
Mutual Influence ◽  
Raw Materials ◽  
Sucrose Solution ◽  
Complex Mixture ◽  
The Body ◽  
Sensory Characteristics ◽  
Apple Pectin ◽  
Low Calorie ◽  
Functional Reserves ◽  
Materials Used

Abstract The inclusion of polysaccharide thickeners in the recipes of sweet dishes increases the functional reserves of the body, contributes to the preservation of health and the prevention of diseases. The purpose of the research is to study the sensory characteristics of polysaccharides of various nature when combined with food acids, to develop a recipe for a basic mixture of low-calorie meals for public catering. The authors analyzed citric, lactic and succinic acids in combinations with polysaccharides of various nature. Organoleptic tests were evaluated by a touch panel. The organization of the tasting analysis corresponded to GOST ISO 6658-2016; the consistency was determined according to GOST 31986-2012, GOST ISO 11036-2017, GOST ISO 8588-2011. The optimal organoleptic combinations of the presented food acids and complex additives of sweeteners (CDP) were identified, which included aspartame, sodium saccharinate, Sucralose, sweetness coefficient – 340: the mixture with citric acid had a long pleasant aftertaste without foreign tastes and the best taste characteristics. Using the “A-not A” method, we found that the sample with the addition of CDP is identical to the sucrose solution. In the second part of the study, polysaccharides were added to model samples of acids with complex sweeteners; the best sensory characteristics were obtained by model samples consisting of a mixture of low-esterified Apple pectin with lactic acid and KDP. The technology of obtaining a stable elastic jelly using low-esterified Apple pectin has been developed, since the complex mixture of sweeteners and food acids does not have a dehydrating effect. Developed a dry mix recipe that can serve as a basic development, low-calorie sweet products for catering and has a variance of use of lactic and succinic acids, depending on the flavor characteristics of the raw materials used and its corrective ability.

Materials for bullet core

2020 ◽  
Vol 2020 (10) ◽  
pp. 8-21
Author(s):  
A. G. Kolmakov ◽  
◽  
I. O. Bannykh ◽  
V. I. Antipov ◽  
L. V. Vinogradov ◽  
...  
Keyword(s):  
High Speed ◽  
Bending Strength ◽  
Low Alloy Steels ◽  
Hard Alloys ◽  
Small Arms ◽  
Alloy Steels ◽  
Materials Used ◽  
Basic Ideas ◽  
New Generation ◽  
Natural Composite

he basic ideas about the process of introducing cores into protective barriers and the most common core patterns and their location in conventional and sub-caliber small arms bullets are discussed. The materials used for manufacture of cores are analyzed. It is concluded that for mass bullets of increased armor penetration the most rational choice can be considered the use of high-carbon low-alloy steels of a new generation with a natural composite structure and hardness of up to 70 HRC. For specialized armor-piercing bullets, cores made from promising economically-alloyed high-speed steels characterized by a high complex of «hardness—bending strength» are better alternative than ones made of hard alloys or tungsten alloys.

Detection and Assessment of Interleukin 6 in Irreversible Pulp Inflamation

2017 ◽  
Vol 68 (2) ◽  
pp. 323-327
Author(s):  
Cristian Levente Giuroiu ◽  
Maria Vataman ◽  
Gabriel Melian ◽  
Dragos Bularda ◽  
Ludmila Lozneanu ◽  
...  
Keyword(s):  
Dental Caries ◽  
Interleukin 6 ◽  
Dental Pulp ◽  
The Other ◽  
Control Group ◽  
Study Group ◽  
Pulp Tissue ◽  
Immunohistochemical Technique ◽  
Systemic Distribution ◽  
Cell Zone

The study aimed to assess the number, localization and distribution of interleukin 6 (IL-6) positive cells in healthy pulp, acute and chronic pulpitis. The study group included 48 patients aged between 18-72, treated in University of Medicine and Pharmacy Grigore T. Popa Iasi, Romania. The pulpectomy was performed on 42 patients diagnosed with acute and chronic pulpitis. The other 6 patients, without signs of dental caries or periodontal disease, were submitted to extractions of teeth for orthodontic purposes, with pulpectomy performed before extraction. The pulp samples were examined with optic microscope. The detection and assessment of IL-6 were performed using immunohistochemical technique. Data were statistically analysed using non-parametric tests. According to morphopathological criteria, 42.85% were classified as acute pulpitis and 57.14% as chronic pulpitis. The pulp samples in control group were not associated with IL-6 positive cells. The analysis of all samples with acute and chronic pulpitis identified 73.80% samples with IL-6 and 26.20% associated with the absence of IL-6. The highest frequency of IL-6 positive cells was recorded in rich-cell zone of crown dental pulp. The systemic distribution of IL-6 positive cells was mostly diffused without well-defined orientation. IL-6 release in acute and chronic pulpitis is significantly higher comparing with healthy pulp tissue.

The Funerary Architecture of the La Tène Period in North-western Gaul and Southern Britain

2020 ◽  
Vol 86 ◽  
pp. 285-304
Author(s):  
Emilie Vannier
Keyword(s):  
Human Remains ◽  
The Body ◽  
Common Features ◽  
Architectural Elements ◽  
Funerary Architecture ◽  
La Tène ◽  
Materials Used ◽  
La Tene ◽  
North Western

This paper concerns the architecture of formal burials from the La Tène period in north-western Gaul and southern Britain. The research focuses on the shape and dimensions of sepulchral pits containing inhumed or burnt human remains, on the different materials used for the internal elements, and the external constructions and structures covering, framing, or marking the burials. The study of these data exposes the preferred choices in the funerary architecture of Gallic and British communities during the last five centuries bc. The results reveal different regional funerary groups within three main cross-Channel zones according to the architectural elements of the graves and the main treatments of the body. The distinct characteristics of these groups highlight their common features and relationships with neighbouring areas of the Continental and Atlantic zones.

Embodying the culture of achievement: Culture between illness and perfection is a ‘thin line’ – obtaining the ideal female body as an act of achievement

2021 ◽  
pp. 1354067X2110040
Author(s):  
Josefine Dilling ◽  
Anders Petersen
Keyword(s):  
Experimental Study ◽  
Human Body ◽  
Female Body ◽  
The Body ◽  
Thin Line ◽  
Complex Processes ◽  
The Individual ◽  
Different Levels ◽  
The Ideal ◽  
Body Ideals

In this article, we argue that certain behaviour connected to the attempt to attain contemporary female body ideals in Denmark can be understood as an act of achievement and, thus, as an embodiment of the culture of achievement, as it is characterised in Præstationssamfundet, written by the Danish sociologist Anders Petersen (2016) Hans Reitzels Forlag . Arguing from cultural psychological and sociological standpoints, this article examines how the human body functions as a mediational tool in different ways from which the individual communicates both moral and aesthetic sociocultural ideals and values. Complex processes of embodiment, we argue, can be described with different levels of internalisation, externalisation and materialisation, where the body functions as a central mediator. Analysing the findings from a qualitative experimental study on contemporary body ideals carried out by the Danish psychologists Josefine Dilling and Maja Trillingsgaard, this article seeks to anchor such theoretical claims in central empirical findings. The main conclusions from the study are used to structure the article and build arguments on how expectations and ideals expressed in an achievement society become embodied.

scholarly journals Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Erfan Dashtimoghadam ◽  
Farahnaz Fahimipour ◽  
Andrew N. Keith ◽  
Foad Vashahi ◽  
Pavel Popryadukhin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Reconstructive Surgery ◽  
Biomedical Applications ◽  
The Body ◽  
Surrounding Tissue ◽  
Curing Time ◽  
Materials Used ◽  
Significant Health

AbstractCurrent materials used in biomedical devices do not match tissue’s mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation.

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