scholarly journals FORMULATION DEVELOPMENT AND PHYSICAL TEST OF LEAF ETHANOL EXTRACT CREAM NONI (Morinda Citrifolia L) AS A WOUND HEALER

2018 ◽  
Vol 1 (1) ◽  
pp. 20-26
Author(s):  
Anom Parmadi
Keyword(s):  
Leaf Extract ◽  
Ethanol Extract ◽  
Test Method ◽  
Homogeneity Test ◽  
Formulation Development ◽  
Physical Test ◽  
Power Test ◽  
Healing Power ◽  
Dispersion Test ◽  
Made In

Injuries are lost or damaged part of the body's tissues. Wounds are also defined as physical damage due to the opening or destruction of the skin which can cause abnormal skin function and anatomy. These plants widely used traditionally from fresh noni leaves used as a medicine for broken bones, cuts, burns and pain by boiling and drinking the juice. These studys to make use of more effective and efficient Noni leaf extract made in cream preparations as a wound medicine, so that people are easy to use. This study used an experimental research method, namely the cream formulation of noni concentrated ethanol extract of 5%, 10% and 15%. Cream preparation evaluation test included: Organoleptic, pH test, cream type test, homogeneity test, sticky power test, dispersion test and protection power test. The test method was carried out on mice by means of cream preparations applied to the back of mice which were given an incision wound. Its effectiveness is seen from the measurement of wound length for seven days to calculate the percentage of wound healing power. The results of the One Way ANOVA test showed that there were significant differences between concentrations of 5%, 10% and 15% with significant values <0.05. The percentage of healing power of noni leaf extract cream concentration of 5% = 7,69%, concentration of 10% = 17,26%, and concentration of 15% = 29,35%. The results showed that the ethanol extract of noni leaves can be made in cream dosage form and has the effectiveness to accelerate the healing of incision wounds in mice.

scholarly journals FORMULASI SEDIAAN KRIM KOMBINASI EKSTRAK DAUN SELEDRI (Apium graveolens L.) DAN DAUN JATI (Tectona grandis Linn.F) SEBAGAI ANTIBAKTERI TERHADAP Staphylococcus aureus

PHARMACON ◽  
2020 ◽  
Vol 9 (2) ◽  
pp. 259
Author(s):  
Riska Tuloli ◽  
Hosea Jaya Edi ◽  
Imam Jayanto
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Leaf Extract ◽  
Tectona Grandis ◽  
Test Method ◽  
Apium Graveolens ◽  
Homogeneity Test ◽  
Cycling Test ◽  
Physical Tests ◽  
Dispersion Test

ABSTRACT Celery plants (Apium graveolens L.) and teak plants (Tectona grandis Linn.f) are plants that contain flavonoids, tannins, and saponins and has antibacterial activity against Staphylococcus aureus. This study aims to test the antibacterial effectiveness of combination of celery and teak leaf cream and evaluate cream with parameters of physical tests (organoleptic, homogeneity, pH, spreadability, adhesion) and physical stability with cycling test method. This study used an experimental laboratory method by making 5 variations concentration of extracts. Celery and teak leaf extract was extracted by maceration method. Antibacterial test used the wells method. Results of the evaluation of physical tests for organoleptic test (odor: a typical combination of extracts;color: brown;shape: semi-solid), homogeneity test (homogeneous), average of pH test is 6.02, dispersion test is 4.27 cm, adhesion test is 18.42 seconds. Based on the results of this study, concluded that the combination of celery leaf and teak leaf extract can be formulated into a cream. The cream of combination of celery and teak leafs extract are bacteriostatic and has antibacterial activity with an average diameter for formulation I 13.4 mm, formulation II 9.23 mm, formulation III 16.23 mm, formulation IV 11 mm, and formulation V 12.06 mm. Keywords : Celery (Apium graveolens L.), Teak (Tectona grandis Linn.f), Antibacterial, Cream. ABSTRAK Tanaman seledri (Apium graveolens L.) dan tanaman jati (Tectona grandis Linn.f) merupakan tanaman yang mengandung flavonoid, tanin dan saponin dan memiliki aktivitas antibakteri terhadap Staphylococcus aureus. Penelitian ini bertujuan untuk menguji aktivitas antibakteri sediaan krim kombinasi ekstrak daun seledri dan daun jati serta mengevaluasi sediaan krim dengan parameter uji sifat fisik (uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat) dan stabilitas fisik dengan metode cycling test. Penelitian ini menggunakan metode eksperimental laboratorium dengan membuat 5 variasi konsentrasi ekstrak. Ekstrak diperoleh dengan cara maserasi. Uji antibakteri dilakukan dengan metode sumuran. Hasil evaluasi sifat fisik untuk uji organoleptik (bau: khas kombinasi ekstrak;warna:coklat;bentuk:setengah padat), uji homogenitas (susunan homogen), rata-rata uji pH 6,02, daya sebar 4,27 cm, daya lekat 18,42 detik. Berdasarkan hasil penelitian disimpulkan bahwa kombinasi ekstrak daun seledri dan daun jati dapat diformulasikan menjadi sediaan krim. Sediaan krim kombinasi ekstrak daun seledri dan daun jati bersifat bakteriostatik dan memiliki aktivitas antibakteri dengan diameter rata-rata untuk formula I 13,4 mm, formula II 9,23 mm, formula III 16,23 mm, formula IV 11 mm, dan formula V 12,06 mm. Kata Kunci : Seledri (Apium graveolens L.), Jati (Tectona grandis Linn.f), Antibakteri, Krim

Analgesic Effectivty Of Nanoparticles Chitosan-Ethanol Leaf Extract Papaya (Carica Papaya L.) In White Male Mice (Mus Mucculus)

2017 ◽  
Vol 15 (2) ◽  
pp. 228
Author(s):  
Juliferd Gredi ◽  
Wintari Taurina ◽  
Mohamad Andrie
Keyword(s):  
Leaf Extract ◽  
Carica Papaya ◽  
White Male ◽  
Ethanol Extract ◽  
Test Method ◽  
Ionic Gelation ◽  
Male Mice ◽  
Writhing Test ◽  
Effi Ciency ◽  
Optimal Formula

Papaya leaves has been shown to have efficacy as an analgesic. Analgesic effect caused by the flavonoids in leaves of papaya. To enhance the analgesic effi cacy papaya into dosage formulatio of nanoparticles. The purpose of this research was to create and characterized nanoparticles from ethanol extract of papaya leaves then tested for effectiveness as an analgesic. This study used polymer chitosan and NaTPP to created nanoparticles through ionic gelation method and analgesic activity tested using writhing test method and statistical tested. Optimal formula of nanoparticles were produced at concentration of 0.2% chitosan, Na-TPP extract 0.1% and 4% with a ratio of 6: 1: 1. The nanoparticles was formed a size of 255.4 nm with polidispers index of 0.7, the zeta potential of + 11,1mV, the adsorption effi ciency by 87% and rounded morphology (spherical). Analgesic effectiveness tested by comparison between the groups ethanol extract of papaya and the groups nanoparticles of chitosan-ethanol extract papaya statistically using the T-test Independent. The results of this research indicate that there are statistically signifi cant differences (p <0.05). This results shows that the preparation nanoparticles of chitosan-ethanol extract papaya is more effective as an analgesic than the ethanol extract of papaya leaves.

scholarly journals FORMULASI DAN UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL DAUN SESEWANUA (Clerodendron squamatum Vahl.)

PHARMACON ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 261
Author(s):  
Meyla C. M. Pratasik ◽  
Paulina V. Y. Yamlean ◽  
Weny I Wiyono
Keyword(s):  
Experimental Method ◽  
Leaf Extract ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Adhesion Test ◽  
Cycling Test ◽  
Physical Evaluation ◽  
Before And After ◽  
Dispersion Test ◽  
The Right

ABSTRACT Sesewanua Leaves (Clerodendron squamatum Vahl.) have the potential to be made as skin care cosmetic preparations but must be in the right formulation to achieve the desired effect. The aim of this study was to determine the physical stability of a cream from Sesewanua leaf extract. This study used a experimental method by making ethanol extract of Sesewanua leaves with a concentration of 0.5% and physical stability test. Physical evaluation was carried out before and after cycling test through organoleptic observation, homogenety test, pH test, dispersion test, adhesion test, viscosity test, centrifugation test and cream type determination. The results of the physical evaluation showed that F1 without Sesewanua leaf extract and F2 with Sesewanua leaf extract creams met the requirements of physical stability, so can be concluded that Sesewanua leaf extract can be formulated into cream preparations with concentration of 0.5% which is physically stable before and after cycling test. Keywords: Sesewanua Leaves, Cream, Physical Stability  ABSTRAK Daun Sesewanua (Clerodendron squamatum Vahl.) berpotensi untuk dibuat sebagai sediaan kosmetik perawatan kulit namun harus dengan formulasi yang tepat agar mencapai efek yang diinginkan. Penelitian ini bertujuan untuk mengetahui stabilitas fisik sediaan krim ekstrak daun sesewanua. Penelitian ini menggunakan metode eksperimental dengan membuat krim ekstrak etanol daun Sesewanua dengan konsentrasi 0,5% dan uji stabilitas fisik. Evaluasi fisik dilakukan sebelum dan sesudah cycling test melalui pengamatan organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, uji viskositas, uji sentrifugasi dan penentuan tipe krim. Hasil evaluasi fisik menunjukkan krim F1 tanpa ekstrak daun Sesewanua dan F2 dengan ekstrak daun Sesewanua memenuhi persyaratan stabilitas fisik. Berdasarkan hasil penelitian dapat disimpulkan ekstrak daun sesewanua dapat diformulasi menjadi sediaan krim dengan konsentrasi 0,5% yang stabil secara fisik sebelum dan sesudah cycling test. Kata Kunci : Daun Sesewanua, Krim, Stabilitas Fisik

scholarly journals FORMULASI DAN EFEK ANTIBAKTERI MASKER PEEL-OFF EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI Staphlococcous epidermidis

PHARMACON ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 686
Author(s):  
Regita Daimunon ◽  
Paulina V. Y. Yamlean ◽  
Imam Jayanto
Keyword(s):  
Staphylococcus Epidermidis ◽  
Ethanol Extract ◽  
Homogeneity Test ◽  
Power Test ◽  
Cycling Test ◽  
Physical Evaluation ◽  
Before And After ◽  
Time Test ◽  
Ethanol Extracts ◽  
Muntingia Calabura

ABSTRACT Kersen leaf (Muntingia calabura L.) contains flavonoids, saponins and tannins, which could inhibit bacterial activity. This study aimed to formulate, evaluate, and to test the effectiveness of antibacterial preparations for the Kersen leaf ethanol extracts mask.  This study uses the experimental method by testing the parameters of the physical evaluation requirements for the masker. Physical evaluation of preparations included organoleptic test, homogeneity test, pH test, scattering power test, dry time test, sticky test and cycling test, all tests were carried out before and after cycling test. The results of the preparation study meet the requirements of physical evaluation before the cycling test but after the cycling test is is not in accordance to the requirements for the preparation of the peel-off mask. The antibacterial test of mask peel-off ethanol extract of Kersen's leaves on Staphylococcus epidermidis bacteria produced a moderate inhibition. So it can be concluded that the ethanol extracts of Kersen leaves at a concentration of 20%.  can be formulated as a peel-off mask that is physically stable and has moderate antibacterial activity.Keywords: Kersen, Peel-off mask, Antibacterial, Staphlococcous epidermidis ABSTRAK Daun Kersen (Muntingia calabura L.) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas bakteri.  Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antibakteri sediaan masker peel-off ekstrak etanol daun Kersen. Penelitian ini menggunakan metode ekperimental dengan melakukan pengujian parameter persyaratan evaluasi fisik masker peel-off. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji waktu sediaan mengering, uji daya lekat dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian sediaan memenuhi persyaratan eveluasi fisik sebelum uji cycling test namun setelahnya tidak sesuai dengan persyaratan sediaan masker peel-off. Penelitian uji antibakteri masker peel-off ekstrak etanol daun Kersen pada bakteri staphylococcus epidermidis menghasilkan daya hambat yang sedang. Dapat disimpulkan pada kosentrasi 20% ekstrak etanol daun Kersen dapat diformulasi sebagai sediaan masker peel-off yang stabil secara fisik dan memiliki aktivitas antibakteri yang sedang .Kata kunci : Kersen, Masker peel-off, Antibakteri, Staphlococcous  epidermidis

scholarly journals FORMULASI SEDIAAN KRIM EKSTRAK ETANOL DAUN KALIANDRA (Calliandra surinamensis) DAN UJI AKTIVITAS ANTIBAKTERINYA TERHADAP BAKTERI Staphylococcus aureus

PHARMACON ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 809
Author(s):  
Gichella C. J. Somba ◽  
Hosea Jaya Edi ◽  
Jainer P. Siampa
Keyword(s):  
Leaf Extract ◽  
Physical Stability ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Physical Test ◽  
Sterility Testing ◽  
Cycling Test ◽  
Test Parameters ◽  
Before And After ◽  
Inhibitory Power

ABSTRACT This study aims to test the antibacterial effectiveness of ethanolic extract of Kaliandra leaf cream and evaluate the preparations using parameters of physical properties, physical stability, and sterility. Kaliandra leaf (Calliandra surinamensis) contains compounds such as flavonoid, saponins and tannins that can inhibit the growth of bacteria. This research uses laboratory experimental methods. Cream preparation formula is made with variations in the concentration of ethanol extract of Kaliandra leaves 2%, 3%, 4%, 5%, 6%. Kaliandra leaf extract was obtained by maceration using 96% ethanol solvent. The study of antibacterial test of ethanol extract of Kaliandra leaf extract using the method of Staphylococcus aures produced inhibitory power of 5.09 ± 0.88 mm at a concentration of 6%. The physical evaluation of the cream preparation includes organoleptic examination (odor, color, shape), homogeneity, pH testing, adhesion, dispersion, cycling test. All tests are carried out before and after the cycling test. The results obtained before and after the cycling test showed that the cream preparations met organoleptic requirements, homogeneity, cream pH 6.07 (4.5-6.5), cream adhesion 4.59 seconds (<4 seconds), cream dispersion  6.19 cm (5-7 cm). Cream sterility testing shows that the cream is sterile. It can be concluded that the ethanol extract of Kaliandra leaves cream meets the physical test parameters, is stable and has moderate antibacterial activity. Keywords : Kaliandra Leaf (Calliandra surinamensis), Cream, Antibacterial, Staphylococcous aureus.  ABSTRAK Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan krim ekstrak etanol daun Kaliandra dan mengevaluasi sediaan dengan menggunakan parameter uji sifat fisik, stabilitas fisik, dan sterilitas. Daun Kaliandra (Calliandra surinamensis) merupakan tanaman yang mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat pertumbuhan bakteri. Penelitian ini menggunakan metode eksperimental laboratorium, Formula sediaan krim dibuat dengan variasi konsentrasi ekstrak etanol daun Kaliandra 2%, 3%, 4%, 5%, 6%. Ekstrak daun Kaliandra diperoleh dengan cara maserasi menggunakan pelarut etanol 96%. Penelitian uji antibakteri sediaan krim esktrak etanol daun Kaliandra menggunakan metode sumuran pada bakteri Staphylococcus aures menghasilkan daya hambat 5,09±0,88 mm pada konsentrasi 6%. Evaluasi fisik sediaan krim meliputi pemeriksaan organoleptis (bau, warna,  bentuk), homogenitas, pengujian pH, daya  lekat,  daya  sebar, uji cycling test. Semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian yang didapat sebelum dan sesudah cycling test menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptis, homogenitas, pH krim 6,07 (4,5-6,5), daya lekat krim 4,59 detik (<4 detik), daya sebar krim 6,19 cm (5-7 cm). Pengujian sterilitas krim menunjukan bahwa krim steril. Dapat disimpulkan bahwa sediaan krim ekstrak etanol daun Kaliandra memenuhi parameter uji fisik, stabil dan memiliki aktivitas  antibakteri yang sedang. Kata kunci : Daun Kaliandra (Calliandra surinamensis), Krim, Antibakteri, Staphlococcous aureus.

scholarly journals Antiseptic gel formulated from ethanol extract of Citronella grass (Cymbopogon nardus) using CMC-Na, arabic gums, and gelatin as gelling agents

2021 ◽  
pp. 258-263
Author(s):  
Reynelda Juliani Sagala ◽  
Lorensia Yolanda ◽  
Michael
Keyword(s):  
Gum Arabic ◽  
Ethanol Extract ◽  
Gelling Agent ◽  
Homogeneity Test ◽  
Gelling Agents ◽  
Cymbopogon Nardus ◽  
Dispersion Test ◽  
Gel Formulations ◽  
Citronella Grass

Introduction: The ethanol extract from citronella grass (Cymbopogon nardus) has been found to contain saponins, phenolics (flavonoids), and polyphenols which have antibacterial activity. As a result, researchers developed an antiseptic gel that contains this ethanol extract. Aims: This study aims to find the optimum concentration of gelling agent required to make the gel and to use physical evaluations in order to understand whether combining gelling agents may increase the quality of the gel. Methods: The gel was made using a melting method, which mixed the base of gel with citronella ethanol extract at a temperature of 40oC to form a homogeneous phase. The gel evaluation was conducted using an organoleptic test, homogeneity test, dispersion test, pH test, and adhesion test. Results: The tests were carried out on 15 formulations respectively (R1, R2, and R3), and resulted in the production of clear, translucent yellow gel with a distinctive citronella grass odor. The homogeneity test showed that all formulations were homogeneous and contained no agglomerated particles. The gel dosage forms made with CMC-Na, gum arabic, and gelatin as gelling agents resulted in having a pH of 7 whilst gels made with a combination of gelling agents resulted in having a pH of 8. The combination of gum arabic and CMC-Na gelling agents showed an increase in spreadability of gel formulas at the same concentration of composition, of which the combinations were 1.25% gum arabic and 1.25% CMC-Na. The gel adhesion time was 0.2-2 minutes for all formula. Conclusion: Based on this test data, it can be concluded that the 15 gel formulations that resulted from this research are good and further testing can be performed to determine the most optimum and stable formula.

scholarly journals FORMULASI DAN UJI EFEKTIVITAS ANTIOKSIDAN SEDIAAN MASKER PEEL-OFF EKSTRAK ETANOL DAUN SESEWANUA (Cleodendron squamatum Vahl.)

PHARMACON ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 388
Author(s):  
Ferrna Rompis ◽  
Paulina V. Y. Yamlean ◽  
Widya A. Lolo
Keyword(s):  
Ethanol Extract ◽  
Homogeneity Test ◽  
Analytic Method ◽  
Drying Time ◽  
Power Test ◽  
Cycling Test ◽  
Physical Evaluation ◽  
Antioxidant Effectiveness ◽  
Before And After ◽  
Time Test

ABSTRACT                Sesewanua leaves (Cleodendron squamatum Vahl.) contain alkaloids and flavonoids which are efficacious as antioxidants. This study aimed to fomulate, evaluate, and test the effectiveness of antioxidants in the form of peel-off mask of ethanol extract from the Sesewanua leaves. This study used descriptive-analytic method with the treatment of variations in concentrations of  PVA 12 % , 14% and 16 %, respectively. Physical evaluation of preparations included organoleptic observation, homogeneity test, pH test, scattering power test, drying time test, and cycling test, all tests were carried out before and after the cycling test. The results showed that all preparations met the requirements of physical evaluation before the cycling test while after the cycling test only preparations with 12% PVA concentrations met the requirement, whereas preparations with 14% and 16% of PVA did not met the requirement after the cycling test and after testing antioxidant effectiveness using the DPPH (1,1-diphenyl-2-pikrilhidrazil) method were obtained. The value of  IC50  before cycling test was 179.120 mg/L and after cycling test was 504.74mg/L. Based on the results of the study it can be concluded that the ethanol extract of Sesewanua leaves can be formulated into a peel-off mask with 12% PVA concentration which is physically stable and has moderate antioxidant effectiveness before the cycling test, while after cycling test the preparation of peel-off mask ethanol extract of Sesewanua leaves is less effective as an antioxidant. Keywords:  Sesewanua leaves (Cleodendron squamatum Vahl.), peel-off mask, antioxidantsABSTRAK               Daun Sesewanua (Cleodendron squamatum Vahl.) mengandung alkaloid dan flavonoid yang berkhasiat sebagai antioksidan. Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antioksidan sediaan masker peel-off ekstrak etanol daun Sesewanua. Penelitian ini menggunakan metode deskriptif-analitik dengan perlakuan variasi konsentrasi PVA 12%, 14% dan 16%. Evaluasi fisik sediaan meliputi pengamatan organoleptik, uji homogenitas, uji pH, uji daya sebar, uji waktu mengering dan uji cycling test semua pengujian dilakukan sebelum dan sesudah uji cycling test. Hasil penelitian menunjukkan bahwa semua sediaan memenuhi persyaratan evaluasi fisik sebelum uji cycling test sedangkan setelah uji cycling test hanya sediaan dengan  konsentrasi PVA 12% yang memenuhi persyaratan sedangkan sediaan dengan konsentrasi PVA 14% dan 16% tidak memenuhi persyaratan setelah uji cycling test, dan setelah dilakukan uji efektivitas antioksidan dengan metode DPPH (1,1-difenil-2-pikrilhidrazil) diperoleh nilai IC50 sebelum uji cycling test sebesar 179,120 mg/L dan sesudah cycling test sebesar 504,74 mg/L. Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak etanol daun Sesewanua dapat diformulasi menjadi sediaan masker peel-off dengan konsentrasi PVA 12% yang stabil secara fisik dan memiliki efektivitas antioksidan yang sedang sebelum uji cycling test sedangkan setelah cycling test sediaan masker peel-off ektrak etanol daun sesewanua kurang efektif sebagai antioksidan. Kata Kunci : Sesewanua (Cleodendron squamatum Vahl.), masker peel-off, Antioksidan. 

scholarly journals FORMULASI DAN UJI EFEKTIVITAS ANTIFUNGI KRIM EKSTRAK ETANOL DAUN SALAM (Syzygium polianthum (Wight) Walp.) TERHADAP JAMUR Candida albicans

PHARMACON ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 841
Author(s):  
Sheren N. Lolowang ◽  
Paulina V.Y. Yamlean ◽  
Karlah L.R. Mansauda
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Leaf Extract ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Average Diameter ◽  
Statistical Test ◽  
Adhesion Test ◽  
Physical Evaluation ◽  
Dispersion Test

ABSTRACT Bay leaf (Syzygium polianthum (Wight) Walp.) are used as natural medicinal ingredients because contain compounds such as flavonoid, saponin and tannin that can inhibit the growth of fungal. The purpose of this study was to test the antifungal effectiveness of bay leaf ethanol extract cream and evaluate the preparation of physical stability. The research that was carried out was laboratory experimental. Bay leaf extract was obtained by maceration using 96% ethanol. The cream preparation was made with variations in the concentration of Bay leaf ethanol extract formula 1%; 3%; 6% and 9%. The method used to test the antifungal effectiveness is the well method. The result of the antifungal test showed an average diameter value for formula I (1%) 6.67 mm; formula II (3%) 9.5 mm; formula III (6%) 10.83 mm and formula IV (9%) 15 mm. Statistical test of ethanol extract cream of Bay leaf produced the largest inhibiton zone of 15 mm at a concentration of 9%. Physical evaluation showed that the cream preparations met organoleptic requirements, homogeneity, pH 4.83, dispersion  test 5.30 cm, adhesion test 7.01 seconds. It can be concluded that the ethanol extract of bay leaf can be formulated into a cream preparation that is physically stable and has strong antifungal activity.  Keywords: Bay Leaf, Antifungal Cream, Candida albicans  ABSTRAK Daun Salam (Syzygium polianthum (Wight) Walp.) dimanfaatkan sebagai bahan obat alami karena memiliki kandungan senyawa flavonoid, saponin dan tannin yang dapat menghambat pertumbuhan jamur. Penelitian ini bertujuan menguji efektivitas antijamur sediaan krim ekstrak etanol daun salam dan mengevaluasi kestabilan fisik sediaan. Penelitian yang dilakukan bersifat eksperimental laboratorium. Ekstrak daun Salam diperoleh dengan cara maserasi menggunakan etanol 96%. Sediaan krim dibuat dengan variasi konsentrasi formula ekstrak daun Salam  1%; 3%; 6% dan 9%. Metode yang digunakan untuk uji efektivitas antijamur yaitu metode sumuran. Hasil pengujian antijamur menunjukkan nilai diameter rata-rata pada formula I (1%) 6.67 mm; formula II (3%) 9.5 mm; formula III (6%) 10.83 mm dan formula IV (9%) 15 mm. Uji statistika krim ekstrak etanol daun salam menghasilkan zona hambat terbesar yaitu 15 mm pada formula IV konsentrasi 9%. Evaluasi fisik menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptik, homogenitas, pH 4.83, daya sebar 5.30 cm, dan daya lekat 7.01 detik. Dapat disimpulkan bahwa ekstrak etanol daun salam dapat diformulasikan menjadi sediaan krim yang stabil secara fisik dan memiliki aktivitas antijamur yang kuat. Kata kunci: Daun Salam, Krim Antijamur, Candida albicans

scholarly journals Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp

2019 ◽  
Vol 2 (1) ◽  
pp. 1-9
Author(s):  
Wa Ode Sitti Zubaydah ◽  
Wahyuni Wahyuni ◽  
Sahidin Sahidin ◽  
Tian Amalia Halik ◽  
Rina Andriani ◽  
...  
Keyword(s):  
Diclofenac Sodium ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Negative Control ◽  
Test Method ◽  
Inflammatory Activity ◽  
Extract Concentration ◽  
Dispersion Test ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The aim of this study was to determine the characteristics of the gel formula based on it�s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% ?-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren�gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.

scholarly journals FORMULASI DAN UJI ANTIBAKTERI GEL EKSTRAK ETANOL DAUN KEDONDONG (Spondias dulcis) TERHADAP BAKTERI Pseudomonas aeruginosa

PHARMACON ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 8
Author(s):  
Kevin Yosua Pakpahan ◽  
Paulina V. Y. Yamlean ◽  
Imam Jayanto
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Ethanol Extract ◽  
Homogeneity Test ◽  
Cycling Test ◽  
Physical Evaluation ◽  
Before And After ◽  
Dispersion Test ◽  
Gel Preparation ◽  
Ethanol Extracts ◽  
Weak Antibacterial Activity

ABSTRACT Kedondong leaves (Spondias dulcis) contain flavonoid compounds, saponins and tannins that inhibit bacterial activity. This study aims to formulate, evaluate, and test the antibacterial effectiveness of the ethanol extracts gel of the Kedondong leaves (Spondias dulcis) at a concentration of 6%, 8%, 10%, respectively. This study uses an experimental method by testing the physical evaluation requirements of gel preparations. Physical evaluation of preparations includes organoleptic test, homogeneity test, pH test, dispersion test, adhesion test and cycling test, all tests are carried out before and after the cycling test. The results of the study on the gel dispersion test did not meet the physical evaluation requirements before the cycling test and after the cycling test there was a synergetic and did not meet the requirements. Antibacterial test of ethanol extracts gel of Kedondong leaves against Pseudomonas aeruginosa produced weak inhibitory properties. It can be concluded that the gel concentration of 6%, 8%, 10% of ethanol extract of Kedondong leaves cannot be formulated as a gel preparation because it is less physically stable and has weak antibacterial activity.  Keywords: Antibacterial, HPMC Gel, Kedondong (Spondias dulcis), Pseudomonas aeruginosa   ABSTRAK Daun Kedondong (Spondias dulcis) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas bakteri.  Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antibakteri sediaan gel ekstrak etanol daun Kedondong (Spondias dulcis) pada kosentrasi 6%, 8%, 10%. Penelitian ini menggunakan metode ekperimental dengan melakukan pengujian parameter persyaratan evaluasi fisik sediaan gel. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian pada uji daya sebar sediaan gel tidak memenuhi persyaratan eveluasi fisik sebelum uji cycling test dan setelah cycling test terjadi sineresis dan tidak memenuhi syarat. Penelitian uji antibakteri sediaan gel ekstrak etanol daun Kedondong pada bakteri Pseudomonas aeruginosa menghasilkan daya hambat yang lemah. Dapat disimpulkan pada gel kosentrasi 6%, 8%, 10% ekstrak etanol daun Kedondong tidak dapat diformulasi sebagai sediaan gel karena kurang stabil secara fisik dan memiliki aktivitas antibakteri yang lemah.  Kata kunci : Antibakteri, Gel HPMC, Kedondong (Spondias dulcis), Pseudomonas aeruginosa

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