scholarly journals Pengaruh Pemberian Minuman Cokelat (Theobroma cacao L.) Terhadap Berat Basah Organ Hati Tikus Diabetes Melitus

2021 ◽  
Vol 2 (3) ◽  
pp. 74-79
Author(s):  
Putri Rahayu Ratri ◽  
Adhiningsih Yulianti ◽  
Arisanty Nur Setia Restuti
Keyword(s):  
Diabetes Mellitus ◽  
Treatment Group ◽  
Theobroma Cacao ◽  
The Body ◽  
Control Group ◽  
Experimental Sample ◽  
Cocoa Powder ◽  
Significant Difference ◽  
Wet Weight ◽  
Theobroma Cacao L

Cacao (Theobroma cacao L.) is known to have enormous potential advantages because they contain vitamins A1, B1, B2, C, D, and E as well as minerals such as iron, zinc, phosphorus, magnesium, and copper. In addition, chocolate is also known to be rich in active antioxidant ingredients such as phenolic compounds, prociandin, and flavonoids which can reduce the bad effects of antioxidants in the body. giving chocolate to experimental animals and consumption interventions in humans can prevent and overcome the problem of several diseases, one of which is diabetes mellitus. The purpose of this study was to see the effect of giving cocoa powder drink to the wet weight of the liver in rats with diabetes mellitus. The research design used was experimental research using a completely randomized design with a post-test only control group design. The experimental sample used fifteen male white rats (Rattus norvegicus) Sprague Dawley strain. The experimental mice were divided into 5 groups, namely the negative control group (K-), namely normal rats without any treatment, the positive group, namely the diabetes mellitus (K +) group; treatment group 1 (KP1), treatment group 2 (KP2), treatment group 3 (KP3), namely the diabetes mellitus group of rats that were given the treatment of chocolate drink with a concentration of cocoa powder drink doses of 2%, 4% and 6%. Data analysis was performed using the One Way ANOVA test. Results: The results showed that the organ weight in the group K- = 10.46 ± 0.44; K + = 11.49 ± 0.39; KP1 = 9.95 ± 0.60; KP2 = 11.30 ± 0.60; KP3 = 11.09± 0.90. Statistical analysis showed that there was no significant difference for each treatment with a value of p = 0.077. The conclusions in the study regarding the effect of giving chocolate drink on the wet weight of the liver in rats with diabetes mellitus showed that giving cocoa powder with a concentration of 2%, 4% and 6% was not able to significantly affect the wet weight of the liver.

scholarly journals PENGARUH PEMBERIAN SEDUHAN DAUN ASAM JAWA ( Tamarindus indica L.) TERHADAP PENURUNAN KADAR GULA DARAH PADA MASYARAKAT DESA TANJUNGBUMI KABUPATEN BANGKALAN MADURA

2021 ◽  
Vol 3 (2) ◽  
pp. 71-85
Author(s):  
arista wahyu ningsih ◽  
◽  
Nur Arzy Samsiyeh ◽  
Martina Kurnia Rohmah ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Treatment Group ◽  
Blood Sugar ◽  
Statistical Tests ◽  
T Test ◽  
The Body ◽  
Control Group ◽  
Tamarindus Indica ◽  
Significant Difference ◽  
Sugar Levels

Diabetes mellitus is a disease or metabolic disorder that is most often found in society, including one of the diseases or metabolic disorders. Tamarind leaves (Tamarindus indica L) is a plant that can be used as an alternative treatment for Diabetes Mellitus which contains flavonoids, sapoin and tannins, which can lower glucose levels and inhibit glucose absorption in the blood. This study aims to determine the differences in blood sugar levels before and after giving tamarind leaves infusion in the village community of Tanjung Bumi. This type of research is Quasy Experiment Design and purposive sampling technique with a sample of 29 respondents. Based on the results of the paired t-test statistical analysis showed a significant difference (p = 0.000) between the blood sugar levels of the group and placebo. Meanwhile, in the posttest the treatment group after giving tamarind leaves showed the same as the control group, namely p = 0.000, which means that there is also a difference in the decrease in blood sugar levels between the sebelum pemberian perlakuan and posttest. The results of statistical tests with the Independent T-Test showed the results in both groups with a value of p = 0.000, meaning that there was a difference in the decrease in blood sugar levels between the control group and the treatment group. Steeping tamarind leaves has an effect in reducing blood sugar levels in the body

scholarly journals Perbedaan Kadar Glutation (GSH) Hepar Tikus Putih Jantan (Rattus norvegicus) yang diinduksi Parasetamol Dosis Toksik dengan Pemberian Ekstrak Daun Kelor (Moringa oleifera)

2020 ◽  
Vol 20 (1) ◽  
pp. 247
Author(s):  
Nur Insani ◽  
H.M.T Kamaluddin ◽  
Swanny Swanny
Keyword(s):  
Oxidative Stress ◽  
Treatment Group ◽  
Leaf Extract ◽  
The Body ◽  
Control Group ◽  
Bb Rat ◽  
Toxic Dose ◽  
Experimental Animals ◽  
Significant Difference ◽  
Group Ii

Glutathione (GSH) transferase deficiency due to paracetamol exposure causes further oxidative stress to liver necrosis. To reduce oxidative stress that can cause damage to the liver of the body requires antioxidants. One plant to treat liver disease is the kelor leaf (because it has an active flavonoid material also has antioxidant activity). This study was conducted to determine the difference of glutathione hepar levels of male white rat induced paracetamol toxic dose by giving kelor leaf extract. The type of research is experimental laboratory in vivo with rancagan randomized post test only control group design. With the stages as follows 1.Leaf Extract Kelor with Ethanol 96%, 2.Perpeteration of experimental animals, 3.Treatment of experimental animals by giving extract of 3-dose of kelor leaf that is KP I 250 mg / 200 gr BB rat, KP II 500 mg / 200 gr BB rat, KP III 1000 mg / 200 gr BB rat  for 14 days combined with paracetamol dose 2 gr / 200 gr BB rat compared with the negative control group (group given only paracetamol dose 2 gr / 200 gr BB rat) and control group positif only fed regular feed for 14 days). The result showed that there was a significant difference mean of GSH levels between all treatment groups obtained p = 0,000 (p <α) p values smaller than 0.05. There was the highest increase of GSH in treatment group II (142,7525 μmol / mg) and lowest dose of GSH in positive control group (57,1812 μmol / mg), dose paracetamol toxic dosage and kelor leaf extract 500 mg / gr BB rat can increase GSH hepar p = 0,000 (p <α) p less than 0 , 05. The conclusion of the test results showed that giving of kelor leaf extract at dose of treatment group II can increase GSH hepar level significantly

scholarly journals Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247662
Author(s):  
Jingjing He ◽  
Desheng Kong ◽  
Zhifen Yang ◽  
Ruiyun Guo ◽  
Asiamah Ernest Amponsah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Treatment Group ◽  
Random Effects ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Control Group ◽  
Efficacy And Safety ◽  
Significant Difference

Background Diabetes mellitus as a chronic metabolic disease is threatening human health seriously. Although numerous clinical trials have been registered for the treatment of diabetes with stem cells, no articles have been published to summarize the efficacy and safety of mesenchymal stem cells (MSCs) in randomized controlled trials (RCTs). Methods and findings The aim of this study was to systematically review the evidence from RCTs and, where possible, conduct meta-analyses to provide a reliable numerical summary and the most comprehensive assessment of therapeutic efficacy and safety with MSCs in diabetes. PubMed, Web of Science, Ovid, the Cochrane Library and CNKI were searched. The retrieval time was from establishment of these databases to January 4, 2020. Seven RCTs were eligible for analysis, including 413 participants. Meta-analysis results showed that there were no significant differences in the reduction of fasting plasma glucose (FPG) compared to the baseline [mean difference (MD) = -1.05, 95% confidence interval (CI) (-2.26,0.16), P<0.01, I2 = 94%] and the control group [MD = -0.62, 95%CI (-1.46,0.23), P<0.01, I2 = 87%]. The MSCs treatment group showed a significant decrease in hemoglobin (Hb) A1c [random-effects, MD = -1.32, 95%CI (-2.06, -0.57), P<0.01, I2 = 90%] after treatment. Additionally, HbA1c reduced more significantly in MSC treatment group than in control group [random-effects, MD = -0.87, 95%CI (-1.53, -0.22), P<0.01, I2 = 82%] at the end of follow-up. However, as for fasting C-peptide levels, the estimated pooled MD showed that there was no significant increase [MD = -0.07, 95%CI (-0.30, 0.16), P<0.01, I2 = 94%] in MSCs treatment group compared with that in control group. Notably, there was no significant difference in the incidence of adverse events between MSCs treatment group and control group [relative risk (RR) = 0.98, 95%CI (0.72, 1.32), P = 0.02, I2 = 70%]. The most commonly observed adverse reaction in the MSC treatment group was hypoglycemia (29.95%). Conclusions This meta-analysis revealed MSCs therapy may be an effective and safe intervention in subjects with diabetes. However, due to the limited studies, a number of high-quality as well as large-scale RCTs should be performed to confirm these conclusions.

scholarly journals The Effectiveness of Passion Fruit Juice Consumption as Pain Reliever for Bruise Trauma in Pencak Silat Athletes

2017 ◽  
Vol 12 (2) ◽  
pp. 212-217
Author(s):  
Roy Januardi Irawan
Keyword(s):  
Treatment Group ◽  
Pain Intensity ◽  
Fruit Juice ◽  
Rating Scale ◽  
The Body ◽  
Passion Fruit ◽  
Intensity Difference ◽  
Control Group ◽  
Significant Difference ◽  
Quasi Experimental

Pencak Silat is a martial art that has a risk of causing micro-trauma due to physical impact. This trauma will stimulate the secretion of prostaglandin, a compound in the body which is a mediator of pain and inflammatory response that promote pain in bruised trauma. Passion fruit contains high level of anti-inflammatory and antioxidant substances. The objective of this study was to understand the effectiveness of passion fruit juice consumption in reducing bruised trauma pain in Pencak Silat athletes of PSHT Belotan Magetan. The research design is a quantitative descriptive with quasi-experimental. The pretest and posttest group of 20 people PSHT Belotan Magetan Pencak Silat athletes with an average age of 13.4 0.94 years were divided into treatment group (K1) and control group (K0) with 10 subjects respectively. Each treatment group (K1) subject was given the juice twice a day for 10 consecutive days. We used paired sample T-test to assess the mean variance of the group. The result showed that there was a decrease of pain intensity in both the treatment group and the control group. The pain intensity difference assessed by a Bourbonnais Rating Scale in the treatment group showed a significant difference with the t value of 7,216 and a probability value of 0,000, while the control group showed t value of 3,000 and probability value of 0,015. There was a decrease in the athletes muscle soreness who were given passion fruit juice twice a day for 10 days. The athletes pain intensity was in middle category.

scholarly journals Effect of Leaf Syzygium aromaticum on Lymphocytes and Macrophages Mice Balb/c

2018 ◽  
Vol 23 (2) ◽  
pp. 79
Author(s):  
Syahran Wael ◽  
Theopilus Wilhelmus Watuguly ◽  
Didik Wahyudi
Keyword(s):  
Treatment Group ◽  
Salmonella Typhimurium ◽  
Lymphocyte Proliferation ◽  
The Body ◽  
Control Group ◽  
Syzygium Aromaticum ◽  
The Third ◽  
Significant Difference ◽  
Post Test ◽  
Proliferation Of Lymphocytes

Syzygium aromaticum as an immunomodulator contains main active compound eugenol which is able to stimulate lymphocyte proliferation and the production of macrophages. Lymphocytes have a very important role to provide protection in the body against infection. This study aims to prove the effects of extract Syzygium aromaticum leaf against increased proliferation of lymphocytes, lymphoblast and macrophages of mice Balb/c of induced Salmonella typhimurium. The method used in this study was experimental with post test only control group. Mice Balb/c were divided into 4 groups as a control group and treatment induced of Salmonella typhimurium. The first treatment group were administrated extracts of 15mg /kgbw, the second treatment 75mg/kgbw, the third treatment of 150mg/kgbw for 12days. ANOVA test showed a significant difference in lymphocyte proliferation but not lymphoblast and macrophages.

scholarly journals Latihan yoga terhadap berat badan, persen lemak tubuh, dan lingkar perut pada wanita dewasa overweight

2018 ◽  
Vol 14 (4) ◽  
pp. 131
Author(s):  
Putri Nur Fatimah ◽  
Fillah Fithra Dieny ◽  
Etisa Adi Murbawani ◽  
Ahmed Fahmy Arif Tsani
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Waist Circumference ◽  
Nutrition Education ◽  
Body Fat ◽  
The Body ◽  
Control Group ◽  
Weight Percentage ◽  
Percentage Of Body Fat ◽  
Significant Difference

Background: Obesity caused diabetes and cardiovascular disease. Yoga considered three aspects, physic, emotion and mental that helped in obesity therapy.Objective: This research aimed to explain the influence of yoga excercise on body weight, percent of body fat, waist circumference and waist to hip ratio (WHR) in overweight women.Method: This research applied quasi experiment design by using pre-post test with control group design. The subjects of research were 31 women aged 19-25 years old and divided into 2 groups, treatment group and control group. Treatment group was prepared to do yoga in 60 minutes for 10 times during 20 days and given nutrition education, whereas control group was given nutrition education only. Data body weight and percentage of body fat were measured by bioimpedance analysis; waist circumference and WHR were measured by tape measures; food intake were assessed by food recall and food frequency questionnaire. Data were analyzed using paired t-test and independent t-test.Results: There was a significant difference of body weight before and after intervention in both groups. The body weight on treatment group decreased by 0.81 ± 1.29 kg (p<0.05), while the body weight on the control group increased. Percentage of body fat and waist circumference decreased on both of groups, however treatment group decreased more than the control group. WHR no significant on both of groups. Yoga excercise resulted no significant influences on body weight, percentage of body fat, waist circumference and WHR in overweight women (p>0.05). Conclusion: Obesity women with 10 times yoga had no significant influences on body weight, percentage of body fat, waist circumference and WHR.

scholarly journals Ex-Vivo Study, The Effect of Standardized Eurycoma longifolia Extract on The Enzyme Activity of Rosiglitazone N-Demethylase

2021 ◽  
Vol 17 (1) ◽  
pp. 38
Author(s):  
Purwantiningsih Purwantiningsih ◽  
Abas Hj Hussin ◽  
Kit Lam Chan
Keyword(s):  
Body Weight ◽  
Enzyme Activity ◽  
Treatment Group ◽  
Ex Vivo ◽  
Herbal Medicines ◽  
The Body ◽  
Control Group ◽  
Eurycoma Longifolia ◽  
Significant Difference ◽  
Demethylase Activity

Eurycoma longifolia (E. longifolia) or also known as Earth Pasak in Indonesia, has been used widely, especially to increase stamina in men. The use of herbal medicines in the long run opens up the opportunities for the influence of herbal medicines on metabolic process of other substances. This study aimed to evaluate the effect of E. longifolia extract on rosiglitazone metabolism after oral administration for one and fourteen days, and its effect on rat body weight. The rats were divided into two groups, group for one day treatment (divided into 8 subgroups with n = 6: I (control), II to VIII (were given extract at doses of 1 to 1000 mg / kg BW) and 14 days (rats divided into 4 subgroups, n = 6 : I (control), II to IV (treated with extracts of doses 5, 25 and 50 mg / kg BW). At the end of the experiment, test animals were sacrificed and rosiglitazone N-demethylase activity in hepatocytes was determined by measuring the amount of formaldehid formed at 415 nm. The rosiglitazone N-demethylase activity in all groups was analyzed by analysis of  variance (ANOVA) and Tukey Test (P <0.05). The percentage of the changing in the body weight in the 14 days treatment group was compared to the control group. The results showed there was a significant increased in the rosiglitazone N-demethylase activity after rats were treated with E. longifolia extract at doses of 5 to 1000 mg / kg BB, but was not significantly different at a dose of 1 mg / kg BW when compared with control group. For the 14 days treatment, there was no significant difference between the treatment group and the control group, both for the rosiglitazone N-demethylase enzyme activity or the changed of rat body weight.

scholarly journals Gambaran Histologi Ginjal Tikus Wistar Yang Terpapar MSG Setelah Perlakuan Diberikan Jus Tomat Dan Diberhentikan Perlakuan Saja

2018 ◽  
Vol 1 (2) ◽  
pp. 62
Author(s):  
Yeti Eka Sispitasari
Keyword(s):  
Treatment Group ◽  
The Body ◽  
Proximal Tubules ◽  
Tomato Juice ◽  
Control Group ◽  
Renal Tubules ◽  
Apparent Difference ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

MSG causes many side effects on the body, but MSG has long been used as a food flavor that can bring tastes (umami) and play a role in strengthening the taste. The chemical structure of MSG is no different from Glutamic Acid (glutamate), it is one of the 20 amino acids that make up proteins in the body. So the use of MSG needs to be discontinued to prevent kidney damage due to continued consumption of MSG, two research were conducted to determine the effect of discharging of MSG consumption by being given tomato juice (1) and discharged without treatment (2), the second study was seen from the histology picture of rats wistar mouse.Methods were experimental with post test only control group design. The research (1) used 15 wistar rats divided into three groups: group I without treatment (pellet AD II and drinking water), group II was given MSG for 14 days and group III was given tomato juice and MSG for 14 days. The study (2) used 27 rats divided by 9 groups. The sample is selected by simple random sampling method. The mice were then gradually turned off on the 29th, 43rd and 57th days. There was no significant difference in mean number of normal and damaged proximal tubules in all treatment groups. The renal histologic features in the treatment group I (MSG) and the treatment group II (MSG and tomato juice) showed normal glomeruli, tubular epithelial tubules, and lumen tubular narrowing whereas in mice discharged without treatment there was no apparent difference between the two MSG Giving groups damage to proximal tubules and renal corpusculum and regeneration after 14 days of discontinuation of MSG. Conclusions from these two experiments occurred damage to the renal tubules Keywords: MSG, Kidney, Wistar Rat

scholarly journals Effect on Ubiquinone MDA Level of Plasma, FEV1% and CAT Score Stable COPD Patients

2018 ◽  
Vol 38 (3) ◽  
pp. 143-149
Author(s):  
Ardorisye Fornia ◽  
Suradi Suradi ◽  
Aphridasari Aphridasari
Keyword(s):  
Treatment Group ◽  
Outpatient Clinic ◽  
The Body ◽  
Control Group ◽  
Oxidation Stress ◽  
Copd Patients ◽  
Significant Difference ◽  
Post Test ◽  
Additional Therapy ◽  
Expiratory Air

Background: Oxidation stress showed clinical evidence of increased in patients with COPD and contribute functionally to expiratory air flow resistance, so the body requires exogenous antioxidants to inhibit oxidative stress. This study was conducted to assess whether there is influence on levels of MDA plasma ubiquinone, FEV1% and patients with stable COPD CAT score. Methods: This study is a clinical trial experimental with pretest and post-test design which aims to determine the effect of plasma MDA, FEV1% and patients with stable COPD CAT score. Subjects consist of 30 patients with stable COPD who came to Pulmonary outpatient clinic of Moewardi hospital Surakarta during June to August 2016. The sample was taken by consecutive sampling. Subjects were divided into two group, the treatment group (n=15) received additional therapy ubiquinone 1x150mg/day and the control group (n=15) received standard therapy. MDA plasma levels, FEV1% and CAT scores were measured at the time of control pulmonary outpatient clinic. Results: Giving ubiquinone can significantly lower CAT score better in the treatment group compared to the control group. There were no statistically significant difference (p=0.744) in plasma MDA treatment group (1.37 ± 0.11) compared to controls (1,39 ± 0.16). There were no statistically significant difference between (p=0.276) the decline in FEV1% treatment group (43.28 ± 20.59) and the control group (36.01 ± 14.73). Conclusion : The use of Ubiquinone in decreasing CAT score for stable COPD patients. There was lowering effect in MDA plasma but there was no excalation value in FEV1%.

scholarly journals The Effect of Young Coconut Water (Cocos Nucifera L.) Consumption on VO2max in Young Adults Non-Athletes

2021 ◽  
Vol 7 (1) ◽  
pp. 49
Author(s):  
Aris Prasetyo ◽  
Dheis Aninditha Suspim
Keyword(s):  
Young Adults ◽  
Treatment Group ◽  
Cocos Nucifera ◽  
The Body ◽  
Coconut Water ◽  
Control Group ◽  
Glucose Levels ◽  
Fitness Index ◽  
Significant Difference ◽  
Cocos Nucifera L

Abstract The availability of carbohydrates and electrolytes in the body greatly affects Volume Oxigen Maximum (VO2max) to maintain stamina and endurance. The administration of young coconut water has the effect of increasing VO2max because it contains carbohydrates and electrolytes. The administration of young coconut water 15-60 minutes before exercise has the potential to delay exhaustion and increasing performance because glucose levels are maintained and muscle glycogen stores are restored. The purpose of this study was to determine the effect of administration of young coconut water on VO2max in young adults non-athletes. This study used a quasi experimental research design with a cross over design clinical trial. A total of 30 male non-athletes aged 18-24 years who fulfill the inclusion criteria were divided into groups randomLy, the treatment group (given 300 mL of coconut water) and the control group (given 300 mL of mineral water) 60 minutes before treatment, then crossover carried out 3 days after treatment. The results showed the control group fitness index was 141.83 ± 44.69, and the fitness index of the treatment group was 176.01 ± 59.07. The sample characteristics based on VO2max showed that the treatment group had a greater VO2max by a mean of 4.84 ± 1.05 compared to the control group with a mean of 4.19 ± 0.78. The results of the Paired T-Test showed a significance value of p= 0.000 (p <0.05) indicating that there was a significant difference between the control group and the treatment group. The conclusion of this study is that giving young coconut water increases VO2max levels in young adults non-athletes.   Keywords: Young coconut water, VO2max,  fitness index

Sign in / Sign up

Export Citation Format

Share Document