scholarly journals Pengaruh Kontrasepsi Suntik DMPA Terhadap Kenaikan Berat Badan Tikus Betina Galur Wistar

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Dwi Retna Prihati

Abstract: DMPA Injectable Contraception, Body Weight. The purpose of this study to determine the effect of contraception DMPA injection to BB in female blood wistar strain female. The benefits of this study are expected to increase public knowledge about injectable contraception especially related to the side effects of weight gain. This type of research is an experimental laboratory. Research design Randomized pre-post test group with control, the sample size of 10 adult female mice Wistar strain divided into 2 groups. Data were analyzed by independent T test. Significant value of p <0.05. The result of this research is there is significant difference between control group and DMPA contraception treatment group (p = 0,008). In conclusion contraceptive DMPA affects body weight wistar female rat strain.

2018 ◽  
Vol 11 (2) ◽  
pp. 166
Author(s):  
Rizky Prihandari ◽  
Lailatul Muniroh

Cigarette smoke contains many hazardous substances and free radical which affect respiratory system. Watermelon “Sugar Baby” juice contain lycopene as antiinfl ammation. The aim of this research was to analyze the effect of watermelon as antiinfl ammation toward neutrophils count in wistar strain male rats exposed by  cigarette smoke. This study was an experimental laboratory research with pre and post test control group design. Sample consisted of 24 wistar strain male rats with ±150-230 grams weight and 3 months old which were divided into four groups. Control group was given placebo (aquadest) and treatment groups were given w atermelon juice with terraced quantity (1.5 ml, 2.5 ml, and 3.5 ml). Every group was given two sticks of cigarette smoked per day during two weeks then smoked with treatment during one week. Neutrophil from peripheral smear was observed by manual method and statistically analyzed using Anova Mixed Design and continued with One Way Anova. The result showed signifi cant increased of  neutrophil at second observation on control group (p=0.002) and treatment groups (p=0.000). Signifi cance decreased also found in the treatment groups’s at third observation p=0.000. Signifi cant between each group p= 0.017. There was signifi cant different between control and treatment groups but there was no signifi cant different between each treatment groups. This study concluded that there was decreased of  neutrophil in wistar strain male rats which were given w atermelon juice 1.5 ml, 2.5 ml, and 3.5 ml during infl ammation. 3.5 ml w atermelon juice which were given showed better result as antiinfl ammation..


2019 ◽  
Vol 3 (4) ◽  
pp. 231 ◽  
Author(s):  
Mohamad Riza ◽  
Andina Putri A

Objective: to compare the effect of administration of energy drinks and coffee on creatinine levels in rats.Methods: an experimental laboratory research using the post test only control group design. The study used 18 male white Sprague Dawley divided into three groups to receive one of the following treatments: 2 cc distilled water,0.072 g /2cc energy drinks and 0.9 g/cc of coffee for 14 days. The creatinine level was evaluated. Data were analyzed by One Way ANOVA test.Results: The mean creatinine level in the aquades group, energy drinks, coffee group was 0.708 mg/dl, 2.05 mg/dl 1.861 mg/dl, respectively. Post Hoc test the LSD test showed a significant difference among these groups (p <0.05).Conclusion: There was a significant different effect between 0.072 g / 2cc energy drinks and 0.9 g/cc coffee on creatinine levels in rat.International Journal of Human and Health Sciences Vol. 03 No. 04 October’19 Page : 231-234


2019 ◽  
Vol 13 (1) ◽  
pp. 58
Author(s):  
Elva Rosiana ◽  
Wiwit Ade Fidiawati ◽  
Darmawi Darmawi

Ischemic-reperfusion injury is defined by a condition of hypoperfusion in the spesific organ followed by reperfusion(reoxygenation) inducing tissue damage. Tissue damage produces reactive oxygen species (ROS) leading to oxidativestress condition. Oxidative stress mediate the lipid peroxidation reactions, harm the cell and finally facilitate the celldeath. The aim of this study was to evaluate the histopathologic feature of white rat’s pancreas post renal ischemiareperfusion.This study was an experimental laboratory research with post-test-only control group design including 20male white rats. Rats were divided into 5 groups, control, treatment 1 (45 minutes ischemia), treatment 2 (45 minutesischemia followed by 1 hour reperfusion), treatment 3 (45 minutes ischemia followed by 2 hours reperfusion) andtreatment 4 (45 minutes ischemia followed by24 hours reperfusion). We found the change of the histopathologicalcharacteristics of white rat’s pancreas in term of edema, leukocyte infiltration and vacuolization.


2018 ◽  
Vol 26 (1) ◽  
pp. 20
Author(s):  
Hesty Widowati ◽  
Hidayat Sujuti ◽  
Karyono Mintaroem

Objective: This study aimed to verify the effect of oral siper-metrin exposure to decrease serum estradiol 17b levels and increased malondialdehyde (MDA) in the uterus level of female Wistar strain rats (Rattus norvegicus).Materials and Methods: The method of this study was true experimental post test only control group in vivo using 24 female rats, divided into 3 groups treated by administering a dose of 5, 10 and 20 mg/kg sipermetrin for 28 days and one control group. Then blood samples were taken from the heart for measurement of serum estradiol 17b levels by ELISA and uterine organs were taken for measurement of Malondialdehyde (MDA) with spectro-photometry method.Results: The results of the measurement of serum estradiol 17b and uterus malondialdehyde (MDA) levels of female Wistar strain rats (Rattus norvegicus) showed an opposite pattern, where there was a decline in serum estradiol 17b levels and an increase in uterus malondialdehyde (MDA) level. There was a significant difference (p=0.000<alpha) in 17b estradiol serum and uterus Malondialdehyde (MDA) levels of female rats between control group and group exposed to sipermetrin treatment for 28 days.Conclusions: Oral sipermetrin exposure can decrease serum levels of estradiol 17b and increase uterine levels of malondi-aldehyde (MDA) of female Wistar strain rats (Rattus norvegicus).


2020 ◽  
Vol 13 (1) ◽  
pp. 69-74
Author(s):  
Prawesty Diah Utami ◽  
Herin Setianingsih

Background:Malaria cases have consistently increased and the number of deaths remains largely unchanged.Malaria associated renal injury has a high level of morbidity and mortality. High level of blood urea nitrogen / BUN and plasma creatinine is one of the major factors associated with mortality in humans infected with malaria, indicating that impairment of renal function. HBO is widely used as an adjunctive therapy for many diseases, it is known that HBO hasan action as antiplasmodium, antiinflammation and antioxidant effects. Objective: The aim of this study was to determine the effect of HBO on BUN and creatinine levels in rats infected with P. berghei ANKA. Methods:This research was conducted experimentally post-test only control group on six groups of rats. The samples used were 24 male Rattus norvegicus wistar strain that have been infected by Plasmodium bergheiANKA and divided into 6 groups. Group 1 was given combination artesunate and 1, 5 ATA HBO, grup 2 was given combination artesunate and 3, 0 ATA HBO, group 3 was given 1, 5 ATA HBO, group 4 was given 3, 0 ATA HBO, group 5 was given artesunate and group 6 was given aquadest. HBO therapy is carried out for 10 days and the observation of the levels of BUN and creatinine in mice after treatment on tenth day. Results:Descriptive analysis and statistical analysis (Kruskal wallis snd Mann whitney U posthoc) showed a significant difference (p < α = 0.05) on mean levels of BUN and creatinine group receiving combination of artesunate and HBO 3,0 ATA compared to other groups.Hyperbaric oxygen has the effect of reducing the levels of BUN and creatinine in rats infected by P.berghei ANKA.


2021 ◽  
Vol 6 (1) ◽  
pp. 197-212
Author(s):  
Taufikkurrachman Taufikkurrachman ◽  
Amy Nilam Wardathi ◽  
Afifi Rusdiawan ◽  
Reno Siska Sari ◽  
Buyung Kusumawardhana

The purpose of this study was to determine the condition of body weight and body fat after cardio and tabata exercises. The research design used was randomized group pre-test and post-test design. The research subjects of PJKR student IKIP Budi Utomo Malang are male, aged 18-22 years with overweight / obese BMI. 27 people were randomly divided into 3 groups, the control group (K1), the cardio group (K2) and the tabata group (K3). The treatment was given 3 times a week for 6 weeks. K1 group only did the test without treatment. K2 was given jogging and skipping exercises for 40 minutes with moderate intensity (55-70% maximum heart rate). K3 was given squat trust and skipping exercises for 20 seconds of exercise and 10 seconds of rest for 8 sets with an intensity of 90-95% maximum heart rate. The exercise is carried out for 20 minutes with 1-minute intervals per set. The results of the LSD test for weight variables showed a significant difference between the K1 and K2 groups (p = 0.001), K1 and K3 (p = 0.000), K2 and K3 (p = 0.038). For the fat variable, there was also a significant difference between the K1 and K2 groups (p = 0.000), K1 and K3 (p = 0.000), K2 and K3 (p = 0.037). The conclusion is that tabata training is better than cardio training in reducing weight and fat.Keywords: Cardio, tabata, fat, body weight, exerciseAbstrakTujuan penelitian ini adalah untuk mengetahui kondisi berat badan dan lemak tubuh setelah melakukan latihan kardio dan tabata. Desain penelitian yang digunakan adalah Randomized group pre test and post test design. Subyek penelitian ini mahasiswa PJKR Ikip Budi Utomo Malang yang berjenis kelamin laki-laki, usia 18-22 tahun dengan IMT overweight/ obesitas. 27 orang coba dibagi secara acak ke dalam 3 kelompok, kelompok kontrol (K1), kelompok kardio (K2) dan kelompok tabata (K3). Perlakuan diberikan 3 kali seminggu selama 6 minggu.. kelompok K1 hanya melakukan test tanpa perlakuan. K2 diberikan latihan jogging dan skipping selama 40 menit dengan intensitas sedang (55-70% DN maks). K3 diberikan latihan squat trust dan skipping selama 20 detik latihan dan 10 detik istirahat sebanyak 8 set dengan intensitas 90-95% DN maks. Latihan dilakukan selama 20 menit dengan interval 1 menit tiap set. Hasil uji LSD variable berat badan menunjukkan perbedaan signifikan kelompok K1 dan K2 (p=0,001), K1 dan K3 (p= 0,000), K2 dan K3 (p= 0,038). Untuk variable lemak juga terdapat perbedaan yang signifikan antara kelompok K1 dan K2 (p= 0,000), K1 dan K3 (p=0,000), K2 dan K3 (p=0,037). Kesimpulannya adalah latihan tabata lebih baik daripada latihan kardio dalam menurunkan berat badan dan lemak. Kata Kunci: Kardio, tabata, lemak, berat badan, Latihan


2019 ◽  
Vol 7 (6) ◽  
pp. 897-902
Author(s):  
Abdul Rohim Tualeka ◽  
Dwi Ananto Wibrata ◽  
Ahsan Ahsan ◽  
Pudji Rahmawati ◽  
Syamsiar S Russeng ◽  
...  

BACKGROUND: For determining the threshold limit value firstly determined the highest dose of ammonia without effect (NOAEL). However, research on the determination of NOAEL ammonia didn't conduct in Indonesia. AIM: The aim of this study to determine the value of the highest dose of ammonia without effect (No Observed Adverse Effect Level/NOAEL) through interleukin-2 (IL-2) expression on white mice. METHODS: This study used experimental laboratory research with post-test only control group design using white mice as experimental subjects. The treatment group divided into 6 groups (a group of controls and five groups with different ammonia exposure through inhalation). The trend curve of Remmele Scale Index (IRS) and histopathologic analysis could be used for determining NOAEL. RESULT: The location of the highest dose of ammonia without any effect (NOAEL) of white mice was in the second group, with 0.0103 mg/kg body weight dose. Analysis of statistical tests Kruskal Wallis stated there was no significant difference in interleukin-2 expression between the control with ammonia exposed group with a significance of p (0.747) > α (0.05). CONCLUSION: There is no difference between some interleukin-2 expression in the lymphocyte cell lung white mice group exposed to ammonia and control group. The highest dose of ammonia without any effect (NOAEL) on white mice was 0.0103 mg/kg body weight.


2018 ◽  
Vol 26 (1) ◽  
pp. 20
Author(s):  
Hesty Widowati ◽  
Hidayat Sujuti ◽  
Karyono Mintaroem

Objective: This study aimed to verify the effect of oral siper-metrin exposure to decrease serum estradiol 17b levels and increased malondialdehyde (MDA) in the uterus level of female Wistar strain rats (Rattus norvegicus).Materials and Methods: The method of this study was true experimental post test only control group in vivo using 24 female rats, divided into 3 groups treated by administering a dose of 5, 10 and 20 mg/kg sipermetrin for 28 days and one control group. Then blood samples were taken from the heart for measurement of serum estradiol 17b levels by ELISA and uterine organs were taken for measurement of Malondialdehyde (MDA) with spectro-photometry method.Results: The results of the measurement of serum estradiol 17b and uterus malondialdehyde (MDA) levels of female Wistar strain rats (Rattus norvegicus) showed an opposite pattern, where there was a decline in serum estradiol 17b levels and an increase in uterus malondialdehyde (MDA) level. There was a significant difference (p=0.000<alpha) in 17b estradiol serum and uterus Malondialdehyde (MDA) levels of female rats between control group and group exposed to sipermetrin treatment for 28 days.Conclusions: Oral sipermetrin exposure can decrease serum levels of estradiol 17b and increase uterine levels of malondi-aldehyde (MDA) of female Wistar strain rats (Rattus norvegicus).


2012 ◽  
Vol 10 (1) ◽  
pp. 23-27
Author(s):  
JUDO YUSTANTO KAHONO ◽  
KISRINI KISRINI ◽  
YUL MARIYAH

Kahono JY, Kisrini, Mariyah Y. 2012. The effect of meniran herbs (Phyllantus niruri) extract to blood triglyceride level in rats. Biofarmasi 10: 23-27. The aim of this experiment was to determine the effect of meniran herbs (Phyllantus niruri L.) extract to blood triglycerides level in Wistar rats (Rattus norvegicus). This experiment was a laboratory experiment with pre and post-test with a control group design. The samples were 30 male Wistar rats with ±200 gram of body weight and ±2 months old. The samples were divided into five groups by using a purposive random sampling technique and each group consisted of six rats. Group I as a negative control, group II as a positive control, and groups III, IV and V as meniran herbs extract groups with first dose, second dose, and third dose. All rats were simultaneously given with hyperlipemic feed. Group II was simultaneously administered with Cholvastin 0.5 mg/200 grams body weight/day. Groups III, IV and V were simultaneously treated with meniran herbs extract at dose of 25 mg, 50 mg and 100 mg/200 grams body weight/day. The total period of this experiment was 21 days. At the day 1st and 21st, blood was collected from rat orbital venous plexus. Serum was analyzed for their pre and post-test blood triglycerides. Statistical analysis was performed by one-way analysis of variance (ANOVA) followed by a post-hoc test. The value of p=0.002 (p<0.05) showed there was a significant difference between pre-test and post-test in delta means of blood triglycerides level among groups. Meniran herbs extract had a significant triglycerides lowering effect against blood triglycerides level of Wistar rats. The most potential of meniran herbs extract dose was 100 mg/200 gram body weight/day.


2021 ◽  
Vol 15 (11) ◽  
pp. 3349-3351
Author(s):  
Ibrahim Efe Etiler ◽  
Turhan Toros

Purpose of this study is to examine the impact of verbal feedbacks given to the player during trainings on the basketball dribbling. The study is performed with total 40 students in two groups having similarities in terms of various factors and having education in Toros University in 2016-2017 academic year. The average age of the research group is (20.87 ± 1.61) for the test group and (20.60 ± 1.09) for the control group. Dribbling Evaluation Form, whose validity and reliability study was conducted by Çamur3 was used as data collection tool. In the data analysis, Shapiro-Wilk test was used to determine whether the scores show normal distribution or not. The Wilcoxon Signed Ranks Test was used to determine the difference between the pre-test and post-test scores of the groups. In the study, 0.05 was used in statistical processes as the level of significance. According to the research findings, there was a significant difference between the test group's pre-test and post-test dribbling values (p <0.05). The Mann-Whitney U Test was used to determine the differences between test and control groups. According to the research findings, a significant difference was found between the test and control groups' post-test dribbling values (p <0.05). As a result, it was observed that verbal feedback during eight weeks of training had a positive effect on dribbling. Keywords: Dribbling, Skill Learning, Basketball, Feedback, Verbal Feedback


Sign in / Sign up

Export Citation Format

Share Document