scholarly journals A novel Ayurvedic medical fumigant powder Bhootastgandha and its effect in Combating Airborne pathogens - A detailed pharmacological activity review

2021 ◽  
Vol 12 (3) ◽  
pp. 500-505
Author(s):  
Sethu R ◽  
Sara Monsy Oommen
Keyword(s):  
Infectious Diseases ◽  
Pharmacological Activity ◽  
Viral Infections ◽  
Preventive Measures ◽  
Practical Application ◽  
Prime Concern ◽  
Bacterial Action ◽  
Pharmacological Screening ◽  
Anti Fungal ◽  
Treatment Aspect

Infectious diseases are becoming popular with every passing day and viral infections among them are the cause for a large number of fatalities since last two decades. All the factors including the lifestyle pave the way to reduced immunity making the human population susceptible to infections. Management of diseases is not only important; prevention of further diseases should also be of prime concern. Infectious diseases that spread through a variety of mediums like air, water etc. requires preventive measures that controls the spread of the microorganisms and keep the preventive aspect intact. Ayurveda treatment has succeeded in achieving both treatment aspect as well as preventative aspect of diseases. Dhoopana Karma is an important modality & primitive method of sterilization which can be used in preventive and curative aspect. The yoga “Bhootastagandha” is taken from the Ayurvedic compilation Sarvaroga Chikitsa Ratnam”. Learning about the practical application of the formulation, the formulation is mentioned among a group of formulations used as fumigating agents. The formulation consists of a group of 8 drugs and all the drugs on pharmacological screening is found to possess Antimicrobial, Antibacterial, Antiviral, Antifungal properties among other pharmacological actions. The details about the pharmacological activity of the drugs are collected from various research articles published. This review article mainly focuses on the phytochemical properties of the ingredient drugs as per Ayurveda classics and the utility of the formulation as an effective fumigant keeping in mind the Antimicrobial, Anti-viral, Anti –Fungal and Anti- Bacterial action of the plants.

Treatment of ebola and other infectious diseases: melatonin “goes viral”

2020 ◽  
Vol 3 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Russel J Reiter ◽  
Qiang Ma ◽  
Ramaswamy Sharma
Keyword(s):  
Mortality Rate ◽  
Infectious Diseases ◽  
Hemorrhagic Shock ◽  
Safety Profile ◽  
Ebola Virus ◽  
Viral Infections ◽  
Virus Disease ◽  
Attractive Potential ◽  
Potential Treatment

This review summarizes published reports on the utility of melatonin as a treatment for virus-mediated diseases. Of special note are the data related to the role of melatonin in influencing Ebola virus disease. This infection and deadly condition has no effective treatment and the published works documenting the ability of melatonin to attenuate the severity of viral infections generally and Ebola infection specifically are considered. The capacity of melatonin to prevent one of the major complications of an Ebola infection, i.e., the hemorrhagic shock syndrome, which often contributes to the high mortality rate, is noteworthy. Considering the high safety profile of melatonin, the fact that it is easily produced, inexpensive and can be self-administered makes it an attractive potential treatment for Ebola virus pathology.  

scholarly journals Is the oral microbiome a source to enhance mucosal immunity against infectious diseases?

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Camille Zenobia ◽  
Karla-Luise Herpoldt ◽  
Marcelo Freire
Keyword(s):  
Infectious Diseases ◽  
Oral Mucosa ◽  
Viral Infections ◽  
Emerging Infectious Diseases ◽  
Humoral Response ◽  
Outer Membrane Vesicles ◽  
Oral Microbiome ◽  
Microbial Pathogens ◽  
Cell Mediated Immunity ◽  
Th17 Response

AbstractMucosal tissues act as a barrier throughout the oral, nasopharyngeal, lung, and intestinal systems, offering first-line protection against potential pathogens. Conventionally, vaccines are applied parenterally to induce serotype-dependent humoral response but fail to drive adequate mucosal immune protection for viral infections such as influenza, HIV, and coronaviruses. Oral mucosa, however, provides a vast immune repertoire against specific microbial pathogens and yet is shaped by an ever-present microbiome community that has co-evolved with the host over thousands of years. Adjuvants targeting mucosal T-cells abundant in oral tissues can promote soluble-IgA (sIgA)-specific protection to confer increased vaccine efficacy. Th17 cells, for example, are at the center of cell-mediated immunity and evidence demonstrates that protection against heterologous pathogen serotypes is achieved with components from the oral microbiome. At the point of entry where pathogens are first encountered, typically the oral or nasal cavity, the mucosal surfaces are layered with bacterial cohabitants that continually shape the host immune profile. Constituents of the oral microbiome including their lipids, outer membrane vesicles, and specific proteins, have been found to modulate the Th17 response in the oral mucosa, playing important roles in vaccine and adjuvant designs. Currently, there are no approved adjuvants for the induction of Th17 protection, and it is critical that this research is included in the preparedness for the current and future pandemics. Here, we discuss the potential of oral commensals, and molecules derived thereof, to induce Th17 activity and provide safer and more predictable options in adjuvant engineering to prevent emerging infectious diseases.

scholarly journals Spread of Epidemic Disease on Edge-Weighted Graphs from a Database: A Case Study of COVID-19

2021 ◽  
Vol 18 (9) ◽  
pp. 4432
Author(s):  
Ronald Manríquez ◽  
Camilo Guerrero-Nancuante ◽  
Felipe Martínez ◽  
Carla Taramasco
Keyword(s):  
Public Health ◽  
Infectious Diseases ◽  
Preventive Measures ◽  
Weighted Graph ◽  
Real Data ◽  
Sir Model ◽  
Weighted Graphs ◽  
Epidemic Disease ◽  
The Real

The understanding of infectious diseases is a priority in the field of public health. This has generated the inclusion of several disciplines and tools that allow for analyzing the dissemination of infectious diseases. The aim of this manuscript is to model the spreading of a disease in a population that is registered in a database. From this database, we obtain an edge-weighted graph. The spreading was modeled with the classic SIR model. The model proposed with edge-weighted graph allows for identifying the most important variables in the dissemination of epidemics. Moreover, a deterministic approximation is provided. With database COVID-19 from a city in Chile, we analyzed our model with relationship variables between people. We obtained a graph with 3866 vertices and 6,841,470 edges. We fitted the curve of the real data and we have done some simulations on the obtained graph. Our model is adjusted to the spread of the disease. The model proposed with edge-weighted graph allows for identifying the most important variables in the dissemination of epidemics, in this case with real data of COVID-19. This valuable information allows us to also include/understand the networks of dissemination of epidemics diseases as well as the implementation of preventive measures of public health. These findings are important in COVID-19’s pandemic context.

Role of cannabinoids in various diseases: A review

2021 ◽  
Vol 23 ◽  
Author(s):  
Simran Kaur ◽  
Nikita Sharma ◽  
Arpita Roy
Keyword(s):  
Infectious Diseases ◽  
Metabolic Disorders ◽  
Viral Infections ◽  
Cannabis Sativa ◽  
Endocannabinoid System ◽  
Psychological Disorders ◽  
Bioactive Compound ◽  
The Body ◽  
Therapeutic Aspect

Background: The plant, Cannabis sativa is heavily explored and researched with many industrial and pharmaceutical applications. The medicinal and therapeutic role of cannabis Sativa has been summarized in the paper, citing its mechanism of action and influence on the human body. Diseases like metabolic disorders, infectious diseases, and psychological disorders pose negative and long-term drastic effects on the body like neurodegeneration and other chronic system failures. Several existing literature has proved its effectiveness against such diseases. Objectives: This review aims to provide an overview of the role of cannabinoids in various diseases like metabolic disorders, infectious diseases, and psychological disorders. Method: Various e-resources like Pubmed, Science Direct, and Google Scholar were thoroughly searched and read to form a well-informed and information-heavy manuscript. Here we tried to summaries the therapeutic aspect of Cannabis sativa and its bioactive compound cannabinoids in various diseases. Result: This review highlights the various constituents which are present in Cannabis sativa, the Endocannabinoid system, and the role of cannabinoids in various diseases Conclusion: Recent research on Cannabis has suggested its role in neurodegenerative diseases, inflammation, sleep disorders, pediatric diseases, and their analgesic nature. Therefore, the authors majorly focus on the therapeutic aspect of Cannabis sativa in various diseases. The focus is also on the endocannabinoid system (ECS) and its role in fighting or preventing bacterial, parasitic, fungal, and viral infections.

A REVIEW OF PHYTOMORPHOLOGICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL ACTIVITY ON IPOMOEA CARNEA

2021 ◽  
Vol 12 (4) ◽  
pp. 166-169
Author(s):  
Mahaveer Sing ◽  
Sravan P Kumar ◽  
Birendra Shrivastava ◽  
Pamula B Reddy ◽  
Suma Rohilla
Keyword(s):  
Wound Healing ◽  
Pharmacological Activity ◽  
Wild Plant ◽  
Toxicological Effects ◽  
Ipomoea Carnea ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Anti Fungal

Ipomoea carnea Jacq. grows as wild plant in India. It is identified as a useful material for several applications including medicinal purposes. Different extracts of Ipomoea carnea plant possess anti-bacterial, anti-fungal, antioxidant, antimicrobial, anti-cancer, anti-convulsant, immune modulatory, antidiabetic, hepatoprotective, anti-inflammatory, anxiolytic, sedative, cardiovascular, inhibition and wound healing activities. However, some toxicological effects have been also reported. In this review the potential of phytochemical, pharmacological and other activities of Ipomoea carnea are discussed.

Infectious Diseases as a Factor Influencing Demography. Historical and Medical Aspect

2020 ◽  
pp. 54-62
Author(s):  
Lyudmila Kaspruk
Keyword(s):  
Health Care ◽  
Life Expectancy ◽  
Infectious Diseases ◽  
Preventive Measures ◽  
Significant Risk ◽  
Medical Aspect ◽  
The Impact ◽  
Improving Health Care

Taking into consideration the forecasts that infectious diseases will pose a significant risk of increasing mortality, as well as shortening life expectancy in the next period of time, an assessment of the impact of infectious diseases on demography in the historical and medical aspect allows us to confirm the existence of uniform combinations in creating a counter-strategy for improving health care. There is no doubt about the historical priority of preventive measures. In this sense, the scoring of infections according to the rating of ''demographic tension'' fully admits the possibility of identifying a vector for improving the work on combating infectious diseases.

Consensus ‘Interferon therapy for patients with influenza, SARS and COVID19’

2021 ◽  
pp. 51-58
Author(s):  
N. D. Yushchuk ◽  
I. V. Maev ◽  
A. L. Vertkin
Keyword(s):  
General Practitioner ◽  
Infectious Diseases ◽  
Secondary Prevention ◽  
Interferon Therapy ◽  
Viral Infections ◽  
Total Duration ◽  
Community Acquired Pneumonia ◽  
Outpatient Clinics ◽  
Primary Contact ◽  
Respiratory Viral Infections

According to the who, the share of acute respiratory viral infections (амма? and influenza) accounts for about 90–95% of all infectious diseases; in russia, influenza and arvi take up to 40% of the total duration of official disability, which determines the significance of this pathology. At the same time, the primary contact of the overwhelming majority of patients with suspected arvi and influenza occurs with a therapist or general practitioner of polyclinics. The proposed consensus of experts is intended to systematize the known approaches to the diagnosis, treatment and secondary prevention of influenza, acute respiratory viral infections and community-acquired pneumonia for their use at outpatient clinics. The schemes of using interferon therapy for arvi and influenza are considered in detail.

The role of PCSK9 in infectious diseases.

2021 ◽  
Vol 28 ◽  
Author(s):  
Laura Magnasco ◽  
Chiara Sepulcri ◽  
Roberta Maria Antonello ◽  
Stefano Di Bella ◽  
Laura Labate ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Malaria Infection ◽  
Bacterial Infections ◽  
Viral Infections ◽  
Physiological Role ◽  
Protective Role ◽  
Loss Of Function ◽  
Pcsk9 Inhibition ◽  
Sepsis And Septic Shock

Background: In recent years, many aspects of the physiological role of PCSK9 have been elucidated, particularly regarding its role in lipid metabolism, cardiovascular risk, and its role in innate immunity. Increasing evidence is available about the involvement of PCSK9 in the pathogenesis of viral infections, mainly HCV, and the regulation of host response to bacterial infections, primarily sepsis and septic shock. Moreover, the action of PCSK9 has been investigated as a crucial step in the pathogenesis of malaria infection and disease severity. Objective: This paper aims to review the available published literature on the role of PCSK9 in a wide array of infectious diseases. Conclusion: Besides the ongoing investigation on PCSK9 inhibition among HIV-infected patients to treat HIV- and ART-related hyperlipidemia, preclinical studies indicate how PCSK9 is involved in reducing the replication of HCV. Interestingly, high plasmatic PCSK9 levels have been described in patients with sepsis. Moreover, a protective role of PCSK9 inhibition has also been proposed against dengue and SARS-CoV-2 viral infections. Finally, a loss of function in the PCSK9-encoding gene has been reported to reduce malaria infection mortality.

scholarly journals Extraintestinal isosporoid coccidian causing atoxoplasmosis in captive green-winged saltators: clinical and hematological features

2017 ◽  
Vol 37 (11) ◽  
pp. 1327-1330
Author(s):  
Sabrina D.E. Campos ◽  
Camila S.C. Machado ◽  
Tatiana V.T. de Souza ◽  
Renan C. Cevarolli ◽  
Nádia R.P. Almosny
Keyword(s):  
Infectious Diseases ◽  
Clinical Improvement ◽  
Peripheral Blood ◽  
Inflammatory Process ◽  
Blood Smear ◽  
Preventive Measures ◽  
Clinical Signs ◽  
Acute Disease ◽  
Illegal Trade ◽  
Hygienic Conditions

ABSTRACT: Populations of green-winged saltators, Saltator similis, are decreasing especially because of illegal trade and infectious diseases. We describe natural cases of an extraintestinal isosporoid coccidian in caged S. similis, and suggest the need of preventive measures in handling these birds. Nonspecific clinical signs were seen in all of them, however, intracytoplasmic Atoxoplasma sp. was found in peripheral blood, reinforcing the idea of systemic isosporosis. Leukocytosis with high number of heterophils and monocytes suggested that atoxoplasmosis in green-winged saltators can progress as an acute disease. The birds showed clinical improvement after treatment. Handling recommendations were proposed to upgrade hygienic conditions of the facilities. We concluded that nonspecific symptoms and an acute inflammatory process can be associated with atoxoplasmosis in young S. similis. We emphasize the importance of blood smear to detect merozoites.

scholarly journals Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity

2021 ◽  
Vol 17 (3) ◽  
pp. e1009324
Author(s):  
Lucas dos Santos Dias ◽  
Hannah E. Dobson ◽  
Brock Kingstad Bakke ◽  
Gregory C. Kujoth ◽  
Junfeng Huang ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Influenza A ◽  
Fungal Pathogens ◽  
Animal Studies ◽  
Structural Basis ◽  
Viral Immunity ◽  
Mucosal Vaccination ◽  
Clinical Observations ◽  
Protective Antibodies ◽  
Anti Fungal

The development of safe subunit vaccines requires adjuvants that augment immunogenicity of non-replicating protein-based antigens. Current vaccines against infectious diseases preferentially induce protective antibodies driven by adjuvants such as alum. However, the contribution of antibody to host defense is limited for certain classes of infectious diseases such as fungi, whereas animal studies and clinical observations implicate cellular immunity as an essential component of the resolution of fungal pathogens. Here, we decipher the structural bases of a newly identified glycoprotein ligand of Dectin-2 with potent adjuvancy, Blastomyces endoglucanase-2 (Bl-Eng2). We also pinpoint the developmental steps of antigen-specific CD4+ and CD8+ T responses augmented by Bl-Eng2 including expansion, differentiation and tissue residency. Dectin-2 ligation led to successful systemic and mucosal vaccination against invasive fungal infection and Influenza A infection, respectively. O-linked glycans on Bl-Eng2 applied at the skin and respiratory mucosa greatly augment vaccine subunit- induced protective immunity against lethal influenza and fungal pulmonary challenge.

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