Therapeutic potential of Hibiscusrosa sinensis - A Review

2021 ◽  
pp. 151-156
Author(s):  
Mohini Shelke ◽  
Shraddha Parjane ◽  
S. D Mankar ◽  
S. S. Siddheshwar
Keyword(s):  
Herbal Medicine ◽  
Therapeutic Potential ◽  
Perennial Plant ◽  
Beneficial Effects ◽  
Hibiscus Rosa Sinensis ◽  
Medicinal Value ◽  
Anti Cancer ◽  
Diabetic Wound Healing ◽  
Medicinal Properties ◽  
Good Range

Hibiscus sinensis is an annual/Perennial plant belongs to Malvaceae family commonly referred to as "roselle" famous for its medicinal value found world wide and native to West and East Africa, South-East Asia, Northeastern India. Roselle is cultivated in humid and warm climate. The plant consist phytoconstituents like malic, citric, tartaric, allo-hydroxycitric acid also reach in vitamin C, Vitamin A. Roselle is popular for it's therapeutic and nutritional value. Seeds, leaves, fruits and roots are utilized in herbal medicine for hair growth treatment. The Roselle, having various medically important compounds called photochemical, is documented for its nutritional and medicinal properties. Many parts of Roselle including seeds, leaves, fruits and roots are utilized in various foods also as in herbal medicine as a possible non-pharmacological treatment. In the treatment of various medical conditions, including several cardiovascular diseases, helmentic disease and cancer, different extracts from Roselle play an important role. Phytochemical research has reported that flavonoids, tannins, terpenoids, saponins, and alkaloids are the most bioactive compounds responsible for their medicinal effects. Experiments from recent studies have shown that different types of extracts from all Hibiscus. The components of rosa sinensis showed a good range of beneficial effects, such as hypotensive, anti-pyritic, anti-inflammatory, anti-cancer, antioxidant, anti-bacterial, anti-diabetic, wound healing, and abortifacient activities. Hibiscus rosa sinensis has been utilized in many herbal mix and drinks. This review plan to highlight the therapeutic application of Hibiscus rosa sinensis.

scholarly journals Acalypha indica L. - an Important Medicinal Plant: A Brief Review of Its Pharmacological Properties and Restorative Potential

2020 ◽  
pp. 1-10
Author(s):  
Sudhakar Chekuri ◽  
Lali Lingfa ◽  
Shivaprasad Panjala ◽  
K. C. Sai Bindu ◽  
Roja Rani Anupalli
Keyword(s):  
Medicinal Plant ◽  
Review Article ◽  
Synthetic Chemicals ◽  
Medicinal Value ◽  
Therapeutic Uses ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Medicinal Properties ◽  
Important Medicinal Plant ◽  
Acalypha Indica

Medicinal plants are moving from border to mainstream use with a more number of people seeking treatment and health approaches free from side effects caused by synthetic chemicals. India officially recognizes over 3500 plants for their medicinal value. It is generally estimated that over 6000 plants in India are in use in folk, traditional and herbal medicine. This review article aims to provide a comprehensive review on the phytochemical and various pharmacological aspects of Acalypha indica. This plant widely used in traditional medicinal system of India and many other countries has been reported to possess anti-cancer, anti-diabetic, anti-oxidant, anti-bacterial, antifungal hepatoprotective, anti-inflammatory, and also used to check anti-ulcers and wounds healing. It is known as a rich source of glycosides, flavanoids and tannins. The medicinal properties and therapeutic uses of Acalypha indica and its secondary metabolites investigations prove its importance as a valuable medicinal plant.

scholarly journals An update review on Hibiscus rosa sinensis phytochemistry and medicinal uses

2018 ◽  
Vol 4 (3) ◽  
pp. 135-146
Author(s):  
Asmaa Missoum ◽  
Keyword(s):  
Therapeutic Potential ◽  
Hematological Parameters ◽  
Gastric Ulcers ◽  
Future Research ◽  
Phytochemical Analysis ◽  
Medicinal Uses ◽  
Beneficial Effects ◽  
Hibiscus Rosa Sinensis ◽  
Wide Range ◽  
Bacteria And Fungi

Hibiscus rosa sinensis is known as China rose belonging to the Malvaceae family. This plant has various important medicinal uses for treating wounds, inflamation, fever and coughs, diabetes, infections caused by bacteria and fungi, hair loss, and gastric ulcers in several tropical countries. Phytochemical analysis documented that the main bioactive compounds responsible for its medicinal effects are namely flavonoids, tannins, terpenoids, saponins, and alkaloids. Experiment from recent studies showed that various types of extracts from all H. rosa sinensis parts exhibited a wide range of beneficial effects such as hypotensive, anti-pyritic, anti-inflammatory, anti-cancer, antioxidant, anti-bacterial, anti-diabetic, wound healing, and abortifacient activities. The few studies on toxicity exhibited that most extracts from all parts of this plant did not show any signs of toxicity at higher doses according to histological analysis. However, some of the extracts did alter biochemical and hematological parameters. Therefore, further research must be conducted to isolate the phytochemicals and explore their specific mechanism of action. This review summarizes the phytochemistry, pharmocology, and medicinal uses of this flower with the purpose of finding gaps demanding for future research and investigating its therapeutic potential through clinical trials.

Comprehensive Profile Of Madhuca Longifolia In Pharma And Food Industry

2021 ◽  
Vol 02 ◽  
Author(s):  
Malesh Prajapati ◽  
Dilip Yamgar ◽  
Bharti fegade
Keyword(s):  
Food Industry ◽  
Therapeutic Potential ◽  
Bone Fractures ◽  
Commercial Application ◽  
Future Research ◽  
Antiestrogenic Activity ◽  
Madhuca Longifolia ◽  
Anti Cancer ◽  
The Family ◽  
Medicinal Properties

: Madhuca longifolia (J.Koenig) J.F.Macbr. belongs to the family Sapotaceae, also commonly known as mahua or butternut tree. Each part of the plant is known for its unique medicinal properties. This review aims to enhance the existence of application and extend the therapeutic potential of Madhuca species in Pharmaceuticals, cosmeceuticals, agriculture and the food industry. Madhuca longifolia and all its products are widely used as a traditional and herbal medicine system. Even though they are used traditionally by a population of local areas, the potential of therapeutic existence is still uncovered. This systematic review is an exhaustive compilation of detailed data on phytochemistry, wide ethnopharmacological uses, medicinal properties and commercial application of mahua in different sectors. With the potential of spasmogenic, oxytocic, uterotonic, anti-bacterial, anti implantation, anti-tumor, anti-progestational, antiestrogenic activity against menorrhagia and anti-cancer, and many more. M. longifolia is also used in stomach ache, snake bite, scorpion bite, bone fractures, treatment of piles, joint pains, increase lactation, etc. It can contribute towards the development of the pharmaceutical sector and food industry too. Positively it will provide a path for future research for the development of herbal drugs and other products for agriculture and the food industry.

scholarly journals Potential of Zerumbone as an Anti-Cancer Agent

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 734 ◽  
Author(s):  
Sosmitha Girisa ◽  
Bano Shabnam ◽  
Javadi Monisha ◽  
Lu Fan ◽  
Clarissa Halim ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Janus Kinase ◽  
Treatment Modalities ◽  
Downstream Target ◽  
Current Review ◽  
Molecular Modulation ◽  
Anti Cancer ◽  
Medicinal Properties ◽  
Cancer Agent ◽  
Transcription 3

Cancer is still a major risk factor to public health globally, causing approximately 9.8 million deaths worldwide in 2018. Despite advances in conventional treatment modalities for cancer treatment, there are still few effective therapies available due to the lack of selectivity, adverse side effects, non-specific toxicities, and tumour recurrence. Therefore, there is an immediate need for essential alternative therapeutics, which can prove to be beneficial and safe against cancer. Various phytochemicals from natural sources have been found to exhibit beneficial medicinal properties against various human diseases. Zerumbone is one such compound isolated from Zingiber zerumbet Smith that possesses diverse pharmacological properties including those of antioxidant, antibacterial, antipyretic, anti-inflammatory, immunomodulatory, as well as anti-neoplastic. Zerumbone has shown its anti-cancer effects by causing significant suppression of proliferation, survival, angiogenesis, invasion, and metastasis through the molecular modulation of different pathways such as NF-κB, Akt, and IL-6/JAK2/STAT3 (interleukin-6/janus kinase-2/signal transducer and activator of transcription 3) and their downstream target proteins. The current review briefly summarizes the modes of action and therapeutic potential of zerumbone against various cancers.

Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances for Drug Discovery

2020 ◽  
Vol 26 ◽  
Author(s):  
Kondeti Ramudu Shanmugam ◽  
Bhasha Shanmugam ◽  
Gangigunta Venkatasubbaiah ◽  
Sahukari Ravi ◽  
Kesireddy Sathyavelu Reddy
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Diabetes Management ◽  
Therapeutic Potential ◽  
Public Health Problem ◽  
In Vivo Studies ◽  
Major Public Health Problem

Background : Diabetes is a major public health problem in the world. It affects each and every part of the human body and also leads to organ failure. Hence, great progress made in the field of herbal medicine and diabetic research. Objectives: Our review will focus on the effect of bioactive compounds of medicinal plants which are used to treat diabetes in India and other countries. Methods: Information regarding diabetes, oxidative stress, medicinal plants and bioactive compounds were collected from different search engines like Science direct, Springer, Wiley online library, Taylor and francis, Bentham Science, Pubmed and Google scholar. Data was analyzed and summarized in the review. Results and Conclusion: Anti-diabetic drugs that are in use have many side effects on vital organs like heart, liver, kidney and brain. There is an urgent need for alternative medicine to treat diabetes and their disorders. In India and other countries herbal medicine was used to treat diabetes. Many herbal plants have antidiabetic effects. The plants like ginger, phyllanthus, curcumin, aswagandha, aloe, hibiscus and curcuma showed significant anti-hyperglycemic activities in experimental models and humans. The bioactive compounds like Allicin, azadirachtin, cajanin, curcumin, querceitin, gingerol possesses anti-diabetic, antioxidant and other pharmacological properties. This review focuses on the role of bioactive compounds of medicinal plants in prevention and management of diabetes. Conclusion: Moreover, our review suggests that bioactive compounds have the potential therapeutic potential against diabetes. However, further in vitro and in vivo studies are needed to validate these findings.

Therapeutic Potential of Citronella Essential Oil: A Review

2019 ◽  
Vol 16 (4) ◽  
pp. 330-339 ◽  
Author(s):  
Ruchi Sharma ◽  
Rekha Rao ◽  
Sunil Kumar ◽  
Sheefali Mahant ◽  
Sarita Khatkar
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Environmental Protection Agency ◽  
Therapeutic Potential ◽  
Biological Properties ◽  
Toxic Encephalopathy ◽  
Practical Applications ◽  
Insect Repellents ◽  
Citronella Oil ◽  
Medicinal Value

Mosquito-borne diseases such as malaria, filariasis, chikunguniya, yellow fever, dengue and Japanese encephalitis are the major cause of remarkable morbidity and mortality in livestock and humans worldwide. Since ancient times, aromatic plants are used for their medicinal value. Essential oils derived from these plants may be used as effective alternatives/adjuvants in pharmaceuticals, biomedical, cosmetic, food, veterinary and agriculture applications. These oils have also gained popularity and interest for prevention and treatment of various disorders. However, several reports on adverse effects including skin eruption, contact artricaria or toxic encephalopathy in children are available for synthetic repellent in the literature. Thus, natural insect repellents like essential oils have been explored recently as an alternative. One such essential oil studied widely, is citronella oil, extracted mainly from Cymbopogon nardus. This essential oil has exhibited good efficacy against mosquitoes. It is a mixture of components including citronellal, citronellol, geraniol as major constituents contributing to various activities (antimicrobial, anthelmintic, antioxidant, anticonvulsant antitrypanosomal and wound healing), besides mosquito repellent action. Citronella essential oil is registered in US EPA (Environmental protection agency) as insect repellent due to its high efficacy, low toxicity and customer satisfaction. However, poor stability in the presence of air and high temperature limits its practical applications. Since specific knowledge on properties and chemical composition of oil is fundamental for its effective application, the present review compiles and discusses biological properties of citronella oil. It also sheds light on various formulations and applications of this essential oil.

Phytochemical, Pharmacological Activities and Ayurvedic Significances of Magical Plant Mimosa pudica Linn

2020 ◽  
Vol 17 ◽  
Author(s):  
Vijay Kumar
Keyword(s):  
Therapeutic Potential ◽  
Wide Spectrum ◽  
Chemical Constituents ◽  
Future Research ◽  
Mimosa Pudica ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Traditional Medicines ◽  
Crude Extracts ◽  
Anti Cancer

: Mimosa pudica Linn is an integrated part of Traditional Medicines Systems of India, China, Africa, Korea and America. It has been used from centuries in traditional medicines to cure different diseases like fever, diabetes, constipation, jaundice, ulcers, biliousness, and dyspepsia. It is an important ingredient of wide class of herbal formulations. To assess the scientific evidence for therapeutic potential of Mimosa pudica Linn and to identify the gaps for future research. The available information on the ethno-medicinal uses, phytochemistry, pharmacology and toxicology of Mimosa pudica Linn was collected via a library and electronic searches in Sci-Finder, Pub-Med, Science Direct, Google Scholar for the period, 1990 to 2020. In traditional medicinal systems, variety of ethno-medicinal applications of Mimosa pudica Linn has been noticed. Phytochemical investigation has resulted in identification of 40 well known chemical constituents, among which alkaloids, phenols and flavionoids are the predominant groups. The crude extracts and isolates have exhibited a wide spectrum of in vitro and in vivo pharmacological activities including anti-cancer, anti-inflammation, osteoporosis, neurological disorders, hypertension etc.. To quantify the Mimosa pudica Linn and its formulations, analytical techniques like HPLC and HPTLC has shown dominancy with good range of recovery and detection limit. Mimosa pudica Linn is the well-known herb since an ancient time. The pharmacological results supported some of the applications of Mimosa pudica Linn in traditional medicine systems. Perhaps, the predominance of alkaloids, phenols and flavionoids are responsible for the pharmacological activities the crude extracts and isolates of Mimosa pudica Linn. Further, there is need to isolate and evaluate the active chemical constituents of Mimosa pudica Linn having significant medicinal values. In future, it is important to study the exact mechanism associated with the phytochemicals of Mimosa pudica Linn especially on anti-cancer activities. Notably, toxicity studies on Mimosa pudica Linn are limited which are to be explored in future for the safe application of Mimosa pudica Linn and its formulations.

Effects of Minor Compounds of Edible Oils on Human Health

2020 ◽  
Vol 16 (8) ◽  
pp. 1196-1208
Author(s):  
Ramin Ghodsi ◽  
Rahmat Nosrati
Keyword(s):  
Human Health ◽  
Food Industry ◽  
Edible Oils ◽  
Food Groups ◽  
Bioactive Constituents ◽  
Beneficial Effects ◽  
Anti Cancer ◽  
Prevention And Treatment ◽  
Minor Compounds ◽  
Anti Inflammation

Background: Oils and fats are the densest sources of food energy among food groups. Vegetable oils are constituted predominantly of triglycerides. Due to the importance of edible oils in nutrition, food industry and human health, great attention has been paid to them in recent years. Some minor bioactive constituents in oils include phospholipids, tocols, sterols, carotenoid, chlorophyll, phenols, phylokynon and terpenes. Objective: The aim of the present study was to examine beneficial effects of minor compounds in edible oils on human health. Results: Minor compounds of edible oils that we use daily can produce remarkable results in the prevention and treatment of various diseases like diabetes, inflammation, hypertension, cancer, allergy and central nervous system disorders due to their antimicrobial, anti-cancer, anti-viral, anti-oxidative, anti-inflammation, anti-mutagenic, hypolipidemic, and hypoglycemic properties, among others. Conclusion: The results of this study showed that the presence of beneficial minor compounds in oils could have significant impact on the prevention and treatment of various diseases. Therefore, the type of consumed oil can play an important role in human health.

scholarly journals Non-Cannabinoid Metabolites of Cannabis sativa L. with Therapeutic Potential

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 400
Author(s):  
Henry Lowe ◽  
Blair Steele ◽  
Joseph Bryant ◽  
Ngeh Toyang ◽  
Wilfred Ngwa
Keyword(s):  
Secondary Metabolites ◽  
Cannabis Sativa ◽  
Therapeutic Potential ◽  
Physiological Activity ◽  
Economic Value ◽  
Therapeutic Window ◽  
Future Directions ◽  
Medicinal Properties ◽  
The Many ◽  
Human Viruses

The cannabis plant (Cannabis sativa L.) produces an estimated 545 chemical compounds of different biogenetic classes. In addition to economic value, many of these phytochemicals have medicinal and physiological activity. The plant is most popularly known for its two most-prominent and most-studied secondary metabolites—Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Both Δ9-THC and CBD have a wide therapeutic window across many ailments and form part of a class of secondary metabolites called cannabinoids—of which approximately over 104 exist. This review will focus on non-cannabinoid metabolites of Cannabis sativa that also have therapeutic potential, some of which share medicinal properties similar to those of cannabinoids. The most notable of these non-cannabinoid phytochemicals are flavonoids and terpenes. We will also discuss future directions in cannabis research and development of cannabis-based pharmaceuticals. Caflanone, a flavonoid molecule with selective activity against the human viruses including the coronavirus OC43 (HCov-OC43) that is responsible for COVID-19, and certain cancers, is one of the most promising non-cannabinoid molecules that is being advanced into clinical trials. As validated by thousands of years of the use of cannabis for medicinal purposes, vast anecdotal evidence abounds on the medicinal benefits of the plant. These benefits are attributed to the many phytochemicals in this plant, including non-cannabinoids. The most promising non-cannabinoids with potential to alleviate global disease burdens are discussed.

scholarly journals The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide

Angiogenesis ◽  
2021 ◽  
Author(s):  
Juan Pablo Robles ◽  
Magdalena Zamora ◽  
Lourdes Siqueiros-Marquez ◽  
Elva Adan-Castro ◽  
Gabriela Ramirez-Hernandez ◽  
...  
Keyword(s):  
Therapeutic Agent ◽  
Clinical Evidence ◽  
Therapeutic Potential ◽  
Peripartum Cardiomyopathy ◽  
Loss Of Function ◽  
Functional Determinant ◽  
Melanoma Tumor ◽  
Linear Motif ◽  
Anti Cancer ◽  
Orally Active

AbstractThe hormone prolactin acquires antiangiogenic and antivasopermeability properties after undergoing proteolytic cleavage to vasoinhibin, an endogenous prolactin fragment of 123 or more amino acids that inhibits the action of multiple proangiogenic factors. Preclinical and clinical evidence supports the therapeutic potential of vasoinhibin against angiogenesis-related diseases including diabetic retinopathy, peripartum cardiomyopathy, rheumatoid arthritis, and cancer. However, the use of vasoinhibin in the clinic has been limited by difficulties in its production. Here, we removed this barrier to using vasoinhibin as a therapeutic agent by showing that a short linear motif of just three residues (His46-Gly47-Arg48) (HGR) is the functional determinant of vasoinhibin. The HGR motif is conserved throughout evolution, its mutation led to vasoinhibin loss of function, and oligopeptides containing this sequence inhibited angiogenesis and vasopermeability with the same potency as whole vasoinhibin. Furthermore, the oral administration of an optimized cyclic retro-inverse vasoinhibin heptapeptide containing HGR inhibited melanoma tumor growth and vascularization in mice and exhibited equal or higher antiangiogenic potency than other antiangiogenic molecules currently used as anti-cancer drugs in the clinic. Finally, by unveiling the mechanism that obscures the HGR motif in prolactin, we anticipate the development of vasoinhibin-specific antibodies to solve the on-going challenge of measuring endogenous vasoinhibin levels for diagnostic and interventional purposes, the design of vasoinhibin antagonists for managing insufficient angiogenesis, and the identification of putative therapeutic proteins containing HGR.

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