scholarly journals Formulation and Evaluation Thermoreversible Gel of Antifungal Agent for Treatment of Vaginal Infection

2020 ◽  
pp. 58-66
Author(s):  
Manisha V. Patil ◽  
Rahul L. Jadhav ◽  
Siraj N. Shaikh ◽  
Santosh N. Belhekar
Keyword(s):  
Rheological Behavior ◽  
Antifungal Agent ◽  
Sodium Dodecyl ◽  
Research Work ◽  
Rheological Behaviour ◽  
Vaginal Infection ◽  
Drug Diffusion ◽  
Peg 400 ◽  
Significant Difference ◽  
Thermoreversible Gel

Aims: The aim this research work is to formulate and evaluate thermoreversible gel of antifungal agent Clotrimazole for treatment of vaginal infection. Place and Duration of Study: Department of Biopharmaceutics, Government College of Pharmacy, Karad, Maharashtra, India, between June 2009 and July 2010. Methodology: Different Formulations of thermoreversible gel of antifungal agent Clotrimazole were prepared by using various concentrations of ethanol, PEG 400, sodium dodecyl sulphate, polycarbophil and pluronic F 127 and pluronic F 68. The gel formulations were subjected for evaluation on the basis of rheological behaviour, mucoadhesive behaviour, in-vitro performance. Results: The results indicate that Polymers such as polycarbophil, PEG- 400 in various concentrations to prepare formulations were found to release drug for period over 12 hrs. Without getting dislodged. The formulations have satisfactory rheological behavior and their diffusion profile is comparable to the marketed gel formulation. Significant difference was observed in the rheological behavior of formulations. Gel strength, spreadability, mucoadhesive strength of formulation B and C were desirable. Drug diffusion of formulation B and C were 95.2% release after 11 hrs 98.5% release after 11 hrs, respectively which was good as compared to marketed formulation showing drug diffusion of 102.2% after 10 hrs. Conclusion: On basis of the results we concluded that developed thermoreversible gel of Clotrimazole will be better alternative to conventional dosage form Clotrimazole & will improve patient compliance.

The Effect of Using Students Peer Teaching on Iraqi EFL Students' Achievement in the Course of Library and Research Work

2019 ◽  
Vol 1 (33) ◽  
pp. 693-714
Author(s):  
. Muntaha Sabbar Jebur
Keyword(s):  
Basic Education ◽  
Teaching Method ◽  
Research Work ◽  
Peer Teaching ◽  
Control Group ◽  
College Of Basic Education ◽  
Significant Difference ◽  
Post Test ◽  
Efl Students ◽  
Experimental Group

          Peer teaching is a strategy that allows the students to teach the new content to each other, and they must be accurately guided by instructors.     The researcher proposes that the use of students peer teaching  may promote students' achievement  and ensure the engagement of all the students in the learning process. Therefore, the researcher employs it as a teaching method aiming at investigating its  effect on Iraqi EFL students' achievement in the course of Library and Research Work .      The study hypothesizes that there is no significant difference between the students' achievement who are taught library and research work by students peer teaching  and that of the students taught by the traditional way. The experimental design of the study is Parallel Groups, Random Assignment, posttest. Each group consists of 35 students, chosen randomly from the Third Year Students at the Department of English in the College of Basic Education. Both groups were matched in terms of their age and parents' education. The experiment was fulfilled in the first course for 15 weeks during the academic year 2016-2017.       The same materials were presented to both groups. This included   units from Writing Research Paper by Lester D. . Post-test was constructed and exposed  The t-test for  independent samples was used to analyze the results and it is found out that there is a statistical difference between the two groups in their achievement because the calculated t- value 2.635 is bigger than the tabulated t- value which is 2.000, and also shown the superiority of the experimental group. The results indicate that the experimental group, who was taught Library and Research Work by peer teaching   was better than the control group, who was taught according to the traditional way. So, the null hypothesis is rejected. Finally, some recommendations and suggestions are presented in the light of the study findings. to a jury of experts to verify its validity and it was administered to both groups.

The Impact of using 3D Interactive Animation Tool in Teaching Computer Programming at the Senior High School Level

2018 ◽  
Vol 3 (2) ◽  
pp. 18-28
Author(s):  
Najim Ussiph ◽  
Hamidu Kwame Seidu
Keyword(s):  
High School ◽  
Research Work ◽  
Instructional Method ◽  
Senior High School ◽  
School Level ◽  
Eastern Region ◽  
3D Animation ◽  
High School Level ◽  
Significant Difference ◽  
The Impact

A quasi experiment with interview was adopted to study the aptness of using 3D animations as an instructional method to introduce programming concepts to students at the Senior High School level. This research work was conducted with 100 students of Akroso Senior High School in the Birim central municipality of the eastern region of Ghana who were generally programming novice. Programming concepts considered included programming environments, loops, functions sequential and conditional execution of programs. A paired t-test carried out on the results of the performance test presents a p-value of 0.008 indicative of a numerically significant difference between the mean marks of participants during the experiments that used 3D animation method as against the experiments that used the text base method. Results from the interview showed that the instructional method used had impact on the performance of the learners. The use of 3D animation method presented programming concepts in a form that the learners can understand, motivates them to pursue programming related courses at a higher level and also impacts positively on their performance.

scholarly journals Biochemical and molecular characterization of Alternaria alternata isolates highly resistant to procymidone from broccoli and cabbage

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Bingran Wang ◽  
Tiancheng Lou ◽  
Lingling Wei ◽  
Wenchan Chen ◽  
Longbing Huang ◽  
...  
Keyword(s):  
Alternaria Alternata ◽  
Single Point ◽  
Sodium Dodecyl ◽  
Cross Resistance ◽  
Molecular Characteristics ◽  
Single Point Mutation ◽  
Wide Range ◽  
Significant Difference ◽  
Leaf Blights ◽  
High Level

AbstractAlternaria alternata, a causal agent of leaf blights and spots on a wide range of hosts, has a high risk of developing resistance to fungicides. Procymidone, a dicarboximide fungicide (DCF), has been widely used in controlling Alternaria leaf blights in China for decades. However, the resistance of A. alternata against DCFs has rarely been reported from crucifer plants. A total of 198 A. alternata isolates were collected from commercial fields of broccoli and cabbage during 2018–2019, and their sensitivities to procymidone were determined. Biochemical and molecular characteristics were subsequently compared between the high-level procymidone-resistant (ProHR) and procymidone-sensitive (ProS) isolates, and also between ProHR isolates from broccoli and cabbage. Compared with ProS isolates, the mycelial growth rate, sporulation capacity and virulence of most ProHR isolates were reduced; ProHR isolates displayed an increased sensitivity to osmotic stresses and a reduced sensitivity to sodium dodecyl sulfate (SDS); all ProHR isolates showed a reduced sensitivity to hydrogen peroxide (H2O2) except for the isolate B102. Correlation analysis revealed a positive cross-resistance between procymidone and iprodione, or fludioxonil. When treated with 10 μg/mL of procymidone, both mycelial intracellular glycerol accumulations (MIGAs) and relative expression of AaHK1 in ProS isolates were higher than those in ProHR isolates. Sequence alignment of AaHK1 from ten ProHR isolates demonstrated that five of them possessed a single-point mutation (P94A, V612L, E708K or Q924STOP), and four isolates had an insertion or a deletion in their coding regions. No significant difference in biochemical characteristics was observed among ProHR isolates from two different hosts, though mutations in AaHK1 of the cabbage-originated ProHR isolates were distinct from those of the broccoli-originated ProHR isolates.

Comparative Analysis of the Rheological Behaviour of Irvingia Gabonensis Ogbono and Foreign Polymer for Bentonite Formulated Mud.

2021 ◽  
Author(s):  
Emmanuel Ayodele ◽  
David Ekuma ◽  
Ikechukwu Okafor ◽  
Innocent Nweze
Keyword(s):  
Rheological Properties ◽  
Oil And Gas ◽  
Drilling Fluid ◽  
Research Work ◽  
Rheological Behaviour ◽  
Oil And Gas Industry ◽  
Drilling Mud ◽  
Gas Industry ◽  
Local Product ◽  
Irvingia Gabonensis

Abstract Drilling fluid are complex fluids consisting of several additives. These additives are added to enhance and control the rheological properties (such as viscosity, gel strength and yield point) of the mud. These properties are controlled for effective drilling of a well. This research work is focused on determining the rheological behavior of drilling mud using industry-based polymer and Irvingia Gabonensis (ogbono) as viscosifiers. Water based muds were formulated from the aforementioned locally sourced viscosifier and that of the conventional used viscosifier (Carboxylmetyl cellulose, CMC). Laboratory tests were carried out on the different muds formulated and their rheological properties (such as yield stress, shear stress, plastic viscosity and shear rate) are evaluated. The concentration of the viscosifiers were varied. The expected outcome of the research work aims at lowering the total drilling cost by reducing the importation of foreign polymer which promotes the development of local content in the oil and gas industry. The research compares the rheology of mud samples and the effect of varying the concentration (2g, 4g, 6g, 8g, and 10g) of both CMC and Ogbono and determining the changes in their rheological properties. The total volume of each mud sample is equivalent to 350ml which represent one barrel (42gal) in the lab. From the result, at concentration of 2g, the ogbono mud has a better rheology than the CMC mud, but at a concentration above 2g, CMC mud shows a better rheology than ogbono mud, that is, as the concentration of CMC is increased, the rheological properties of the mud increased while as the concentration of ogbono is increased the rheological properties decreased. The viscosity of the drilling fluid produced from the ogbono were lower than that of CMC, it could be used together with another local product such as cassava starch, offor or to further improve the rheology and then be a substitute to the conventional viscosifiers.

A study on the safety evaluation of buphrenorphine administered through an autoinjector compared with manual injection using haematological and biochemical variables in rats

2016 ◽  
Vol 36 (9) ◽  
pp. 901-909 ◽  
Author(s):  
D Sheela ◽  
R Vijayaraghavan ◽  
S Senthilkumar
Keyword(s):  
Body Weight ◽  
Research Work ◽  
Safety Evaluation ◽  
Weight Ratio ◽  
The Body ◽  
Control Group ◽  
Body Weight Ratio ◽  
Significant Difference ◽  
Manual Group ◽  
Significant Change

Buprenorphine drug cartridge was made for autoinjector device for use in emergency and critical situations to reduce the morbidity and mortality. Water-filled cartridges were prepared and buprenorphine was injected aseptically in the cartridge, to make 0.05 and 0.10 mg/mL. Rats were injected intraperitoneally, buprenorphine (0.3 and 0.6 mg/kg), repeatedly with the autoinjector and compared with manual injection (7 days and 14 days) using various haematological and biochemical parameters. No significant change was observed in the body weight, organ to body weight ratio and haematological variables in any of the experimental groups compared with the control group. Except serum urea and aspartate aminotransferase, no significant change was observed in glucose, cholesterol, triglycerides, bilirubin, protein, albumin, creatinine, uric acid, alanine aminotransferase, gamma glutamyltransferase and alkaline phosphatase. The autoinjectors deliver the drugs with spray effect and force for faster absorption. In the present study, the autoinjector meant for intramuscular injection was injected intraperitoneally in rats, and the drug was delivered with force on the vital organs. No significant difference was observed in the autoinjector group compared to the manual group showing tolerability and safety of the buphrenorphine autoinjector. This study shows that buprenorphine autoinjector can be considered for further research work.

scholarly journals ANALYSIS OF COST AND RETURNS IN RICE PRODUCTION BY USAID-MARKETS II PROJECT PARTICIPANTS AND NON-PARTICIPANTS IN EBONYI STATE, NIGERIA

2021 ◽  
Vol 21 (1) ◽  
pp. 1-7
Author(s):  
Ogechi Cordelia Nwahia
Keyword(s):  
Research Work ◽  
Primary Source ◽  
Sampling Procedure ◽  
Study Data ◽  
Rice Production ◽  
Farm Income ◽  
International Agencies ◽  
Significant Difference ◽  
Project Participants ◽  
The Government

This research work focused on analysis of cost and returns in rice production by USAID-MARKETS II project participants and non-participants in Ebonyi state, Nigeria. Multi-stage sampling procedure was employed to select 239 participants, and 252 non- participants for the study. Data were collected from primary source, and analyzed using Z statistic, Net Farm Income (NFI) and Returns Per Naira Invested (RNI). The result reveals that the Net Farm Income (NFI) obtained by USAID-MARKETS II project participants, and non-participants were N493, 067.55/ha, and N353, 408. 12/ha respectively while the return on investment obtained by them were N3.28k, and N3.05k respectively. There was a significant difference between the profits obtained by them. Therefore, this study recommended that the teaming unemployed Nigerian youth should be encourage by the government, and international agencies through provision of grant/loan to take up rice farming as a business.

scholarly journals Etude de l’effet rémanent de Mavi MNPV dans un champ de niébé

2020 ◽  
Vol 14 (6) ◽  
pp. 2219-2229
Author(s):  
A. Kindozandji ◽  
B.D. Datinon ◽  
K. Amevoin ◽  
A.N. Nondichao ◽  
A.I. Glitho ◽  
...  
Keyword(s):  
Research Work ◽  
Residual Effect ◽  
Maruca Vitrata ◽  
Sub Saharan Africa ◽  
Important Food ◽  
Food Legumes ◽  
Significant Difference ◽  
Sub Saharan ◽  
Rate Of Emergence ◽  
And Control

Le niébé est l’une des légumineuses alimentaires la plus importante dans toutes les régions de l’Afrique Sub-saharienne. L’objectif de ce travail était d’étudier l’effet rémanent de Mavi Multinucléo polyhedrovirus (Mavi MNPV) après la récolte du niébé au champ. Le champ a été traité 5 fois au biopesticide Mavi MNPV à la fréquence de sept jours. Deux semaines après la récolte, deux plants ainsi que les graines de chaque traitement sur chaque unité parcellaire ayant reçu les traitements de Mavi MNPV de 107, 108 et 109 virions/ml ont été collectés et amenés au laboratoire avec le substrat de développement de la plante (sable). Aucune des formulations issues des substrats sable, racines, feuilles, tiges et graines n’a affecté la mortalité des larves L2 et L3 de Maruca vitrata et aucune différence significative n’a été observée entre les traitements et le témoin. Quels que soient les traitements, le taux d’émergence des adultes est élevé ; ce qui signifie que la variation de la concentration de Mavi MNPV ne conditionne pas sa présence dans le sol, les tiges, les feuilles, les racines et les graines. Le biopesticide Mavi MNPV n’est pas persistant dans la nature.Mots clés : Niébé, Mavi MNPV, Maruca vitrata, Effet rémanent   English Title: Study of the residual effect of Mavi MNPV in a cowpea field Cowpea is one of the most important food legumes in all regions of Sub-Saharan Africa. The objective of this research work was to study the persistence effect of Mavi Multinucleus polyhedrovirus (Mavi MNPV) after field harvest of the cowpea. The field was treated 5 times with Mavi MNPV biopesticide at seven days. Two weeks after harvest, two plants as well as the seeds from each treatment on each plot unit that received Mavi MNPV treatments of 107, 108 and 109 virions / ml were removed and brought to the laboratory with the plant development substrate (sand). None of the formulations from sand, root, leaf, stem and seed substrates did not affect the mortality of L2 and L3 larvae of Maruca vitrata and no significant difference was observed between treatments and control. Regardless of the treatments, the rate of emergence of adults is high; this means that the variation in the concentration of Mavi MNPV does not condition its presence in soil, stems, leaves, roots and seeds. Mavi MNPV biopesticide is not persistent in nature.Keywords: Cowpea, Mavi MNPV, Maruca vitrata, Residual effect.      

scholarly journals PENGARUH VARIASI KONSENTRASI EKSTRAK DAUN BELIMBING WULUH (Averrhoa bilimbi L) TERHADAP KARAKTERISTIK SEDIAAN SALEP DENGAN MENGGUNAKAN BASIS PEG 4000 dan PEG 400

2021 ◽  
Vol 2 (02) ◽  
pp. 7
Author(s):  
Tri Puji Lestari
Keyword(s):  
Leaf Extract ◽  
Homogeneity Test ◽  
Test Results ◽  
Peg 400 ◽  
Cell Tissue ◽  
Peg 4000 ◽  
Significant Difference ◽  
Ointment Formulation ◽  
The Difference ◽  
One Way Anova

ABSTRAK Daun Belimbing Wuluh (Averrhoa bilimbi L) memiliki kandungan tanin dan flavonoid. Kandungan Flavonoid dan Tanin yang terdapat dalam belimbing wuluh mampu memberikan efek untuk menyembuhkan kulit yang mengalami kerusakan jaringan sel akibat luka bakar. Ada beberapa cara untuk pemanfaatan Daun Belimbing Wuluh antara lain dengan dibuat dalam sediaan salep. Pada penelitian ini salep dibuat dengan variasi konsentrasi ekstrak daun belimbing wuluh sebesar 10%, 15%, dan 20%  mengguankan basis PEG 4000 dan PEG 400. Ekstrak daun belimbing wuluh diperoleh menggunakan metode maserasi dengan menggunakan etanol 70% sebagai pelarutnya. Salep yang sudah dibuat kemudian dilakukan uji karakteristik meliputi uji organoleptis, homogenitas, daya lekat dan uji daya sebar. Hasil uji organoleptis dan homogenitas di analisa secara deskrisptif kemudian hasil uji daya lekat dan uji daya sebar di analisa dengan menggunakan analisa statistik one-way ANOVA.  Hasil penelitian menunjukan bahwa salep berbentuk semipadat dengan warna hijau muda sampai hijau kehitaman. Hasil uji homogenitas di dapatkan untuk ketiga formula adalah homogen. Nilai daya sebar pada ketiga formula menunjukan perbedaan yang signifikan, pada hasil uji daya lekat dan pH didapatkan tidak ada perbedaan yang signifikan terhadap ketiga formulasi. Dengan demikian perbedaan konsentrasi zat aktif yang digunakan berpengaruh terhadap daya sebar sediaan salep ekstrak daun belimbing wuluh. Kata kunci: Averrhoa bilimbi L; Salep; PEG   ABSTRACT Carambola leaf Wuluh (Averrhoa bilimbi L) contains tannins and flavonoids. The content of flavonoids and tannins contained in starfruit able to give effect to heal skin damaged cell tissue from burns. There were several ways for  utilization  of  Averrhoa  bilimbi  L.  among  others,  made  some  preparations, especially ointment formulation. This study aims to formulate leaf extract ointment preparation starfruit (Averrhoa bilimbi L) with various concentrations of 10%, 15%, and 20% using the PEG 4000 and PEG 400 as a base. Leaf extract obtained from meserasi leaf Averrhoa bilimbi  L  with  70%  ethanol. The ointment that has been made is then subjected to characteristic tests including organoleptic tests, homogeneity, adhesion and spreadability tests. The results of the organoleptic test and homogeneity were analyzed descriptively, then the results of the adhesion test and the spreadability test were analyzed using one-way ANOVA statistical analysis. The results showed that the ointment was semisolid, light green to blackish green. The homogeneity test results obtained for the three formulas are homogeneous. The value of the spreadability of the three formulas showed a significant difference, the results of the adhesion and pH test showed no significant difference between the three formulations. Thus the difference in the concentration of the active substance used affects the spreadability of the starfruit leaf extract ointment. Keywords: Averrhoa bilimbi L; ointment; PEG

scholarly journals Competency Needs of Postgraduate Students of STEM Education in Research Writing in Universities

2020 ◽  
Author(s):  
Anggi Cecilia Safaningrum
Keyword(s):  
Stem Education ◽  
Research Work ◽  
Simple Random Sampling ◽  
Research Writing ◽  
Response Options ◽  
Postgraduate Students ◽  
South Eastern ◽  
Research Competency ◽  
Significant Difference ◽  
And Mathematics

The study identified research competency needs of postgraduate students of Science Technology Engineering and Mathematics (STEM) education in research writing in Nigerian Universities. The study adopted a survey research design and was carried out in South-Eastern Nigeria. Two research questions and a hypothesis guided the study. The population for the study was 372 comprising 222 master and 150 PhD students of STEM Education in nine Universities in south-eastern Nigeria. Proportionate simple random sampling techniques were used to select 50% of the population, which gave a sample size of 186 (111 master and 75 PhD students). Structured questionnaire developed from the literature which was reviewed by the researchers was used to collect data. Each item in the instrument had two columns of needed and difficult with each of the columns assigned a four response options with values 4, 3, 2 and 1. The instrument was validated by specialists. Cronbach alpha method was used to determine the internal consistency of the items and a coefficient of 0.85 was obtained. Data collected were analyzed using mean while the null hypothesis was tested using t-test. The findings revealed that postgraduate students needed 32 competencies in research writing; 25 of the competencies were difficult to employ by the students. The hypothesis tested revealed that there was no significant difference in the responses of the two groups of students on the difficult competencies. It was recommended that lecturers should utilize the 32 competencies while emphasizing the 25 difficult ones to make students competent in producing a quality research work.

scholarly journals Optimal Design and Testing of a Thermoplastic Pressurized Passenger Door Manufactured Using Thermoforming

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3394
Author(s):  
Roman Růžek ◽  
Josef Křena ◽  
Radek Doubrava ◽  
Josef Tkadlec ◽  
Martin Kadlec ◽  
...  
Keyword(s):  
Numerical Simulations ◽  
Impact Damage ◽  
Research Work ◽  
Variable Cross Section ◽  
Mechanical Tests ◽  
Point Of View ◽  
Topological Optimization ◽  
Variable Cross ◽  
Thermoplastic Resin ◽  
Significant Difference

The present paper documents and discusses research work associated with a newly designed passenger door structure demonstrator. The composite structure was manufactured from carbon-fiber-reinforced thermoplastic resin. A composite frame with a variable cross-section was designed, optimized, and fabricated using thermoforming technology. Both numerical simulations and experiments supported structural verification according to the damage tolerance philosophy; i.e., impact damage is presented. The Tsai-Wu and maximal stress criteria were used for damage analysis of the composite parts. Topological optimization of the metal hinges from the point of view of weight reduction was used. All expected parameters and proposed requirements of the mechanical properties were proved and completed. The door panel showed an expected numerically evaluated residual strength (ultimate structure load) as well as meeting airworthiness requirements. No impact damage propagation in the composite parts was observed during mechanical tests, even though visible impact damage was introduced into the structure. No significant difference between the numerical simulations and the experimentally measured total deformation was observed. Repeated deformation measurements during fatigue showed a nonlinear structure behavior. This can be attributed to the relaxation of thermoplastics.

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