This article examines the cases of Sonoita-Elgin, Arizona, and Cananea, Sonora, as new wine geographies. To characterize these regions and show their potential, problems, and challenges, this article privileges the socio-anthropological study, the ethnographic method, and the analysis of the sense of place. The initial findings show first that the sense of place is not given by geography but by a set of specific interactions that conform the particular character of each region; and second, that the border context offers an opportunity for binational collaboration yet to be explored, which can be translated into competitive advantages and into alternative and innovative constructions of the sense of place. Due to the interpretative extent of this analysis and its focus on emerging production areas, it is expected to contribute to new discussions on the wine industry globally and, specifically, on the region of Sonora-Arizona in the U.S.-Mexico border region.