Positive effects of daily consumption of biscuits enriched with legume flours on the results of a 12-week dietary intervention on healthy subjects with overweight/ obesity

The halal food industry is no longer underrated. Since consumers became very concerned about their daily consumption considering the hygiene that should be maintained. This research was aimed to measure the Indonesian consumers’ willingness to buy halal food, especially meat products, based on trust, awareness, packaging information, and food safety. However, Indonesian consumers’ demand for halal food is not proportional comparing to a large number of the Muslim population. Contrast to previous similar studies that adopting the Theory of Planned Behavior (TPB) or Theory of Reasoned Action (TRA) that focused more on halal awareness and halal labels, this study was adopting Hedonic Theory. This research using 186 data that were collected by online questionnaires. Data then analyzed using multiple linear regression and Ordinal Least Square (OLS). Results showed that only halal awareness and food safety are proven to have significant positive effects on willingness to buy. Regardless of Muslim and non-Muslim, halal awareness and food safety attract consumers’ willingness to buy halal-labeled meat products. To increase the willingness to buy halal meat products in Indonesia, the government and producers must be able to encourage awareness of the importance of eating halal food. Furthermore, they also must ensure the safety of that food. Hopefully, these findings can become input for stakeholders.

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Disentangling the Effects of Monounsaturated Fatty Acids from Other Components of a Mediterranean Diet on Serum Metabolite Profiles: A Randomized Fully Controlled Dietary Intervention in Healthy Subjects at Risk of the Metabolic Syndrome

Molecular Nutrition & Food Research ◽

10.1002/mnfr.201801095 ◽

2019 ◽

Vol 63 (9) ◽

pp. 1801095 ◽

Cited By ~ 10

Author(s):

Charlotte C. J. R. Michielsen ◽

Roland W.J. Hangelbroek ◽

Edith J. M. Feskens ◽

Lydia A. Afman

Keyword(s):

Metabolic Syndrome ◽

At Risk ◽

Fatty Acids ◽

Mediterranean Diet ◽

Healthy Subjects ◽

Dietary Intervention ◽

Monounsaturated Fatty Acids ◽

The Metabolic Syndrome ◽

Metabolite Profiles

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Altered metabolomic profiling of overweight and obese adolescents after combined training is associated with reduced insulin resistance

Scientific Reports ◽

10.1038/s41598-020-73943-y ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Renata G. Duft ◽

Alex Castro ◽

Ivan L. P. Bonfante ◽

Wendell A. Lopes ◽

Larissa R. da Silva ◽

...

Keyword(s):

Insulin Resistance ◽

Exercise Training ◽

Dietary Intervention ◽

Metabolic Changes ◽

Fat Free Mass ◽

Control Group ◽

Resonance Spectroscopy ◽

Obese Adolescents ◽

Combined Training ◽

Positive Effects

Abstract Exercise training and a healthy diet are the main non-pharmacological strategies for treating chronic conditions, such as obesity and insulin resistance (IR), in adolescents. However, the isolated metabolic changes caused by exercise training without dietary intervention have not yet been established. We investigated how combined training (CT) without dietary intervention altered the concentrations of serum metabolites, biochemical, anthropometric and functional parameters in overweight and obese adolescents. Thirty-seven adolescents (14.6 ± 1.05 years), of both sexes, were randomly assigned to the control group (CG, n = 19) or the training group (TG, n = 18). The CT was composed by resistance training and aerobic training performed in the same session (~ 60 min), three times a week, for 12 weeks. All assessments were performed pre and post-intervention. Metabolomics analyses were conducted using nuclear magnetic resonance spectroscopy (1H NMR) in a 600 MHz spectrometer. There was a decrease in body weight (BW), body mass index (BMI), waist circumference (WC), % body fat (%BF), fasting glucose, insulin levels, and insulin resistance (IR), by HOMA-IR, in the TG. An increase in fat-free mass (FFM) was also observed in the CG. The metabolic changes were given mainly by changes in the levels of metabolites 2-oxoisocaproate (↓TG), 3-hydroxyisobutyrate (↑CG and ↓TG), glucose (↓TG), glutamine (↓CG and ↑TG) and pyruvate (↓TG). These findings demonstrate the positive effects of CT program without dietary intervention on metabolomic profile, body composition, biochemical markers, and glucose metabolism in overweight and obese adolescents.

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The Short-Term Effects of Prunes in Preventing Inflammation and Improving Indices of Bone Health in Osteopenic Men

Current Developments in Nutrition ◽

10.1093/cdn/nzaa040_005 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 5-5

Author(s):

Bahram Arjmandi ◽

Kelli George ◽

Lauren Ormsbee ◽

Neda Akhavan ◽

Joseph Munoz ◽

...

Keyword(s):

Blood Pressure ◽

Bone Loss ◽

Bone Turnover ◽

Systolic Blood Pressure ◽

Dietary Intervention ◽

Male Rats ◽

Health Concern ◽

Control Group ◽

Daily Consumption ◽

Significant Group

Abstract Objectives Osteoporosis is a public health concern for both women and men. Chronic inflammation contributes to bone loss; therefore, foods rich in antioxidants, such as prunes, are of great interest. Previously, dietary intervention with prunes has been shown to prevent orchidectomy-induced decreases in BMD, microstructure, and biomechanics in male rats; however, there is a need for this to be studied in a clinical setting in adult males. Methods Thirty-five men between the ages of 55 and 80 with moderate bone loss were included. The men were randomized into one of three groups: 100 g prunes daily, 50 g prunes daily, or control group. All three groups also consumed a multivitamin containing 450 mg calcium and 800 IU vitamin D. Serum samples from the baseline and three-month time points were analyzed for biomarkers of bone turnover, inflammation, and oxidative stress. Results After three months, daily consumption of 100 g prunes was associated with a significant decrease in serum concentrations of osteocalcin (P < 0.001). Consumption of 50 g of prunes was associated with significant decreases in systolic blood pressure, and serum osteocalcin concentrations (P = 0.040), and an increase in the OPG: RANKL ratio (P = 0.041). There were also significant decreases in systolic blood pressure, OPG (P = 0.004), RANKL (P = 0.010), and osteocalcin (P = 0.049) in control group. There was a significant group*time effect for changes in OPG (P = 0.019) and the OPG: RANKL ratio (P = 0.029). Conclusions Decreases in osteocalcin indicate a decrease in bone turnover, and a higher OPG: RANKL ratio indicates that more RANKL is bound to OPG, and not to osteoclasts, thus downregulating osteoclast activity. Therefore, regular consumption of either 100 g or 50 g dried plum for three months may make some contributions to bone formation and bone turnover activity, and minimal contribution to decreasing inflammation and improving bone density and quality. Funding Sources USDA/NIFA, California Prune Board, and Shaklee.

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High tea consumption diminishes salivary 17β-estradiol concentration in Polish women

British Journal Of Nutrition ◽

10.1079/bjn20061755 ◽

2006 ◽

Vol 95 (5) ◽

pp. 989-995 ◽

Cited By ~ 13

Author(s):

Maria Kapiszewska ◽

Malgorzata Miskiewicz ◽

Peter T. Ellison ◽

Inger Thune ◽

Grazyna Jasienska

Keyword(s):

Menstrual Cycle ◽

Dietary Intervention ◽

Epigallocatechin Gallate ◽

Black Tea ◽

The United States ◽

Reproductive Age ◽

United States Department ◽

Daily Consumption ◽

Urban Group ◽

17Β Estradiol

We hypothesized that among reproductive-age women consuming large quantities of tea, the production of estradiol would be suppressed. It has been shown that catechins and theaflavines, the major constituents of tea, inhibit aromatase, an enzyme which catalyses the conversion of androgens to oestrogens. Our study included Polish women living in urban (n 61) and rural (n 48) areas. Women collected daily saliva samples for one complete menstrual cycle and filled out dietary questionnaires. Saliva samples were analysed by RIA for concentration of 17β-estradiol (E2). Women with high (above the median) average daily consumption of black tea had reduced levels of salivary E2 in comparison with women who drank less black tea (below the median). This effect was observed within the whole study group, as well as separately within urban (P=0·0006) and rural (P=0·013) groups. High intake of the sum of subclasses of tea catechins and epigallocatechin gallate, assessed using the United States Department of Agriculture database (http://www.nal.usda.gov), was also associated with lower concentrations of E2 within all women (P=0·01 and P=0·0001, respectively) and within the urban group (P=0·0001 and P0·004, respectively). Similar relationships were observed between the sum of subclasses of theaflavines and thearubigines and E2 levels for the whole group (P=0·002) and for urban women (P=0·02). Women with high consumption of tea had lower levels of E2 concentration throughout the entire menstrual cycle. These results may have implications for reducing hormone-related cancer risk by a relatively easy dietary intervention.

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Rice bran supplementation modulates growth, microbiota and metabolome in weaning infants: a clinical trial in Nicaragua and Mali

Scientific Reports ◽

10.1038/s41598-019-50344-4 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 4

Author(s):

Luis E. Zambrana ◽

Starin McKeen ◽

Hend Ibrahim ◽

Iman Zarei ◽

Erica C. Borresen ◽

...

Keyword(s):

Rice Bran ◽

High Performance ◽

Dietary Intervention ◽

Animal Feed ◽

Intervention Strategy ◽

Amplicon Sequencing ◽

Metabolite Profile ◽

Daily Consumption ◽

Middle Income ◽

Liquid Chromatography Tandem Mass

Abstract Rice bran supplementation provides nutrients, prebiotics and phytochemicals that enhance gut immunity, reduce enteric pathogens and diarrhea, and warrants attention for improvement of environmental enteric dysfunction (EED) in children. EED is a subclinical condition associated with stunting due to impaired nutrient absorption. This study investigated the effects of rice bran supplementation on weight for age and length for age z-scores (WAZ, LAZ), EED stool biomarkers, as well as microbiota and metabolome signatures in weaning infants from 6 to 12 months old that reside in Nicaragua and Mali. Healthy infants were randomized to a control (no intervention) or a rice bran group that received daily supplementation with increasing doses at each month (1–5 g/day). Stool microbiota were characterized using 16S rDNA amplicon sequencing. Stool metabolomes were analyzed using ultra-high-performance liquid-chromatography tandem mass-spectrometry. Statistical comparisons were completed at 6, 8, and 12 months of age. Daily consumption of rice bran was safe and feasible to support changes in LAZ from 6–8 and 8–12 months of age in Nicaragua and Mali infants when compared to control. WAZ was significantly improved only for Mali infants at 8 and 12 months. Mali and Nicaraguan infants showed major differences in the overall gut microbiota and metabolome composition and structure at baseline, and thus each country cohort demonstrated distinct microbial and metabolite profile responses to rice bran supplementation when compared to control. Rice bran is a practical dietary intervention strategy that merits development in rice-growing regions that have a high prevalence of growth stunting due to malnutrition and diarrheal diseases. Rice is grown as a staple food, and the bran is used as animal feed or wasted in many low- and middle-income countries where EED and stunting is prevalent.

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Abstract 3277: Sustained Benefits in Vascular Function through Flavanol-Containing Cocoa in Medicated Diabetic Patients: A Double-Masked, Randomized, Controlled Trial

Circulation ◽

10.1161/circ.118.suppl_18.s_1123 ◽

2008 ◽

Vol 118 (suppl_18) ◽

Author(s):

Jan Balzer ◽

Tienush Rassaf ◽

Christian Heiss ◽

Petra Kleinbongard ◽

Thomas Lauer ◽

...

Keyword(s):

Endothelial Function ◽

Vascular Function ◽

Dietary Intervention ◽

Controlled Trial ◽

Daily Intake ◽

Inverse Correlation ◽

Diabetic Patients ◽

Daily Consumption ◽

Potential Health ◽

Test Feasibility

Purpose Epidemiological investigations revealed an inverse correlation between the dietary intake of flavanols, the mortality of cardiovascular disease, and the incidence of diabetes. Controlled trials evaluating longer-term effects of flavanol-containing cocoa on endothelial function in diabetic patients are missing. This study was designed to test feasibility and efficacy of a dietary intervention based on daily intake of flavanol-containing cocoa for improving vascular function of medicated diabetic patients. Methods In a feasibility study with 10 diabetic patients, we assessed vascular function as flow-mediated dilation (FMD) of the brachial artery, plasma levels of flavanol metabolites, and tolerability following an acute, single-dose ingestion of cocoa, containing increasing concentrations of flavanols (75,371,963mg). In a subsequent efficacy study, changes in vascular function in 41 medicated diabetics were assessed following a 30-day, thrice-daily dietary intervention with either flavanol-rich cocoa (321mg flavanols per dose) or a nutrient-matched control (25mg flavanols per dose). Both studies were undertaken in a randomized, double-masked fashion. Results A single ingestion of flavanol-containing cocoa was dose-dependently associated with significant acute increases in circulating flavanols and FMD (at 2h: from 3.7±0.2% to 5.5±0.4%, p<0.001). A 30-day, thrice-daily consumption of flavanol-containing cocoa increased baseline FMD by 30% (p<0.0001), while acute increases of FMD upon ingestion of flavanol-containing cocoa continued to be manifest throughout the study. Treatment was well tolerated without evidence of tachyphylaxia. Endothelium-independent responses, blood pressure, heart rate, and glycemic control were unaffected. Conclusions Our study clearly establishes improvements of endothelial function after regular consumption of flavanol-containing cocoa in patients with type 2 diabetes, highlighting the potential of flavanol-containing diets, and underscoring the potential health care benefit for reducing the risk of cardiovascular events in diabetic patients.

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Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice

Scientific Reports ◽

10.1038/s41598-019-50841-6 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 3

Author(s):

Emilia Galli ◽

Jari Rossi ◽

Thomas Neumann ◽

Jaan-Olle Andressoo ◽

Stefan Drinda ◽

...

Keyword(s):

Neurotrophic Factor ◽

Metabolic Regulation ◽

Dietary Intervention ◽

Human Subjects ◽

Normal Diet ◽

Enzyme Linked Immunosorbent Assay ◽

Protective Effects ◽

Knock Out ◽

Positive Effects ◽

Age Related

Abstract Dietary restriction induces beneficial metabolic changes and prevents age-related deterioration. Mesencephalic astrocyte-derived neurotrophic factor (MANF) shows protective effects on cells in various models of degenerative diseases. Here we studied whether circulating concentrations of MANF are associated with fasting-induced positive effects. We quantified the levels of circulating MANF from 40 human subjects before and after therapeutic fasting. As measured by an enzyme-linked immunosorbent assay (ELISA), the mean concentration of plasma MANF increased after an average fasting of 15 days. Plasma MANF levels correlated inversely with adiponectin, a hormone that regulates metabolism, thus suggesting that MANF levels are related to metabolic homeostasis. To study the effects of dietary intervention on MANF concentrations in mice, we developed an ELISA for mouse MANF and verified its specificity using MANF knock-out (KO) tissue. A switch from high-fat to normal diet increased MANF levels and downregulated the expression of unfolded protein response (UPR) genes in the liver, indicating decreased endoplasmic reticulum (ER) stress. Liver MANF and serum adiponectin concentrations correlated inversely in mice. Our findings demonstrate that MANF expression and secretion increases with dietary intervention. The MANF correlation to adiponectin and its possible involvement in metabolic regulation and overall health warrants further studies.

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Dietary strategies for improving folate status in institutionalized elderly persons

British Journal Of Nutrition ◽

10.1017/s0007114508118736 ◽

2008 ◽

Vol 101 (11) ◽

pp. 1611-1615 ◽

Cited By ~ 7

Author(s):

Laura M. Bermejo ◽

Aránzazu Aparicio ◽

Elena Rodríguez-Rodríguez ◽

Ana M. López-Sobaler ◽

Pedro Andrés ◽

...

Keyword(s):

Folic Acid ◽

Dietary Intervention ◽

Vegetable Intake ◽

Folate Intake ◽

Elderly Persons ◽

Daily Consumption ◽

Folate Status ◽

Fortified Food ◽

Control Centre ◽

Dietary Strategies

The aim of this work was to compare the efficacy of two strategies designed to improve folate status: increasing the intake of vegetables, and the consumption of a folic acid-fortified food. Residents (126) from three old people's homes in the Madrid region (Spain) were studied. To each centre a dietary intervention was assigned to be followed for 6 months: (1) the consumption of margarine fortified with 200 μg folic acid/10 g portion (centre M), (2) increasing the consumption of vegetables to three servings per day (centre V), (3) control (centre C). At the beginning and end of the intervention period the subjects' intakes, serum and erythrocyte concentrations of folate were measured. The use of fortified margarine (centre M) led to a significant increase in folate intake (260·9 μg/d), serum concentration (10·3 (sd8·3) nmol/l) and erythrocyte concentration (638·4 nmol/l). At centre V the increase in total vegetable intake achieved was very poor; these foods met with very poor acceptance, although the intake of certain vegetables particularly rich in folate improved. Therefore, the intake of this vitamin increased a little (26·7 (sd33·0) μg/d); erythrocyte folate concentration also increased somewhat (460·5 nmol/l), althought less than centre M. The daily consumption of margarine fortified with folic acid was the more effective strategy for improving the folate status of the study subjects.

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