scholarly journals Tetracyclines in Food and Feedingstuffs: From Regulation to Analytical Methods, Bacterial Resistance, and Environmental and Health Implications

2017 ◽  
Vol 2017 ◽  
pp. 1-24 ◽  
Author(s):  
Fabio Granados-Chinchilla ◽  
César Rodríguez
Keyword(s):  
Analytical Methods ◽  
Bacterial Resistance ◽  
Tetracycline Resistance ◽  
Animal Husbandry ◽  
The United States ◽  
Resistant Bacteria ◽  
The European Union ◽  
Growth Promoters ◽  
Correct Usage ◽  
Nontarget Species

Antibiotics are widely used as growth promoters in animal husbandry; among them, the tetracyclines are a chemical group of relevance, due to their wide use in agriculture, surpassing in quantities applied almost every other antibiotic family. Seeing the considerable amounts of tetracyclines used worldwide, monitoring of these antibiotics is paramount. Advances must be made in the analysis of antibiotics to assess correct usage and dosage of tetracyclines in food and feedstuffs and possible residues in pertinent environmental samples. The tetracyclines are still considered a clinically relevant group of antibiotics, though dissemination of tolerance and resistance determinants have limited their use. This review focuses on four different aspects: (i) tetracyclines, usage, dosages, and regulatory issues that govern their food-related application, with particular attention to the prohibitions and restrictions that several countries have enforced in recent years by agencies from both the United States and the European Union, (ii) analytical methods for tetracyclines, determination, and residues thereof in feedstuffs and related matrices with an emphasis on the most relevant and novel techniques, including both screening and confirmatory methods, (iii) tetracycline resistance and tetracycline-resistant bacteria in feedstuff, and (iv) environmental and health risks accompanying the use of tetracyclines in animal nutrition. In the last two cases, we discuss the more relevant undesirable effects that tetracyclines exert over bacterial communities and nontarget species including unwanted effects in farmers.

scholarly journals Incidence of Tetracycline and Erythromycin Resistance in Meat-Associated Bacteria: Impact of Different Livestock Management Strategies

2021 ◽  
Vol 9 (10) ◽  
pp. 2111
Author(s):  
Cecilia Fontana ◽  
Vania Patrone ◽  
Constanza Maria Lopez ◽  
Lorenzo Morelli ◽  
Annalisa Rebecchi
Keyword(s):  
Antibiotic Resistance ◽  
Bacterial Infections ◽  
Bacterial Resistance ◽  
Management Strategies ◽  
Tetracycline Resistance ◽  
Animal Husbandry ◽  
Growth Promoters ◽  
Erythromycin Resistance ◽  
Coagulase Negative Staphylococci ◽  
Associated Bacteria

The extensive use of antibiotics as growth promoters, or their continued abusive misuse to cure or prevent the onset of bacterial infections as occurs in the intensive farming, may have played a pivotal role in the spread of reservoirs of antibiotic resistance (AR) among food-associated bacteria including pathogens representing risks to human health. The present study compares the incidence of tetracycline and erythromycin resistances in lactic acid bacteria (LAB) and coagulase negative staphylococci (CNS) from fermented products manufacturing using meat from intensive animal husbandry (industrialized manufacturing Italian salami) and from extensive farms (artisanal sausages facilities pork and llama Argentinean sausages). A higher incidence of tetracycline resistance (TET-R) compared to erythromycin resistance (ERY-R) was observed among the 205 isolates. Unlike CNS strains, the LAB showed a significant correlation between the TET-R and the ERY-R phenotypes. Genotypic assessment shows a high correlation with tetK and tetM for the TET-R strains and with ermB and ermC for the ERY-R strains. Multiple correspondence analyses have highlighted the association between AR phenotypes and CNS species isolated from Italian salami, while the susceptible phenotypes were associated with the LAB species from Argentinean sausages. Since antibiotic resistance in meat-associated bacteria is a very complex phenomenon, the assessment of bacterial resistance in different environmental contexts with diverse farming practices and food production technologies will help in monitoring the factors influencing AR emergence and spread in animal production.

scholarly journals Consumer perceptions of antimicrobial use in animal husbandry: A scoping review

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0261010
Author(s):  
Jaime R. Barrett ◽  
Gabriel K. Innes ◽  
Kelly A. Johnson ◽  
Guillaume Lhermie ◽  
Renata Ivanek ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Scoping Review ◽  
Grey Literature ◽  
Animal Husbandry ◽  
The United States ◽  
Consumer Perceptions ◽  
Primary Data ◽  
Meat Production ◽  
Antimicrobial Use ◽  
The European Union

Antimicrobial use in animal agriculture is often perceived to play a role in the emerging threat of antimicrobial resistance. Increased consumer awareness of this issue places pressure on animal husbandry to adopt policies to reduce or eliminate antimicrobial use. We use a scoping review methodology to assess research on consumer perceptions of antimicrobial drugs in meat products in the United States, Canada, or the European Union. Evaluating peer-reviewed and grey literature, we included studies for assessment if they met these topical and geographic requirements, involved primary data collection, and were originally published in English. Our screening process identified 124 relevant studies. Three reviewers jointly developed a data charting form and independently charted the contents of the studies. Of the 105 studies that measured consumer concern, 77.1% found that consumers were concerned about antimicrobial use in meat production. A minority of studies (29.8% of all studies) queried why consumers hold these views. These studies found human health and animal welfare were the main reasons for concern. Antimicrobial resistance rarely registered as an explicit reason for concern. A smaller group of studies (23.3%) measured the personal characteristics of consumers that expressed concern about antimicrobials. Among these studies, the most common and consistent features of these consumers were gender, age, income, and education. Regarding the methodology used, studies tended to be dominated by either willingness-to-pay studies or Likert scale questionnaires (73.64% of all studies). We recommend consideration of qualitative research into consumer views on this topic, which may provide new perspectives that explain consumer decision-making and mentality that are lacking in the literature. In addition, more research into the difference between what consumers claim is of concern and their ultimate purchasing decisions would be especially valuable.

Advanced training of veterinary specialists on the spread of antibiotic resistance and the implementation of measures to contain it

2021 ◽  
Vol 1 (11) ◽  
pp. 16-26
Author(s):  
Igor S. Koba ◽  
◽  
Viktor V. Stepanishin ◽  
Tatiana E. Denisenko ◽  
Sergey Yu. Filippov ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Crop Production ◽  
Significant Contribution ◽  
Animal Husbandry ◽  
Farm Animals ◽  
Resistant Bacteria ◽  
Growth Promoters ◽  
Human Resource Capacity ◽  
Treatment And Prevention ◽  
Resource Capacity

Currently, antibiotic resistance poses a serious threat to humanity. The resistance of microorganisms to antibiotics does not increase the financial costs of fighting pathogens, but it is also a problem of ensuring food security. The use of antibiotics in animal husbandry and veterinary medicine for the treatment and prevention of diseases or as growth promoters allows resistant bacteria and resistance genes to be transmitted through the food chain from farm animals to humans. In crop production and horticulture, these drugs are also used to suppress pathogens, prevent diseases and increase the shelf life of finished products. Uncontrolled and unjustified use of antibiotics in agriculture, the scale of which in many countries exceeds the scale of the use of antibiotics for the treatment of people, makes a significant contribution to the formation of the problem of antibiotic resistance in the health system. This situation requires additional efforts to inform society and develop a special policy to curb antibiotic resistance, including from the standpoint of food safety. The article considers the possibilities of preventing and containing antibiotic resistance through interinstitutional coordination and cooperation, including high-quality training of specialists and human resource capacity building, supervision and monitoring of trends in resistance and use of antibiotics, dissemination of information and research on this problem, as well as educational and explanatory work to draw attention to the problem in society.

scholarly journals Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance

2001 ◽  
Vol 65 (2) ◽  
pp. 232-260 ◽  
Author(s):  
Ian Chopra ◽  
Marilyn Roberts
Keyword(s):  
Outer Membrane ◽  
Bacterial Resistance ◽  
Animal Feed ◽  
Animal Health ◽  
Tetracycline Resistance ◽  
Shigella Dysenteriae ◽  
Growth Promoters ◽  
New Genes ◽  
Wide Range ◽  
Energy Dependent

SUMMARY Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. They are inexpensive antibiotics, which have been used extensively in the prophlylaxis and therapy of human and animal infections and also at subtherapeutic levels in animal feed as growth promoters. The first tetracycline-resistant bacterium, Shigella dysenteriae, was isolated in 1953. Tetracycline resistance now occurs in an increasing number of pathogenic, opportunistic, and commensal bacteria. The presence of tetracycline-resistant pathogens limits the use of these agents in treatment of disease. Tetracycline resistance is often due to the acquisition of new genes, which code for energy-dependent efflux of tetracyclines or for a protein that protects bacterial ribosomes from the action of tetracyclines. Many of these genes are associated with mobile plasmids or transposons and can be distinguished from each other using molecular methods including DNA-DNA hybridization with oligonucleotide probes and DNA sequencing. A limited number of bacteria acquire resistance by mutations, which alter the permeability of the outer membrane porins and/or lipopolysaccharides in the outer membrane, change the regulation of innate efflux systems, or alter the 16S rRNA. New tetracycline derivatives are being examined, although their role in treatment is not clear. Changing the use of tetracyclines in human and animal health as well as in food production is needed if we are to continue to use this class of broad-spectrum antimicrobials through the present century.

scholarly journals Tetracyclines in veterinary medicine and bacterial resistance to them

2012 ◽  
Vol 49 (No. 3) ◽  
pp. 79-100 ◽  
Author(s):  
E. Michalova ◽  
PNovotna ◽  
J. Schlegelova
Keyword(s):  
Resistance Genes ◽  
Bacterial Resistance ◽  
Tetracycline Resistance ◽  
Growth Promoters ◽  
Active Efflux ◽  
Tetracycline Resistance Genes ◽  
Enzymatic Inactivation ◽  
Resistant Strains ◽  
Horizontal Spread ◽  
Transporter Systems

Since their discovery in 1945, tetracyclines have been used extensively in the therapy and prophylaxis of infectious diseases and as growth promoters. These wide applications have led to the equally fast spread of tetracycline resistant strains of gram-positive and gram-negative bacterial genera, including strains belonging to pathogenic as well as nonpathogenic species. Nonpathogenic bacteria could act as a reservoir of resistance determinants, which can be disseminated by horizontal transfer into pathogens. More than thirty different tetracycline resistance genes have been characterized. They encode two major mechanisms of resistance: 1 – active efflux of the antibiotic, and 2 – protection of ribosomes. Further mechanisms of tetracycline resistance include enzymatic inactivation of antibiotic, permeability barriers, mutations or multidrug transporter systems. Effective horizontal spread is favoured by the location of tetracycline resistance genes on mobile genetic elements such as plasmids and transposons. Their exchange, enhanced by the use of tetracyclines, is observed between bacteria of the same or different species and genera as well. Thus, questions of reevaluating and global reducing of tetracyclines in human and animal healthcare and food production are extensively discussed.

scholarly journals A Methylene Blue Assisted Electrochemical Sensor for Determination of Drug Resistance of Escherichia coli

2021 ◽  
Vol 9 ◽  
Author(s):  
Rongshuai Duan ◽  
Xiao Fang ◽  
Dongliang Wang
Keyword(s):  
Escherichia Coli ◽  
Methylene Blue ◽  
Drug Sensitivity ◽  
Bacterial Resistance ◽  
Animal Husbandry ◽  
Sensitivity Test ◽  
Test Method ◽  
Resistant Bacteria ◽  
Drug Resistant ◽  
Drug Sensitivity Test

Due to the abuse of antibiotics in clinical, animal husbandry, and aquaculture, drug-resistant pathogens are produced, which poses a great threat to human and the public health. At present, a rapid and effective drug sensitivity test method is urgently needed to effectively control the spread of drug-resistant bacteria. Using methylene blue as a redox probe, the electrochemical signals of methylene blue in drug-resistant Escherichia coli strains were analyzed by a CV method. Graphene ink has been used for enhancing the electrochemical signal. Compared with the results of the traditional drug sensitivity test, we proposed a rapid electrochemical drug sensitivity test method which can effectively identify the drug sensitivity of Escherichia coli. The sensitivity of four E. coli isolates to ciprofloxacin, gentamicin, and ampicillin was tested by an electrochemical drug sensitivity test. The respiratory activity value %RA was used as an indicator of bacterial resistance by electrochemical method.

scholarly journals Frequency of pathogens in routine bacteriological diagnosis in fish and their antimicrobial resistance

2021 ◽  
Vol 42 (6) ◽  
pp. 3259-3272
Author(s):  
Arthur Roberto da Costa ◽  
◽  
Roberta Torres Chideroli ◽  
Larissa Melo Chicoski ◽  
Diego Candido de Abreu ◽  
...  
Keyword(s):  
Bacterial Resistance ◽  
Disease Outbreaks ◽  
Animal Husbandry ◽  
Multidrug Resistant ◽  
Health Concern ◽  
Resistant Bacteria ◽  
Production Chain ◽  
Plesiomonas Shigelloides ◽  
Bacteriological Diagnosis ◽  
Zoonotic Bacteria

Aquaculture is one of the sectors of animal husbandry with the fastest growth rate. However, the increase in the sector’s production chain without proper management can result in factors that favor the development of diseases, especially infectious diseases caused by bacteria. Many factors, such as agriculture or industry resides, improper use of antibiotics in animals or humans, have contributed to increased environmental pressure and the appearance of antibiotic-resistant bacteria, while residues from these drugs can remain in the carcasses and in water a risk to public and environmental health. From that, we identified the bacterial genus/species and their bacterial resistance to antibiotics from samples received from fish disease outbreaks for bacteriosis diagnosis between January 2017 and October 2020. Isolated bacteria were subjected to the Kirby and Bauer sensitivity test for five classes of antibiotics (penicillins, fluoroquinolones, aminoglycosides, amphenicols, and tetracyclines). Of the 181 analyzed outbreaks, 232 bacteria were isolated, including Streptococcus spp., Aeromonas spp., Edwardsiella spp., Plesiomonas shigelloides, Pseudomonas aeruginosa, Chromobacterium violaceum, Flavobacterium spp., Citrobacter spp., Enterococcus spp., Vibrio spp., Enterobacter spp., Chryseobacterium meningosepticum. Of the 232 bacteria, 40 strains were classified as multidrug resistant (MDR), with Plesiomonas shigelloides, Aeromonas spp., and Edwardsiella spp. representing more than half of this number (22/total). With several bacteria demonstrating resistance to Brazilian aquaculture-legalized drugs (tetracycline and florfenicol), it is mandatory to research, not only for alternatives to the use of antibiotics, but also for other drugs effective against the main circulating bacterial pathogens. In addition, vigilance over the occurrence of resistant bacteria is necessary, considering the appearance of zoonotic bacteria with multi-resistant characteristics, becoming a public health concern.

scholarly journals USE OF CORN GRAIN IN PRODUCTION OF FOOD PRODUCTS

2018 ◽  
Vol 18 (2) ◽  
Author(s):  
S. M. SOTS ◽  
O. V. BNYIAK
Keyword(s):  
Raw Materials ◽  
Animal Husbandry ◽  
Food Products ◽  
The United States ◽  
Raw Material ◽  
Farm Animals ◽  
The European Union ◽  
Plant Materials ◽  
The World ◽  
Corn Grain

In Ukraine, the following basic crops are used as raw materials for the production of cereals, flour, flakes: wheat, barley, buckwheat, oats, corn, rice, millet, peas. The volume of world grain production in recent years has grown significantly. In Ukraine, corn is the main fodder crop, and only in small quantities is used as food. Corn takes the leading place among the main grain crops in the world agricultural production. The production of corn for grain is concentrated in warm regions. In some regions, corn is the basis of the traditional food of the population, but mostly it is part of the feed in the feeding of farm animals. Corn does not accumulate nitrates and is an environmentally friendly product. Corn is a plant of versatile use. Currently, corn is one of the most important food crop cultivated by man. As to the largest producers of this cereal are the United States, China, Mexico, India, Brazil, Argentina, Indonesia, South Africa, France and Italy. Today, about 3500 food and technological products are made from corn. Corn is able to largely meet the needs of animal husbandry, its share is almost 30% in the composition of concentrated feed. Corn is used in food, starch, brewing and alcohol industries. With the advent of new directions in the development of biotechnology in the world, the importance of this culture is growing even more. In the countries of the European Union in recent years, the production of various types of fuels from plant materials - biodiesel, bioethanol, biomethanol and biofuel is actively developing. Bioethanol is obtained from all cultures with a high content of starch and sugar, for example, potatoes, sugar beet, corn, various types of cereals, and therefore a significant expansion of the acreage under corn is projected. In the article volumes of corn grain collection in different years in Ukraine for the production of cereals and groats are considered. Various types of maize as a perspective raw material for use in the food industry are considered. It is shown that two subspecies of maize are most widespread in Ukraine - a dentate (large grain of elongated form) and siliceous (a rounded grain). The presence of vitamins B (B1, B2, PP), calcium, magnesium, phosphorus and iron, as well as trace elements (copper, nickel, etc.) in maize makes it possible to recommend corn products as a separate product or in combination with other people with blood diseases, allergies, diabetes mellitus, obesity and other forms of metabolic disorders and pathology of the gastrointestinal tract. The authors analyzed the chemical composition of corn grain of various botanical groups intended for the production of cereals and products from them. The composition of micro- and macronutrients of corn groats used in the production of food products (snacks, breakfast cereals, instant cereals, cereals, etc.) is given.

DEVELOPMENT TRENDS AND PROSPECTS OF ECONOMIC AND TRADE COOPERATION BETWEEN CHINA AND UKRAINE

2018 ◽  
Vol 2018 (6) ◽  
pp. 3-12
Author(s):  
Zhang DONGYANG ◽  
Keyword(s):  
Free Trade ◽  
Bilateral Trade ◽  
The United States ◽  
Economic Cooperation ◽  
Free Trade Zone ◽  
Asia Pacific ◽  
Economic Downturn ◽  
The European Union ◽  
Association Agreement ◽  
The Eu

The status and prospects of development of trade and economic relations between Ukraine and China are considered. It is proved that bilateral cooperation in the trade and economic sphere has made significant progress. In 2012–2017, China was the second largest trading partner of Ukraine after Russia. However, the problem of imbalance in imports and exports between Ukraine and China has not yet been resolved. In addition, the scale and number of projects in which Ukraine attracts Chinese investment is much less than investments from European countries and the United States. It is justified that trade and economic cooperation between Ukraine and China is at a new historical stage. On the one hand, Ukraine signed the Association Agreement with the European Union, and on January 1, 2016, the rules of the free trade zone between Ukraine and the EU entered into force. This helps to accelerate the integration of Ukrainian economy into European one. On the other hand, the global economic downturn requires the introduction of innovations in the model of cooperation. The Chinese initiative “One belt is one way” is one of the variants of the innovation model of cooperation. Its significance is to unite the Asia-Pacific region with the EU in order to join the Eurasian Economic Union, create a new space and opportunities for development and achieve prosperity with the Eurasian countries. All this forms unprecedented opportunities for development of bilateral economic and trade relations. It seems that to fully open the potential of Ukrainian economy and expand bilateral trade and economic cooperation, it is necessary to take into account such proposals as the establishment of the Sino-Ukrainian industrial park, the promotion of cooperation in the field of electronic commerce, the formation of the Sino-Ukrainian free trade zone and enhanced interaction within multilateral mechanisms (for example, the Shanghai Cooperation Organization and the interaction of China and the countries of Central and Eastern Europe in the 16 + 1 format).

The Central Asian Economies in the Twenty-First Century

2019 ◽  
Author(s):  
Richard Pomfret
Keyword(s):  
Migrant Workers ◽  
Global Economy ◽  
Oil And Gas ◽  
The United States ◽  
Kyrgyz Republic ◽  
The European Union ◽  
Central Asian ◽  
Asian Economies ◽  
Belt And Road ◽  
External Powers

This book analyzes the Central Asian economies of Kazakhstan, the Kyrgyz Republic, Tajikistan, Turkmenistan, and Uzbekistan, from their buffeting by the commodity boom of the early 2000s to its collapse in 2014. The book examines the countries' relations with external powers and the possibilities for development offered by infrastructure projects as well as rail links between China and Europe. The transition of these nations from centrally planned to market-based economic systems was essentially complete by the early 2000s, when the region experienced a massive increase in world prices for energy and mineral exports. This raised incomes in the main oil and gas exporters, Kazakhstan and Turkmenistan; brought more benefits to the most populous country, Uzbekistan; and left the poorest countries, the Kyrgyz Republic and Tajikistan, dependent on remittances from migrant workers in oil-rich Russia and Kazakhstan. The book considers the enhanced role of the Central Asian nations in the global economy and their varied ties to China, the European Union, Russia, and the United States. With improved infrastructure and connectivity between China and Europe (reflected in regular rail freight services since 2011 and China's announcement of its Belt and Road Initiative in 2013), relaxation of UN sanctions against Iran in 2016, and the change in Uzbekistan's presidency in late 2016, a window of opportunity appears to have opened for Central Asian countries to achieve more sustainable economic futures.

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