scholarly journals The use of probiotics in animal feeding for safe production and as potential alternatives to antibiotics

2021 ◽  
Vol 14 (2) ◽  
pp. 319-328
Author(s):  
Mbarga M. J. Arsène ◽  
Anyutoulou K. L. Davares ◽  
Smolyakova L. Andreevna ◽  
Ermolaev A. Vladimirovich ◽  
Bassa Z. Carime ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Current Knowledge ◽  
Fish Farming ◽  
Well Being ◽  
Feed Additives ◽  
Feed Additive ◽  
Human Consumption ◽  
Growth Promoters ◽  
Suitable Alternative

Although the production of safe food for human consumption is the primary purpose for animal rearing, the environment and well-being of the animals must also be taken into consideration. Based on microbiological point of view, the production of healthy food from animals involves considering foodborne pathogens, on the one hand and on the other hand, the methods used to fight against germs during breeding. The conventional method to control or prevent bacterial infections in farming is the use antibiotics. However, the banning of these compounds as growth promoters caused many changes in animal breeding and their use has since been limited to the treatment and prevention of bacterial infections. In this function, their importance no longer needs to be demonstrated, but unfortunately, their excessive and abusive use have led to a double problem which can have harmful consequences on consumer health: Resistance to antibiotics and the presence of antibiotic residues in food. The use of probiotics appears to be a suitable alternative to overcome these problems because of their ability to modulate the immune system and intestinal microflora, and further considering their antagonistic role against certain pathogenic bacteria and their ability to play the role of growth factor (sometimes associated with prebiotics) when used as feed additives. This review aims to highlight some of the negative effects of the use of antibiotics in animal rearing as well as emphasize the current knowledge on the use of probiotics as a feed additive, their influence on animal production and their potential utility as an alternative to conventional antibiotics, particularly in poultry, pig, and fish farming.

scholarly journals Dietary Supplementation of Inorganic, Organic, and Fatty Acids in Pig: A Review

Animals ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1740
Author(s):  
Giulia Ferronato ◽  
Aldo Prandini
Keyword(s):  
Fatty Acids ◽  
Gastrointestinal Tract ◽  
Organic Acids ◽  
Pathogenic Bacteria ◽  
Tricarboxylic Acid Cycle ◽  
Antimicrobial Properties ◽  
Feed Additives ◽  
Feed Additive ◽  
Growth Promoter ◽  
Growth Promoters

Reduction of antibiotic use has been a hot topic of research over the past decades. The European ban on growth-promoter use has increased the use of feed additivities that can enhance animal growth performance and health status, particularly during critical and stressful phases of life. Pig farming is characterized by several stressful periods, such as the weaning phase, and studies have suggested that the proper use of feed additives during stress could prevent disease and enhance performance through modulation of the gastrointestinal tract mucosa and microbiome. The types of feed additive include acids, minerals, prebiotics, probiotics, yeast, nucleotides, and phytoproducts. This review focuses on commonly used acids, classified as inorganic, organic, and fatty acids, and their beneficial and potential effects, which are widely reported in the bibliography. Acids have long been used as feed acidifiers and preservatives, and were more recently introduced into feed formulated for young pigs with the goal of stabilizing the stomach pH to offset their reduced digestive capacity. In addition, some organic acids represent intermediary products of the tricarboxylic acid cycle (TCA), and thus could be considered an energy source. Moreover, antimicrobial properties have been exploited to modulate microbiota populations and reduce pathogenic bacteria. Given these potential benefits, organic acids are no longer seen as simple acidifiers, but rather as growth promoters and potential antibiotic substitutes owing to their beneficial action on the gastrointestinal tract (GIT).

The effects and mechanisms of acids on the health of piglets and weaners – a review

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Piotr Nowak ◽  
Anita Zaworska-Zakrzewska ◽  
Andrzej Frankiewicz ◽  
Małgorzata Kasprowicz-Potocka
Keyword(s):  
Digestive System ◽  
Buffer Capacity ◽  
Growth Parameters ◽  
Feed Additives ◽  
Feed Additive ◽  
Growth Promoters ◽  
Qualitative And Quantitative ◽  
Inorganic Acids ◽  
Low Activity ◽  
The Eu

AbstractThe rearing of piglets is the most difficult period in the pigs’ production because of their poorly developed digestive system and the low activity of digestive enzymes. Problems in nutrition and stress cause some disorders in the functioning of the digestive system leading to diarrhea and the mortality of piglets. Starting in 2006 in the EU, a total ban on antibiotics in their use as growth promoters was introduced. Since then, new and safe feed additives have been sought in order to replace antibiotics. Organic and inorganic acids as well as their salts were recognized as effective and safe additives. Due to their properties, they can improve feed palatability and digestibility, reduce the buffer capacity of feed, impact the development and functioning of the pig’s digestive system and improve the health and growth parameters. However, the effectiveness of acids is related to their qualitative and quantitative share in the feed additive. In this review, some strategies for using organic acids, their mixtures and also some new multi-component products will be discussed.

scholarly journals Perspectives for rare earth elements as feed additive in livestock — A review

2020 ◽  
Vol 33 (3) ◽  
pp. 373-381 ◽  
Author(s):  
Hujaz Tariq ◽  
Amit Sharma ◽  
Srobana Sarkar ◽  
Lamella Ojha ◽  
Ravi Prakash Pal ◽  
...  
Keyword(s):  
Rare Earth ◽  
Rare Earth Elements ◽  
Feed Additives ◽  
Egg Laying ◽  
Farm Animals ◽  
Feed Additive ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Potential Growth ◽  
Safe Alternative

There is a need for newer feed additives due to legal prohibition on inclusion of growth promoting antibiotics in livestock diets in several countries due to antimicrobial resistance. In this context, rare earth elements (REE) have gained attention among animal nutritionists as potential growth promoters. Currently, several studies have reported better weight gain, milk production, egg laying capacity and feed conversion efficiency among different breeds of farm animals following supplementation with REE, with however largely inconsistent results. Furthermore, REE supplementation has also shown to improve ruminal fibrolytic and proteolytic activities as well as flavor of meat with negligible residues in edible tissue, however the mechanism behind this action is still unclear. According to existing research, due to their poor absorption and similarity with calcium REE might exert their action locally on gut microbial populations within the gastrointestinal tract (GIT). Moreover, REE have also shown anti-inflammatory, anti-oxidative as well as immune stimulating effects. The present review aims to broaden the knowledge about use of REE as feed additives for livestock and sum up efficacy of REE supplementation on performance and health of animals by comparing the findings. Till date, researches with REE have shown properties that make them a promising, new and safe alternative feed additive but further exploration is recommended to optimize effects and clarify discrepancy of various results before practical proposals can be drafted.

Improving the Quality of Broiler Duck Carcasses with the Addition of Meniran Plan (Phylanthus niruri L.) Extract as a Feed Additive

2021 ◽  
Vol 5 (2) ◽  
pp. 201-205
Author(s):  
Lestariningsih Lestariningsih ◽  
Fatra Nonggala Putra
Keyword(s):  
Feed Additives ◽  
Feed Additive ◽  
Human Consumption ◽  
Carcass Quality ◽  
Alternative Feed ◽  
Operational Costs ◽  
Randomized Design ◽  
Level 3 ◽  
Completely Randomized Design

The purpose of this research was to determine the improvement of the carcass quality of broiler ducks with the addition of meniran extract as a feed additive. This is based on the fluctuating price of feed 70 – 80% is part of the operational costs and the prohibition on the use of antibiotics requires alternative feed additives that are safe for human consumption. This research was carried out in Juni – August 2021 in Dayu Village, Nglegok District Blitar Regency. The method used is experimental with 4 treatments and 3 replications. The design used is Completely Randomized Design. The result showed that giving meniran extract as a feed additive could improve the carcass quality of broiler duck including carcass weight and carcass percentage and dit not have a significant effect on slaughter weight. It is recommended to use meniran plan extract level 3% to improve the carcass quality of broiler ducks.

scholarly journals Residual Antibiotics Disrupt Meat Fermentation and Increase Risk of Infection

mBio ◽  
2012 ◽  
Vol 3 (5) ◽  
Author(s):  
Jette Kjeldgaard ◽  
Marianne T. Cohn ◽  
Pat G. Casey ◽  
Colin Hill ◽  
Hanne Ingmer
Keyword(s):  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Starter Cultures ◽  
Farm Animals ◽  
Veterinary Antibiotics ◽  
Growth Promoters ◽  
Content Type ◽  
Fermented Sausages ◽  
Serovar Typhimurium ◽  
Meat Fermentation

ABSTRACTFermented sausages, although presumed safe for consumption, sometimes cause serious bacterial infections in humans that may be deadly. Not much is known about why and when this is the case. We tested the hypothesis that residual veterinary antibiotics in meat can disrupt the fermentation process, giving pathogenic bacteria a chance to survive and multiply. We found that six commercially available starter cultures were susceptible to commonly used antibiotics, namely, oxytetracycline, penicillin, and erythromycin. In meat, statutorily tolerable levels of oxytetracycline and erythromycin inhibited fermentation performance of three and five of the six starter cultures, respectively. In model sausages, the disruption of meat fermentation enhanced survival of the pathogensEscherichia coliO157:H7 andSalmonella entericaserovar Typhimurium compared to successful fermentations. Our work reveals an overlooked risk associated with the presence of veterinary drugs in meat.IMPORTANCEAntibiotics have for a long time been used as growth promoters in farm animals, and while they are banned as such in Europe, their clinical use in farm animals still accounts for the majority of consumption. Here, we examined how acceptable levels of antibiotics in meat influence fermentation. Our results show that commonly used bacterial starter cultures are sensitive to residual antibiotics at or near statutorily tolerable levels, and as a result, processed sausages may indeed contain high levels of pathogens. Our findings provide a possible explanation for outbreaks and disease cases associated with consumption of fermented sausages and offer yet another argument for limiting the use of antimicrobials in farm animals.

The Influence of Probios or Tylosin on Growth of Pigs and Development of the Gastrointestinal Tract

1988 ◽  
Vol 1988 ◽  
pp. 128-128
Author(s):  
G.K. Collington ◽  
D.S. Parker ◽  
M. Ellis ◽  
D.G. Armstrong
Keyword(s):  
Growth Rate ◽  
Gastrointestinal Tract ◽  
Structure And Function ◽  
Feed Additives ◽  
Feed Additive ◽  
Growth Promoters ◽  
Modes Of Action ◽  
And Function

Both antibiotic and probiotic feed additives are in independent use in the pig industry. The modes of action of these two groups of growth-promoters remain to be established. The present study was designed to investigate the effect of inclusion of an antimicrobial feed additive (Tylosin) or a probiotic (ProbiosR, Pioneer Overseas Corporation) on growth rate and the development of intestinal structure and function of pigs from birth to 80 days of age.

scholarly journals Emerging Role of Exosomes in Diagnosis and Treatment of Infectious and Inflammatory Bowel Diseases

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1111 ◽  
Author(s):  
Anaïs Larabi ◽  
Nicolas Barnich ◽  
Hang Thi Thu Nguyen
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Intestinal Inflammation ◽  
Current Knowledge ◽  
Biological Fluids ◽  
Bowel Diseases ◽  
Therapeutic Molecules ◽  
Inflammatory Bowel

To communicate with each other, cells release exosomes that transfer their composition, including lipids, proteins and nucleic acids, to neighboring cells, thus playing a role in various pathophysiological processes. During an infection with pathogenic bacteria, such as adherent-invasive E. coli (AIEC) associated with Crohn disease, exosomes secreted by infected cells can have an impact on the innate immune responses of surrounding cells to infection. Furthermore, inflammation can be amplified via the exosomal shuttle during infection with pathogenic bacteria, which could contribute to the development of the associated disease. Since these vesicles can be released in various biological fluids, changes in exosomal content may provide a means for the identification of non-invasive biomarkers for infectious and inflammatory bowel diseases. Moreover, evidence suggests that exosomes could be used as vaccines to prime the immune system to recognize and kill invading pathogens, and as therapeutic components relieving intestinal inflammation. Here, we summarize the current knowledge on the role of exosomes in bacterial infections and highlight their potential use as biomarkers, vaccines and conveyers of therapeutic molecules in inflammatory bowel diseases.

scholarly journals BacFITBase: a database to assess the relevance of bacterial genes during host infection

2019 ◽  
Author(s):  
Javier Macho Rendón ◽  
Benjamin Lang ◽  
Gian Gaetano Tartaglia ◽  
Marc Torrent Burgas
Keyword(s):  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Well Being ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Bacterial Fitness ◽  
Considerable Impact ◽  
Host Infection ◽  
Bacterial Genes

Abstract Bacterial infections have been on the rise world-wide in recent years and have a considerable impact on human well-being in terms of attributable deaths and disability-adjusted life years. Yet many mechanisms underlying bacterial pathogenesis are still poorly understood. Here, we introduce the BacFITBase database for the systematic characterization of bacterial proteins relevant for host infection aimed to enable the identification of new antibiotic targets. BacFITBase is manually curated and contains more than 90 000 entries with information on the contribution of individual genes to bacterial fitness under in vivo infection conditions in a range of host species. The data were collected from 15 different studies in which transposon mutagenesis was performed, including top-priority pathogens such as Acinetobacter baumannii and Campylobacter jejuni, for both of which increasing antibiotic resistance has been reported. Overall, BacFITBase includes information on 15 pathogenic bacteria and 5 host vertebrates across 10 different tissues. It is freely available at www.tartaglialab.com/bacfitbase.

scholarly journals Cinnamon (Cinnamomum zeylanicum) Oil as a Potential Alternative to Antibiotics in Poultry

Antibiotics ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 210 ◽  
Author(s):  
Mohamed E. Abd El-Hack ◽  
Mahmoud Alagawany ◽  
Abdel-Moneim E. Abdel-Moneim ◽  
Noureldeen G. Mohammed ◽  
Asmaa F. Khafaga ◽  
...  
Keyword(s):  
Essential Oils ◽  
Antimicrobial Activities ◽  
Feed Additives ◽  
Feed Additive ◽  
Volatile Components ◽  
Poultry Production ◽  
Growth Promoters ◽  
Cinnamomum Zeylanicum ◽  
Cinnamon Oil ◽  
Antibiotic Growth Promoters

The removal of antibiotic growth promoters (AGPs) as feed additives in poultry nutrition from the market in many countries has compelled researchers to find unconventional and safe alternatives to AGPs. Probiotics, prebiotics, enzymes, organic acids, herbs, immune-stimulants and essential oils (EO) have been investigated as feed additives in poultry production. Cinnamon (Cinnamomum zeylanicum), one of the oldest medicinal plants and widely used around the world, can be used in poultry rations in the form of powder or essential oil. Essential oils produced from aromatic plants have become more interesting owing to their potential effects as hypocholesterolaemic agents, antioxidants, antimicrobials, antifungals and stimulants of digestive enzymes. The potential insecticidal and antimicrobial activities of EO against pathogens that cause spoilage in agriculture crops and human diseases might be attributed mainly to the high content of volatile components (mainly cinnamaldehyde, eugenol and carvacrol) in cinnamon oil. The present review focuses on the effects of cinnamon oil as a feed additive on poultry performance, carcass traits, meat quality, hypocholesterolaemic impact, antioxidant activity, immunity and microbiological aspects.

scholarly journals Efficacy of Phytogenic Feed Additive on Performance, Production and Health Status of Monogastric Animals – A Review

2017 ◽  
Vol 17 (4) ◽  
pp. 929-948 ◽  
Author(s):  
Santi Devi Upadhaya ◽  
In Ho Kim
Keyword(s):  
Health Status ◽  
Current Knowledge ◽  
Feed Additives ◽  
Feed Additive ◽  
Growth Promoter ◽  
Full Understanding ◽  
Plant Parts ◽  
Livestock Feed ◽  
Wide Range ◽  
Cold Pressed

AbstractThe growing concerns of consumers on the use of antibiotic as a growth promoter in livestock feed have fueled the interest in alternative products. In the recent years a group of natural products known as phytogenics has been a focus of several studies. Phytogenics are a heterogeneous group of feed additives originating from plants and consist of herbs, spices, fruit, and other plant parts. These feed additives are reported to have a wide range of activities including antimicrobial, anthelminthic, antioxidant, growth enhancer, and immune modulator. Besides these properties they are also reported to stimulate feed intake and endogenous secretion and enhance production. They include many different bio-active ingredients such as alkaloids, bitters, flavonoids, glycosides, mucilage, saponins, tannins phenolics, polyphenols, terpenoids, polypeptide, thymol, cineole, linalool, anethole, allicin, capsaicin, allylisothiocyanate, and piperine. These feed additives have been tested in the form of extracts, cold pressed oils, essential oils in a number of animals but the results are variable. Therefore, their application as feed additive has been limited, largely owing to their inconsistent efficacy and lack of full understanding of the modes of action. The future of these feed additives depend on the characteristics of herbs, the knowledge on their major and minor constituents, the in-depth knowledge on their mode of action and their value based on the safety to animal and their products. The aim of this review is to summarize on the current knowledge on the use of phytogenic as a feed additive in monogastric animals.

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