scholarly journals 18. POTENSI EKSTRAK AIR DAUN SERNAI (Wedelia biflora) SEBAGAI ANTINYERI PADA MENCIT (Mus musculus) The Potency of Wedelia biflora Leaf Water Extract as Pain killer on Mice (Mus musculus)

2016 ◽  
Vol 8 (1) ◽  
Author(s):  
Abdul Hayi Amarta Ali
Keyword(s):  
Mus Musculus ◽  
Water Extract ◽  
Positive Control ◽  
Negative Control ◽  
Hot Plate ◽  
Plate Method ◽  
Treatment Groups ◽  
Randomized Design ◽  
Group 2 ◽  
Analgesic Potency

The purpose of this research was to find out the potency of Wedelia biflora water extract as pain killer. Completely randomized design (CDR) was used in this study. A total of 30 mice (Mus musculus) were divided into five treatment groups. Mice in group 1 (P0) were administered with mefenamat (positive control) and mice group 2 (P1) were only given aquadest (negative control). Mice in another3 groups (P2, P3, and P4) were administered with Wedelia biflora water extract with the concentration of 100, 75, and 50%, respectively. The painful response time was done using hot plate method and observed at 0, 30, 60, and 90 minutes, whereas abdominal writhing method was applied to count the total of writhing. Data were analyzed using ANOVA followed by Duncan. Result showed that Wedelia biflora water extract with various levels of concentration were affect significantly (P0.05) compared to negative control but no significant different (P0.05) with positive control. The analgesic potency showed significant effect (P0.05) at concentration of 100 and 75% compared to negative control, but no significant different (P0.05) compare to positive control on both hot plate methods and abdominal writhing method, whereas 50% concentration showed analgesic potency (P0.05) only on hot plate method. In conclusion, Wedelia biflora water extract is potential as analgesic on mouse and shows no significant different with mefenamat. ____________________________________________________________________________________________________________________ Key words: analgesik, Wedelia biflora, painful, total of writhe

scholarly journals 14. The Potency of Sernai (Wedelia biflora) Leaf N-hexan Extract as Analgesic Compared to Ibuprofen on Mice (Mus musculus)

2018 ◽  
Vol 12 (2) ◽  
pp. 84-90
Author(s):  
Zulkarnaini Zulkarnaini ◽  
Rinidar Rinidar ◽  
Rosmaidar Rosmaidar ◽  
T. Armansyah TR ◽  
Abdul Harris ◽  
...  
Keyword(s):  
Body Weight ◽  
Positive Control ◽  
Negative Control ◽  
Male Mice ◽  
Hot Plate ◽  
Plate Method ◽  
Treatment Groups ◽  
Significant Difference ◽  
Plot Design ◽  
Leaf N

This study aimed to determine the analgesic potential of sernai leaves n-Hexan extract on 24 male mice, aged 2-3 month with 20-25 g weighed. This study used split-plot design consisted of 6 groups. P0 as negative control was given aquades and P1 as positive control was given ibuprofen (10 mg/kg Body Weight). Treatment groups including P2, P3, P4, and P5 were given n-Hexan extract of sernai leaves with dosage of 15, 30, 45, and 60 mg/kgBW, respectively. Pain assessment was conducted using Hot Plate method. Observation of mice behaviour including licking it's front and back leg, or by jumping. This study showed there was significant difference (P0,05) between dosage and time. Duncan’s test showed P1 was significantly different (P0,05) from P2, but P3 and P5 were not significantly different from P1. P3 and P4 were significantly different (P0,05) from P2 and not significantly different from P1, while P5 was not significantly different from P3 and significantly different from P1. We can conclude that dosage of 30 and 45 mg/kgBW of n-Hexan extract of sernai leaves had analgesic potential on mice, and 60 mg/kgBW was comparable to ibuprofen as pain relieve in mice

scholarly journals PENGUJIAN EFEKTIVITAS DIURETIK KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.) DAN DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TIKUS JANTAN

2020 ◽  
Vol 3 (1) ◽  
pp. 106-111
Author(s):  
Delisma Simorangkir
Keyword(s):  
Leaf Extract ◽  
Elaeis Guineensis ◽  
Urine Volume ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Treatment Groups ◽  
White Rats ◽  
Group 2 ◽  
Palm Leaf

African Leaf and palm leaf crops have a secondary metabolite content such as alkaloids and flavonoids that are efficacious as diuretics. The purpose of this study is to know the effectiveness of diuretics from the combination  African leaf ethanol extract and palm leaf ethanol extract. Methods used Eksperiemental. The test of diuretic activity is conducted divided into 6 treatment groups. Each group consists of 3 tails of white rats. Group 1 (positive control) administered Furosemide 3.6 mg/kgBB, Group 2 (negative control) was given suspension Na-CMC 0.5%, group 3 without treatment as well as groups of 4.5, and 6 in a row administered a combination of African leaf extract doses and extracts Oil palm leaf ethanol in a row of "50 mg/kgBB + 67, 5mg/kgBB"; "100mg/kgBB + 135 mg/kgBB"; and "200 mg/kgBB + 270 mg/kgBB". Each mouse is then given a 20ml NaCl/kgBB as an oral loading dose. Measured urine volume is recorded every hour for 6 hours after it continues to measure urine volume. The results showed that the combination of African leaf ethanol extract dosage and palm leaf ethanol extract had a diuretic effect if it was compared with negative control. The conclusion of the study was the results of the study showed that the combination of African leaf extract dosage and palm leaf extract is the most effective dose of Group 6 (African leaf extract 200 mg/kgBB + palm leaves 270 mg/kgBB ). Because it produces the highest urine volume of 23.01 ml.

scholarly journals UJI AKTIVITAS ANALGESIK GEL BULUNG BONI (Caulerpa Sp.) TERHADAP MENCIT PUTIH (Mus musculus)

2021 ◽  
Vol 7 (1) ◽  
pp. 27-31
Author(s):  
Ni Luh Putu Erika Putri Jayantini ◽  
Ni Putu Trisna Ayundita ◽  
I Putu Aditya Mahaputra ◽  
Firlyandhika Dwi Fatturochman ◽  
Anak Agung Gede Rai Yadnya Putra
Keyword(s):  
Mus Musculus ◽  
Area Under The Curve ◽  
Positive Control ◽  
P Value ◽  
General Anesthetics ◽  
Meaningful Difference ◽  
Test Results ◽  
Hot Plate ◽  
Plate Method ◽  
One Way Anova

Abstrak: Nyeri merupakan perasaan emosional dan sensoris yang menimbulkan rasa tidak nyaman, berhubungan dengan (ancaman) jaringan yang rusak. Analgetika merupakan suatu zat yang mengurangi  rasa nyeri tanpa membuat pingsan atau hilang kesadaran (perbedaan dengan anestetika umum). Hewan yang digunakan sebagai hewan coba yaitu mencit (Mus musculus). Tujuan dari penelitian ini adalah untuk mengetahui perbandingan onset dari masing-masing konsentrasi gel boni yang diuji. Penelitian yang dilakukan berupa eksperimental dengan menggukan metode hot plate. Hasil penelitian menunjukkan bahwa tidak ditemukan onset pada gel boni dengan konsentrasi 0.25% karena kurva masih menaik. Onset yang diperoleh pada gel boni dengan konsentrasi 0.5% yaitu terjadi pada menit ke 90 dimana area di bawah kurva yaitu 4248 yang menunjukan persen aktivitas yang dimiliki. Onset yang diperoleh pada gel boni dengan konsentrasi 0.75 % yaitu terjadi pada menit ke 90 dimana area di bawah kurva yaitu 5112 yang menunjukan persen aktivitas yang dimiliki. Semakin besar konsentrasi yang diberikan maka efek analgesik yang timbul akan semakin besar. Berdasarkan penelitian tersebut maka diperoleh data yang tedistribusi normal dan homogen serta memiliki hasil uji ANOVA one way dengan nilai P>0.05 yang berarti tidak ada perbedaan bermaknan anatara ketiga konsentrasi terhadap kontrol positif. Dari ketiga konsentrasi tersebut yang paling efektif memberikan efek analgesik yaitu konsentrasi 0.75%. Abstract: Pain is an emotional and sensory feeling that causes discomfort, associated with (threat) the damaged tissue. Analgesics are substances that reduce pain without causing fainting or loss of consciousness (in contrast to general anesthetics). The animal used as the experimental animal is mice (Mus musculus). The purpose of this study was to determine the onset comparison of each tested Boni gel concentration. This research was conducted in the form of experimental using the hot plate method. The results showed that no onset was found for the Boni gel with a concentration of 0.25% because the curve was still increasing. The onset obtained on the Boni gel with a concentration of 0.5% occurred at 90 minutes where the area under the curve was 4248, which shows the percentage of activity owned. The onset obtained on the Boni gel with a concentration of 0.75% occurred at 90 minutes where the area under the curve was 5112 which shows the percentage of activity that is owned. The greater the concentration is given, the greater the analgesic effect. Based on this research, data were obtained that were normally distributed and homogeneous and had one-way ANOVA test results with a P value> 0.05, which means that there was no meaningful difference between the three concentrations of the positive control. Of the three concentrations, the most effective was a concentration of 0.75%.

scholarly journals LAXATIVE EFFECT OF GREEN GEDI LEAVES INFUSES (Abelmoschus manihot (L.) Medik) ON MALE WHITE MICE (Mus musculus)

2019 ◽  
Vol 19 (2) ◽  
Author(s):  
Birgitta Vania Rarasati
Keyword(s):  
Experimental Study ◽  
Mus Musculus ◽  
Positive Control ◽  
Negative Control ◽  
P Value ◽  
Laxative Effect ◽  
Significant Difference ◽  
Group 5 ◽  
Group 2

Abstract. Background: Gedi plant (Abelmoschus manihot (L.) Medik) of the Malvaceae family is a plant which leaf is used by peoples for the treatment of several illnesses such as constipation. Purpose: To investigate the laxative activity of green gedi leaves infuses (Abelmoschus manihot (L.) Medik) on male white mice.Method: This study is an experimental study. Mice were divided in 5 groups of 6 animals each, first group as negative control (CMC Na 0.5%) while group 2, 3 and 4 were treated with green gedi leaves infuses (Abelmoschus manihot (L.) Medik) at doses of 130, 260 and 520 mg/kgBW, per as respectively and group 5 as positive control (bisacodyl). The laxative activity was determined based on the frequency of defecation, weight of feces and consistency of feces.Results: It is found that 520 mg/kgBW dose has the highest mean of defecating frequency (7.17) and 260 mg/kgBW dose has the highest mean of feces weight (0.20). Statically however, there is no significant difference between the groups overall with p value of 0.132 and 0.246 for defecating frequency and feces weight respectively. There is no difference between the groups in term of feces consistency with both not defecating and hard feces.Conclusion: The research concludes that there is no significant laxative activity between each groups after administration of several dosages in 6 hours on mice thus the use of green gedi leaves as laxative in society can not be proven empirically in the laboratory.Keywords: gedi leaf, Abelmoschus manihot (L.) Medik, laxative effect, constipation

scholarly journals Uji Efektivitas Ekstrak Paku Pedang (Nephrolepis exaltata) Terhadap Pertumbuhan Jamur Candida albicans

2020 ◽  
Vol 13 (01) ◽  
pp. 33-38
Author(s):  
Diana Mey Merlina ◽  
Ngadiani
Keyword(s):  
Candida Albicans ◽  
Inhibition Zone ◽  
Positive Control ◽  
Negative Control ◽  
Treatment Groups ◽  
Randomized Design ◽  
Experimental Type ◽  
Spss Software ◽  
Negative Controls ◽  
Positive Controls

Plant swords (Nephrolepis exaltata) are ferns in the Lomariopsidaceae tribe which are easily found on the banks of rivers, cliffs, and contain flavonoids and alkaloids that can inhibit the growth of albicans candida fungi. This study aims to determine the effectiveness of Sword nail extract (Nephrolepis exaltata) on the growth of albicans candida fungi. This research is a quantitative laboratory experimental type using a completely randomized design (RAL) with 4 different treatment groups, 1 negative control (pz sterile) and 1 positive control (ketocenazole). The parameters observed were the number of colonies (CFU) and the average area of ​​the inhibition zone (mm). The data was analyzed using SPSS software using one way ANOVA analysis which was then followed by a test using DMRT. The results showed that all concentrations differed from the negative controls, while the extract concentration of 1000 ppm compared to the positive controls had no difference. Sword nail extract (Nephrolepis exaltata) has an influence on the growth of candida albicans mushrooms, namely the number of colonies of 6.78 CFU (6x106) at a concentration of 1000 ppm and inhibition zone 33.10 mm at a concentration of 1000 ppm.   Keywords : Candida albicans, Sword spikes (Nephrolepis exaltata), Inhibitory Zone, Colony Count.

UJI AKTIVITAS ANALGETIK EKSTRAK ETANOL HERBA SEMBUKAN (Paederia foetida L.) PADA MENCIT PUTIH JANTAN (Mus musculus) YANG DIINDUKSI DENGAN ASAM ASETAT

2020 ◽  
Vol 5 (2) ◽  
pp. 358-363
Author(s):  
Triswanto Sentat ◽  
◽  
Fitri Handayani ◽  
Ellen Indraswari
Keyword(s):  
Body Weight ◽  
Analgesic Activity ◽  
Mus Musculus ◽  
Ethanol Extract ◽  
Optimal Dose ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Treatment Groups ◽  
Paederia Foetida

Sembukan plants (Paederia foetida L.) are wild vines that are usually used by people as potential medicinal plants for pain. The purpose of this study was to determine the ethanol extract of sembukan’s herbal analgesic activity in male white mice (Mus musculus) and determine the optimal dose of the ethanol extract from sembukan’s herbal (Paederia foetida L.) which has the potential as an analgesic. Sembukan’s herbal is extracted with 70% ethanol solvent and an analgesic activity test is divided into 5 treatment groups namely positive control group (potassium diclofenac), negative control, dose I (80 mg / kg body weight), dose II (160 mg / kg body weight) ) and dose III (320 mg / kg body weight) by oral administration. Thirty minutes after administration, the mice were given an indicator of pain, 0.5% acetic acid. Analgesic power is calculated by counting the amount of stretching of mice for 1 hour. From the results of the study, the ethanol extract of sembukan’s herbal has analgesic activity in male white mice with percent dose analgesic power 35.18%, dose II 53.58% and dose III 68.98%. The optimal dose that has potential as an analgesic in male white mice is dose III with 68.98% analgesic power.

scholarly journals UJI AKTIVITAS PENURUNAN KADAR ASAM URAT EKSTRAK ETANOL BUAH PINANG YAKI (Areca vestiaria) PADA TIKUS PUTIH GALUR WISTAR (Rattus norvegicus) YANG DIINDUKSI KALIUM OKSONAT

PHARMACON ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 465
Author(s):  
Christani Rambi ◽  
Edwin De Queljoe ◽  
Herny E. I. Simbala
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Positive Control ◽  
Statistical Test ◽  
Negative Control ◽  
Randomized Design ◽  
Unhealthy Diet ◽  
Group 2 ◽  
Ethanol Extracts ◽  
Potassium Oxonate

ABSTRACTAn unhealthy diet in a high society protein, especially animal protein that contains a lot of purine, causes hyperuricemia (excess uric acid) to increase. The use of allopurinol that is too frequent or excessive  can cause dangerous side effects. Based on these things, it is necessary to do research on antihyperuricemia substances that have high effectiveness and guaranted safety. This study aims to determine the potential for decreasing uric acid levels of areca nut fruit. This type of research as laboratory experiments using a Completely Randomized Design (CRD), with 5 types of treatment each treatment with 3 replications. Group 1 as a negative control was given induction of potassium oxonate, Group 2 as a positive control was given induction of potassium oxonate and allopurinol. Group 3-5 was trated with betel nut extract with different doses of 3,6 mg; 7,2 mg and 14,4 mg. Based on the results of the ANOVA statistical test, serum uric acid levels were significantly different from p = 0,002 (< 0,05). The results of the ethanol extracts of pinangyaki fruit at doses of 3,6 mg / 200gr BW, 7.2mg / 200gr BW and 14,4mg / 200gr BW can reduce serum uric acid levels by anova statistical test with a confidence level of 95%. Keywords: Yaki Areca Fruit, Anthihiperurisemia, Anova ABSTRAKPola makan yang tidak sehat dalam masyarakat yang berprotein tinggi,terutama protein hewani yang banyak mengandung purin, menyebabkan penyakit hiperurisemia (kelebihan asam urat) semakin meningkat. Penggunaan allopurinol yang terlalu sering atau berlebihan dapat menimbulkan efek samping yang berbahaya. Berdasarkan hal-hal tersebut, perlu dilakukan penelitian mengenai zat antihiperurisemia yang memiliki efektivitas tinggi dan terjamin keamanannya . Penelitian ini bertujuan untuk mengetahui potensi aktivitas penurunan kadar asam urat dari Buah Pinang Yaki. Jenis penelitian ini ialah eksperimen laboratorium menggunakan Rancangan Acak Lengkap (RAL), dengan 5 macam perlakuan masing-masing perlakuan dengan 3 ulangan. Kelompok 1 sebagai kontrol negatif diberi induksi kalium oksonat), Kelompok 2 sebagai kontrol positif diberi induksi kalium oksonat dan Allopurinol. Kelompok3-5 diberi perlakuan ekstrak buah pinang yaki dengan dosis yang berbeda-beda yaitu 3,6 mg; 7,2 mg dan 14,4 mg. Berdasarkan hasil uji statistik  Anova didapatkan kadar asam urat serum berbeda secara bermakna dengan p = 0,002 (<0,05). Hasil dari ekstrak etanol buah pinang yaki di dosis 3,6mg/200grBB, 7,2mg/200grBB dan 14,4mg/200grBB dapat menurunkan kadar asam urat serum dengan uji statistik Anova dengan tingkat kepercayaan 95% Kata kunci : Buah Pinang Yaki, Antihiperurisemia, Anova

scholarly journals Efek Ekstrak Air Biji Pepaya (Carica papaya L.) terhadap Fertilitas Mencit (Mus musculus L.) Betina

2018 ◽  
Vol 35 (2) ◽  
pp. 223
Author(s):  
Muhammad Feraldi Firdaus ◽  
Agung Janika Sitasiwi ◽  
Siti Muflichatun Mardiati
Keyword(s):  
Sex Ratio ◽  
Mus Musculus ◽  
Water Extract ◽  
Treatment Groups ◽  
Contraceptive Pills ◽  
Randomized Design ◽  
End Of Treatment ◽  
Fertility Effect ◽  
Papaya Seeds ◽  
Completely Randomized Design

Papaya seeds were known as medicinal plant which have anti-fertility potencies. So it could be used as a herbal contraceptive. The purpose of this study was to test the anti-fertility effect of Papaya seed water extract on mice (Mus musculus L.) fertility which proved by pregnancy rate, litters number and sex ratio of litters. This study was designed by Completely Randomized Design, using 15 female Swiss Webster mice that were divided into 5 treatment groups with triplicates. The K(-) group were treated by distilled water; K(+) group were treated by contraceptive pills; P1, P2, P3 groups that were treated by papaya seeds extract with 1.4, 3.5 and 7 mg/animal/day respectively. Each treatment was given orally with 0.5 ml in volume for 21 days. At the end of treatment, mice was mated. The observed parameters were pregnancies occurence, litters number and sex ratio of the litters. The litters number data were analyzed by Analysis of Variance. The results showed there was differences in pregnancy time and sex ratio between control and treatment groups, but there was not significantly different in litters number. It could be concluded that the fertility of mice was inihibited by water extract of papaya seeds.

scholarly journals Pemberian Salep Ekstrak Bunga Biduri (Calotropis gigantea) untuk Penyembuhan Luka pada Mencit (Mus musculus) Secara Klinis dan Histopatologis

2019 ◽  
Vol 6 (2) ◽  
pp. 139
Author(s):  
Marphirah Marphirah
Keyword(s):  
Wound Healing ◽  
Mus Musculus ◽  
Experimental Treatment ◽  
Positive Control ◽  
Negative Control ◽  
Calotropis Gigantea ◽  
Randomized Design ◽  
Ketamine Anesthesia ◽  
Diameter Reduction ◽  
Histopathological Result

Milkweed (Calotropis gigantea) flower has some important compounds in wound healing such as alkaloids, flavonoids, tannins, karbohydrates, glikosides, phenols, saponins, protein and amino acid, and calothropin. The aim of this study was to determine the clinical and histopathological effect of milkweed extract ointment towards wound healing in mice (Mus musculus). The research was carried out in January to August 2018. This study used experimental method with Completely Randomized Design (CRD) with five treatments: betadine oinment as positive control, vaseline oinment as negative control, and three experimental treatment with milkweed extract ointments in 5%, 10% and 15% concentration. Every treatment contains of 6 mice each, which were wounded with 1 cm diameter excision on its back after injected with ketamine anesthesia. Data were analyzed using Analysis of Varians (ANOVA) and continued with Duncan Test α 0,05.  The clinical result showed that the fastest time of wound diameter reduction found on experimental treatment with 15% milkweed extract ointment. The histopathological result showed that the highest fibroblast number found on the experimental treatment with 15% milkweed extract ointment. It was concluded that the milkweed extract ointment have an effect on wound healing in mice clinically and histopathologically with 15% concentration being the best in promoting wound healing.

scholarly journals Efek Pemberian Ekstrak Etanol Daun Mimba (Azadirachta indica A. Juss) terhadap Struktur Histologis Pankreas Tikus Putih (Rattus norvegicus L.) Hiperglikemia

2021 ◽  
Vol 6 (2) ◽  
pp. 115-123
Author(s):  
Nunuk Shofiati ◽  
Siti Muflichatun Mardiati ◽  
Agung Janika Sitasiwi ◽  
Sri Isdadiyanto
Keyword(s):  
Azadirachta Indica ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Histological Structure ◽  
Distilled Water ◽  
Treatment Groups ◽  
Randomized Design ◽  
Neem Leaves ◽  
Neem Leaf Extract

Indikator klinis penyakit Diabetes Melitus adalah hiperglikemia. Mimba (Azadirachta indica A. Juss) merupakan salah satu tumbuhan yang berpotensi sebagai alternatif obat herbal hiperglikemia. Penelitian ini bertujuan untuk menganalisis pengaruh ekstrak etanol daun mimba terhadap struktur histologis pankreas pada tikus hiperglikemia. Penelitian ini mengunakan Rancangan Acak Lengkap (RAL) dengan jumlah tikus 24 ekor yang dibagi menjadi 6 kelompok perlakuan dan 4 kali ulangan. P0 (kontrol normal) adalah kelompok tikus normal yang diberi akuades, P1 (kontrol negatif) adalah tikus hiperglikemia yang diberi akuades. P2 (kontrol positif) adalah kelompok tikus hiperglikemia yang diberi glibenklamid dosis 2,25 mg/kg BB. P3, P4, dan P5 adalah kelompok tikus yang diberi ekstrak etanol daun mimba dosis 100, 200, dan 400 mg/kg BB. Data dianalisis dengan ANOVA pada signifikansi 95%. Hasil penelitian menunjukkan bahwa perlakuan ekstrak etanol daun mimba dosis 100, 200, dan 400 mg/kg BB tidak memberikan pengaruh nyata terhadap bobot pankreas, diameter, luas, dan densitas pulau Langerhans (P>0,05). Skoring struktur pulau Langerhans berdasarkan uji Mann-Whitneymenunjukkan hasil beda nyata pada kelompok  tikus yang diberi daun mimba (P≤0,05). Kesimpulan dari penelitian ini, pemberian ekstrak daun mimba dosis 400mg/kg BB menunjukkan adanya perbaikan morfologi pulau Langerhans. The clinical indicator of Diabetes mellitus was hyperglycemia. Azadirachta indica A. Juss was a plant has the potential to alternative medicine for hyperglycemia. The study was to analyze the ethanol neem leaf extract effect on histological structure of hyperglycemic rat pancreas. This study used a completely randomized design (CRD) with 24 rats were divided into 6 treatment groups and 4 replications. P0 (control) was a normal rats group were given distilled water, P1 (negative control) was a hyperglycemic rats group were given distilled water. P2 (positive control) was a hyperglycemic rats were given 2.25 mg/kg BW of glibenclamide. P3, P4, and P5 were rats were given 100, 200, and 400 mg/kg BW of ethanolic neem leaf extract.The data analyzed by ANOVA at 95% significance showed the treatment of 100, 200, and 400 mg/kg BW ethanolic neem leaf extract had no significant effect on the pancreatic weight, diameter, area, and density of Langerhans islet (P> 0.05). The score of Langerhans islet structure based on the Mann-Whitney test showed significant differences in the groups of mice given neem leaves (P≤0.05). Treatment of 400mg/Kg BW neem leaf extract showed an improvement in the morphology of the islets of Langerhans. 

Sign in / Sign up

Export Citation Format

Share Document