A clinical study on the effect of Bilvapatra Ghana in the management of Madhumeha with respect to Type II Diabetes Mellitus

2018 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. Prashant P. Budhwat ◽  
Dr. Rajendra G. Wagh ◽  
Dr. Pravin A. Patil
Keyword(s):  
Free Radicals ◽  
Human Life ◽  
Blood Stream ◽  
Type Ii Diabetes Mellitus ◽  
The Body ◽  
Living Standards ◽  
Positive Health ◽  
Beneficial Effects ◽  
Herbal Medicinal ◽  
Sugar Levels

In the course of evolution of human life, man has struggled a lot to obtain the best of living standards. Among all necessities, health care is given the best attention because, only healthy individual can enjoy the benefits of beauties of the nature. Positive health doesn’t mean only physical but physiological, mental, social and spiritual wellbeing also. If the principles of Ayurveda are studied in modern scientific way, both in respect of its approach to disease and therapy, especially in relation to Madhumeha. Diabetes results when the body makes too little insulin or does not use insulin properly, allowing sugar levels to build up in the blood stream. The free radicals are one of the important etiological factors for the development of diabetes and its complications. Antioxidants capable of protecting against the damage induced by free radicals and it also have a role in reducing the effects of diabetes. There are many herbal medicinal plants like Babul, Bilva, Davana, Neem, Jambu etc. with proven antidiabetic and related beneficial effects. Bilvapatra is effective in the treatment for diabetes by reducing blood glucose level. So in present study Bilvapatra Ghana is used in the management of Madhumeha.

scholarly journals RIDING AS A SPORT OF TERAPEUTIC NATURE NARRATIVE STUDY

2020 ◽  
Vol 6 ◽  
pp. 99
Author(s):  
Katarzyna Renata Burzawa
Keyword(s):  
Sports Medicine ◽  
Human Life ◽  
The Body ◽  
Narrative Study ◽  
Beneficial Effects ◽  
Horse Riding ◽  
State Of Mind ◽  
Long Time ◽  
Equestrian Sport ◽  
Relationship Of

The healing effects of horse riding have been known for a long time. These qualities were already recognized in ancient times - Hippocrates believed that riding a horse stimulates the functioning of the body, while Socrates noticed its impact on the exercise of the body and senses. In turn, Avicenna considered horse riding to be an excellent exercise for the body. In the sixteenth century, doctors confirmed the beneficial effects of horse riding, considering it useful for health. In 1750, Francisco Fuller mentioned horse riding in the first study of sports medicine, noticing its impact on the state of mind and human body (Bednarczyk 2015). The horse played a huge role in human life, and the nature of this relationship has changed over the years. The subject of the article focuses on the equestrian sport, which therapeutic effect takes place through the constant dialogue between the rider and the horse. This relationship is manifested in a special relationship of man and animal, which has an emotional character. The phenomenon of this interaction was presented in the Amazon narrative, which through riding and communing with these animals, has found a new dimension of life. The research was embedded in qualitative orientation, which allowed to understand a fragment of the narrator's reality and her experience of everyday life. 

scholarly journals Free Radicals as a Double-Edged Sword: The Cancer Preventive and Therapeutic Roles of Curcumin

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5390
Author(s):  
Nehal Gupta ◽  
Kshitij Verma ◽  
Sarath Nalla ◽  
Alok Kulshreshtha ◽  
Rajiv Lall ◽  
...  
Keyword(s):  
Free Radicals ◽  
Cancer Cells ◽  
The Body ◽  
Chemotherapeutic Drugs ◽  
Protein Markers ◽  
Dual Nature ◽  
Beneficial Effects ◽  
Cancer Cell Death ◽  
Anticancer Effects

Free radicals, generally composed of reactive oxygen species (ROS) and reactive nitrogen species (RNS), are generated in the body by various endogenous and exogenous systems. The overproduction of free radicals is known to cause several chronic diseases including cancer. However, increased production of free radicals by chemotherapeutic drugs is also associated with apoptosis in cancer cells, indicating the dual nature of free radicals. Among various natural compounds, curcumin manifests as an antioxidant in normal cells that helps in the prevention of carcinogenesis. It also acts as a prooxidant in cancer cells and is associated with inducing apoptosis. Curcumin quenches free radicals, induces antioxidant enzymes (catalase, superoxide dismutase, glutathione peroxidase), and upregulates antioxidative protein markers–Nrf2 and HO-1 that lead to the suppression of cellular oxidative stress. In cancer cells, curcumin aggressively increases ROS that results in DNA damage and subsequently cancer cell death. It also sensitizes drug-resistant cancer cells and increases the anticancer effects of chemotherapeutic drugs. Thus, curcumin shows beneficial effects in prevention, treatment and chemosensitization of cancer cells. In this review, we will discuss the dual role of free radicals as well as the chemopreventive and chemotherapeutic effects of curcumin and its analogues against cancer.

scholarly journals The role of ozone therapy in maintaining the articular function and in relieving the pain for patients with knee osteoarthritis

2014 ◽  
Vol 20 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Ciobotaru Camelia ◽  
Iliescu Madalina ◽  
Mandru Tatiana ◽  
Panait Marilena ◽  
Arghir Oana
Keyword(s):  
Blood Stream ◽  
Pharmacological Therapy ◽  
The Body ◽  
Whole Body ◽  
Ozone Therapy ◽  
Beneficial Effects ◽  
System Functioning ◽  
Immunomodulatory Action ◽  
Stimulation Of

ABSTRACT Ozone Therapy is thought to be a non-pharmacological therapy, which makes use of oxygen and ozone, It is based on the ozone characteristics, such as the antibacterial and antimycotic, anti-inflammatory and immunomodulatory, of systemic modulation of homeostasy and of the optimization of the way the organs and systems function, but also of tissue bionourishing. Some of the beneficial effects of the ozone are: the enhancement of the oxygen supply in the tissues affected by inflammation and pain, the increase of the blood stream and the removal of the metabolic waste in the joints affected, the obstruction of the substances which maintain the inflammation and pain, an immunomodulatory action upon the whole body, the stimulation of the health improving mechanisms in the body, a mio-relaxing action and thus, a better joint mobility and a better body system functioning

scholarly journals ACEI-Inhibitory Peptides Naturally Generated in Meat and Meat Products and Their Health Relevance

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1259 ◽  
Author(s):  
Leticia Mora ◽  
Marta Gallego ◽  
Fidel Toldrá
Keyword(s):  
Bioactive Peptides ◽  
Health Effect ◽  
Meat Products ◽  
Intestinal Barrier ◽  
Blood Stream ◽  
The Body ◽  
Gastrointestinal Digestion ◽  
Positive Health ◽  
Inhibitory Peptides ◽  
Target Organs

Meat and meat products have been described as a very good source of angiotensin I converting enzyme (ACEI)-inhibitory peptides. The generation of bioactive peptides can occur through the action of endogenous muscular enzymes during processing, gastrointestinal digestion, or by using commercial enzymes in laboratory or industry under controlled conditions. Studies of bioavailability are necessary in order to prove the positive health effect of bioactive peptides in the body as they should resist gastrointestinal digestion, cross the intestinal barrier, and reach blood stream and target organs. However, in order to better understand their effect, interactions, and bioavailability, it is necessary to consider food matrix interactions and continue the development of quantitative methodologies in order to obtain more data that will enable advances in the field of bioactive peptides and the determination of their influence on health.

scholarly journals Taurine as a Natural Antioxidant: From Direct Antioxidant Effects to Protective Action in Various Toxicological Models

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1876
Author(s):  
Peter F. Surai ◽  
Katie Earle-Payne ◽  
Michael T. Kidd
Keyword(s):  
Free Radicals ◽  
Free Radical ◽  
Human Life ◽  
Protective Action ◽  
The Body ◽  
Stress Conditions ◽  
Poultry Production ◽  
Protective Effects ◽  
Free Radical Production ◽  
Radical Production

Natural antioxidants have received tremendous attention over the last 3 decades. At the same time, the attitude to free radicals is slowly changing, and their signalling role in adaptation to stress has recently received a lot of attention. Among many different antioxidants in the body, taurine (Tau), a sulphur-containing non-proteinogenic β-amino acid, is shown to have a special place as an important natural modulator of the antioxidant defence networks. Indeed, Tau is synthesised in most mammals and birds, and the Tau requirement is met by both synthesis and food/feed supply. From the analysis of recent data, it could be concluded that the direct antioxidant effect of Tau due to scavenging free radicals is limited and could be expected only in a few mammalian/avian tissues (e.g., heart and eye) with comparatively high (>15–20 mM) Tau concentrations. The stabilising effects of Tau on mitochondria, a prime site of free radical formation, are characterised and deserve more attention. Tau deficiency has been shown to compromise the electron transport chain in mitochondria and significantly increase free radical production. It seems likely that by maintaining the optimal Tau status of mitochondria, it is possible to control free radical production. Tau’s antioxidant protective action is of great importance in various stress conditions in human life, and is related to commercial animal and poultry production. In various in vitro and in vivo toxicological models, Tau showed AO protective effects. The membrane-stabilizing effects, inhibiting effects on ROS-producing enzymes, as well as the indirect AO effects of Tau via redox balance maintenance associated with the modulation of various transcription factors (e.g., Nrf2 and NF-κB) and vitagenes could also contribute to its protective action in stress conditions, and thus deserve more attention.

scholarly journals Manoeuvres for management of diabetes

2019 ◽  
Vol 7 (2) ◽  
pp. 656
Author(s):  
Amod Hansdak
Keyword(s):  
Blood Sugar ◽  
Blood Stream ◽  
The Body ◽  
Dietary Control ◽  
Lifestyle Modifications ◽  
Hypoglycaemic Agents ◽  
Modifiable Factor ◽  
Sugar Levels ◽  
Calf Muscles

Type 2 diabetes is the scourge of our times. Globally there are over 425 million diabetics which is projected to rise to 629 million by 2045, suffering devastating consequences resulting in significant morbidity and mortality.1-3Bringing blood sugars down can be challenging. Dietary control, lifestyle modifications and exercise can help but these can be difficult to implement.4 Medically, drugs are the usual method of bringing blood sugar levels under control but they come with their attendant risks and ongoing costs.5 Apart from drugs, the main arsenal against diabetes is exercise but due to one reason or another it is not very popular or practical. In the absence of antidiabetic medications and episodic exercises there seems to be no alternative left. So, when a person is unable to exercise or is not on hypoglycaemic agents, he is rendered defenceless against the deleterious effects of raised blood sugar levels. Regardless, muscles form the frontline defence against diabetes since muscles are the main modifiable factor in utilization of glucose by the body which they can do even in the absence of insulin.6,7 Hence, muscles need to be the first line agents to fight diabetes. However, the muscles need to be activated when the blood sugars are high, that is, within minutes or hours after meals rather than exercising in the morning or evening when the blood sugar may be relatively low. The question is ‘How do we get the muscles to start using up glucose right when it enters the blood stream?’ This is where the manoeuvres described below can help since these can be done almost anytime and anywhere. Following are the proposed manoeuvres:Calf contractions: Alternate contractions of calf muscles of each leg while sitting, giving a good squeeze to the calf muscles. Alternatively, one or both calves can be contracted and held for some time. This manoeuvre can be done even while lying in bed.Pectoral pressure: One or both pectorals can be contracted and held for 30-60 seconds-longer the better. The strength of contractions will depend on one’s motivation and ability. Alternatively, moderate contractions can be maintained for a longer duration.Shoulder squeezes: The back has some of the strongest muscles which can be used to ‘pulverise’ the sugars. In this method the person can sit slightly bent forwards and the shoulders are pulled back and held in that position for 30-60 seconds.These manoeuvres can be done either singly or combined with other manoeuvres described or with dietary modifications, regular exercises or medications for greater efficacy.Of course, like the antidiabetic medications, these manoeuvres need to be titrated, especially when combined with hypoglycaemic agents, otherwise they can lead to hypoglycaemia.8 Even without antidiabetic medication they have the ability to cause hypoglycaemia, if done excessively. Once the muscles get used to these manoeuvres it will be easier for them to use glucose and keep blood sugars down.

Chronic Hypoxia as a Potential Factor in Human Life-threatening Diseases

2017 ◽  
Vol 10 (4) ◽  
pp. 3759-3762
Author(s):  
Sandhya MNVS ◽  
Vanitha K ◽  
Ramesh A
Keyword(s):  
Chronic Hypoxia ◽  
Atmospheric Oxygen ◽  
Human Life ◽  
The Body ◽  
Cellular Damage ◽  
Otto Warburg ◽  
Regular Treatment ◽  
Breathing Exercises ◽  
Hypoxic Conditions ◽  
Cancerous Cell

The review article focuses on the importance of adequate oxygen levels in the body as cure and therapy for many ailments. It is known that hypoxia is the cause for cellular damage and if it can be applied to major patho-physiology’s, it can be observed that slow and chronic hypoxic conditions are the cause for most of the diseases. On the contrary, providing each cell of the body with proper oxygen may be helpful in maintaining the immunity of the body and therefore treating many disease conditions. This theory, if tested may show positive results in heart related diseases, neuronal disorders, stresses, digestive disorders and the unresolved cancer too. Slow decrease in the levels of atmospheric oxygen could be a reason to induce chronic hypoxia. According to Dr. Otto Warburg, a Noble laurate, a normal cell when deprived of oxygen, may get converted to a cancerous cell, whereas a cancerous cell cannot survive in aerobic conditions. If this part of his research be concentrated on, there could be fruitful results in the treatment of cancer. To maintain adequate levels of oxygen in the body, simple yogic breathing practices are helpful. And to maintain the adequate atmospheric oxygen, trees and plants which cleanse the atmospheric air are useful. Clinical surveys on volunteers who have been practicing regular breathing exercises can prove the fact that proper and concentrated respiration could prevent many diseases. Thus, supplementing breathing exercises along with the regular treatment for cancer patients could be helpful in alleviating cancer and other diseases.

Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Male Smokers

2019 ◽  
Vol 22 (7) ◽  
pp. 496-501
Author(s):  
Fatemeh Ahmadi-Motamayel ◽  
Parisa Falsafi ◽  
Hamidreza Abolsamadi ◽  
Mohammad T. Goodarzi ◽  
Jalal Poorolajal
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Free Radicals ◽  
Antioxidant Capacity ◽  
Cigarette Smoke ◽  
Total Antioxidant Capacity ◽  
The Body ◽  
Total Antioxidant ◽  
The Mean ◽  
And Oxidative Stress

Background: Cigarette smoke free radicals can cause cellular damage and different diseases. All the body fluids have antioxidants which protect against free radicals. Objective: The aim of this study was to evaluate salivary total antioxidant capacity and peroxidase, uric acid and malondialdehyde levels in smokers and a nonsmoking control group. Methods: Unstimulated saliva was collected from 510 males. A total of 259 subjects were current smokers and 251 were non-smokers. The levels of salivary total antioxidant capacity, uric acid, peroxidase and malondialdehyde were measured using standard procedures. Data were analyzed with t test and ANOVA. Results: The smokers were younger and dental hygiene index was higher than healthy nonsmoking controls. The mean total antioxidant capacity in smokers and nonsmokers was 0.13±0.07 and 0.21±011, respectively (P=0.001). Smokers had significantly lower peroxidase and uric acid levels than healthy controls. In addition, the mean malondialdehyde levels in the smokers and nonsmokers were 4.55 ±2.61 and 2.79 ±2.21, respectively (P=0.001). Conclusion: Cigarette smoke produces free radical and oxidative stress, causing many side effects. Salivary antioxidant levels decreased and malondialdehyde levels increased in smokers, indicating the high oxidative stress among smokers compared to nonsmokers. Cigarette smoke had deleterious effects on main salivary antioxidants levels.

scholarly journals Migration of Silver and Copper Nanoparticles from Food Coating

Coatings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 380
Author(s):  
Hamed Ahari ◽  
Leila Khoshboui Lahijani
Keyword(s):  
Copper Nanoparticles ◽  
Inductively Coupled Plasma ◽  
Food Packaging ◽  
Human Life ◽  
Analytical Techniques ◽  
Optical Emission ◽  
Atomic Emission ◽  
The Body ◽  
Toxic Effects ◽  
Inductively Coupled

Packaging containing nanoparticles (NPs) can increase the shelf life of products, but the presence of NPs may hazards human life. In this regard, there are reports regarding the side effect and cytotoxicity of nanoparticles. The main aim of this research was to study the migration of silver and copper nanoparticles from the packaging to the food matrix as well as the assessment techniques. The diffusion and migration of nanoparticles can be analyzed by analytical techniques including atomic absorption, inductively coupled plasma mass spectrometry, inductively coupled plasma atomic emission, and inductively coupled plasma optical emission spectroscopy, as well as X-ray diffraction, spectroscopy, migration, and titration. Inductively coupled plasma-based techniques demonstrated the best results. Reports indicated that studies on the migration of Ag/Cu nanoparticles do not agree with each other, but almost all studies agree that the migration of these nanoparticles is higher in acidic environments. There are widespread ambiguities about the mechanism of nanoparticle toxicity, so understanding these nanoparticles and their toxic effects are essential. Nanomaterials that enter the body in a variety of ways can be distributed throughout the body and damage human cells by altering mitochondrial function, producing reactive oxygen, and increasing membrane permeability, leading to toxic effects and chronic disease. Therefore, more research needs to be done on the development of food packaging coatings with consideration given to the main parameters affecting nanoparticles migration.

scholarly journals SARS-CoV-2: is there neuroinvasion?

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Conor McQuaid ◽  
Molly Brady ◽  
Rashid Deane
Keyword(s):  
Respiratory Distress ◽  
Vascular Dysfunction ◽  
Multiorgan Failure ◽  
Neurological Complications ◽  
Wide Distribution ◽  
The Body ◽  
Health Conditions ◽  
Main Body ◽  
Beneficial Effects ◽  
The Brain

Abstract Background SARS-CoV-2, a coronavirus (CoV), is known to cause acute respiratory distress syndrome, and a number of non-respiratory complications, particularly in older male patients with prior health conditions, such as obesity, diabetes and hypertension. These prior health conditions are associated with vascular dysfunction, and the CoV disease 2019 (COVID-19) complications include multiorgan failure and neurological problems. While the main route of entry into the body is inhalation, this virus has been found in many tissues, including the choroid plexus and meningeal vessels, and in neurons and CSF. Main body We reviewed SARS-CoV-2/COVID-19, ACE2 distribution and beneficial effects, the CNS vascular barriers, possible mechanisms by which the virus enters the brain, outlined prior health conditions (obesity, hypertension and diabetes), neurological COVID-19 manifestation and the aging cerebrovascualture. The overall aim is to provide the general reader with a breadth of information on this type of virus and the wide distribution of its main receptor so as to better understand the significance of neurological complications, uniqueness of the brain, and the pre-existing medical conditions that affect brain. The main issue is that there is no sound evidence for large flux of SARS-CoV-2 into brain, at present, compared to its invasion of the inhalation pathways. Conclusions While SARS-CoV-2 is detected in brains from severely infected patients, it is unclear on how it gets there. There is no sound evidence of SARS-CoV-2 flux into brain to significantly contribute to the overall outcomes once the respiratory system is invaded by the virus. The consensus, based on the normal route of infection and presence of SARS-CoV-2 in severely infected patients, is that the olfactory mucosa is a possible route into brain. Studies are needed to demonstrate flux of SARS-CoV-2 into brain, and its replication in the parenchyma to demonstrate neuroinvasion. It is possible that the neurological manifestations of COVID-19 are a consequence of mainly cardio-respiratory distress and multiorgan failure. Understanding potential SARS-CoV-2 neuroinvasion pathways could help to better define the non-respiratory neurological manifestation of COVID-19.

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