scholarly journals Hubungan antara Soluble Fms-Like Tyrosine Kinase-1 (sFlt-1) pada Ibu Preeklampsia Berat dengan fetal outcome

2020 ◽  
Vol 5 (1) ◽  
pp. 126
Author(s):  
Mona Dewi Utari ◽  
Fenny Fenny ◽  
Andina Andina ◽  
Ria Ria

<p><em>Preeclampsia is a major source of maternal morbidity and mortality throughout the world including Indonesia. Regulatory failure and imbalance of proangiogenic and anti angiogenic placental vasoactive agents such as soluble fms-like tyrosine kinase-1 (sFlt-1) proven to play an important role in the pathogenesis of preeclampsia. Preeclampsia is very dangerous because otherwise it can cause morbidity and mortality in the mother also gives a very bad effect for the fetus. The purpose of this study was to determine correlate sflt-1 in severe preeclampsia with fetal outcome. This research is an observational study with research desain </em><em>cross-sectional. The sample of this study was maternity who were diagnosed with severe preeclampsia as many as 27 sample by consecutive sampling. sFlt-1 levels were examined by ELISA. The result showed there is correlate sFlt-1 with new born body weight (Pvalue=0,01), there is no correlate between sFlt-1 and score apgar (Pvalue=0,91), there is no correlate between sFlt-1 and stillborn (Pvalue=0,84). The conclution of this study there is correlate sFlt-1 with new born body weight. Health workers are expected to be able to reduce the risk of severe preeclampsia / eclampsia as early as possible starting from the physical and mental preparation of each expectant mother especially nutrition and stressing the importance of regular and periodic antenatal visits.</em></p><p><em><br /></em></p><p><em><em>Preeklampsia merupakan sumber utama morbiditas dan mortalitas ibu di seluruh dunia termasuk Indonesia. Kegagalan pengaturan dan ketidakseimbangan agen vasoaktif proangiogenik dan anti angiogenik plasenta <em>seperti soluble fms-like tyrosine kinase-1</em>(sFlt-1) terbukti memainkan peranan penting dalam patogenesis preeclampsia. Preeklampsia sangat berbahaya karena selain dapat menyebabkan morbiditas dan mortalitas pada ibu juga memberikan efek yang sangat buruk bagi janin. Tujuan Penelitian ini adalah untuk mengetahui hubungan antara <em>sFlt-1 </em>pada ibu preeklampsia berat dengan <em>fetal outcome. </em>Penelitian ini merupakan penelitian observasional dengan desain penelitian <em>cross-sectional</em>. Sampel penelitian ini adalah ibu bersalin yang terdiagnosa Preeklampsia Berat sebanyak 27 orang dengan cara <em>consecutive sampling. </em>Kadar sFlt-1 diperiksa dengan ELISA. Hasil penelitian menunjukkan bahwa terdapat hubungan antara sFlt-1 dengan berat badan bayi baru lahir dengan nilai p=0,01, tidak terdapat hubungan antara sFlt-1 dengan APGAR Score dengan nilai p=0,91, tidak terdapat hubungan antara sFlt-1 dengan lahir mati dengan nilai p=0,84. Kesimpulan hasil penelitian diketahui terdapat hubungan kadar sFlt-1 pada ibu preeklampsia berat dengan Berat badan bayi baru lahir. Petugas kesehatan diharapkan mampu mengurangi resiko terjadinya preeklampsia berat/eklampsia sedini mungkin dimulai dari persiapan fisik dan mental pada setiap calon ibu terutama nutrisi dan menekankan pentingnya kunjungan antenatal yang teratur dan berkala</em>.</em></p>

2020 ◽  
Author(s):  
Addisu Yeshambel ◽  
Walellign Anmut

Abstract Background: Eclamptic disorder of pregnancy is one of the common problems in sub-Saharan countries and forms one of the deadly triads along with hemorrhage and infection which complicates maternal and fetal outcomes of pregnancy. To assess the prevalence of eclampsia and its maternal and fetal outcome in Ghandi Memorial Hospital, Addis Ababa Ethiopia, 2019.Methods: A descriptive retrospective cross-sectional study was used on randomly selected 185 women who attended delivery at Ghandi memorial Hospital from 1st of September 2017 to –last of August 2018. Data were analyzed using SPSS version 25 software. Descriptive statistics were used to calculate frequencies and percentages and data was presented using texts and, tables. Results: Out of the 2,973 deliveries, the prevalence of eclampsia was found to be 16.1%. About 89.7% had reported a history of prior pregnancy-induced hypertension and 73.5% induced their current pregnancy following eclampsia. From mothers required interventions to terminate the pregnancy by induction, 47.8% ended by cesarean section secondary to non-reassuring fetal status (29.2%). The majority (91.9%) had taken magnesium sulfate for the management of convulsion and 86.5% had taken hydralazine for hypertension management. Abruption of the placenta (96.2%), postpartum-hemorrhage (89.2%), and HEELP syndrome (83.8 %) were major maternal adverse outcomes reported, and 33% of pregnancy was ended as stillbirth followed by low birth weight (28.6%). Over 53.6% of delivered babies had an APGAR score of less 4 and 30.4% of neonates required admission to nursery/NICU referral. Conclusion: The prevalence of eclampsia was high, with corresponding high maternal and perinatal morbidity and mortality. Increasing early detection before pregnancy, antenatal screening, and use of magnesium sulfate to control convulsions will reduce the disorder and associated morbidity and mortality for both mother and fetus.


2018 ◽  
Vol 1 (1) ◽  
pp. 78
Author(s):  
Maya Atikasuri ◽  
Henny Suzana Mediani ◽  
Nita Fitria

Masalah kenakalan remaja telah menjadi salah satu masalah pokok yang dihadapi oleh Indonesia. Kejadian dan kualitas kenakalannya terus meningkat hingga menjurus pada tindak kriminalitas yang menyebabkan remaja terjerat di ranah hukum. Stigma negatif di masyarakat yang diberikan kepada mantan tahanan membuat Andikpas enggan keluar dari LPKA dan cenderung merasakan kecemasan menjelang masa kebebasannya, terlebih lagi usia remaja merupakan usia dimana keadaan emosional dan psikologis yang belum stabil membuat remaja mudah mengalami kecemasan dan berdampak tidak baik jika terus dibiarkan. Tujuan dari penelitian ini adalah untuk mengetahui gambaran tingkat kecemasan pada Andikpas menjelang bebas di LPKA Kelas II Bandung.Metode penelitian yang digunakan adalah deskriptif-kuantitatif dan teknik consecutive sampling dengan populasi Andikpas menjelang bebas sebanyak 56 orang. Instrumen yang digunakan adalah Zung’s Self-Rating Anxiety Scale (ZSAS) dengan skala likert.Hasil penelitian menunjukkan bahwa dari 56 Andikpas yang diteliti hampir setengahnya yaitu 25 Andikpas (44,64%) tidak mengalami kecemasan, sementara sebagian besar Andikpas yang mengalami kecemasan yaitu 19 Andikpas (33,93%) mengalami kecemasan ringan-sedang, dan sebagian kecil yaitu sebanyak 9 Andikpas (16,07%) mengalami kecemasan berat, serta yang paling sedikit yaitu sebanyak 3 Andikpas (5,35%) mengalami panik.Simpulan dari penelitian ini adalah bahwa hampir setengahnya dari Andikpas yang diteliti tidak mengalami kecemasan, namun lebih dari setengahnya juga Andikpas pada penelitian ini mengalami kecemasan baik dari tingkatan ringan sampai dengan panik. Peningkatan program pembinaan dan konseling serta pemberdayaan tenaga kesehatan di LPKA sangat dibutuhkan agar dapat menurunkan tingkat kecemasan pada Andikpas.Kata kunci : Andikpas, kenakalan remaja, menjelang bebas, tahanan. Description of Anxiety Disorder among Inmate 14–18 Years Old Pre Release at Lembaga Pembinaan Khusus Anak Class IIAbstractJuvenile delinquency has become one of the main problems in Indonesia. The incidence and mischievousness quality increase which is lead to crime action. This situation may cause adolescent entangled in the realm of law. The negative stigma in society given to inmates former make inmate reluctant to get out of LPKA and tends to feel anxiety ahead of their pre-release. Adolescent is a phase of a transitional period from children into adulthood where emotional and psychological states are not stable, and anxiety is need to be noticed. Moreover, psychological burden that experienced by adolescent was harder when they lived in LPKA. This study aims to identify anxiety scale of pre-release juvenile inmates at LPKA Class II Bandung.This study use quantitative descriptive research with cross-sectional approach and consecutive sampling technique with 56 pre-release juvenile inmates as population and used Zung’s Self-Rating Anxiety Scale (ZSAS) with Likert Scale as data analyze. The result showed that 25 Andikpas (44.64%) did not experience anxiety, then most of them experienced anxiety with the explenation: 19 Andikpas (33,93%) experience mild-moderate anxiety, 9 Andikpas (16.07%) experiencing severe anxiety, and 3 Andikpas (5.35%) experiencing panic.The conclusion of this study is the level of anxiety experienced by Andikpas is nearly half of Andikpas did not experience anxiety, but more than half of Andikpas in this study experienced anxiety either from mild to panic levels. Improvement of coaching and counseling programs and the empowerment of health workers in LPKA is needed to reduce the level of anxiety in Andikpas.Keyword: Andikpas, inmates, juvenile delinquency, pre-release.


2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Laila Rahmi ◽  
Rahmatina B. Herman ◽  
Yusrawati Yusrawati

AbstrakPreeklampsia merupakan sumber utama morbiditas dan mortalitas ibu di seluruh dunia. Kegagalan pengaturan dan ketidakseimbangan agen vasoaktif proangiogenik dan antiangiogenik plasenta, soluble fms-like tyrosine kinase-1 (sFlt-1), vascular endothelial growth factor (VEGF) dan placental growth factor (PlGF) memainkan peran penting dalam patogenesis preeklampsia. Tujuan penelitian ini adalah menentukan perbedaan rerata kadar sFlt-1 serum pada penderita early onset, late onset preeklampsia berat/ eklampsia dan kehamilan normal. Penelitian dilakukan di RSUP Dr. M. Djamil, RS TK. III dr. Reksodiwiryo dan Laboratorium Biologi Molekuler Fakultas Kedokteran Universitas Andalas Padang dari Februari sampai  Desember 2014 dengan desain cross sectional. Subjek berjumlah 84 orang, terdiri dari tiga kelompok, yaitu kelompok early onset preeklampsia berat/ eklampsia, late onset preeklampsia berat/ eklampsia, dan kehamilan normal sebagai kelompok kontrol yang diambil dengan teknik consecutive sampling. Darah dikumpulkan dari subjek penelitian dengan cara intravena kemudian diukur dengan metode ELISA. Rerata kadar sFlt-1 pada kelompok early onset, late onset preeklampsia berat/ eklampsia dan kehamilan normal secara berturut-turut adalah 4,69±0,96 ng/ml, 2,39±0,57 ng/ml, dan 1,23±0,42 ng/ml. Perbedaan ini sangat signifikan dengan uji statistik ANOVA (p<0,05) dan uji Post Hoc Test Multiple Comparisons. Kesimpulan penelitian adalah terdapat perbedaan yang sangat signifikan antara kadar sFlt-1 serum pada kelompok early onset preeklampsia berat/ eklampsia, late onset preeklampsia berat/ eklampsia dan kehamilan normal.Kata kunci: sFlt-1, antiangiogenik, preeklampsia berat/ eklampsia, kehamilan normal AbstractPreeclampsia is a major cause maternal morbidity and mortality in the world. Failure regulation and imbalance of vasoactive agents and antiangiogenic proangiogenik placenta, soluble fms-like tyrosine kinase-1 (sFlt-1), vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) have an important role in the pathogenesis of preeclampsia. The objective of this study was to determine the differences between the mean serum levels of sFlt-1 in patients with early onset, late onset severe preeclampsia/eclampsia and normal pregnancy. This study was conducted in Dr. M. Djamil hospital, dr. Reksodiwiryo TK. III hospital and Biology Moleculer Laboratory Medicine Faculty of Andalas University Padang from February until December 2014 with a cross sectional design. The total subjects were 84 persons, consist of three groups, there was early onset severe preeclampsia/ eclampsia, late onset severe preeclampsia/ eclampsia and normal pregnancy as control group. The subjects were selected by consecutive sampling technique. The blood was collected by intravenous,  then sFlt-1 serum measured by ELISA. The mean levels of sFlt-1 in the early onset group, late onset severe preeclampsia/ eclampsia group and normal pregnancy group were 4.69±0.96 ng/ml, 2.39±0.57 ng/ml and 1.23±0.42 ng/ml. This difference very significant by ANOVA statisctical test (p<0,05) and Multiple Comparisons Post Hoc Test. The conclusion of this study is very significant differences between serum levels of sFlt-1 in early onset severe preeclampsia/ eclampsia group, late onset severe preeclampsia/ eclampsia on  normal pregnancy.Keywords: sFlt-1, antiangiogenic, severe preeclampsia/ eclampsia, normal pregnancy


2018 ◽  
Vol 14 (2) ◽  
pp. 163-171
Author(s):  
Fatma Zulaikha ◽  
Rina Triasih ◽  
Purwanta Purwanta

Pneumonia is the most common cause of morbidity and mortality among young children worldwide. Integrated Management of Childhood Illness (IMCI) is a procedural form in the care of childhood illness which aims to minimize morbidity and mortality rate in children, including pneumonia. This was a cross-sectional study at Samarinda and Kutai Kartanegara community health center from July to October 2015. The health workers’ knowledge was assessed through questionnaire. The quality of IMCI implementation was evaluated through direct observation in primary health care. A total of 46 health workers were involved in this study. Observation of IMCI implementation quality was conducted in 104 children. The majority of respondents (73.9) had sufficient knowledge; however, in terms of direct implementation on the field, most of the respondents (87%) were included in incompetent category. It can be concluded that level of knowledge was related to implementation of cough IMCI in community health center, but the correlation was weak.


2021 ◽  
pp. 60-61
Author(s):  
Naveed Tamboli ◽  
Hemant Murdeshwar ◽  
Gulafroz SK Samad

Introduction- Pre eclampsia and eclampsia is one of the leading cause of maternal and fetal morbidity and mortality. This study was undertaken to correlate coagulation prole in patients with pre-eclampsia and eclampsia with maternal and fetal outcome. Materials And Methods- A prospective study was conducted on 164 cases and 70 controls over a period of 2 years. The coagulation prole was carried out on the semiautomated TRINITY coagulometer. The haematological parameters were assessed on fully automated 3 part haematological analyser- TRIVITRON Model-CELLENIUM-19. The patients were classied into mild preeclamptic, severe preeclamptic and eclamptic based on the clinical and haematological parameters. Observations- The maternal and the foetal outcomes were studied and correlated with the coagulation prole. All the cases of mild preeclampsia had favourable maternal and fetal outcome. Out of total 102 cases of severe preeclampsia and eclampsia, 78 had normal coagulation prole and 24 had deranged prole. Thus out of 24 patients with deranged coagulation prole, 21 (87.5%) women had adverse maternal outcome and 24 (100%) had unfavourable fetal outcome. Conclusion- Deranged coagulation prole in preeclampsia and eclampsia is signicantly associated with adverse maternal and fetal outcome. Thus suspecting a deranged coagulation status early in the course of the disease will guide us in management before the patient goes into complications.


2017 ◽  
Vol 15 (2) ◽  
pp. 6-9
Author(s):  
Husneyara Haque ◽  
Kalpana Kumari Thapa

Introduction: Eclampsia is an acute and life-threatening complication of pregnancy associated with elevated maternal and fetal morbidity and mortality. This study was done with the aim to evaluate the maternal and fetal outcome in eclampsia patients and to observe various factors affecting its occurrence and outcome. Methods: A retrospective cross-sectional hospital based study carried out in Nepalgunj Medical College, Nepalgunj from January 2015 to December 2016. Details and data obtained from maternity register were analysed. All patients with eclampsia were included and fetomaternal outcomes measured in terms of complications. Simple descriptive statistical method was applied for analysis. Result: Out of 6056 pregnant women, 46 had eclampsia with the incidence of 7.59 per 1000 deliveries. 58.7% of study population belonged to age group of 21-30 years followed by 36.96% from age less than 20 years. 78.26% cases were unbooked. 73.91% eclamptic patients were primi gravida and 60.87% had gestational age less than 37 weeks. Half of pregnancies with eclampsia underwent ceasarian for delivery and 30.44% required ICU care. One third women developed eclampsia related complications and 2(4.35%) died. Common complications were atonic postpartum heamorrhage (15.21%), psychosis (8.71%) acute renal failure (4.35%). 60.86% newborn were preterm and 56.52% were low birth weight. In 50% newborn, Apgar score at 5 minutes was less than 7. Fetal death was 10.85%. Conclusion: Eclampsia continues to be one of the prime etiological factors for maternal and fetal morbidity and mortality. Therefore early recognition and proper management are vital to tackle this challenge.


2018 ◽  
Vol 2 (1) ◽  
pp. 52
Author(s):  
Fitriana Noor Khayati ◽  
Ririn Munawaroh

ABSTRAKTujuan penelitian: untuk menganalisis hubungan pengetahuan ibu tentang gizi balita dan pola pemberian makanan terhadap status gizi anak usia toddler. Metode: Penelitian ini bersifat deskriptif analitik dengan pendekatan cross sectional. Populasi dalam penelitian ini yaitu ibu yang memiliki anak usia 1-3 tahun di Desa Kunden, Karanganom, Klaten. Sampel berjumlah 56 orang yang diambil dengan teknik concecutive sampling. Penelitian dilaksanakan pada bulan Juni-Juli 2016. Instrumen yang digunakan ialah kuesioner pengetahuan ibu tentang status gizi, kuesioner pola pemberian makanan, timbangan berat badan, serta stature meter. Pengukuran status gizi menggunakan indeks BB/TB. Analisis data menggunakan uji koefisien kontingensi untuk mengetahui korelasi. Hasil: Ibu yang memiliki pengetahuan tentang gizi balita cukup baik sejumlah 41,1% dan ibu yang memiliki pengetahuan tentang pola pemberian makanan baik sejumlah 78,6%. Balita di Desa Kunden sebagian besar memiliki status gizi normal, yaitu sejumlah 62,5%. Hasil uji statistik menunjukkan tidak ada hubungan pengetahuan ibu (p=0,166) dan pola pemberian makanan (p=0,313) terhadap status gizi balita (a=0,05). Kesimpulan: Tidak ada hubungan antara pengetahuan ibu tentang gizi anak usia toddler dan pola pemberian makanan terhadap status gizi anak usia toddler.Kata Kunci: pengetahuan ibu, pola pemberian makanan, status gizi, toddlerCORRELATION OF MOTHER’S KNOWLEDGE AND FEEDING PATTERN WITH NUTRITIONAL STATUS IN TODDLERSABSTRACTObjective: to analyze the correlation of mother’s knowledge about toddler’s nutrition and feeding pattern with nutritional status of toddlers. Methods: This research was analytical descriptive with cross sectional approach. The population was mothers who had children aged 1-3 years in Kunden, Karanganom Village, Klaten. Samples consisted of 56 people taken using consecutive sampling technique. The research was conducted in June-July 2016. The instruments used were a questionnaire of mother’s knowledge about nutritional status, feeding pattern questionnaire, body weight scales, and stature meter. The nutritional status was measured using Weight/Height index. Data were analyzed using contingency coefficient test to figure out the correlation. Results: 41.1% of mothers had relatively good knowledge about nutrition of toddler and 78.6% mothers had good knowledge about feeding pattern. 62.5% of toddlers in Kunden Village mostly had normal nutritional status. The results of statistical test showed that there was no correlation of mother’s knowledge (p=0.166) andfeeding pattern (p=0.313) with nutritional status of toddles (a=0.05). Conclusion: There is no correlation of mother’s knowledge about toddlers’ nutrition and feeding pattern with nutritional status of toddlers.Keywords: mother’s knowledge, feeding pattern, nutritional status, toddlers


2020 ◽  
Vol 19 (2) ◽  
pp. 23-27
Author(s):  
Monira Jamal ◽  
Rajat Kumar Biswas

Background: The leading cause of perinatal morbidity and mortality is prematurity in developed and underdeveloped countries. In one third of the patients with preterm labour, there is associated premature rupture of membranes. The study was conducted to evaluate the clinical presentation of Pre-labour Rupture of Membrane (PROM) in pregnancy and obstetric outcome. Materials and methods: This is a cross sectional study carried out in the Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University, Dhaka, between September 2013 to February 2014. About 50 women having PROM with more than 32 weeks gestational age who admitted in the above department for delivery were enrolled in this study. Results: The mean age was found 27.4 ± 4.42 years with range from 17 to 41 years. Forty eight percent of PROM patient were primi and 52.0 percent of patients were multigravida. Six percent patients were illiterate. Almost two third patients were housewives. More than half (54.0%) of the patients were came from poor class income group family. Majority (64.0%) patients had term PROM (>37 weeks) gestational age and the mean gestational age was 38.1 ± 2.7 weeks with range from 32- 40 weeks. More than half (54.0%) didn't received any antenatal checkup. A total of (56.0%) patients had associated disease, out of which anaemia was more common. Twelve percent had diabetes mellitus and 8.0% had UTI infection. Almost two third (64.0%) was vaginal delivery and 18(36.0%) were caesarean section and common indication for caesarean section was fetal distress (38.9%). Two third patients were healthy and 17 patients had morbidities, wound infection is highest (29.4%). The mean birth weight was found 2.74 ± 0.7 kg. APGAR score >7 at 1 minute was found (92.0%) and (94.0%) at 5 minutes of birth of baby after birth. Fetal outcome take home alive (98.0%) and neonatal death 2.0%. Among 50 foetus morbidity develop in 26 cases. Among them respiratory insufficiency is highest (38.5%). Conclusion: Motivation of the patients, health education, improvement of nutritional status of mother, neonatal care service, early diagnosis, treatment, overall institutional delivery is needed for reduction of neonatal morbidity and mortality, as well as maternal morbidity. Chatt Maa Shi Hosp Med Coll J; Vol.19 (2); July 2020; Page 23-27


2013 ◽  
Vol 12 (3) ◽  
pp. 20-22
Author(s):  
Adiba Malik ◽  
Kamrun Nessa ◽  
Rokeya Begum

Background: In Bangladesh a large number of women attending the major urban hospitals with the complications directly due to abortion like, hemorrhage, fever, peritonitis, visceral injuries. Among all types of abortion, septic abortion is a significant health problem with short and long term complications that affect the quality of life of those fortunate enough to avoid mortality. Aim: This study was conducted to assess the septic abortion related morbidity and mortality in a tertiary level hospital in one year. Methods: This study was a cross sectional observational study in the Department of Obstetrics and Gynaecology, Chittagong Medical college hospital form October 2008 to September 2009, where 60 patients of septic abortions in above period were collected by history examination, management, complications and associated morbidity and mortality. Results : 58.3% of septic abortion patients came from lower class, 70% of them were residing in urban slum area, 96.7% were married 44% of them were illiterate, 85% of them did not use any contraceptive methods although they didn't want to increase their family. 78.3% needed surgical treatment, 23.7% needed major surgery like laparotomy, average duration of hospital stay was 12.08 days and 8.33% patients came with septicemic shock and died. Conclusion: Septic abortion is an important contributor to maternal morbidity and mortality, increasing the burden not only the patients but health workers and their resources. Chattagram Maa-O-Shishu Hospital Medical College Journal Volume 12, Issue 3, September 2013: 20-22


2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Yunike Veronika ◽  
Joserizal Resudji ◽  
Susila Sastri

AbstrakPreeklampsia dan eklampsia merupakan penyebab utama morbiditas dan mortalitas ibu dan bayi di dunia, dimana terjadi penurunan albumin serum (hipoalbuminemia) sehingga tekanan hipovolemik intravaskular berkurang. Tujuan penelitian ini adalah untuk mengetahui hubungan kadar albumin serum dengan morbiditas dan mortalitas maternal pasien preeklampsia berat dan eklampsia. Penelitian ini bersifat analitik observasional retrospektif dilakukan dengan desain cross sectional study. Populasi penelitian adalah seluruh data rekam medis pasien preeklampsia berat dan eklampsia di RSUP Dr. M. Djamil Padang periode Januari 2012 – Desember 2012. Sampel ditetapkan dengan teknik total sampling sehingga didapatkan sampel sebanyak 133 kasus. Pengolahan data dilakukan secara komputerisasi dan analisis dengan uji chi-square. Hasil penelitian menunjukkan angka kejadian morbiditas maternal adalah 33,8%, mortalitas maternal 3,8% dan 3,8% pasien dengan hipoalbuminemia. Dari hasil analisis, tidak terdapat hubungan yang bermakna antara kadar albumin serum dengan morbiditas dan mortalitas maternal pasien preeklampsia berat dan eklampsia, dimana nilai p=1 untuk hubungan kadar albumin serum dengan morbiditas maternal dan p=0,177 untuk hubungan kadar albumin serum dengan mortalitas maternal pasien preeklampsia berat dan eklampsia (p>0,05).Kata kunci: preeklampsia berat, eklampsia, albumin serum AbstractPreeclampsia and eclampsia are major causes of maternal and fetal morbidity and mortality in the world, in which serum albumin decreases (hypoalbuminemia) so hypovolemic intravascular pressure will be reduced. The objective of this study was to determine the relation between serum albumin levels and maternal morbidity and mortality of severe preeclampsia and eclampsia patients. A retrospective observational analytical research was conducted with a cross sectional study design. The study population was the entire medical records of severe preeclampsia and eclampsia patients in RSUP Dr. M. Djamil Padang, period January 2012 – December 2012. The sample was determined by total sampling technique which obtained a sample of 133 cases. Data processing was computerized and analyzed by chi-square test. The incidence of maternal morbidity was 33.8%, maternal mortality was 3.8%, and 3.8% patients were with hypoalbuminemia. The analysis result obtained there was no significant correlation between serum albumin levels and maternal morbidity and mortality of severe preeclampsia and eclampsia patients, in which p=1 for serum albumin levels correlation with maternal morbidity and p=0.177 for serum albumin levels correlation with maternal mortality of severe preeclampsia and eclampsia patients (p>0.05).Keywords: severe preeclampsia, eclampsia, serum albumin


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