scholarly journals The Potency of Artocarpus Heterophyllus Leaf as a Facial Skin Care Ingredient in Clay Mask Formulation

2019 ◽  
Vol 7 (6) ◽  
pp. 51-54
Author(s):  
Tri Widyawati ◽  
Siti Syarifah ◽  
Milahayati Daulay ◽  
Fitri Mustanti Lolyta
Keyword(s):  
Antioxidant Activity ◽  
Ethanol Extract ◽  
Skin Care ◽  
Control Group ◽  
Facial Skin ◽  
Artocarpus Heterophyllus ◽  
Whitney Test ◽  
Group A ◽  
Antimicrobial And Antioxidant Activity ◽  
Skin Moisture

Artocarpus heterophyllus (Ah), common name as nangka,  has been reported to have antidiabetic, antihyperlipidemia, antimicrobial and antioxidant activity. Balinese women used its leaves for facial treatment. This study aims to evaluate its leaf potency for facial skin care. Ethanol extract of Ah (EEAh) that obtained by maceration was prepared into 3 clay mask formulations (FI: 1%, FII:3% and FIII:5%). F0 was used as control group. A total of 12 volunteers were treated with clay mask to evaluate its effect on moisture and pores size after intervention. The data were analysed using Kruskall Wallis and Mann Whitney test. The results showed that skin moisture increased after intervention (FI:3.7%; FII:4.7%;FIII:7.3%). Pores size decreased in FI (6.3%) and FII (13.4%). Statistically, there were significant different between F0-F1 (p=0.043), F0-F2 and F0-F3 (p=0.046 of each). The present study conclude that clay mask containing A. heterophyllus leaf ethanol extract have potency to be used as facial skin care.  

scholarly journals Anti-Aging Activities of Asparagus Gel Ethanol Extract in Cosmetic Gel Agent for Facial Skin

2021 ◽  
Vol 53 (3) ◽  
pp. 119-125
Author(s):  
Henny Safrita Ginting ◽  
◽  
Edy Fachrial ◽  
I Nyoman Ehrich Lister ◽  
Adek Amansyah
Keyword(s):  
Antioxidant Activity ◽  
Free Radicals ◽  
Oil Content ◽  
Spectroscopic Method ◽  
Antioxidant Properties ◽  
Ethanol Extract ◽  
Total Phenol ◽  
Facial Skin ◽  
Antioxidant Assay ◽  
Skin Moisture

Asparagus is a vegetable that contains phenolic compounds with antioxidant properties that scavenges aging-triggering free radicals. This study aimed to investigate the components and anti-aging potentials of Ethanol Extract form Asparagus (EEA). The study was performed in February 2020 at the Pharmacy Laboratory, University of North Sumatera. The EEA was obtained through maceration using 96% ethanol. An antioxidant assay was performed and the total phenol and flavodoid content were determined using the spectroscopic method. Three gel formulas with different concentrations of EEA was prepared (F1: 1.5%, F2: 2.5%, and F3: 3.5%), and F0 was used as control. The parameters evaluated were moisture, oil content, texture, collagen, wrinkle, pigment, sensitivity, and pore. The result showed that asparagus had a moderate antioxidant activity (IC50: 118,992) with the total phenol and flavonoid contents of 15,9407 mg GAE/g and 3,2286 mg QE/g extract, respectively. The highest aging activities was seen in F3 (3.5%), followed by F2 (2.5%) and F1 (1.5%). The percentage of moisture, oil, texture, collagen, wrinkle, spot, sensitivity, and pore recovery were found to be 40.15%, 49.73%, 71.76%, 17.70%, 70.93%, 49.34%, 42.56% and 25.31%, respectively. Hence, it can be concluded that the EEA Gel at the highest concentration (3.5%) has a high content of phenol and flavonoid which can improve the skin moisture, oil content, texture, collagen, wrinkles, spots, sensitivity, and pores, which promotes anti-aging activities.

Effect of Opuntia dejecta (Salm-Dyck) flowers in liver of fructose-fed rats: Biochemicals, enzymatic and histological studies

2021 ◽  
pp. 096032712110134
Author(s):  
O Zouaoui ◽  
K Adouni ◽  
A Jelled ◽  
A Thouri ◽  
A Ben Chrifa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Body Weight ◽  
Diabetes Type 2 ◽  
Male Rats ◽  
Control Group ◽  
Standard Drug ◽  
High Fructose ◽  
Group A ◽  
Histological Architecture

Phytochemical composition and antioxidant activity of flowers decoction at post-flowering stage (F3D) of Opuntia dejecta were determined. The obtained findings demonstrate that F3D has a marked antioxidant activity in all tested assays. Furthermore, the present study was designed to test the protective activity of F3D against induced Diabetes type 2 (DT2) in male rats. Those metabolic syndromes were induced by a high-fructose diet (HFD) (10% fructose solution) for a period of 20 weeks. F3D was administered orally (100 and 300 mg/kg body weight) daily for the last 4 weeks. Metformin (150 mg/kg body weight) was used as a standard drug and administrated orally for the last 4 weeks. The results showed a significant increase in blood glucose, triglycerides and hepatic markers (ALAT, ASAT and ALK-P) in HFD group. A significant increase in hepatic TBARS and a significant decrease in SOD, CAT and GPX were observed in fructose fed rats compared to control group. Administration of F3D showed a protective effect in biochemical and oxidative stress parameters measured in this study. Also, oral administration of F3D restored the histological architecture of rat liver in comparison with rats fed HFD. In conclusion, F3D attenuated hepatic oxidative stress in fructose-fed rats.

scholarly journals Antioxidant activity test of ethyl acetate fraction of binjai (Mangifera Caesia) leaf ethanol extract

2018 ◽  
Vol 51 (4) ◽  
pp. 164
Author(s):  
K. Khairiah ◽  
Irham Taufiqurrahman ◽  
Deby Kania Tri Putri
Keyword(s):  
Antioxidant Activity ◽  
Ascorbic Acid ◽  
Ethyl Acetate ◽  
Secondary Metabolite ◽  
Antioxidant Properties ◽  
Linear Connection ◽  
Sampling Technique ◽  
Ethanol Extract ◽  
Ethyl Acetate Fraction ◽  
Control Group

Background: Binjai (Mangifera caesia) is a herb derived from South Kalimantan possessing antioxidant properties which promote wound healing inhibiting oxidation radicals. The natural antioxidants present in binjai leaves can be extracted by fractionation. Purpose: This study aimed to analyze the antioxidant activity of ethyl acetate fraction in 96% ethanol extract of binjai leaf. Methods: The study constituted a pure experimental study incorporating a post-test design with only random sampling technique consisting of two groups, namely; an ethyl acetate fraction as the treatment group and ascorbic acid as the positive control group. The leaves were treated in accordance with the soxhlet method and subsequently fractionated to extract ethyl acetate fraction. This was used to measure antioxidant activity with DPPH radical damping method using a UV-Vis spectrophotometer. A linear regression calculation was performed with a standard curve to quantify the IC50 value, before the ethyl acetate fraction underwent a qualitative test of secondary metabolite. Results: An independent t-test indicated significant differences between groups, an average value of IC50 in ascorbic acid of 13.812 ppm with 0.996 linearity and a fraction of ethyl acetate 38.526 ppm with a linearity of 0.999. In contrast, at this linearity value ascorbic acid and ethyl fraction acetate demonstrate a very high linear connection between concentration and inhibition. A secondary metabolite test conducted on the ethyl acetate fraction produced positive results for flavonoid, tannins, and phenol. Conclusion: Based on the IC50 parameters, the fraction of ethyl acetate in 96% ethanol extract of binjai leaf produces very strong antioxidant activity in the content of the compounds in the fraction, namely: flavonoid, tannins and phenol.

scholarly journals Effect of Drying and Steeping Temperatures on the Phenolic Content, Antioxidant Activity, Aromatic Compounds and Sensory Properties of Cunila polyantha Benth. Infusions

Processes ◽  
2020 ◽  
Vol 8 (11) ◽  
pp. 1378
Author(s):  
Karla Araceli Silva-Ramírez ◽  
Dioselina Álvarez-Bernal ◽  
Ernesto Oregel-Zamudio ◽  
Cecilia Guízar-González ◽  
José Roberto Medina-Medrano
Keyword(s):  
Antioxidant Activity ◽  
High Performance ◽  
Phenolic Content ◽  
Epigallocatechin Gallate ◽  
Sensory Properties ◽  
Control Group ◽  
Preparation Conditions ◽  
Tea Infusions ◽  
Group A ◽  
Nutraceutical Properties

Cunila polyantha Benth. (Lamiaceae), an aromatic plant endemic to Mexico, is used in traditional medicine as tea infusions. In this study, the effects of different drying and steeping temperatures on the phenolic content and composition, antioxidant activity, volatile composition, and sensory properties of C. polyantha infusions were determined. Commercial green tea (Camellia sinensis L. Kuntze) was used as a control. The phenolic compounds identified in the C. polyantha infusions by high-performance liquid chromatography (HPLC) include phenolic acids such as gallic acid, chlorogenic acid, caffeic acid, and p-coumaric acid, flavonoids such as epigallocatechin gallate, protocatechin, quercetin, and naringenin, as well as the phenolic aldehyde vanillin. The C. polyantha infusions showed scavenging activity of DPPH• and ABTS•+ radicals as well as relevant antioxidant capacity, which was dependent on tea preparation conditions. A total of 46 volatile organic compounds (VOCs) were detected from the leaves and flowers of C. polyantha, while in the control group, a total of 30 VOCs were identified. Differences in consumer acceptability of C. polyantha infusions prepared at different conditions were observed. This research highlights the importance of linking sensory and chemical data to obtain the best sensorial quality and the optimal nutraceutical properties in C. polyantha infusions.

scholarly journals Elaeagnus glabra f. oxyphylla Attenuates Scopolamine-Induced Learning and Memory Impairments in Mice by Improving Cholinergic Transmission via Activation of CREB/NGF Signaling

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1205 ◽  
Author(s):  
Eunjin Sohn ◽  
Hye-Sun Lim ◽  
Yu Jin Kim ◽  
Bu-Yeo Kim ◽  
Joo-Hwan Kim ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Ethanol Extract ◽  
Treated Group ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Tunel Staining ◽  
Therapeutic Effects ◽  
Memory Impairments ◽  
Group A ◽  
Ngf Signaling

We aimed to investigate the therapeutic effects of an Elaeagnus glabra f. oxyphylla (EGFO) ethanol extract in mice with scopolamine-induced memory dysfunction. Fifty male mice were randomly divided into a normal control group, a scopolamine-treated group, a scopolamine and EGFO extract-treated group, and a scopolamine and tacrine-treated group. EGFO (50 or 100 mg/kg/day) was received for 21 days. Step-through passive avoidance and Y-maze tests were performed to examine the effects of treatment on learning and memory impairments. Acetylcholine (Ach) levels and acetylcholinesterase (AchE) activity were measured via an enzyme-linked immunosorbent assay (ELISA). Levels of choline acetyltransferase (ChAT), nerve growth factor (NGF), cAMP response element-binding protein (CREB), and apoptosis-related protein expression were determined via Western blot analysis. EGFO pretreatment significantly attenuated scopolamine-induced memory impairments, relative to findings observed in the scopolamine-treated group. Levels of cholinergic factors in the brain tissues were markedly attenuated in the scopolamine-treated group. EGFO treatment also attenuated neural apoptosis in scopolamine-treated mice by decreasing the expression of apoptosis-related proteins such as Bax, Bcl2, cleaved caspase-3, and TUNEL staining. These results suggest that EGFO improves memory and cognition in a mouse model of memory impairment by restoring cholinergic and anti-apoptotic activity, possibly via activation of CREB/NGF signaling.

scholarly journals UJI EFEK ANTELMINTIK EKSTRAK ETANOL DAUN PINANG YAKI (Areca vestiaria) TERHADAP CACING GELANG (Ascaris lumbricoides) SECARA IN VITRO

PHARMACON ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 457
Author(s):  
Tirza Roring ◽  
Herny E. I. Simbala ◽  
Edwin De Queljoe
Keyword(s):  
Cell Membrane ◽  
Ascaris Lumbricoides ◽  
Endemic Species ◽  
Ethanol Extract ◽  
Control Group ◽  
Whitney Test ◽  
Post Test ◽  
Ethanol Extracts ◽  
Anthelmintic Effect

ABSTRACT Pinang Yaki (Areca vestiaria) is an endemic species of Sulawesi palm, which has unique characteristics that have been used as medicine , to treat various. Ethanol extracts of pinang yaki leaves contains tannin compounds that can inhibit the work of enzymes, interfere with digestive metabolic processes, and damage the worm cell membrane. This study aims to determine the anthelmintic effect of ethanol extract of pinang yaki leaves obtained from the Tomohon area against roundworms (Ascaris lumbricoides). The sample was extracted by maceration method using ethanol solvent. The test used ethanol extracts f pinang yaki leaves with a concentration of 5%, 10%, and 20%, respectively. The worms were incubated at a temperature of 37ºC, and examined for 24 hours at 6 hour intervals. The number of lysis worms and paralysis was recorded every 6 hours and the data were analyzed using the Kruskal Wallis test and continued using the Mann Whitney test. The results showed an anthelmintic effect of ethanol extracts of pinang yaki leaves on roundworms (Ascaris lumbricoides) in vitro.Keywords         : Anthelmintic, Ethanol extracts of areca leaf, Areca vestiaria, Ascaris lumbricoides  ABSTRAK Pinang Yaki (Areca vestiaria) merupakan jenis palem endemik Sulawesi yang memiliki karakteristik yang unik telah dimanfaatkan sebagai obat, untuk mengobati berbagai penyakit. Ekstrak etanol daun pinang yaki mengandung senyawa tanin yang dapat menghambat kerja enzim, mengganggu proses metabolisme pencernaan, serta merusak membran sel cacing. Penelitian ini bertujuan untuk mengetahui adanya efek antelmintik dari ekstrak etanol daun pinang yaki yang diperoleh dari daerah Tomohon terhadap cacing gelang (Ascaris lumbricoides). Sampel diekstraksi dengan metode maserasi menggunakan pelarut etanol. Metode penelitian ini ialah eksperimen laboratorium dengan desain post test only control group. Pengujian menggunakan ekstrak etanol daun pinang yaki dengan konsentrasi 5%, 10%, dan 20%. Cacing diinkubasi pada suhu 37ºC, dan diteliti selama 24 jam dengan interval waktu 6 jam. Jumlah cacing lisis dan paralisis dicatat setiap 6 jam dan selanjutnya data dianalisis menggunakan uji Kruskal Wallis dan dilanjutkan menggunakan uji Man Whitney. Hasil penelitian menunjukkan adanya efek antelmintik dari ekstrak etanol daun pinang yaki terhadap cacing gelang (Ascaris lumbricoides) secara in vitro. Kata kunci      : Antelmintik, Ekstrak Etanol Daun Pinang Yaki, Areca vestiaria, Ascaris lumbricoides

Safety Evaluation of Crude Ethanol Extract of Waltheria Indica Linn. Root In Male Wistar Rats

2021 ◽  
Vol 3 (1) ◽  
pp. 112-125
Author(s):  
A. Basiru
Keyword(s):  
Wistar Rats ◽  
Safety Evaluation ◽  
Ethanol Extract ◽  
Serum Levels ◽  
Hepatic Necrosis ◽  
Control Group ◽  
Percentage Increase ◽  
Male Wistar Rats ◽  
Group A ◽  
Renal Tubular

Safety evaluation of Waltheria indica Linn. root was carried out in Wistar rats. Twenty adult male Wistar rats were randomly divided into four groups (n=5); A–D. Group A served as control group while groups B, C and D were administered with 200, 400 and 800 mg/Kg of crude ethanol extract of Waltheria indica Linn. root. After 28 days of administration, the rats were sacrificed and blood samples were collected and serum prepared. Haematological and biochemical parameters, as well as serum electrolyte were determined according to standard procedures. The 200 mg/Kg of Waltheria indica Linn. root caused the highest percentage increase in body weight. The kidney was also significantly increased at 400 mg/kg. The total WBC and lymphocytes counts were significantly increased at 400 mg/kg. The serum levels of ALT and chloride were significantly increased at 800 mg/kg. Waltheria indica Linn. root also caused hepatic necrosis and renal tubular degeneration in Wistar rats. Therefore, Waltheria indica Linn. root should be used with caution especially at higher dose despite its therapeutic potentials.

EFFECTIVENESS OF ANTIOXIDANT PSIDIUM GUAJAVA L LEAF EXTRACT TO MINOR TYPE RECURRENT STOMATITIS AFTOSA (RAS)

2016 ◽  
Vol 19 (2) ◽  
pp. 142-148
Author(s):  
Aida Fadhilla Darwis ◽  
Wilda Hafni Lubis
Keyword(s):  
Antioxidant Activity ◽  
Healing Process ◽  
Ethanol Extract ◽  
Psidium Guajava ◽  
Oral Disease ◽  
Group Method ◽  
Control Group ◽  
Bioactive Component ◽  
Guava Leaves ◽  
Pain Symptoms

Minor Recurrent Athous Stomatitis (RAS), known as sore that often occurs in oral disease. That characterized by ulcers and pain symptoms for 3-10 days which disrupt the activities that prompt patients seeking medication to relieve these symptoms. RAS etiology is not known clearly, some studies associate it with free radicals. Guava leaves/ Psidium guajava L have much content of bioactive component that are efficacious as analgesic, anti-inflammatory, antimicrobial / antidiarrheal, hepatoprotective and antioxidant. The purpose of this study to determine the effectiveness of antioxidant leaves of Psidium guajava L against Minor RAS by reduction of the diameter of ulcers and pain. This clinical trial was carried out using a single-blind randomized pretest posttest control group method. That consisted of 30 participants who had minor RAS with 15 people got extract gel Psidium guajava L 3% as a treatment group and 15 others received placebo (basic gel) as a control group. Ethanol extract was obtained by maceration method and antioxidant activity test by DPPH (dipheniyl picrylhidrazil) method. This study shows the results of the ethanol extract of leaves of Psidium guajava L has a very strong antioxidant activity with IC50 value of 22.39 ppm. Gel extracts give a a meaningful effect on the healing SAR with statistically significant in the reduction of ulcers diameter p 0.007 by repeated Annova test and a reduction in pain scores p <0.001 by Friedman test. In conclusion, extract Psidium guajava Linn leaves as a high antioxidant content effective promotion the healing process by reduced diameter ulcer and pain of Minor SAR.

scholarly journals Ekstrak Etanol Daun Kacang Panjang (Vigna unguiculata (L.) Walp): Kajian Morfometri Insula Pankreatika Model Tikus Diabetes

2019 ◽  
Vol 5 (2) ◽  
pp. 183
Author(s):  
Puput Octaviani Solehah ◽  
Fikhta Agnesya Tarusu ◽  
Joni Tandi ◽  
Niluh Puspita Dewi ◽  
Gabriella Bamba Ratih Lintin ◽  
...  
Keyword(s):  
Pancreatic Islet ◽  
Vigna Unguiculata ◽  
Therapy Group ◽  
Statistical Tests ◽  
Ethanol Extract ◽  
Diabetic Rat ◽  
Control Group ◽  
Blood Levels ◽  
Group A ◽  
Group B

Diabetes is characterized by an increasing of blood levels and progressive changes in the structure of pancreatic islet of pancreas. Natural ingredients that contain antioxidants such as some cowpea leaves can be an alternative treatment for diabetes. This study aims to examine the effect of ethanol extract of some cowepea leaves (Vigna unguiculata (L.) Walp) on morphometry (perimeter and diameter) of pancreatic islet of diabetic rat models. The type of research is quasi-experimental with posttest group design. Samples were 30 male wistar rats, age 8 weeks, BW 250-300 grams, that induced by single dose of STZ 40 mg/kg BW. Rats were divided into 5 groups. Group A: normal control, Group B: negative control, Group C: positive control, Group D: DM rats with 100mg/Kg BW extract therapy, Group E: DM rats with 200mg/Kg BW extract therapy, Group F: DM rats with extract therapy 300mg/Kg BW. Blood sugar levels were measured on days 7, 14 and 21. Pancreatic tissue was prepared with 5μm thickness and stained with Hematoxylin Eosin. The sample was observed under 400x magnification microscope. The observation uses Image J software to measure the perimeter and diameter of the pancreatic insula. Data were analyzed by non-parametric Kruskal Wallis and post hoct Mann Whitney statistical tests. Blood glucose level was obtained on 21st day with the highest mean in group B (246.8±156.3) and lowest in group A (67.2 ±7.85), perimeter of pancreatic islet was significantly different (p=0.026), the diameter is significantly different (p =0.046). Ethanol extract of some cowpea (Vigna unguiculata (L.) Walp) leaves with dose of 300mg/kgBB helps to restore the blood and morphometry of pancreatic islet model of diabetic rats.

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