Mesenchymal Stromal Cells Adapt to Chronic Tendon Disease Environment with an Initial Reduction in Matrix Remodeling

Tendon lesions are common sporting injuries in humans and horses alike. The healing process of acute tendon lesions frequently results in fibrosis and chronic disease. In horses, local mesenchymal stromal cell (MSC) injection is an accepted therapeutic strategy with positive influence on acute lesions. Concerning the use of MSCs in chronic tendon disease, data are scarce but suggest less therapeutic benefit. However, it has been shown that MSCs can have a positive effect on fibrotic tissue. Therefore, we aimed to elucidate the interplay of MSCs and healthy or chronically diseased tendon matrix. Equine MSCs were cultured either as cell aggregates or on scaffolds from healthy or diseased equine tendons. Higher expression of tendon-related matrix genes and tissue inhibitors of metalloproteinases (TIMPs) was found in aggregate cultures. However, the tenogenic transcription factor scleraxis was upregulated on healthy and diseased tendon scaffolds. Matrix metalloproteinase (MMPs) expression and activity were highest in healthy scaffold cultures but showed a strong transient decrease in diseased scaffold cultures. The release of glycosaminoglycan and collagen was also higher in scaffold cultures, even more so in those with tendon disease. This study points to an early suppression of MSC matrix remodeling activity by diseased tendon matrix, while tenogenic differentiation remained unaffected.

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Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

European Surgical Research ◽

10.1159/000366418 ◽

2014 ◽

Vol 54 (1-2) ◽

pp. 1-13 ◽

Cited By ~ 17

Author(s):

Tyge Nordentoft ◽

Hans-Christian Pommergaard ◽

Jacob Rosenberg ◽

Michael Patrick Achiam

Keyword(s):

Systematic Review ◽

Fibrin Glue ◽

Healing Process ◽

Gastrointestinal Surgery ◽

Experimental Studies ◽

Positive Influence ◽

Qualitative Synthesis ◽

Negative Effect ◽

The Difference ◽

Positive Effect

Background/Aim: Anastomotic leakage remains a frequent and serious complication in gastrointestinal surgery. In order to reduce its incidence, several clinical and experimental studies on anastomotic sealing have been performed. In a number of these studies, the sealing material has been fibrin glue (FG), and the results in individual studies have been varying. The positive effect of anastomotic sealing with FG might be due to the mechanical/physical properties, the increased healing of the anastomoses or both. The aim of this systematic review was to evaluate the existing evidence on the healing effects of FG on gastrointestinal anastomoses. Methods: PubMed, EMBASE and the Cochrane databases were searched for studies evaluating the healing process of gastrointestinal anastomoses after any kind of FG application. The search period was from 1953 to December 2013. Results: Twenty-eight studies were included in the qualitative synthesis. These studies were all experimental studies, since no human studies used histological or biochemical evaluation of healing. In 7 of the 28 studies, a positive effect of FG on healing was found, while 8 studies reported a negative effect and 11 studies found no effect. Furthermore, 2 studies reported unclear results. The difference in the study outcome was independent of the study design and the type of FG used. Conclusion: In the available studies, FG did not consistently have a positive influence on the healing of gastrointestinal anastomoses. It is consequently plausible that the positive effect of FG sealing of gastrointestinal anastomoses, if there is any, may be due to a mechanical sealing effect rather than due to improved healing per se.

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The Influence of Effectiveness Managerial, Task Commitment and Work Ethic for Employee Performance Regional Water Company (Pdam) Tirta Bhagasasi Bekasi

International Journal of Science and Engineering Invention ◽

10.23958/ijsei/vol04-i08/04 ◽

2018 ◽

Vol 4 (08) ◽

Author(s):

Kusnadi .

Keyword(s):

Work Ethic ◽

Employee Performance ◽

Positive Influence ◽

Managerial Effectiveness ◽

Performance Task ◽

Water Company ◽

Managerial Task ◽

Positive Effect ◽

Regional Water ◽

Task Commitment

The purpose of this study was to test the effect of managerial effectiveness to employee performance, task commitment to employee performance, work ethic on the performance of employees, managerial effectiveness to task commitment, managerial effectiveness to the work ethic and the work ethic of the commitment of the employee's duties Regional Water Company (PDAM) Tirta Bhagasasi Bekasi. This research was conducted using the method suryey with path analysis in hypothesis testing. In this study, employees were selected as sample there are 96 employees who selected a random sample by strata or stratified random sampling from a total population of 127 respondents. Took this instrument before being used for the data to test the validity and reliability. The results of this study are as follows: There is a direct positive influence on employee performance managerial effectiveness. There is a direct positive influence on employee performance task commitment. There is a direct positive influence on employee performance work ethic. There is a direct positive influence on the effectiveness of managerial task commitment. There is a direct positive effect managerial effectiveness to the work ethic. There is a direct positive effect on the work ethic of commitment to the task.

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Analisis Peranan Kepuasan Dan Komitmen Sebagai Perantara Pengaruh Kualitas Jasa Tutorial Online Terhadap Loyalitas Mahasiswa

Jurnal Manajemen ◽

10.31937/manajemen.v9i2.718 ◽

2018 ◽

Vol 9 (2) ◽

pp. 18-32

Author(s):

Andy Mulyana ◽

Devi Ayuni

Keyword(s):

Service Quality ◽

Structural Equation ◽

Positive Influence ◽

Management Program ◽

Equation Modeling ◽

Online Tutorial ◽

Student Loyalty ◽

The Relationship ◽

Positive Effect

This study aims to evaluate the role of satisfaction and commitment as mediating the effect of service quality on student loyalty as the user of Open University's Online Tutorial. Based on data analysis on student of Management program 229 as respondents with Structural Equation Modeling (SEM), this study found the relationship between: (1) positive influence of service quality to satisfaction and loyalty of students using tuton; (2) the positive effect of satisfaction on student loyalty using tuton; (3) satisfaction is a mediator between service quality and loyalty of students using tuton. Conversely, commitment has no positive effect on student loyalty as a tuton user. In addition, commitment does not mediates the effect of satisfaction on the loyalty of tuton users. Keywords: service quality, satisfaction, commitment, loyalty

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Analisa Pengaruh Professionalism dan Rewards Terhadap Job Satisfaction Serta Implikasinya Pada Organizational Commitment; Telaah Pada Sopir Taksi Konvensional Bandara Soekarno-Hatta

Jurnal Manajemen ◽

10.31937/manajemen.v9i2.716 ◽

2018 ◽

Vol 9 (2) ◽

pp. 1-17

Author(s):

Aldo Winata

Keyword(s):

Job Satisfaction ◽

Organizational Commitment ◽

Structural Equation ◽

Sampling Technique ◽

Positive Influence ◽

Primary Data ◽

Equation Modeling ◽

Taxi Driver ◽

Probability Method ◽

Positive Effect

Jakarta is the place where the largest number of land transportation in Indonesia, according to Djarot in Kompas.com article, vehicles every day increased about 1500 units. And according to an article from Liputan 6, revenue from conventional taxi drivers dropped dramatically after the entry of online transport by 40-50% during 2016 due to the entry of online transport. Conventional taxi companies must immediately anticipate this phenomenon so that their human resources can survive in the company. The purpose of this research are first, to know is there a positive effect from professionalism factors to organizational commitment and job satisfaction. Second, to know job satisfaction factors have a positive effect to organizational commitment. And the last is to know is there a positive effect from rewards factors to job satisfaction and organizational commitment’s factors. This research uses descriptive method with non-probability method. Through judgmental sampling technique, primary data collection was obtained from questionnaire distribution to conventional taxi driver of Soekarno-Hatta Airport. The data has been collected and then obtained by using Structural Equation Modeling (SEM). The result of this research indicates that there is positive influence from professionalism to organizational commitment but the data do not support the hypothesis, there is positive influence from professionalism to job satisfaction, but there’s negative effect between job satisfaction and organizational commitment, there is positive relation of rewards to job satisfaction, Finally there is a positive effect of rewards on organizational commitment. Keywords: organizational commitment, professionalism, rewards, job satisfaction, ecommerce, conventional taxi driver.

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Evaluation of the Significance of Constant Laser Therapy, 532 nm, in Various Exposure Times on the Healing Process of Wounds Infected by Acinetobacter baumannii

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734620984039 ◽

2021 ◽

pp. 153473462098403

Author(s):

Zahra Al-Timimi

Keyword(s):

Acinetobacter Baumannii ◽

Laser Therapy ◽

Continuous Wave ◽

Healing Process ◽

Positive Influence ◽

Semiconductor Diode ◽

Thickness Skin ◽

Scale Range ◽

The Times ◽

532 Nm

Many considerable investigations focused on the stimulation of therapeutic manners of infected injuries in mice. The exaggerated pathogens that induced wounds were gram-positive like staphylococcal and gram-negative, for example, Pseudomonas aeuroginosa and Acinetobacter baumannii. Acinetobacter can generate a scale range of an infection that may be received in a hospital or any wellness concern facility. In order to know the significance of laser 532 nm with a constant irradiance at various exposure times on the healing process of wounds infected by Acinetobacter baumannii, this study was performed on the BALB/C mice. An elliptical full-thickness skin injury was made on the backside of 45 adult female (BALB/C) mice. Injuries were affected via Acinetobacter baumannii and were randomly assigned into 3 groups. Semiconductor diode continuous wave laser, λ = 532 nm, with output power 40 mW was used. The power density was 5.71 mW/cm2, while the fluencies were 1.7 J/cm2 and 5.14 J/cm2. Fifteen mice were classified according to the times of irradiation. The first group was infected and presented as control, without irradiation. The second group was infected and irradiated for 5 minutes. The third group, likewise, was infected but irradiated for 15 minutes. All groups were subdivided according to the following period, 3, 5, and 10 days, after irradiation and the animals were killed after the treatment. Wound healing was made by measuring the rate of wound closure and histopathological evaluation. The study determined that 532 nm laser therapy had an obvious and positive influence on the healing of infected wounds with fluence (5.14 J/cm2).

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Sustainable Competitive Advantage through Entrepreneurship, Market-Oriented Culture, and Trust

Sustainability ◽

10.3390/su13073986 ◽

2021 ◽

Vol 13 (7) ◽

pp. 3986

Author(s):

Jun-Chul Ha ◽

Jun-Woo Lee ◽

Jee Young Seong

Keyword(s):

Work Engagement ◽

Risk Taking ◽

Choice Theory ◽

Business Environment ◽

Positive Influence ◽

Mediating Effect ◽

Sustainable Competitive Advantage ◽

The Relationship ◽

Positive Effect ◽

Significant Positive Influence

In a rapidly changing business environment, the entrepreneurship of top management is essential for the survival and sustainable development of the enterprise. Building on the view of the strategic choice theory, this study identifies the relationship between entrepreneurship, market-oriented culture, and work engagement. Data were collected from 493 employees regularly working in small and medium-sized firms in South Korea. The results of this study indicate: (1) entrepreneurship (consisting of innovation, proactiveness, and risk-taking) has a significant positive influence on market-oriented culture, (2) entrepreneurship positively affects work engagement, (3) market-oriented culture has a significant positive effect on work engagement, (4) the effects of innovation and proactiveness on work engagement are significant, controlling for market-oriented culture, showing the partial mediating effect of market-oriented culture on work engagement, and (5) CEO trust moderates the relationship between risk-taking and work engagement. Theoretical and practical implications are suggested.

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Get Close to the Robot: The Effect of Risk Perception of COVID-19 Pandemic on Customer–Robot Engagement

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18126314 ◽

2021 ◽

Vol 18 (12) ◽

pp. 6314

Author(s):

Jifei Wu ◽

Xiangyun Zhang ◽

Yimin Zhu ◽

Grace Fang Yu-Buck

Keyword(s):

Risk Perception ◽

Perceived Risk ◽

Hospitality Industry ◽

Positive Influence ◽

Mediating Effect ◽

Service Robots ◽

Industry Analysis ◽

Social Distancing ◽

Risk Seeking ◽

Positive Effect

The purpose of this study was to examine the effect of the COVID-19 pandemic on customer–robot engagement in the Chinese hospitality industry. Analysis of a sample of 589 customers using service robots demonstrated that the perceived risk of COVID-19 has a positive influence on customer–robot engagement. The positive effect is mediated by social distancing and moderated by attitudes towards risk. Specifically, the mediating effect of social distancing between the perceived risk of COVID-19 and customer–robot engagement is stronger for risk-avoiding (vs. risk-seeking) customers. Our results provide insights for hotels when they employ service robots to cope with the shock of COVID-19 pandemic.

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Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair

Cells ◽

10.3390/cells7100167 ◽

2018 ◽

Vol 7 (10) ◽

pp. 167 ◽

Cited By ~ 52

Author(s):

Muhammad Nawaz ◽

Neelam Shah ◽

Bruna Zanetti ◽

Marco Maugeri ◽

Renata Silvestre ◽

...

Keyword(s):

Extracellular Matrix ◽

Extracellular Vesicles ◽

Tissue Repair ◽

Metabolic Diseases ◽

Bioactive Molecules ◽

Tissue Inhibitors Of Metalloproteinases ◽

Matrix Remodeling ◽

Pathological Conditions ◽

Potential Applications ◽

Non Coding Rnas

Extracellular vesicles (EVs) are membrane enclosed micro- and nano-sized vesicles that are secreted from almost every species, ranging from prokaryotes to eukaryotes, and from almost every cell type studied so far. EVs contain repertoire of bioactive molecules such as proteins (including enzymes and transcriptional factors), lipids, carbohydrates and nucleic acids including DNA, coding and non-coding RNAs. The secreted EVs are taken up by neighboring cells where they release their content in recipient cells, or can sail through body fluids to reach distant organs. Since EVs transport bioactive cargo between cells, they have emerged as novel mediators of extra- and intercellular activities in local microenvironment and inter-organ communications distantly. Herein, we review the activities of EV-associated matrix-remodeling enzymes such as matrix metalloproteinases, heparanases, hyaluronidases, aggrecanases, and their regulators such as extracellular matrix metalloproteinase inducers and tissue inhibitors of metalloproteinases as novel means of matrix remodeling in physiological and pathological conditions. We discuss how such EVs act as novel mediators of extracellular matrix degradation to prepare a permissive environment for various pathological conditions such as cancer, cardiovascular diseases, arthritis and metabolic diseases. Additionally, the roles of EV-mediated matrix remodeling in tissue repair and their potential applications as organ therapies have been reviewed. Collectively, this knowledge could benefit the development of new approaches for tissue engineering.

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Insights into the Positive Effect of Pyraclostrobin on Sugarcane Productivity

Agronomy ◽

10.3390/agronomy8070122 ◽

2018 ◽

Vol 8 (7) ◽

pp. 122 ◽

Cited By ~ 3

Author(s):

Amanda Moreira Lopes ◽

Pedro Schumacher ◽

Aurora Terylene Pérez Martínez ◽

Antônio Paulino da Costa Netto ◽

Antonio Chalfun-Junior

Keyword(s):

Block Design ◽

Positive Influence ◽

Randomized Block Design ◽

Rate Of Photosynthesis ◽

Enzyme Superoxide Dismutase ◽

Management Techniques ◽

Stalk Yield ◽

Sugarcane Productivity ◽

High Yields ◽

Positive Effect

Achieving high yields is a challenge for sugarcane producers due to the diverse environmental conditions to which the crop is subjected. In tropical and subtropical regions, where sugarcane is typically cultivated, crop diseases are common. This necessitates the development of disease management techniques. Among these techniques, chemical control is of particular significance due to the development of new antifungal agents, such as pyraclostrobin. For some crops, pyraclostrobin has a positive influence on yield due to its effects on plant physiology. The aim of this study was to evaluate the physiological responses and yield of three sugarcane cultivars treated with the fungicide, pyraclostrobin. The experiment was performed in a randomized block design (RBD) with a split-plot arrangement; the variables analyzed were the application or non-application of fungicide in the plots and, in the subplots, the evaluation times after fungicide application. Both the rate of photosynthesis and the antioxidant enzyme (Superoxide Dismutase, Catalase and Ascorbate Peroxidades) activity increased in plants treated with fungicide in comparison to untreated plants, and in the RB855156 cultivar the stomatal conductance, transpiration, and nocturnal respiratory rate were increased. Furthermore, application of pyraclostrobin increased stalk yield and the green biomass index in the RB855156 and RB86751 sugarcane cultivars. In certain cultivars of sugarcane, application of pyraclostrobin leads to an increased yield.

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INFLUENCE OF STATE GRANTS UPON EFFECTIVENESS OF THE ENTERPRISES IN THE AGRICULTURAL SECTOR

Trakia Journal of Sciences ◽

10.15547/tjs.2020.s.01.097 ◽

2020 ◽

Vol 18 (Suppl.1) ◽

pp. 607-613

Author(s):

D. Stoyanova ◽

D. Stoyancheva

Keyword(s):

Empirical Data ◽

Agricultural Sector ◽

Positive Influence ◽

Innovation Activity ◽

Investment Activity ◽

Agricultural Enterprises ◽

State Grants ◽

The Impact ◽

Positive Effect

This report aims to analyze the impact of state grants upon the effectiveness efficiency of the enterprises in the Agricultural sector. The presence/absence of the correlation between the “received state grants - financial results from the activity of the agricultural enterprises” was studied. The efficiency of agricultural enterprises is expressed through the indicators of profitability and productivity. The empirical data for a period of 10 years 2008 – 2017 were shown in the study. The main activities of the surveyed enterprises are crop, livestock and combined - crop-livestock. Based on the results obtained, it is expected that the receipt of grants will have a positive influence on the performance of enterprises in the agricultural sector, measured by indicators of effectiveness and productivity. The following research hypotheses have been proved: the positive effect of the grant is more obvious in larger agricultural enterprises, which have higher productivity and profitability compared to small and medium-sized farms; agricultural enterprises which receive grants and are characterized by higher investment activity and are also characterized by higher innovation activity; based on the predominant number of crop enterprises, it is assumed that this type of activity leads to the achievement of higher financial results as a result of the activity of the agricultural enterprises; the age of the enterprises, expressed through the years of their activity, contributes significantly to higher profitability and productivity of the carried out activity.

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