Features of the formation of the bacterial community of the rumen and the biochemical status of the cows depending on the protein source

2021 ◽  
pp. 3-22
Author(s):  
N. P. Buryakov ◽  
G. Yu. Laptev ◽  
M. A. Buryakova ◽  
L. A. Ilyina ◽  
D. E. Aleshin ◽  
...  
Keyword(s):  
Total Protein ◽  
Pathogenic Bacteria ◽  
Maximum Level ◽  
Rumen Content ◽  
Control Group ◽  
Protein Concentrate ◽  
Cellulolytic Bacteria ◽  
Lactating Cows ◽  
Biochemical Status ◽  
Ayrshire Breed

The results of scientific and economic experiment on the use of protein concentrate “AgroMatic” in feeding highly productive cows of Ayrshire breed during lactation have been provided in the article. The use of protein concentrate “Agro-Matic” in the rations of dairy cattle in the amount of 1,0 and 1,5 kg/head/day has been leaded to an increase in the content of cellulolytic microflora at the end of lactation compared with the control group. At the same time, the level of microorganisms that stimulate and promote immunity (bacilli, bifid bacterium) and suppress the development of pathogenic bacteria has been observed in high amounts throughout lactation in the experimental groups whose ration was put with protein concentrate. In the rumen content of cows have been receiving 1,5 kg/head/day of protein concentrate “Agro-Matic”, the increased content of bifid bacterium by 0,03 abs.% and bacilli by 0,91 abs.% has been noted. The inclusion of the maximum level of protein concentrate was characterized by the decrease in the number of pathogenic microorganisms like pathogens of mastitis and other diseases (lactobacilli, actinomycetes and enterobacteria). The total number of cellulolytic bacteria in the rumen content at the end of lactation when using 1,0 kg/head/day of protein concentrate in animals increased compared to animals that consumed the basic ration. The inclusion of protein concentrate throughout lactation contributed to the increase in the blood content of total protein and nitrogen of free amino acids. Thus, the use of protein concentrate during the feeding period increased the intensity of protein metabolism in animals. The inclusion of 1,5 kg of protein concentrate in the ration contributed to the increase in total protein in the blood by 4,6 g/l, at the level of 1,0 kg by 9,1 g/l (P > 0,95). The index of insemination when using protein concentrate in lactating cows has been decreased by 21,7 % and the duration of the period of open days by 28,2 days.

Efficiency of protein concentrate application in the rations of highly productive cows

2021 ◽  
pp. 15-25
Author(s):  
N. P. Buryakov ◽  
M. A. Buryakova ◽  
A. S. Zaikina ◽  
I. A. Kasatkina ◽  
D. E. Aleshin
Keyword(s):  
Feed Additives ◽  
The Body ◽  
Control Group ◽  
Protein Concentrate ◽  
Lactating Cows ◽  
New Information ◽  
Ayrshire Breed ◽  
Quality Of Milk ◽  
Dispensable Amino Acids

The association between science and production is gradually developing due to the arrival of new information and discoveries about the composition of feed and the transformation of nutrients in the body of cows. One of the most important links in the formation of animal productivity during lactation is the use of new feed products and feed additives in feeding. The results of scientific and economic experiment on the use of protein concentrate “Agro-Matic” in feeding of highly productive lactating cows of Ayrshire breed are contained the article. The inclusion of protein concentrate “AgroMatic” in the daily rations of lactating cows in the amount of 1,0 and 1,5 kg/head/day increases the level of indigestible protein by 6,1 and 8,9 %, respectively. The use of protein concentrate in the amount of 1,5 kg in cows feeding helps to increase the digestibility of nutrients in rations the quality of milk and the productivity of cows. When feeding protein concentrate in the amount of 1,5 kg the milk productivity of cows during the period of increasing the milk yield was 4297,5 kg of milk, the yield of essential and dispensable amino acids with milk was significantly higher. The yield of milk protein in cows that received protein concentrate in the ration in the amount of 1,0 kg was 137,7 kg, and when using 1,5 kg – 141,4 kg, which was signifi cantly higher than in the control group by 10,2 and 13,6 kg, respectively. The use of protein concentrate “Agro-Matic” in the ration had a benefi cial eff ect on the digestibility of protein. The digestibility of raw protein of the feed mixture with the inclusion of 1,5 kg of protein concentrate was 71,1 % compared to 68,0 % in the basic ration, which are used at the Maysky complex in the “Plemzavod Maysky”

Application of protein concentrate from white lupine and meat and bone meal in feeding of lactating cows

2021 ◽  
pp. 14-26
Author(s):  
N. P. Buryakov ◽  
M. A. Buryakova ◽  
A. S. Zaikina ◽  
I. A. Kasatkina ◽  
D. E. Aleshin
Keyword(s):  
Nitrogen Balance ◽  
Animal Health ◽  
Nitrogen Retention ◽  
Control Group ◽  
Protein Concentrate ◽  
Waste Products ◽  
Lactating Cows ◽  
Ayrshire Breed ◽  
Alternative Sources ◽  
High Level

The main sources of protein in the rations of lactating cows in the farms of our country are waste products of the oil extraction industry. Using them in the rations of highly productive cows in high amount is fraught with loss of productivity and deterioration of animal health due to the high level of digestible protein. With an increase in milk production the role of by-pass protein in feeding cows increases. By-pass protein in the market of feed products of our country is mainly represented by processed beans and fi shmeal. They are an excellent source of protein, which is slowly digest in the rumen, but due to its high cost, deterioration of quality, seasonality of supply the search for alternative sources of protein is relevant. The article contains practical material on the use of protein concentrate in the rations of lactating cows of Ayrshire breed. It has been noted during the studies that the inclusion of protein concentrate in the ration in the amount of 1,0 and 1,5 kg/head/day instead of other protein feeds increased the level of bypass protein. The introduction of the maximum amount of protein concentrate into the ration contributed to a change in the nitrogen balance in cows during the increasing the milk yield period. Thus, the inclusion of protein concentrate in the ration of the nitrogen balance in the experimental groups was positive, and in the control it was negative. According to the degree of use of nitrogen in the ration, the best values have been observed in cows of the 2nd and 3rd experimental groups, which had protein concentrate “Agro-Matic” in the ration, where the nitrogen retention was 189,6 and 201,2 g, respectively. The use of protein concentrate did not have a negative eff ect on the biochemical parameters of the blood. The level of total protein in the blood serum when feeding protein concentrate in the amount of 1,0–1,5 kg increased by 11,7 (P > 0,95) and 5,9 %. The level of urea decreased both when using 1,0 kg of protein concentrate (P > 0,95) and 1,5 kg, which was lower than the level in animals from the control group.

Extruded lupine as a part of energy-protein concentrate in the ration of lactating cows

2020 ◽  
pp. 65-73
Author(s):  
Z. Fedorova
Keyword(s):  
Farm Animals ◽  
Feed Consumption ◽  
Control Group ◽  
Protein Concentrate ◽  
Cattle Farm ◽  
Black And White ◽  
Lactating Cows ◽  
White Breed ◽  
Kaliningrad Region ◽  
Experimental Group

In order to fi ll the existing protein defi ciency in the rations of farm animals in particular dairy cows it is necessary to input feed lupins as widely as possible in crop rotations. Lupin is a very versatile forage crop it can be used in feed as herbage, in the form of haylage, silage, in compound feed as a protein additive, as well as a green manure crop to increase soil fertility. Questions of protein nutrition should be to be quickly resolved, both in the production of protein and in its standardized rational use. Unbalanced protein rations increase feed consumption per unit of production, thereby increasing its prime cost. In the world soya is generally recognized as a protein feed, but in the Kaliningrad region as in most of regions in our country, it does not maturate being a heat-loving crop. Under these environments the inclusion of extruded lupine grain in the composition of energy-protein concentrates for the production of compound feed has become an alternative to replacing expensive soya. The researches have been carried out it the cattle farm of LLC “Temp” in the Guryevsky area in the Kaliningrad region (March-May 2019) on feeding lactating cows energy-protein concentrate from extruded grain of narrow-leaved lupine, fl ax, triticale, subjected to heat treatment on a press extruder. For this purpose two groups of lactating cows of Black-and-White breed (control and experimental) have been formed using the method of pairs of analogs per 11 heads in each. Cows of the control group have received the main ration of the farm, and cows of the experimental group in addition to the main ration have received compound feed with extruded energy-protein concentrate based on lupine. As a result of research, the positive infl uence of energy-protein concentrate based on lupine in compound feed on the dairy productivity of cows has been established. Recipes of concentrate and compound feed with concentrate for lactating cows, the volume of inclusion of components in the concentrate and in the compound feed have been calculated. During the experiment, the milk yield in the experimental group of cows has increased by 62,4 kg or 8,0 %, than in the control group. From the cows of the experimental group the conditional profi t has been received in the amount of 1684,8 rubles per head.

scholarly journals DYNAMICS OF PROTEIN METABOLISM IN COWS WITH PROBIOTIC VETOM 1 BASED ON APATHOGENIC BACILLI

2019 ◽  
pp. 73-78
Author(s):  
G. A. Nozdrin ◽  
O. V. Lagoda ◽  
K. E. Surodina ◽  
A. G. Nozdrin ◽  
O. M. Gorshkova
Keyword(s):  
Blood Serum ◽  
Total Protein ◽  
Protein Metabolism ◽  
Biochemical Parameters ◽  
Control Group ◽  
Lactating Cows ◽  
Experimental Group

The researchers investigated the effect of new probiotic Vetom 1 based on apathogenic bacilli on the biochemical parameters of blood serum, exactly protein, albumins and urea in lactating cows. The experiment was carried out at OOO “Uchkhoz Tulinskoe”. According to the principle of pair-analogues, the researchers arranged a control group and two experimental groups of cows; each group contained 7 cows. The cows of the 1st experimental group were fed with probiotic Vetom 1 dosed 50 mg/kg once a day in the morning before milking; They received Vetom 1 every day during 5 days, then in a day during a month. The cows from the 2nd experimental group received probiotic Vetom 1 dosed 50 mg/kg once a day in the morning before milking, every day during 30 days. The application of the specimen contributed to a decrease in the concentration of total protein in the blood serum within the physiological norm. The aftereffect caused by Vetom 1 when the specimen was applied 5 days every day, then in a day during a month, the authors observed an increase in the concentration of total protein in the blood serum above the physiological standard on the 180 day of application. The similar effect was not observed when Vetom 1 was applied daily. When using Vetom 1, the authors observed a slight increase in the concentration of albumins in the blood serum, both during the period of application and up to 180 days. The specimen contributes to less prominent increase in the concentration of urea in the blood serum in comparison with the control group. Changes in concentrations of albumins and urea occurred within the physiological norm.

Influence of feeding cows with plant adaptogens on the physiological and biochemical status of lactating cows

2022 ◽  
pp. 92-99
Author(s):  
N. Yarovan ◽  
V. Masalov ◽  
K. Leshchukov ◽  
E. Ryzhkova ◽  
A. Mamaev
Keyword(s):  
Sea Buckthorn ◽  
Control Group ◽  
Lactating Cows ◽  
Biochemical Status ◽  
Group 3 ◽  
Group 2 ◽  
Daily Milk Yield ◽  
Positive Effect ◽  
Physiological And Biochemical ◽  
Vegetable Lecithin

Purpose: development of a method for correcting the physiological biochemical status of lactating cows and increasing their productivity in industrial stress conditions using vegetable adaptogens based on the sea buckthorn, hawthorn and lecithin.Materials and methods. The work reflects the results of a study on the effect of phytocompositions, including the fruits of sea buckthorn (SB), blood-red hawthorn (BH) and vegetable lecithin (L), on the physiological and biochemical status and productivity of lactating cows. The following groups of animals were formed, 5 animals each (n = 5), duration 30 days: group 1 (control) received only the basic diet of the farm (BD); Group 2 (BD + SB + BH) - the main diet of the farm, sea buckthorn fruits at a dose of 130 g / cow / day, blood-red hawthorn fruits dried at a dose of 40 g / cow/ day; Group 3 (BD + SB + BH + L) - the main diet of the farm, sea buckthorn fruits at a dose of 130 g / cow / day, blood-red hawthorn fruits dried at a dose of 40 g / cow / day, lecithin at a dose of 70 g / cow / day Revealed a positive effect on the indicators of protein, carbohydrate, lipid metabolism and milk productivity. By the end of the experiment, the experimental cows had the highest average daily milk yield in cows of group №. 3 that received, in addition to the main diet, a composition of hawthorn, sea buckthorn and vegetable lecithin (5.5% higher relative to the control group) and in group of cows №. 2 that received composition from the fruits of hawthorn and sea buckthorn (an increase of 4%).Results. Revealed positive effect on indicators of protein, carbohydrate, lipid exchanges and dairy productivity. By the end of the experiment, the experimental cows are the largest average daily fishing of the group of group No. 3, which additionally received the main diet from the fruits of hawthorn, sea buckthorn and vegetable lecithin (above 5.5% relative to the control group) and in the group of cows No. 2, which received the composition Of the fruits of hawthorn and sea buckthorn (the increase was 4%).Conclusion. The analysis of the results of the study of biochemical indicators shows that the composition comprising the fruits of sea buckthorn, hawthorn blood-red and vegetable lecithin has the greatest adaptogenic properties.

Effect of opioid peptides on liver function after patial hepatectomy

2018 ◽  
pp. 67-71
Author(s):  
А.В. Солин ◽  
А.Ю. Ляшев ◽  
Ю.Д. Ляшев
Keyword(s):  
Lactate Dehydrogenase ◽  
Liver Failure ◽  
Partial Hepatectomy ◽  
Opioid Receptors ◽  
Total Protein ◽  
Pronounced Effect ◽  
Male Rats ◽  
Control Group ◽  
Peptide Molecule ◽  
Selective Agonists

Цель исследования - сравнительный анализ влияния селективных агонистов отдельных классов опиоидных рецепторов на белковосинтетическую функцию печени, развитие цитолитического и холестатического синдромов у крыс, подвергшихся частичной гепатэктомии. Методика. Работа выполнена на 152 крысах-самцах Вистар массой 200-250 г. Частичную гепатэктомию выполняли по методу, описанному Higgins G.M. и Anderson R.M. с удалением 70% ткани печени. В плазме крови определяли концентрации общего белка, альбуминов, общего билирубина, активность аланинтрансаминазы (АЛТ), аспартаттрансаминазы (АСТ), лактатдегидрогеназы (ЛДГ) традиционными методами. Опиоиды: DAGO в дозе 6,3 мкг/кг, DSLET в дозе 10,0 мкг/кг, динорфин А (1-13) в дозе 20,1 мкг/кг, вводили внутрибрюшинно ежедневно 1 раз в сутки в течение 5 сут. эксперимента в объеме 0,2 мл. Контрольным животным аналогично вводили физраствор. Результаты. Удаление 70% ткани печени у крыс-самцов Вистар сопровождается развитием печеночной недостаточности, проявляющейся гипербилирубинемией, гипоальбуминемией, гипопротеинемией, повышением активности трансаминаз и лактатдегидрогеназы. Применение селективных агонистов опиоидных рецепторов у крыс, которым моделировали частичную гепатэктомию, оказывало гепатопротективное действие и снижало выраженность проявлений печеночной недостаточности, начиная с 3-х сут. после резекции. Активность трансаминаз, лактатдегидрогеназы и концентрация общего билирубина у животных, которым вводили опиоиды, были существенно ниже, чем в контрольной группе. Содержание общего белка и альбуминов было статистически значимо выше в группах, которые получали исследованные пептиды, по сравнению с контрольной группой на 7-е сут. после частичной гепатэктомии. Наиболее выраженное действие проявлял селективный агонист опиоидных мю-рецепторов DAGO. По нашему мнению, такое влияние пептидов объясняется присущими им антиоксидантным и антигипоксическим эффектами, что снижает повреждающее действие оперативного вмешательства на печень. Более выраженное влияние DAGO связано, по-видимому, с особенностями распределения опиоидных рецепторов или устойчивостью пептида к действию эндопептидаз благодаря модификациям в молекуле пептида. Заключение. Применение опиоидов стимулирует восстановление функциональной активности печени после частичной гепатэктомии. Наибольший эффект отмечается при введении мю-агониста DAGO. Aim. The aim of the study was to compare effects of selective agonists of opioid receptors from different classes on the protein-synthesizing function of liver and development of cytolytic and cholestatic syndromes in rats after partial hepatectomy. Methods. The study was conducted on 152 Wistar male rats weighing 200-250 g. The animals were subjected to partial hepatectomy according to the Higgins and Anderson method. Concentrations of total protein, albumin, total bilirubin, and activities of alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase were measured in plasma using standard methods. The opioids, DAGO (6.3 mg/kg), DSLET (10.0 mg/kg), and dynorphin A (1-13) (20.1 mg/kg), were injected in 0.2 ml of saline daily for 5 days. Control animals were injected with 0.2 ml of saline for 5 days. Results. Resection of 70% of liver tissue resulted in development of liver failure as evidenced by hyperbilirubinemia, hypoalbuminemia, hypoproteinemia, and increased transaminase and lactate dehydrogenase activities. Selective agonists of opioid receptors administered to the rats after partial hepatectomy exerted a hepatoprotective effect and alleviated the signs of liver failure beginning from the 3 day after resection. Transaminase and lactate dehydrogenase activities were significantly lower in opioid-treated rats than in the control group. Levels of total protein and albumins were significantly higher in the groups injected with the study peptides compared to the control group on the 7 day after partial hepatectomy. The selective agonist of opioid m-receptors, DAGO, exerted the most pronounced effect. Apparently, the similar effects of peptides were due to their antioxidant and anti-hypoxic action, which alleviated the detrimental effect of liver surgery. The more pronounced effect of DAGO apparently resulted from peculiarities of opioid receptors distribution or peptide resistance to endopeptidase action due to modifications of the peptide molecule. Conclusion. Administration of opioids stimulated restoration of liver functional activity after partial hepatectomy. Injections of the m-agonist, DAGO, produced the most pronounced effect.

The effectiveness of use RUSMA additive in the rations of lactating cows

2020 ◽  
pp. 28-37
Author(s):  
S. Sukhanova ◽  
N. Pozdnyakova ◽  
F. Yaroslavtsev
Keyword(s):  
Milk Fat ◽  
Raw Materials ◽  
Fat Content ◽  
Feed Additives ◽  
Control Group ◽  
New Mineral ◽  
Milk Productivity ◽  
Black And White ◽  
Lactating Cows ◽  
Experimental Group

The results of researches on the development of new mineral feed additives based on raw materials produced by Uralchem and the study of the eff ectiveness of their use in the rations of lactating cows have been presented in the article. The experiment has been carried out in the conditions of LLC “PF Barabinskoe” in the Dalmatovsky area in the Kurgan region where 3 groups of lactating cows of Black-and-White breed have been formed. Animals in the control group have been received the ration adopted in the farm, the 1st experimental group with the additive RusMA No. 1 at a dose of 150 g, the 2nd experimental group– with the additive RusMA No. 2 at the dose of 350 g. The use of experimental mineral additives in feeding lactating cows allowed us to increase their milk productivity and profi tability of production. At the same time, the best eff ectiveness was shown by the additive RusMA No. 2 at the dose of 350 g/head/day. The use of RusMA additives during the experiment period (105 days) allowed to increase the milk productivity of cows in the 1st experimental group by 6,03 % and in the 2nd experimental group by 8,24 %. Taking into account the fat content in milk, this diff erence was 6,31 and 8,53 %, respectively. The energy value of milk from cows of the experimental groups was higher compared to the control group by 2,45 and 1,76 %, respectively. According to the content of dry matter in milk, cows of the 2nd experimental group exceeded the control and 1st experimental group by 0,39 and 0,12 abs.%, respectively. The maximum milk fat content has been observed in the milk of cows of the 1st experimental group by 0,03 and 0,01 abs.% more than in the control and 2nd experimental groups, respectively. In terms of protein content, the cows of the 2nd experimental group signifi cantly exceeded the control group by 0,10 abs.% and the 1st experimental by 0,04 abs.%. The content of milk sugar in the 2nd experimental group was higher than in the control by 0,30 abs.% and compared to the 1st experimental by 0,11 %. Signifi cantly more calcium and phosphorus were contained in the milk of cows of the 2nd experimental group by 4,58 % (Р ≤ 0,001) and 2,86 % (Р ≤ 0,05), compared with the control group. The expenditures of feed in the EFU for the production of 1 kg of milk in animals of the 2nd experimental group was less by 5,13 % than in control cows and by 2,63 % compared to the 1st experimental group. The prime cost of 1 centner of milk was lower in the 2nd experimental group by 3,94 %, in the 1st experimental group by 2,65 % compared to the control group. The level of profi tability of milk production in the 2nd experimental group was higher by 9,0 and 1,0 abs.% in comparison with the control and 1st experimental groups, respectively.

Alteration in the oxidative status of Drosophila melanogaster Meigen (Diptera: Drosophilidae) fed with a diet containing Centaurea depressa M. Bieb. (Asteraceae)

2020 ◽  
Vol 70 (2) ◽  
pp. 227-237
Author(s):  
Eda Güneş
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Total Protein ◽  
Protein Carbonyl ◽  
Control Group ◽  
Carbonyl Content ◽  
Protein Carbonyl Content ◽  
Freeze Dried ◽  
Dried Extract

Abstract The aim of the this study was to evaluate the effects of fresh, dried and freeze-dried Centaurea depressa M. Bieb. (Asteraceae) on the oxidant and antioxidant status of the model organism D. melanogaster Meigen (Diptera: Drosophilidae) experimentally. The study was carried out from 2016 to 2019, and plant leaf extracts (0-50 mg/l) were added to insect standard artificial diets. The total protein, protein carbonyl content and glutathione-S-transferase, superoxide dismutase and catalase activities were quantified at the insect’s third larval stage. Our data showed that protein carbonyl content varied from 2.70 nmol/mg protein in the control group to 59.11 nmol/mg protein in the group fed with fresh leaf extract signifying induction of oxidative stress. All extracts increased the levels of all antioxidant enzymes and decreased the amounts of total protein. Meanwhile, the group fed with the freeze-dried extract showed no significant difference in the levels of total protein and protein carbonyl content except at the 50 mg/l concentration of the extract. Moreover, this group had superoxide dismutase and catalase activities 4 to 5 times higher than in the control group. In conclusion, induction of oxidative stress indicates that the fresh form of C. depressa leaves may have potential as a natural pesticide, whereas induction of endogenous antioxidant enzymes by the freeze-dried extract suggest its potential as an antioxidant.

Glycine and L-Arginine supplementation ameliorates gastro-duodenal toxicity in a rat model of NSAID (Diclofenac)-gastroenteropathy via inhibition of oxidative stress

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Akinleye Stephen Akinrinde ◽  
Halimot Olawalarami Hameed
Keyword(s):  
Oxidative Stress ◽  
Total Protein ◽  
Therapeutic Index ◽  
Control Treatment ◽  
Control Group ◽  
Protective Effects ◽  
Serum Total Protein ◽  
Significant Amelioration ◽  
Group A ◽  
Group B

Abstract Objectives This study examined the possible protective roles of exogenous glycine (Gly) and L-Arginine (l-Arg) against Diclofenac (DIC)-induced gastro-duodenal damage in rats. Methods Rats were divided into Group A (control), Group B (DIC group) and Groups C–F which were pre-treated for five days with Gly1 (250 mg/kg), Gly2 (500 mg/kg), l-Arg1 (200 mg/kg) and l-Arg2 (400 mg/kg), respectively, before co-treatment with DIC for another three days. Hematological, biochemical and histopathological analyses were then carried out. Results DIC produced significant (p<0.05) reduction in PCV (13.82%), Hb (46.58%), RBC (30.53%), serum total protein (32.72%), albumin (28.44%) and globulin (38.01%) along with significant (p<0.05) elevation of serum MPO activity (83.30%), when compared with control. In addition, DIC increased gastric H2O2 and MDA levels by 33.93 and 48.59%, respectively, while the duodenal levels of the same parameters increased by 19.43 and 85.56%, respectively. Moreover, SOD, GPx and GST activities in the DIC group were significantly (p<0.05) reduced in the stomach (21.12, 24.35 and 51.28%, respectively) and duodenum (30.59, 16.35 and 37.90%, respectively), compared to control. Treatment with Gly and l-Arg resulted in significant amelioration of the DIC-induced alterations although l-Arg produced better amelioration of RBC (29.78%), total protein (10.12%), albumin (9.93%) and MPO (65.01%), compared to the DIC group. The protective effects of both amino acids against oxidative stress parameters and histological lesions were largely similar. Conclusions The data from this study suggest that Gly or l-Arg prevented DIC-induced gastro-duodenal toxicity and might, therefore be useful in improving the therapeutic index of DIC.

scholarly journals Multi-Drug Resistant Organisms Infection Impact on Patients Length of Stay in Respiratory Care Ward

Antibiotics ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 608
Author(s):  
Yi-Ping Chen ◽  
Xian-Wen Tasi ◽  
Ko Chang ◽  
Xuan-Di Cao ◽  
Jung-Ren Chen ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Length Of Hospital Stay ◽  
Selective Medium ◽  
Respiratory Care ◽  
Control Group ◽  
Resistant Organism ◽  
Case Group ◽  
Drug Resistant ◽  
Factors Affecting ◽  
Care Ward

This study aimed to investigate the effects of multi-drug-resistant organism (MDRO) infection and other factors on the length of hospital stay (LOS) of patients in the respiratory care ward (RCW) of a regional hospital in Taiwan. In this retrospective study, we collected cases from MDRO-infected patients in the RCW from January 2016 to March 2020. The RCW comprises 13 beds in total. There were 106 infected patients, of which 42 were in the case group (infected with MDROs) and 64 were in the control group (not infected with MDROs). Clinical specimens were inoculated in a selective medium to isolate the pathogenic bacteria by standard procedures. The results showed the main factors affecting the LOS were: patients with MDRO infection, patients discharged from the RCW, and patients who underwent catheterization. The LOS of patients infected with MDROs was significantly longer than that of patients without MDRO infection (β = 0.55, 95% CI = 0.02–1.09), with the case group and the control group being 479.8 ± 546.5 and 307.3 ± 436.2 days, respectively. Infection with carbapenem-resistant Pseudomonas aeruginosa (CRPA) was associated with a longer LOS than other MDRO strains. These findings have important implications for infection control in RCW and in better tracking the health of patients.

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