Uji Efektivitas Antibakteri Sediaan Salep Ekstrak Daun Puring (Codiaeum variegatum (L.) Rumph. Ex A.Juss) Terhadap Bakteri Staphylococus aureus

2021 ◽  
Vol 1 ◽  
pp. 1005-1015
Author(s):  
Isna Fatimatunnisa ◽  
S Slamet ◽  
St Rahmatullah ◽  
Dwi Bagus Pambudi
Keyword(s):  
Buffer Zone ◽  
Extraction Methods ◽  
Positive Control ◽  
Codiaeum Variegatum ◽  
The Rich ◽  
Single Formula ◽  
Post Hoc ◽  
Rich Countries ◽  
Bacterial Skin Infections ◽  
One Way Anova

AbstractIndonesia is one of the rich countries among the plant’s potential medicinal properties is the puring leaf (Codiaem variegatum (L.) Rumph. Ex A.Jus) as an antibacterial. The puring leaves contain flavonoid, steroids, alkaloids, tannins, saponins and fenols. which serve as antibacterial. The use of antibacterial ointments can treat bacterial skin infections. Balm is a half-denser is intended for topical wear on the skin or the mucous membranes. Among the causes of infection is the Staphylococus aureus bacteria. The study aims to test the effectiveness of a suppressive antibacterias, the leaf extract ointment against the Staphylococus aureus bacteria. Extraction methods maceration method use a 96% solution. The research method used was oriental. The extract of the puring leaves used is 2,5%, 5%, 7,5%, 10%, the negative cotrol of the ointment without the extract and the positive control with the gentamicin ointment. Zone research is inhibiting every single formula. Averag buffer zone on formula 1 6.25 mm, formula 2 7.55 mm, formula 3 9.23 mm and formula 4 11.68 mm. Data acquired by the formation of a clear buffer zone around the commonwealth for 24 hours after treatment. The data was analyzed with one way ANOVA continues the post hoc test (Tukey). The result is that partial extract of puring leave can be made into unguent and effective Staphylocous aureus ATCC 25923Keywords: Extract of puring leaves; antibacterial; ointment and staphylococus aureus AbstrakIndonesia merupakan salah satu negara yang kaya akan keaneragaman tanaman yang memiliki potensi sebagai bahan obat, salah satunya yaitu daun puring (Codiaeum variegatum (L.) Rumph. Ex A.Juss) sebagai antibakteri. Daun puring memiliki senyawa flavonoid, steroid, alkaloid, tannin, saponin dan fenol yang berfungsi sebagai antibakteri. Penggunaan salep antibakteri dapat mengobati infeksi kulit yang disebabkan oleh bakteri. Salep merupakan sediaan setengah padat yang ditujukan untuk pemakaian topikal pada kulit atau selaput lendir. Salah satu penyebab infeksi adalah bakteri Staphylococcus aureus. Penelitian ini bertujuan untuk menguji efektivitas antibakteri sediaan salep ekstrak daun puring terhadap bakteri Staphylococus aureus. Metode ekstraksi menggunakan metode maserasi dengan pelarut 96%. Metode penelitian yang digunakan yaitu sumuran. Konsentrasi ekstrak daun puring yang digunakan adalah 2,5%, 5%, 7,5%, 10%, kontrol negatif yaitu salep tanpa ekstrak dan kontrol positif dengan salep gentamicin. Hasil penelitian zona hambat setiap formula berbeda. Rata-rata zona hambat pada formula 1 6,25 mm, formula 2 7,55 mm, formula 3 9,23 mm dan formula 4 11,68 mm. Data yang diperoleh dengan terbentuknya zona hambat bening di sekeliling sumuran selama 24 jam setelah perlakuan. Data dianalisa dengan one way ANOVA dilanjutkan uji post Hoc (Tukey). Kesimpulannya Ekstrak daun puring bisa dibuat sediaan salep dan ekstrak daun puring efektif terhadap bakteri Staphylococus aureus ATCC 25923Kata Kunci: Ekstrak daun puring; antibakteri; salep dan staphylococus aureus

scholarly journals PENGARUH KURMA (PHOENIX DACTYLIFERA L.) TERHADAP BERAT BADAN TIKUS PUTIH JANTAN (RATTUS NOVERGICUS)

2018 ◽  
pp. 181-188
Author(s):  
F Fadila ◽  
Brian Wasita ◽  
Paramasari Dirgahayu
Keyword(s):  
Positive Control ◽  
Negative Control ◽  
T Test ◽  
Test Weight ◽  
Control Group ◽  
Significant Difference ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova ◽  
Paired T Test

ABSTRAK Kurma merupakan salah satu buah dengan kandungan gizi terlengkap. Selain tinggi energi terutama karbohidrat (glukosa, fruktosa), kurma juga mengandung mineral besi yang berperan dalam metabolisme energi. Tujuan penelitian ini untuk mengetahui pengaruh kurma terhadap berat badan tikus (Rattus novergicus). Jenis penelitian eksperimental laboratorik dengan pre-post test with control grup. Sampel adalah 24 ekor tikus putih jantan (Rattus novergicus) strain Wistar, dibagi menjadi 4 kelompok, yaitu kelompok K1 (kontrol negatif), dan K2 (kontrol positif (diberikan suplemen FeSO )), P1 (perlakuan ekstrak air kurma mentah), dan P2 (perlakuan sari kurma). Analisis data dengan uji paired t-test untuk mengetahui perbedaan berat badan pre-post test, ANOVA untuk mengetahui perbedaan berat badan post test antar kelompok, yang dilanjutkan dengan post hoc test LSD, dengan α=0,01. Hasil penelitian menunjukan terjadi peningkatan berat badan pada semua kelompok sampel (K1, K2, P1, dan P2). Peningkatan berat badan tertinggi pada kelompok kontrol positif (K1) 11,12%, diikuti oleh kelompok perlakuan SK (P2) 11,00%, dan perlakuan EAKM (P1) 10,90%, sedangkan yang terendah pada kelompok kontrol negatif (K1) hanya 5,32%. Hasil analisis paired t-Test pada kelompok kontrol positif (K2), perlakuan EAKM (P1) dan SK (P2) menunjukan terdapat perbedaan berat badan pre- post test yang signifikan (p<0,01). Hasil analisis One Way Anova, diperoleh nilai p=0,000 (p<0,01) yang menandakan terdapat perbedaan berat badan post test yang signifikan antar 4 kelompok, di mana post hoc test LSD menunjukan perbedaan terletak antara kontrol negatif (K1) dengan kelompok yang diberikan perlakuan (K2, P1, dan P2), sedangkan diantara kelompok K2, P1, dan P2 tidak ada perbedaan yang signifikan. Kesimpulan: Kurma dapat meningkatkan berat badan tikus yang mengalami anemia defisiensi besi. Pengaruh kurma terhadap berat badan tikus sama dengan pengaruh dari pemberian suplemen FeSO4. Peningkatan berat badan tikus tanpa perlakuan sangat rendah jika dibandingkan dengan peningkatan berat badan tikus yang diberikan kurma dan suplemen FeSO .Kata Kunci: kurma (Pheonix dactylifera L.); ekstrak air kurma mentah (EAKM), sari kurma (SK), suplemen FeSO4, berat badan tikus. ABSTRACT Dates are one of the most nutritious fruits. In addition to high energy, especially carbohydrates, dates also contain iron minerals that play a role in energy metabolism. The purpose of this study was to determine the effect of dates on rat body weight (Rattus novergicus). Types of laboratory experimental studies with pre-post test with control group. The sample was 24 male white rats (Rattus novergicus) Wistar strain, divided into 4 groups, ie group K1 (negative control), and K2 (positive control (given FeSO4 supplement)), P1 (crude dates juice treatment), and P2 (dates juice treatment). Analysis of data with paired t-test to determine the difference of pre-post test weight, One Way Anova to know difference of post test between group weight, followed by post hoc test of LSD, with α = 0,01. The results showed that there was an increase in weight across all sample groups (K1, K2, P1, and P2). The highest weight gain in the positive control group (K1) was 11.12%, followed by the group of dates juice treatment (P2) 11.00%, and crude dates juice treatment (P1) 10.90%, while the lowest in the negative control group (K1) only 5 , 32%. The result of paired t-test analysis in positive control group (K2), crude dates juice treatment (P1) and dates juice treatment (P2) showed significant difference of pre-post test weight (p <0,01). The results of One Way Anova analysis showed that p = 0,000 (p <0,01) indicated that there was significant difference of post test weight between 4 groups, where post hoc test of LSD showed the difference between negative control (K1) and group that given treatment (K2, P1, and P2), whereas between groups K2, P1, and P2 there was no significant difference. Conclusion: Dates can increase the weight of rats with iron deficiency anemia. The effect of dates on body weight of rats is similar to that of FeSO4 supplementation. Increased rats weight without treatment is very low when compared with the increased weight of rats given dates and supplements of FeSO4.   Keywords: dates (Pheonix dactylifera L.); raw dates crude extract, dates juice, FeSO4 supplement, weight of rats.

scholarly journals PENGARUH KONSUMSI KEJU CHEDDAR 10 GRAM TERHADAP pH SALIVA - Studi terhadap Mahasiswa Fakultas Kedokteran Gigi Universitas Islam Sultan Agung Semarang

2014 ◽  
Vol 1 (1) ◽  
pp. 34
Author(s):  
Nadia Fitri Hapsari ◽  
Ade Ismail ◽  
Oedijono Santoso
Keyword(s):  
Cheddar Cheese ◽  
Positive Control ◽  
T Test ◽  
Positive Control Group ◽  
Control Group ◽  
Anova Test ◽  
Salivary Ph ◽  
Post Hoc ◽  
One Way Anova ◽  
Paired T Test

Background: Dental caries is the main problem of oral health in the world. The preventive is consumption cheddar cheese with caseinfosfoprotein and calcium. This study aimed to determine whether the consumption of 10 grams cheddar cheese can increase salivary pH. Method: The type of this research method is experimental with pre and post design. The samples in this research were 30 students FKG Unissula who inclusion criteria, 10 people the treatment group (consuming 10 grams of cheddar cheese), 10 people positive control group (consuming chocolate biscuits), and 10 people negative control group. The data analysis techniques using Paired T Test to determine the salivary pH before and after treatment. Furthermore, to know differences among the three groups using One Way Anova Test and Post Hoc Test . Result: Based Test Paired T Test showed that the treatment and negative group increased salivary pH. Positive control group decreased salivary pH. Based on One Way Anova test significant value 0.000 (p≤0.05), it means differences between 3 groups. Based on Post Hoc Test found significant value p≤0.05, it means differences between one group to another. Conclusion: From study result concluded that consumption 10 grams of cheddar cheese can raise the salivary pH.

scholarly journals Serum Immunoglobulin E and Serotonin levels in Chronic Supporative Otitis Media Patients with and without treatment

2021 ◽  
Vol 37 (5) ◽  
Author(s):  
Shafaque Mehboob Khan ◽  
SM Tariq Rafi ◽  
MS Mehjabeen Mehjabeen ◽  
Hurtimania Khan
Keyword(s):  
Otitis Media ◽  
Immunoglobulin E ◽  
Positive Control ◽  
Serum Immunoglobulin ◽  
Negative Group ◽  
Healthy Individuals ◽  
Tukey Test ◽  
Significant Difference ◽  
Post Hoc ◽  
One Way Anova

Objective: To determine the serum immunoglobulin E and serotonin levels of patients with chronic suppurative otitis media (CSOM) with and without treatment. Methods: This is a case-control study carried out in ENT ward of Jinnah Postgraduate Medical Centre Karachi Pakistan from May to September 2018.. Sample (n=160) was divided into four groups (40 individuals per group) as G1: control negative (group-1 without any disease), G2: positive control (patients didn’t received medicines), G3: group (patients treated with co-amoxicillin 1000mg per day) and G4: group (patients treated with ciprofloxacin1000mg per day). After treatment period of One week serum immunoglobulin E and serotonin concentrations were evaluated by Elisa method at 450nm. Statistical evaluation was carried out using one-way ANOVA (p<0.05) followed by post hoc (tukey test) for further group comparison. In order to find out correlation between IgE and serotonin with CSOM Pearson’s correlation was applied. Results: There was no significant (p>0.05) association found between genders with serotonin as well as with IgE levels in CSOM patients. One way ANOVA showed significant difference (p<0.05) for IgE and serotonin levels and post hoc (tukey test) showed significant higher of IgE levels in CSOM patients of G2 positive control (diseased patients) was observed when compared to the control negative group (healthy individuals) and also from treated groups of G3 and G4. This also showed that serotonin levels were significantly low in G2 (positive control) as well as in treated groups of G3 and G4 in contrast with healthy individuals of group G1. Conclusion: Antibiotics may revert the higher levels of IgE but cannot attenuate the decreased levels of neurotransmitter (serotonin) like healthy individuals, therefore, depression levels of CSOM patients should be monitored, scored and attenuated with proper intervention of antidepressants or counseling. doi: https://doi.org/10.12669/pjms.37.5.2414 How to cite this:Mehboob S, Rafi SMT, Mehjabeen, Khan H. Serum Immunoglobulin E and Serotonin levels in Chronic Supporative Otitis Media Patients with and without treatment. Pak J Med Sci. 2021;37(5):---------. doi: https://doi.org/10.12669/pjms.37.5.2414 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Hot Oil Exposure on Styrofoam and Black Crackle Bag Effect on Malondialdehyde MDA Level of White Rat (Rattus norvegicus) Wistar Strain

2019 ◽  
Vol 1 (2) ◽  
pp. 9
Author(s):  
Marcella ◽  
Kristina Simanjuntak ◽  
Yuni Setyaningsih
Keyword(s):  
Oxidative Stress ◽  
Positive Control ◽  
Negative Control ◽  
Wistar Strain ◽  
Plastic Bag ◽  
Black Plastic ◽  
Mixed Oil ◽  
Post Hoc ◽  
Oil Exposure ◽  
One Way Anova

ABSTRACT This study purposed to determine the effect of hot oil exposure on styrofoam and black plastic bag on MDA levels in rats. The study was purely experimental, a sample of 28 Wistar rats, weight ±200gram, age 3 months, divided into 4 groups, treatment was given for 28 days. Negative control was given feed and drink; styrofoam group was given feed, drink, oil on styrofoam; the black plastic group was given feed, drink, oil on black plastic; positive control was given feed, drink, toluene mixed oil. On 14th and 28th-day blood was taken from the tail and examined for plasma MDA by spectrophotometer λ=532nm. One-way ANOVA shows there is an effect of hot oil exposure on styrofoam and black plastic on MDA levels on the 14th and 28th days (p=0.000). Post hoc showed the styrofoam group had a significant increase in MDA levels on 14th (p=0.003) and 28th (p=0.043) compared to negative controls, the black plastic group as well on 14th (p=0.000) and 28th (p=0.000). MDA levels between styrofoam and black plastic groups significantly different on 14th (p=0.012), but not on 28th (p=0.340). There was a significant MDA increase in the styrofoam group between 14th and 28th days (p=0.009), and in the black plastic group (p=0.031). This shows that hot oil exposure on styrofoam and black plastic cause cell oxidative stress. Keyword: Black Plastic Bag, MDA, Oxidative Stress, Styrofoam     ABSTRAK Penelitian bertujuan mengetahui pengaruh paparan minyak panas pada stirofoam dan kresek hitam terhadap kadar MDA. Penelitian merupakan eksperimental murni, sampel 28 ekor tikus putih galur Wistar, berat badan ±200gram, usia 3 bulan, dibagi menjadi 4 kelompok, perlakuan selama 28 hari. Kontrol negatif diberi pakan biasa dan air minum; kelompok stirofoam diberi pakan, minum, dan minyak pada stirofoam; kelompok kresek hitam diberi pakan, minum, dan minyak pada kresek hitam; kontrol positif diberi pakan, minum, dan minyak dicampur toluene. Mengambil darah dari vena ekor pada hari ke-14 dan ke-28 lalu memeriksa MDA plasma dengan spektrofotometer λ=532 nm. Hasil One-way Anova menunjukkan peningkatan MDA kelompok stirofoam dan kresek hitam hari ke-14 dan ke-28 (p=0.000). Uji post hoc menunjukkan MDA kelompok stirofoam meningkat signifikan pada hari ke-14 (p=0.003) dan ke-28 (p=0.043) dibanding kontrol negatif, begitu juga kelompok kresek hitam hari ke-14 (p=0.000) dan ke-28 (p=0.000). Kadar MDA antara kelompok stirofoam dan kresek hitam berbeda signifikan pada hari ke-14 (p=0.012), tetapi tidak pada hari ke-28 (p=0.340). MDA berbeda bermakna antara hari ke-14 dan ke-28 pada kelompok stirofoam (p=0.009) dan kelompok kresek hitam (p=0.031). Hal ini menunjukkan paparan minyak panas pada stirofoam dan kresek hitam dapat menimbulkan stres oksidatif sel. Kata Kunci: Kresek Hitam, MDA, Stirofoam, Stres Oksidatif

scholarly journals The effect of ethanol extract of soursop leaf (Annona muricata L.) on Adhesion of Streptococcus mutans ATCC 35668 to hydroxyapatite discs

2018 ◽  
Vol 4 (1) ◽  
pp. 22
Author(s):  
Friska Ani Rahman ◽  
Tetiana Haniastuti ◽  
Trianna Wahyu Utami
Keyword(s):  
Streptococcus Mutans ◽  
Dental Plaque ◽  
Ethanol Extract ◽  
Positive Control ◽  
Tooth Surface ◽  
Annona Muricata ◽  
Dental Hard Tissues ◽  
Attachment Mechanism ◽  
Post Hoc ◽  
One Way Anova

The demineralization of dental hard tissues can be caused by dental plaque. Dental plaque contains various components, especially bacteria attached to the extracellular matrix. Streptococcus mutans (S. mutans) has extracellular glucan as adhesin that is important in the attachment mechanism of tooth surface. The natural substance can be used for preventing plaque formation by inhibiting the attachment of S. mutans. Soursop plant has been used in treating various diseases. The leaves of the soursop (Annona muricata L.) are used as a material to inhibit potential attachment of bacteria S. mutans. Common surfaces that is used in adhesion testing is hydroxyapatite (HA). The aim of this study was to evaluate the effect of ethanol extract of soursop leaf (EESL) on the adhesion of S. mutans ATCC 35668 to HA discs. Soursop leaves were extracted by the maceration method using 70% ethanol. The experiment was carried out by analyzing the inhibition adhesion of S. mutans ATCC 35668 on HA discs after incubation with different concentrations of soursop leaf extract. The concentrations of extract tested were: 150; 125; 100; 75; and 50 mg/ml. Chlorhexidine 0.2% was used as a positive control while DMSO 5% was used a negative one. Data were evaluated by One Way Anova. This study statistically showed significant differences of S. mutans colony count between groups (p<0.05).The results of a post hoc Dunnett T3 test showed that the 2 highest concentrations of extract (125 and 150 mg/ml) reduced S. mutans adhesion on HA discs.The obtained results showed that ethanol extract of soursop leave inhibits the adherence of S. mutans to the HA disc.

Analgesic and Antipyretic Activities of Ethanolic Extract of Sappan wood (Caesalpinia sappan L.) Leaves

2021 ◽  
pp. 5213-5216
Author(s):  
Nyi Mekar Saptarini ◽  
Dytha Andri Deswati
Keyword(s):  
Reduction Method ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Optimum Dose ◽  
Phytochemical Screening ◽  
Caesalpinia Sappan ◽  
Experimental Animals ◽  
Antipyretic Activity ◽  
Post Hoc ◽  
One Way Anova

Sappan wood (Caesalpinia sappan L.) is used as an analgesic and antipyretic by the Indonesian people, empirically. The aim of this study was to determine the analgesic and antipyretic activity of ethanolic extract of sapan wood leaves in Webster mice as experimental animals. The writhing method was used to determine the analgesic activity in acetic acid-induced mice with mefenamic acid as a positive control. The temperature reduction method was used to determine the antipyretic activity in yeast-induced mice with paracetamol as a positive control. One-way ANOVA was conducted for statistical analysis, followed by Tukey-Kramer post hoc test. Phytochemical screening showed that sappan wood contains alkaloids, flavonoids, saponins, monoterpenoids, and sesquiterpenoids. The optimum dose of analgesic and antipyretic activity was 6.3 mg and 8.4 mg/20 g BW of mice, respectively. The conclusion was ethanolic extract of sappan wood leaves has analgesic and antipyretic activities.

scholarly journals The Photobiomodulation Effect of 940nm Laser Irradiation on Enterococcus faecalis in Human Root Dentin Slices of Varying Thicknesses

2021 ◽  
Vol 12 (1) ◽  
pp. e48-e48
Author(s):  
Bryan Martin Sher ◽  
Riaan Mulder ◽  
Norbert Gutknecht
Keyword(s):  
Laser Irradiation ◽  
Enterococcus Faecalis ◽  
Continuous Wave ◽  
Laser Energy ◽  
Positive Control ◽  
Significance Level ◽  
Colony Forming Units ◽  
Root Dentin ◽  
Post Hoc ◽  
One Way Anova

Introduction: An increase in dentine thickness could result in an inadequate depth of laser energy penetration. This study aimed to evaluate the effect of a 940 nm laser on Enterococcus faecalis through varying thicknesses of human root dentin slices. Methods: Thirty-five dentin slices of root dentin with thicknesses ranging between 500 and 3000 µm were produced. Six experimental groups (500, 1000, 1500, 2000, 2500, and 3000 µm (n=5 each) were lased and the seventh, non-lased group served as the positive control with a dentine thickness of 2000 µm. The slices were inoculated with 2 µL of E. faecalis suspension of 1.5 × 108 E. faecalis cells/mL. All the lased slices were lased from the opposing side of the inoculation. A non-initiated 200 μm bare end fibre at the power of 1 W, in a continuous wave was used. Four doses of laser irradiation of 5 seconds with a side to side movement with the tip held at a 5º angle to the dentine slice were performed. The colony-forming units of E. faecalis were determined and the bacterial photobiomodulation effect analysed using one-way ANOVA with a Bonferroni and Holm post hoc test at a significance level of P>0.05. Results: There were statistical differences between the dentin slices of 500, 1000, and 1500 μm treated with the laser compared to the positive control (P<0.01). However, there were no statistical differences between the lased 2000 and 2500 μm slices compared to the positive control. There was significantly more photobiomodulation of the E. faecalis for the dentine slices of 3000 μm than the positive control (P<0.01). Conclusion: Laser treatment through dentine slices of 2000 μm and thinner significantly reduced bacterial growth. The photobiomodulation effects started to occur in dentine slices thicker than 2500 μm compared to the positive control.

Generating Prosperity for Working Families in Affluent Countries

2018 ◽  
Keyword(s):  
Economic Growth ◽  
Real Income ◽  
Living Standards ◽  
Financial Strain ◽  
Inclusive Growth ◽  
Working Families ◽  
The Rich ◽  
Rich Countries ◽  
Analysis Of Performance

This book addresses the central challenge facing rich countries: how to ensure that ordinary working families see their living standards and the prospects for their children improve rather than stagnate over time. It presents the findings from a comprehensive analysis of performance over recent decades across the rich countries of the OECD, in terms of real income growth around and below the middle. It relates this performance to overall economic growth, exploring why these often diverge substantially, and to the different models of capitalism or economic growth embedded in different countries. In-depth comparative and UK-focused analyses also focus on wages and the labour market and on the role of redistribution. Going beyond income, other indicators and aspects of living standards are also incorporated including non-monetary indicators of deprivation and financial strain, wealth and its distribution, and intergenerational mobility. By looking across this broad canvas, the book teases out how ordinary households have fared in recent decades in these critically important respects, and how that should inform the quest for inclusive growth and prosperity.

The Contest for Olympic Success as a Public Good

2013 ◽  
Author(s):  
Loek Groot
Keyword(s):  
Lorenz Curve ◽  
Gini Index ◽  
World Population ◽  
Level Playing Field ◽  
Actual Distribution ◽  
Playing Field ◽  
Inequality Measures ◽  
The Rich ◽  
The Lorenz Curve ◽  
Rich Countries

In this study it is demonstrated that standard income inequality measures, such as the Lorenz curve and the Gini index, can successfully be applied to the distribution of Olympic success. Olympic success is distributed very unevenly, with the rich countries capturing a disproportionately higher share compared to their world population share, which suggests that the Olympic Games do not provide a level playing field. The actual distribution of Olympic success is compared with alternative hypothetical distributions, among which are chosen the distribution according to population shares, the welfare optimal distribution under the assumption of zero government expenditures, and the non-cooperating Nash-Cournot distribution. By way of conclusion, a device is proposed to make the distribution of Olympic success more equitable.

scholarly journals Coenzyme q10 is potentially usedto improve lipid profile in diabetic hypercholesterolemia-induced periodontitis in the coastal area

2018 ◽  
Vol 47 ◽  
pp. 07006
Author(s):  
Saryono Saryono ◽  
Hesti Devinta ◽  
Abdul Haris Budi Widodo ◽  
Arif Imam Hidayat
Keyword(s):  
Lipid Profile ◽  
Coenzyme Q10 ◽  
Coastal Area ◽  
Positive Control ◽  
Atherogenic Index ◽  
Control Group ◽  
Treatment Groups ◽  
Significant Difference ◽  
Pap Method ◽  
Post Hoc

Contaminated water often affects the occurrence of periodontitis in the coastal area. The diabetic hypercholesterolemia-induced periodontitis in Indonesia is very high. The use of coenzyme Q10 to treat this disease has never been investigated yet. Therefore, this study aimedto analyze the effect of coenzyme Q10 on the lipid profile of diabetic hypercholesterolemia-induced periodontitis.Twenty four rats were randomized into 6 groups (G1-G6). The groups (G1-G3) are healthy, negative and positive control group respectively. The treatment groups (G4-G6) are diabetic hypercholesterolemia-induced rats given coenzyme q10 dose of 13,5; 27 and 54 mg/kg respectively. Rats were induced by periodontitis, hypercholesterolemia and diabetes mellitus. Coenzyme Q10 was administered orally using 2 mL gastric tube once a day for 14 days. Lipid profile including triglycerides, HDL, and atherogenic index (IA) was measured enzymatically by the CHOD-PAP method. Data were analyzed by one-way ANOVA test and followed by the Least Significant Difference (LSD) post hoc test.Coenzyme Q10 with a dose of 54 mg/kgis effective in lowering triglyceride, and atherogenic index and increasing HDL level in diabetic hyperlipidemia-induced periodontitis rats model. This research supports the potential effects of coenzyme Q10 supplementation to improve lipid profile in diabetic hypercholesterolemia-induced periodontitis in the coastal area.

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