Effectiveness Test of Juwet Leaf Extract and Juwet Cortex Against Desreasing Blood Glucose Levels of Hiperglemic Mice

Diabetes melitus drugs are currently quite expensive, so they require a cheaper and more effective substitute for drugs to control glucose levels in people with diabetes melitus. Exploring local potentials using medicinal plants can be an alternative to chemical drugs. One of the medicinal plants that is thought to be used for people with diabetes mellitus is juwet. Juwet leaves are suspected to have hypoglycemic activity, because they contain flavonoid and saponin compounds. Juwet bark also contains chemical compounds, namely flavonoids, saponins, and tannins. This study aims to determine the decrease in blood glucose levels in dextrose-induced mice by giving juwet leaf extract and juwet bark extract (Syzygium cumini L.). The test animals used were 36 male mice (Mus musculus) aged 2-3 months with a weight of 20-30 grams. This type of research was carried out experimentally and the design of this study used was Completely Randomized Design (CRD), which was divided into 12 treatments and 3 replications. The 12 treatments are juwet leaf extract and juwet bark with the same dose, namely the dose of 0 mg/kg BB, 150 mg/kg BB, 200 mg/kg BB, 250 mg/kg. Data from the research were analyzed statistically using One Way ANOVA and continued with the LSD test. The results showed that administration of juwet leaf extract and juwet bark extract at various doses had a significant effect on decreasing blood glucose levels of mice. The most effective dose to reduce blood glucose levels is juwet bark extract with a dose of 250 mg/kg BB.

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Pengaruh Ekstrak Rebusan Daun Tithonia diversifolia (Hemsl.) A. Gray Terhadap Kadar Glukosa Darah

BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan ◽

10.22373/biotik.v7i1.5470 ◽

2019 ◽

Vol 7 (1) ◽

pp. 41

Author(s):

Rinawati Rinawati ◽

E Suharyanto ◽

Nastiti Wijayanti

Keyword(s):

Blood Glucose ◽

Young Leaf ◽

Tithonia Diversifolia ◽

Treatment Groups ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Randomized Design ◽

Adult Leaf ◽

Reduce Blood Glucose ◽

Completely Randomized Design

Tithonia diversifolia is a plant that has the potential to reduce blood glucose levels that is crucial in Diabetes Mellitus therapy. This study aims to determine the active compounds contained in the extract of T. diversifolia leaves decoction, the effect of decoction extract on the reduction of blood glucose, and the most effective decoction extract to reduce blood glucose levels as well. The study used a Completely Randomized Design (CRD) with the research treatment groups, namely: Kn = normal control (normal mice and not given leaves decoction extract), Ka = STZ control (DM mice, which are normal mice induced by 65mg/Kg of STZ), Kp = treatment control (normal mice given leaf decoction extract) , P1 = DM + mice were given young leaf decoction extract, P2 = DM + mice were given a mixture of young leaf and adult leaf decoction extract, P3 = DM + mice were given adult leaf decoction extract. The leaves used for decoction were 1-6 leaves from the shoots. The analysis of T. diversifolia leaves decoction compounds is using the visible spectrophotometers for tannins, phenols and flavonoids and GC-MS for terpenoid analysis. The result found that Tithonia diversifolia leaves decoction extracts contain tannins, flavonoids and phenols, while terpenoids are not detected. The leaves decoction extracts of T. diversifolia influenced the decreases in blood glucose levels of DM mice, especially the decoction extract of adult leaves which reduced blood glucose levels to 71.16%.

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Uji Efek Antidiabetik Ekstrak Daun Trembesi (Albizia saman (Jacq.) Merr) Terhadap Mencit (Mus musculus L)

WARTA FARMASI ◽

10.46356/wfarmasi.v8i2.94 ◽

2019 ◽

Vol 8 (2) ◽

pp. 43-52

Author(s):

Muhammad Azdar Setiawan ◽

Muhammad Syaiful Saehu ◽

Kartini Kartini

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Mus Musculus ◽

Leaf Extract ◽

Positive Control ◽

Negative Control ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Reduce Blood Glucose ◽

Albizia Saman

ABSTRAK Daun trembesi (Albizia saman (Jacq.) Merr) adalah salah satu tanaman berkhasiat menurunkan kadar glukosa darah dimana kandungan kimianya berpotensi menurunkan kadar glukosa darah antara lain flavonoid yang bekerja dengan cara menstimulasi sel- sel beta dari pulau langerhans, sehingga sekresi insulin ditingkatkan.Penelitian ini bertujuan untuk mengetahui efek antidiabetes ekstrak daun trembesi (Albizia saman (Jacq.) Merr) pada mencit (Mus musculus). Metode Penelitian ini merupakan penelitian Eksperimen dimana sebanyak 20 ekor mencit dibuat diabetes dengan menggunakan Streptozotosin 150 mg/kgBB secara Intraperitonial. Kemudian dibagi menjadi 5 kelompok perlakuan, yaitu: Ekstrak dosis 25 mg/kgBB, 50 mg/kgBB, 100 mg/kgBB, sebagai kontrol positif Glibenclamid 5 mg dan kontrol negatif suspensi Na.CMC 0,5%. Data yang diperoleh dianalisis dengan uji ANOVA. Hasil analisa statistik menunjukan pada konsentrasi ekstrak 100 mg/kgBB memberikan efek yang optimum dengan perlakuan kontrol positif Glibenklamid. Kata Kunci : Ekstrak Daun Trembesi, Antidiabetik. ABSTRACT Trembesi leaf (Albizia saman (Jacq.) Merr) is one of the efficacious plants to reduce blood glucose levels where the chemical content has the potential to reduce blood glucose levels, among others, flavonoids that work by stimulating beta cells of the island langerhans, so that insulin secretion is increased. It aims to determine the antidiabetic effect of trembesi leaf extract (Albizia saman (Jacq.) Merr) in mice (Mus musculus). This research method is an experimental study in which as many as 20 mice were made diabetic using Streptozotosin 150 mg / kgBW intraperitonially. Then divided into 5 treatment groups, namely: Extract dose 25 mg / kg body weight, 50 mg / kg body weight, 100 mg / kg body weight, as positive control Glibenclamid 5 mg and negative control suspension Na.CMC 0.5%. The data obtained were analyzed by ANOVA test. The results of statistical analysis showed that the extract concentration of 100 mg / kgBB gave the optimum effect with the positive control of Glibenclamide. Keywords: Trembesi Leaf Extract, Antidiabetic.

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PENGARUH JUS LIDAH BUAYA TERHADAP KADAR GLUKOSA DARAH PUASA DAN 2 JAM PP(Post Prandial) PADA PENDERITA DIABETES MELITUS

Jurnal Kesehatan Medika Saintika ◽

10.30633/jkms.v10i1.311 ◽

2019 ◽

Vol 10 (1) ◽

pp. 77

Author(s):

Febria Syafyu Sari ◽

Ridhyalla Afnuhazi

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Blood Sugar ◽

Fasting Blood Glucose ◽

Aloe Vera ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Patients With Diabetes ◽

Paired T Test ◽

Diabetes Melitus

ABSTRAK Diabetes Melitus merupakan penyakit yang paling menonjol yang disebabkan oleh gagalnya pengaturan gula darah. Lidah buaya berkhasiat untuk menurunkan kadar gula dalam darah bagi penderita diabetes dan dapat mengontrol tekanan darah. Tujuan penelitian untuk mengetahui pengaruh jus lidah buaya (AloeBarbadensis Miller) terhadap penurunan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Desain penelitian merupakan Quasi Eksperimental dengan pendekatan one group pretest – postest design. Sampel terbagi menjadi 14 responden. Data dianalisis dengan paired t-test. Hasil menunjukan rata-rata penurunan glukosa darah puasa pada intervensi (28,42 gr/dl) dan glukosa darah 2 jam pp pada intervensi (40,57 gr/dl). Untuk analisis bivariat terdapat perbedaan antara glukosa puasa dan 2 jam pp dengan glukosa darah puasa GDP) dan 2 Jam PP (Post Prendial) pada penderita DM (Diabetes Melitus). Kesimpulan didapatkanlidah buaya dapat menurunkan kadar glukosa darah.Berdasarkan hasil penelitian jus lidah buaya dapat menjadi salah satu alternatif keperawatan non farmakologi dalam penyakit diabetes melitus. Kata Kunci : Lidah Buaya ; Diabetes Mellitus THE EFFECT OF VEGETABLE VOCATIONAL JUICE ON FAST BLOOD GLUCOSE LEVELS AND 2 HOURS OF PP (Post Prandial) IN DIABETES MELLITUS ABSTRACT Diabetes mellitus is the most prominent disease caused by the failure of blood sugar regulation. Aloe vera is efficacious can to reduce blood sugar levels for diabetics and can control blood pressure. The purpose of this study was to determine the effect of Aloe Barbadensis Miller on the reduction of fasting blood glucose GDP and 2 hours of PP (post prendial) in patients with diabetes mellitus. The research design is Experimental Quasi with one group pretest - postest design approach. The sample is divided into 14 respondents. Data were analyzed by paired t-test. The results showed an average decrease in fasting blood glucose at intervention (28.42 gr / dl) and 2 hours pp blood glucose at intervention (40.57 gr / dl). For bivariate analysis there was a difference between fasting glucose and 2 hours pp with fasting blood glucose GDP) and 2 hours PP (Post Prendial) in patients with diabetes mellitus. The conclusion is that aloe vera can reduce blood glucose levels. Based on the results of research on aloe vera juice can be an alternative non-pharmacological nursing in diabetes mellitus. Keywords: Aloe Vera ; Diabetes Mellitus

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Comparative evaluation of anti-diabetic action and pancreatic histopathology of rats treated with two alkaloidal plant extracts

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl4.4387 ◽

2020 ◽

Vol 11 (SPL4) ◽

pp. 1841-1846

Author(s):

Bonagiri Sreedevi ◽

Vijaya Kuchana ◽

Shobharani S

Keyword(s):

Blood Glucose ◽

Ethanolic Extract ◽

Bark Extract ◽

Albino Rats ◽

Histopathological Study ◽

Standard Group ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Soxhlet Apparatus ◽

Ethanolic Extracts

This study aimed to understand Strychnosnuxvomica and Holarrhena pubescens Stem bark extract action towards M3 receptor in controlling blood glucose levels. Strychnos nux vomica and Holarrhena pubescens are both alkaloidal drugs can help in controlling Hyperglycemic level. This will be useful in the formulation of a new herbal drug molecule for treating diabetes. Chloroform and ethanolic extracts of selected alkaloidal plants were extracted using the soxhlet apparatus and obtained quotes were tested for acute toxicity studies and carried out anti-diabetic action on Wister albino rats for 21 days. Results obtained from Blood glucose levels and histopathological study of test groups are compared with blood glucose levels of standard group, and highly significant action was identified by the chloroform extract of Strychnos nux vomica and Holarrhena pubescens group. Moderate anti-diabetic action was observed remaining two groups of ethanolic extracts. Strychnos nux vomica and Holarrhena pubescens ethanolic extract groups are acting on M3 receptors and controlling Hyperglycemic levels.

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Effectiveness of Graptophyllum pictum (L.) Griff leaf extraction on blood glucose level in alloxan-induced Wistar rat

Food Research ◽

10.26656/fr.2017.4(s3).s12 ◽

2020 ◽

Vol 4 (S3) ◽

pp. 123-126

Author(s):

A. Leonoreza ◽

T. Excelinda ◽

J. Elnitiarta ◽

H.S. Heri-Nugroho ◽

M. Hendrianingtyas ◽

...

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Treatment Group ◽

Wistar Rats ◽

Leaf Extract ◽

Negative Control ◽

Normal Group ◽

Treatment Groups ◽

Glucose Levels ◽

Blood Glucose Levels

Diabetes mellitus is a metabolic disease that always increasing in prevalence. Excessive glucose intake and oxidative stress that can lead to damage to the pancreatic cell or insulin resistance, are such factors that influence the occurrence of diabetes mellitus. Graptophyllum pictum (L.) Griff leaf contains active metabolites such as flavonoid which able to decrease free radical levels. This study aimed to prove the effectiveness of Graptophyllum pictum (L.) Griff leaves extract on blood glucose levels in alloxan-induced Wistar rats. In this study, twenty-five male Wistar rats were divided into five groups. On day 0, the negative control and each treatment group injected with 125 mg/kg dose of alloxan and would be checked on 4th day. On the 4th day after the rats had diabetes, normal group (K-1) was given only standard feed, Negative control (K-2) was given only alloxan intraperitoneally on day 0, first treatment group (K-3) was given 50 mg/kg dose of Graptophyllum pictum (L.) Griff, second treatment group (K-4) was given 100 mg/kg dose of the leaf extract, and the third treatment group (K-5) was given the leaf 200 mg/kg dose of the leaf extract. On the 10th day, fasting blood glucose was taken from the rats. Post-test only group design was used to be the experimental design. There were significant differences in the treatment groups (K-3, K-4, and K-5) compared to the negative control group (K-2) after treatment. The mean of blood glucose levels decreased with the increased doses of Graptophyllum pictum (L.) Griff leaf extract treatment. The treatment groups (K-3, K-4, and K-5) were not significant compared to the normal group (K-1).

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UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ECENG GONDOK (Eichhornia crassipes (Mart.)Solms) DAN DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) PADA MENCIT

Jurnal Insan Farmasi Indonesia ◽

10.36387/jifi.v4i1.602 ◽

2021 ◽

Vol 4 (1) ◽

pp. 44-53

Author(s):

Andri Priyoherianto ◽

◽

Panji Ratih Suci ◽

Putri Rizki Cahya Fatimah ◽

Atik Nur Wijayanti

Keyword(s):

Blood Glucose ◽

Blood Sugar ◽

Water Hyacinth ◽

Leaf Extract ◽

Positive Control ◽

Negative Control ◽

Glucose Levels ◽

Normal Limits ◽

Blood Glucose Levels ◽

Sugar Levels

Diabetes mellitus is a chronic metabolic disorder that occurs due to destruction of pancreatic ? cells characterized by blood glucose levels that exceed normal limits. The purpose of this study was to determine the therapeutic effect of the combination of water hyacinth leaf extract and Sintrong leaf in reducing blood glucose levels in alloxan-induced experimental animals. Water hyacinth leaf powder and Sintrong leaves were extracted using the maceration method with 70% ethanol as a solvent. A total of 25 mice were divided into 5 groups, namely negative control CMC-Na 0.5%, positive control glibenclamide 0.00065 mg / g BW, water hyacinth leaf extract 17.5 mg / kg BW, Sintrong leaf extract 10.5 mg/ kg BW and a combination of water hyacinth leaf extract 17.5 mg / kg BW and sintrong leaf 10.5 mg / kg BW. The results showed that a single extract of water hyacinth and Sintrong leaves was able to reduce blood sugar levels for 7 days. The combination dose was effective in reducing blood sugar levels with a combination dose of 17.5 mg/ kg water hyacinth leaf extract in combination for 7 days.

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Levels of Blood Glucose in Animals Try Wistar White Mix (Rattus Norvegicus) Dined by Green Beans of Sari Bean Packaging

International Journal of Studies in Nursing ◽

10.20849/ijsn.v4i2.559 ◽

2019 ◽

Vol 4 (2) ◽

pp. 17

Author(s):

Maruni Wiwin Diarti ◽

Siti Zaetun ◽

Urip . ◽

Yunan Jiwintarum ◽

Baiq Anies Trisnasanti

Keyword(s):

Blood Glucose ◽

Functional Food ◽

Green Bean ◽

Green Beans ◽

Experimental Animals ◽

High Fiber ◽

Glucose Levels ◽

White Rats ◽

Blood Glucose Levels ◽

Reduce Blood Glucose

Functional food is food that is naturally or through a process that is beneficial to health. One functional food is a green bean juice packaging beverage that can reduce blood glucose levels. High fiber content, low glycemic index and flavonoids, and polyphenols in green beans (Phaseolus radiatus L) can reduce glucose levels in the blood. This study used experimental animals 7 tails. All experimental animals were given packaged mung bean juice 2 times a day for 9 days by means of a round. The mean results of an examination of blood glucose levels in white rat experimental animals before giving packaged green bean juice drinks was 85 mg dl, while the average results of an examination of blood glucose levels in experimental rats after administration of packaged green bean juice were 75 mg/dl. The results of the Paired T-test statistical test obtained p = 0,000 <α = 0.05. Packaged green bean juice can reduce blood glucose levels in animals testing white rats.

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LAYANAN PESAN SINGKAT PENGINGAT MENINGKATKAN KEPATUHAN MINUM OBATPASIEN DIABETES MELITUS DI RSUD ULIN BANJARMASIN

Jurnal Ilmiah Manuntung ◽

10.51352/jim.v1i1.13 ◽

2017 ◽

Vol 1 (1) ◽

pp. 57

Author(s):

Riza Alfian

Keyword(s):

Blood Glucose ◽

Medication Adherence ◽

Short Message Service ◽

Patient Adherence ◽

Fasting Blood Glucose ◽

Short Message ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Message Service ◽

Diabetes Melitus

Diabetes melitus is one ofthe metabolic disorders with characteristic hyperglycemia that occurs due to abnormal insulin secretion, insulin resistance or both. The non adherence patients of taking antidiabetic drugs are the main factors that could cause high blood glucose levels, so it is necessary an intervention to achievedoutcome therapy desired. Giving of short message service reminder intervention in diabetes mellitus patients was expected to improved the medication adherence and achieved normal blood glucose levels.This study was conducted to determine the effect of a short message service reminder on medication adherence of ambulatory diabetes melitus patients in Ulin General Hospital Banjarmasin.This study was conducted with quasi-experimental design,the data were taken prospectively during May to June, 2014. The subjects were ambulatory diabetes melitus patients in Ulin General Hospital Banjarmasin who had received oral antidiabetic drugs. Subject who met the inclusion and exclusion criteria were 39 patients and had given an intervention for seven days. The data collected by interviews and pill counting on filling sheet. The blood glucose levels data was taken from their medical records.The result showed that giving of a short message service reminder intervention improve patient adherence (p<0,05). Fasting blood glucose level and blood glucose level two hours post prandial have decreased significantly (p<0,05). There were correlation between the patient adherence and the decreasing in fasting blood glucose levels (p=0,050; r=0,316) and blood glucose two hours post prandial levels (p=0,010; r=0,040).Based on these result, it can be concluded that the giving of short message service reminder in diabetes melitus patientshas been improved patient adherence.

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EVALUATION OF ANTIDIABETIC AND ANTIOXIDANT EFFECTS OF ETHANOLIC LEAF EXTRACT OF ERYTHRINA ABBYSINICA LAM, EX DC

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i8.24207 ◽

2018 ◽

Vol 11 (8) ◽

pp. 300

Author(s):

Kamadyaapa Davie Rexon ◽

Gondwe Mavuto Masopera ◽

Shauli Mathulo ◽

Sewani Rusike Constance ◽

Nkeh Chungag Benedicta

Keyword(s):

Blood Glucose ◽

Leaf Extract ◽

Antioxidant Properties ◽

Diabetic Rats ◽

Control Group ◽

Oral Glucose ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Ethanolic Leaf Extract ◽

Antioxidant Effects

Objective: This study was conducted to scientifically evaluate the antidiabetic and antioxidant effects of ethanolic leaf extract of Erythrina abbysinica (EEA).Methods: Acute and sub-chronic effects of EEA at 100, 200, and 400 mg/kg/bwt and glibenclamide (GL) at 5 mg/kg/bwt. were evaluated in both normal and streptozotocin (STZ)-induced diabetic male Wistar rats (250–300 g). The acute studies were performed using oral glucose tolerance test (OGTT). In sub-chronic studies, animals were orally administered with EEA and GL daily for 6 w. Brine shrimp assay was used to determine the toxicity of EEA. 1, 1-diphenyl-2-picrylhydrazyl, ferric reducing capacity of plasma, and thiobarbituric acid reactive substances assays were used to determine antioxidant properties of EEA.Results: Following OGTT, EEA significantly (p<0.05) and dose-dependently (100, 200, and 400 mg/kg/bwt) decreased blood glucose levels in both normal and STZ-induced diabetic rats when compared with positive and negative control counterparts at all-time points, whereas GL significantly (p<0.05) decreased blood glucose only in normal rats but not in diabetic rats. Daily, oral administration of EEA for 6 w significantly (p<0.05) and dose-dependently (100, 200, and 400 mg/kg/bwt) decreased blood glucose levels in STZ-induced diabetic rats when compared with the diabetic control group. EEA revealed weak toxicity with a lethal concentration50 value of 997 μg/ml). Furthermore, EEA showed significant free radical scavenging, total antioxidant, and anti-lipid peroxidative capacities.Conclusion: The study has shed more light on the scientific basis for the use of E. abbysinica in management of diabetes in some communities of Eastern Cape of South Africa.

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Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study

Nutrition & Metabolism ◽

10.1186/s12986-021-00571-2 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Pariyarath Sangeetha Thondre ◽

Helen Lightowler ◽

Lis Ahlstrom ◽

Andrew Gallagher

Keyword(s):

Blood Glucose ◽

Leaf Extract ◽

Lifestyle Changes ◽

Glycaemic Response ◽

Double Blind ◽

Glucose Levels ◽

Mulberry Leaf ◽

Blood Glucose Levels ◽

Mulberry Leaf Extract ◽

White Mulberry

Abstract Background There are many benefits of maintaining healthy blood glucose levels, and studies have shown that lifestyle changes such as changes to diet can successfully restore normoglycaemia in participants with dysglycaemia. Significant health-related lifestyle changes are often difficult to implement and functional ingredients that can reduce glycaemic and insulaemic responses may help at risk populations. The aim of this study was to investigate whether a mulberry leaf extract could lower the glycaemic and insulinaemic responses to 75 g sucrose in healthy individuals. Methods A double-blind, randomised, placebo-controlled, crossover design trial was conducted by the Oxford Brookes Centre for Nutrition and Health. Thirty-eight participants were recruited into the trial and, after an overnight fast, were given 75 g sucrose + white mulberry leaf extract, or 75 g sucrose alone. Capillary blood samples were collected at 15-min intervals in the first hour and at 30-min intervals over the second hour to determine glucose and plasma insulin levels. Data analysis was conducted using a paired samples T test or a Wilcoxon signed rank test. Results The addition of mulberry leaf extract to sucrose resulted in a significantly lower glycaemic response and insulinaemic response compared to a matched placebo (sucrose alone). The change in blood glucose measurements were significantly lower at 15 min (p < 0.001), 30 min (p < 0.001), 45 min (p = 0.008), and 120 min (p < 0.001) and plasma insulin measurements were significantly lower at 15 min (p < 0.001), 30 min (p < 0.001), 45 min (p < 0.001), 60 min (p = 0.001) and 120 min (p < 0.001). The glucose iAUC (− 42%, p = 0.001), insulin iAUC (− 40%, p < 0.001), peak glucose (− 40.0%, p < 0.001) and peak insulin (− 41%, p < 0.001) from baseline were significantly lower for white mulberry leaf extract compared with the placebo. White mulberry leaf extract was well tolerated and there were no reported adverse events. Conclusions Mulberry leaf extract can be used as part of lifestyle changes that may lead to healthy blood glucose levels. Trial registration: ISRCTN99601810 (23 October 2020, retrospectively registered)

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