Time in creating human situation. On the regulatory function of time

2017 ◽  
Vol 54 (12) ◽  
pp. 123-133
Author(s):  
Zofia Ratajczak
Keyword(s):  
Human Behaviour ◽  
Regulatory Function ◽  
Objective Condition ◽  
Human Situation ◽  
Instrumental Values ◽  
Task Oriented ◽  
Difficult Situations ◽  
Destructive Factor ◽  
Fundamental Objective

The article dwells on the role of time in regulating human behaviour. A twofold role (subjective and objective) of time was shown in the context of activity theory by Tomaszewski. The twofold role of time is a reflection of a character of a task-oriented situation. Time, being a fundamental objective condition of action, has both autotelic and instrumental values. Human behaviour in a given situation depends on an ability to use the time as a creator of actions as well as a destructive factor, leading to difficult situations. When analyzing behaviour, both instrumental and autotelic characters of time should be taken into account.

Magistri Legis. Eine Studie zur dogmatischen Funktion im industriellen System

2011 ◽  
Vol 2 (2) ◽  
pp. 69-112
Author(s):  
Pierre Legendre
Keyword(s):  
Social Function ◽  
Modern Human ◽  
Human Behaviour ◽  
Cultural Reproduction ◽  
Industrial System ◽  
The West ◽  
History Of ◽  
History Of Law ◽  
New Look

"Der Beitrag reevaluiert die «dogmatische Funktion», eine soziale Funktion, die mit biologischer und kultureller Reproduktion und folglich der Reproduktion des industriellen Systems zusammenhängt. Indem sie sich auf der Grenze zwischen Anthropologie und Rechtsgeschichte des Westens situiert, nimmt die Studie die psychoanalytische Frage nach der Rolle des Rechts im Verhalten des modernen Menschen erneut in den Blick. </br></br>This article reappraises the dogmatic function, a social function related to biological and cultural reproduction and consequently to the reproduction of the industrial system itself. On the borderline of anthropology and of the history of law – applied to the West – this study takes a new look at the question raised by psychoanalysis concerning the role of law in modern human behaviour. "

scholarly journals Modulation of Cathepsin S (CTSS) Regulates the Secretion of Progesterone and Estradiol, Proliferation, and Apoptosis of Ovarian Granulosa Cells in Rabbits

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1770
Author(s):  
Guohua Song ◽  
Yixuan Jiang ◽  
Yaling Wang ◽  
Mingkun Song ◽  
Xuanmin Niu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Granulosa Cells ◽  
Hormone Secretion ◽  
Vital Role ◽  
Regulatory Function ◽  
Cathepsin S ◽  
Related Gene ◽  
Ovarian Granulosa Cells ◽  
Proliferation And Apoptosis

Cathepsin S (CTSS) is a member of cysteine protease family. Although many studies have demonstrated the vital role of CTSS in many physiological and pathological processes including tumor growth, angiogenesis and metastasis, the function of CTSS in the development of rabbit granulosa cells (GCS) remains unknown. To address this question, we isolated rabbit GCS and explored the regulatory function of the CTSS gene in cell proliferation and apoptosis. CTSS overexpression significantly promoted the secretion of progesterone (P4) and estrogen (E2) by increasing the expression of STAR and CYP19A1 (p < 0.05). We also found that overexpression of CTSS increased GCS proliferation by up-regulating the expression of proliferation related gene (PCNA) and anti-apoptotic gene (BCL2). Cell apoptosis was markedly decreased by CTSS activation (p < 0.05). In contrast, CTSS knockdown significantly decreased the secretion of P4 and E2 and the proliferation of rabbit GCS, while increasing the apoptosis of rabbit GCS. Taken together, our results highlight the important role of CTSS in regulating hormone secretion, cell proliferation, and apoptosis in rabbit GCS. These results might provide a basis for better understanding the molecular mechanism of rabbit reproduction.

SUBSTANTIATION OF NECESSITY OF APPLICATION OF PHOSPHOLIPIDS IN THE PRODUCTION OF FUNCTIONAL FOODSTUFFS

2018 ◽  
Author(s):  
Н.Н. КОРНЕН ◽  
С.А. КАЛМАНОВИЧ ◽  
Т.А. ШАХРАЙ ◽  
Е.П. ВИКТОРОВА
Keyword(s):  
Nutritional Status ◽  
Dietary Supplements ◽  
Physiological Role ◽  
Regulatory Function ◽  
Medical Sciences ◽  
Cellular Processes ◽  
Level Of Knowledge ◽  
Protective Fabrics ◽  
Technological University

Проведен анализ современных научных представлений о роли фосфолипидов (ФЛ) в обеспечении функционирования биомембран и их регуляторной функции в важнейших клеточных процессах. Из ФЛ состоит 50% печени, 1/3 мозговых изолирующих и защитных тканей, окружающих головной и спинной мозг. По рекомендациям РАМН, физиологическая потребность взрослого человека в ФЛ составляет 5–7 г/сут. Согласно проведенным исследованиям, в пищевом статусе населения РФ дефицит ФЛ составляет от 50 до 80%. Показано, что современный уровень знаний о физиологической роли ФЛ способствует созданию и внедрению в производство фосфолипидных продуктов на основе ФЛ и фосфолипидных БАД на основе растительных лецитинов, употребление которых может нормализовать пищевой статус. Дано описание фосфолипидных продуктов и БАД серии Тонус (Супер-Тонус, Фито-Тонус, Тонус-Плюс) и серии Витол (Витол, Витол-Холин и Витол-ФЭИ), разработанных учеными Кубанского государственного технологического университета. Показаны возможности применения растительных лецитинов, фосфолипидных продуктов и БАД на их основе в качестве многофункциональных рецептурных компонентов при производстве пищевых продуктов функционального и специализированного назначения. The analysis of modern scientific ideas about the role of phospholipids (FL) in ensuring the functioning of biomembranes and their regulatory function in the most important cellular processes is carried out. So, 50% of a liver, 1/3 brain isolating and protective fabrics surrounding a brain and spinal cord consist of FL. According to the recommendations of the Russian Academy of Medical Sciences, the physiological need of an adult in FL is 5–7 g/day. According to the conducted studies, in the nutritional status of the Russian population, the deficit of FL is from 50 to 80%. It is shown that the current level of knowledge about the physiological role of FL contributes to the creation and introduction of phospholipid products based on FL and phospholipid supplements on the basis of vegetable lecithins, the use of which can normalize the nutritional status. The description of phospholipid products and dietary supplements developed by scientists of the Kuban State Technological University of the Tonus series (Super Tonus, Phyto Tonus, Tonus Plus) and the Vitol series (Vitol, Vitol Kholin and Vitol FEI) is given. The possibilities of using vegetable lecithins, phospholipid products and dietary supplements on their basis are shown as multifunctional prescription components in the production of functional and specialized food products.

scholarly journals Cryptic Transcription and Early Termination in the Control of Gene Expression

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Jessie Colin ◽  
Domenico Libri ◽  
Odil Porrua
Keyword(s):  
Gene Expression ◽  
Rna Polymerase Ii ◽  
Regulatory Function ◽  
Large Set ◽  
Control Of Gene Expression ◽  
Alternative Transcription ◽  
Cryptic Transcription ◽  
Nuclear Exosome ◽  
The Impact

Recent studies on yeast transcriptome have revealed the presence of a large set of RNA polymerase II transcripts mapping to intergenic and antisense regions or overlapping canonical genes. Most of these ncRNAs (ncRNAs) are subject to termination by the Nrd1-dependent pathway and rapid degradation by the nuclear exosome and have been dubbed cryptic unstable transcripts (CUTs). CUTs are often considered as by-products of transcriptional noise, but in an increasing number of cases they play a central role in the control of gene expression. Regulatory mechanisms involving expression of a CUT are diverse and include attenuation, transcriptional interference, and alternative transcription start site choice. This review focuses on the impact of cryptic transcription on gene expression, describes the role of the Nrd1-complex as the main actor in preventing nonfunctional and potentially harmful transcription, and details a few systems where expression of a CUT has an essential regulatory function. We also summarize the most recent studies concerning other types of ncRNAs and their possible role in regulation.

scholarly journals Circ_0000215 Exerts Oncogenic Function in Nasopharyngeal Carcinoma by Targeting miR-512-5p

2021 ◽  
Vol 9 ◽  
Author(s):  
Xinping Chen ◽  
Weihua Xu ◽  
Zhichao Ma ◽  
Juan Zhu ◽  
Junjie Hu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Cell Lines ◽  
Cell Counting ◽  
Regulatory Subunit ◽  
Luciferase Reporter ◽  
Regulatory Function ◽  
Migration And Invasion ◽  
Circular Rnas

Background: Increasing circular RNAs (circRNAs) are reported to participate in cancer progression. Nonetheless, the role of circRNAs in nasopharyngeal carcinoma (NPC) has not been fully clarified. This work is aimed to probe the role of circ_0000215 in NPC.Methods: Circ_0000215 expression in NPC tissues and cell lines was examined by quantitative real-time polymerase chain reaction (qRT-PCR). Cell counting kit-8 (CCK-8) assay, 5-bromo-2′-deoxyuridine (BrdU) assay, scratch healing assay and Transwell experiment were executed to investigate the regulatory function of circ_0000215 on the proliferation, migration and invasion of NPC cells. RNA immunoprecipitation (RIP), pull-down and dual-luciferase reporter experiments were utilized to determine the binding relationship between circ_0000215 and miR-512-5p, and between miR-512-5p and phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) 3′UTR. The effects of circ_0000215 on NPC growth and metastasis in vivo were examined with nude mice model. Western blot was applied to detect the regulatory effects of circ_0000215 and miR-512-5p on PIK3R1 expression.Results: Circ_0000215 was overexpressed in NPC tissues and cell lines. The functional experiments confirmed that knockdown of circ_0000215 impeded the growth and metastasis of NPC cells in vitro and in vivo. Additionally, circ_0000215 could also work as a molecular sponge to repress miR-512-5p expression. PIK3R1 was validated as a target gene of miR-512-5p, and circ_0000215 could increase the expression level of PIK3R1 in NPC cells via suppressing miR-512-5p.Conclusion: Circ_0000215 is overexpressed in NPC and exerts oncogenic effects in NPC through regulating miR-512-5p/PIK3R1 axis.

The role of the WTO in achieving equity and efficiency in international markets for agricultural products

2005 ◽  
Vol 4 (2) ◽  
pp. 229-247 ◽  
Author(s):  
DONALD MACLAREN
Keyword(s):  
International Markets ◽  
Agricultural Products ◽  
Differential Treatment ◽  
The Other ◽  
Doha Round ◽  
Equity And Efficiency ◽  
Slow Progress ◽  
The One ◽  
Fundamental Objective

The fundamental objective of the negotiations on agriculture that are taking place in the Doha Round is to establish a new set of rules, which will correct current distortions and prevent future distortions in international markets for agricultural products while taking into account non-trade concerns and special and differential treatment. A summary of the chronology of the very slow progress to date in the negotiations is provided. This rate of progress is explained through considering the weights the different groups of governments are giving to removing trade distortions, on the one hand, and to non-trade concerns and special and differential treatment, on the other. Some results from the economic theory of distortions and welfare are used to explain the conditions under which the twin pursuits of non-trade concerns domestically and fairness internationally are compatible. These results are contrasted with the realities of the current negotiations on the agriculture component of the ‘July 2004 package’.

Towards a Rhetoric of Experience: the Role of Enargeia in the Essays of Montaigne.

2002 ◽  
Vol 20 (2) ◽  
pp. 173-192 ◽  
Author(s):  
Gerard Paul Sharpling
Keyword(s):  
Visual Representation ◽  
Human Experience ◽  
Human Behaviour ◽  
Linguistic Expression ◽  
French Renaissance ◽  
Verbal Language ◽  
Insight Into

The aim of this paper is to explore the Montaigne's use of enargeia in three essays: ''Des Cannibales,'' ''Des Coches'' and ''De l'exercitation.'' During the French Renaissance, enargeia remained a central means by which writers transferred living experience into language. The elaborate visual possibilities offered by enargeia, encapsulated in the writings of Quintilian, were popularised in France through the diffusion of Erasmus's rhetorical handbook De diuplici copia verborum ac rerum. However, the sense of graphic presence and truth conveyed by Erasmus's handbook came to be challenged through the increasing awareness of the disparity between living experience and verbal language. In his Essais, Montaigne's awareness of the deceptive properties of visual representation allows him to explore, often playfully, the pleasures and instabilities of linguistic expression, and to gain a heightened insight into the perceptual inadequacy which characterize much human behaviour. In this way, Montaigne poignantly demonstrates the instructive nature of rhetorical theories on which he draws to illustrate his understanding of human experience.

The Effect of Status on Identity Stability

2016 ◽  
Vol 60 (3) ◽  
pp. 497-509 ◽  
Author(s):  
Jenny L. Davis ◽  
Tony P. Love
Keyword(s):  
Identity Theory ◽  
High Status ◽  
Identity Change ◽  
Lower Status ◽  
Task Oriented

Using 77 status-imbalanced dyads, we experimentally test the effect of status on identity stability, setting the stage for research on identity change. From an identity theory perspective, we hypothesize that those with higher status will maintain greater identity stability over the course of a task-oriented interaction than their relatively lower status partners. We further test the role of identity-discrepant information. Results indicate that higher status actors are better able to maintain stable identity meanings than those with lower status. However, this relationship dissipates when situational meanings contrast with high-status actors’ self-views. More generally, this indicates that high status positively affects identity stability, yet high-status actors remain vulnerable to situational inputs.

scholarly journals Discovery of pluripotency-associated microRNAs in rabbit preimplantation embryos and embryonic stem-like cells

Reproduction ◽  
2013 ◽  
Vol 145 (4) ◽  
pp. 421-437 ◽  
Author(s):  
Pouneh Maraghechi ◽  
László Hiripi ◽  
Gábor Tóth ◽  
Babett Bontovics ◽  
Zsuzsanna Bősze ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Cell Biology ◽  
Embryonic Stem ◽  
Blastocyst Stage ◽  
Expression Level ◽  
Preimplantation Embryos ◽  
Regulatory Function ◽  
Low Level ◽  
Non Coding Rnas

MicroRNAs (miRNAs) are small non-coding RNAs that regulate multiple biological processes. Increasing experimental evidence implies an important regulatory role of miRNAs during embryonic development and in embryonic stem (ES) cell biology. In the current study, we have described and analyzed the expression profile of pluripotency-associated miRNAs in rabbit embryos and ES-like cells. The rabbit specific ocu-miR-302 and ocu-miR-290 clusters, and three homologs of the human C19MC cluster (ocu-miR-512, ocu-miR-520e, and ocu-miR-498) were identified in rabbit preimplantation embryos and ES-like cells. The ocu-miR-302 cluster was highly similar to its human homolog, while ocu-miR-290 revealed a low level of evolutionary conservation with its mouse homologous cluster. The expression of the ocu-miR-302 cluster began at the 3.5 days post-coitum early blastocyst stage and they stayed highly expressed in rabbit ES-like cells. In contrast, a high expression level of the ocu-miR-290 cluster was detected during preimplantation embryonic development, but a low level of expression was found in rabbit ES-like cells. Differential expression of the ocu-miR-302 cluster and ocu-miR-512 miRNA was detected in rabbit trophoblast and embryoblast. We also found that Lefty has two potential target sites in its 3′UTR for ocu-miR-302a and its expression level increased upon ocu-miR-302a inhibition. We suggest that the expression of the ocu-miR-302 cluster is characteristic of the rabbit ES-like cell, while the ocu-miR-290 cluster may play a crucial role during early embryonic development. This study presents the first identification, to our knowledge, of pluripotency-associated miRNAs in rabbit preimplantation embryos and ES-like cells, which can open up new avenues to investigate the regulatory function of ocu-miRNAs in embryonic development and stem cell biology.

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