Topical issues of formation state anti-corruption policy in Ukraine

The purpose of the article is to identify existing problems in the formation and implementation of anti-corruption policy in Ukraine based on the analysis of research results of the current state of corruption in Ukraine, analysis of relevant regulations and practice of its implementation. The methodology is based on the dialectical method of scientific knowledge, as well as special research methods based on modern scientific principles of legal, political, managerial and related sciences. Results of the research. The article analyzes the current issues of state anti-corruption policy in Ukraine at the present stage. It is noted that corruption is one of the biggest problems of Ukrainian society and has a great resistance to the development of Ukraine as a state. Ukraine currently has a whole system of anti-corruption bodies, some of which perform purely anti-corruption functions, while others perform anti-corruption functions as well. At the same time, the Basic Anti-Corruption Law defines a limited list of specially authorized entities in the field of anti-corruption. It is proved that the reserve of influence of public organizations in combating corruption offenses is still poorly used by the state on the initiative of the state itself.

Exsolution in La and Ni co-doped strontium titanate: a suitable anode for running SOFCs on ammonia as alternative fuel

Ammonia exhibits interesting features as fuel to feed Solid Oxide Fuel Cell. Herein, Ni and La co-doped strontium titanate was synthetized using wet chemistry route. Ni nanoparticles emerged via exsolution in reducing environment to decorate the surface. X-Ray Diffraction measurements exhibits perovskite structure was also preserved after the exsolution, as expected. H2 – Temperature Programmed Reduction highlights the great resistance of titanates in anode operation condition. Ammonia conversion in nitrogen and hydrogen were investigated by catalytic tests. It begins to decompose at 560°C and the full yield was achieved at 720°C. Electrochemical measurements were recorded at 800°C using 10% of ammonia in Ar. They were analysed though the model of equivalent circuit and two processes were attributed. Results certify Ni exsolution strongly enhances the hydrogen oxidation and the total polarisation resistance in ammonia approaches to the one in hydrogen.

Stability-Indicating UHPLC Method for the Determination of Desvenlafaxine: Application to Degradation Kinetics

This study was aimed to investigate the degradation behavior and physicochemical stability of desvenlafaxine using reversed-phase ultra-high-performance liquid chromatography (RP-UHPLC) system. The chromatogram was developed on Eclipse XDB-C8 column (150 x 4.6 mm, 5μm). The eluents were monitored through a photo diode array plus (PDA+) detector at 210 nm using an isocratic method with a flow rate of 1.5 ml/min. Mobile phase composition was 30:70 v/v mixture of 0.1 % trifluoroacetic acid (TFA) in water and methanol. Forced degradation studies were performed on drug substance of desvenlafaxine as per International Conference on Harmonization (ICH) prescribed stressed conditions (Q1A(R2) and Q1B) using hydrolytic (acidic, basic, and neutral), oxidative and photolytic methods. The drug substance was found highly labile to acidic (0.5 N hydrochloric acid, 18.65 % degradation in 2 hours at 70°C), basic (1.0 N sodium hydroxide, 11.01 % degradation in 12 hours at 70°C) and oxidative (3 % hydrogen peroxide, 17.05 % degradation in 2 hours at 50°C) stressed conditions, but a great resistance was observed towards dry heat (maximum degradation 0.27 % in 10 days from ambient to higher temperature, 80°C), moist heat (maximum degradation 0.25 % in 2 hours at 80°C and 75 % relative humidity) as well as in photolytic degradation (maximum degradation 0.23 % in 10 days at UV light of 315 - 400 nm). A pseudo-first order kinetic was followed in acidic, basic and peroxide degradation methods which paved a way to calculate the half-life of the drug substance desvenlafaxine under ICH mentioned stressed conditions. The results were also statistically analyzed and the % RSD values were compared with recommended guidelines. Dhaka Univ. J. Pharm. Sci. 20(2): 167-176, 2021 (December)

Performance Optimization and Economic Evaluation of CO2 Heat Pump Heating System Coupled with Thermal Energy Storage

CO2 air source heat pump (ASHP), as a kind of clean and efficient heating equipment, is a promising solution for domestic hot water and clean heating. However, the promotion of CO2 ASHP encounters a great resistance when it is used for space heating; namely, the return water temperature is too high that cased higher throttle loss, which decreases the COP of the CO2 ASHP unit. To solve this problem, a heating system of CO2 ASHP coupled with thermal energy storage (TES) is developed in this work. The simulation model of the studied system is established using TRNSYS software, and the model is verified by experimental data. Additionally, the performance of the studied system is optimized, and its economy is analyzed by life cycle cost (LCC). The results showed that, compared with the system before optimization, the cost of the optimized system increased, the annual operating cost of the system was reduced, and the COP of the system (COPsys) increased by 7.4%. This research is helpful in improving the application of the CO2 ASHP unit in cold server and cold areas.

Technological Transformation Processes and Resistance—On the Conflict Potential of 5G Using the Example of 5G Network Expansion in Germany

The expansion of fifth-generation wireless technology (5G) has been assigned the significance of a ‘key technology’ in connection with technological advances in the context of the digitalization of societies, which is a central goal of current governments in leading industrialized nations. As with other large-scale infrastructure projects such as the expansion of renewable energies as part of the energy transition in Germany, the plans for implementation are meeting with great resistance from the population, sometimes resulting in arson attacks on 5G transmission masts. Current research on 5G focuses primarily on technical­–economic, health-related and, in the context of the COVID-19 pandemic, increasingly conspiracy-theoretical aspects, while questions of acceptance or conflict potential have received little attention to date. This article aims to address this research gap and, on the basis of a conflict-theoretical perspective according to Dahrendorf combined with a socio-economic contextualization in the sense of Bourdieu, approaches the question of the extent to which social conflict has already progressed and what regulatory possibilities socio-economic contexts assume in terms of significance. For this purpose, about 70 identifiable internet presences of citizens’ initiatives against 5G were qualitatively and quantitatively evaluated.

Multi-disciplinary Approach for Drug and Gene Delivery Systems to the Brain

Drug delivery into the brain has for long been a huge challenge as the blood–brain barrier (BBB) offers great resistance to entry of foreign substances (with drugs inclusive) into the brain. This barrier in healthy individuals is protective to the brain, disallowing noxious substances present in the blood to get to the brain while allowing for the exchange of small molecules into the brain by diffusion. However, BBB is disrupted under certain disease conditions, such as cerebrovascular diseases including acute ischemic stroke and intracerebral hemorrhage, and neurodegenerative disorders including multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and cancers. This review aims to provide a broad overview of present-day strategies for brain drug delivery, emphasizing novel delivery systems. Hopefully, this review would inspire scientists and researchers in the field of drug delivery across BBB to uncover new techniques and strategies to optimize drug delivery to the brain. Considering the anatomy, physiology, and pathophysiological functioning of the BBB in health and disease conditions, this review is focused on the controversies drawn from conclusions of recently published studies on issues such as the penetrability of nanoparticles into the brain, and whether active targeted drug delivery into the brain could be achieved with the use of nanoparticles. We also extended the review to cover novel non-nanoparticle strategies such as using viral and peptide vectors and other non-invasive techniques to enhance brain uptake of drugs. Graphical abstract

Age-old transformation of oil hydrocarbons in polluted Grey-Brown Soil in the Absheron Peninsula

Oil production, transportation and refining are a source of the extensive environmental pollution. The study of oil pollutants allows the identification of their behavior pattern necessary in order to elaborate efficient decontamination technologies. The Absheron oil field is one of the most long-term exploited deposit in the world. Today this area is a unique place to investigate the long-lasting natural oil transformation processes. Grey-Brown Soils contaminated with crude oil 100 and 40 years ago and currently were investigated. Hexane-extractable fraction of oil compounds was examined by chemical methods, gas chromatography and mass spectrometry. In the process of natural degradation, molecular weight of oil hydrocarbons and degree of oxidation significantly increased, while the contents of carbon and hydrogen slightly decreased with time. The results obtained have shown the accumulation of high-molecular weight aromatic molecules with high degree of unsaturation in the upper layer of the soil contaminated 100 years ago. These aromatic structures exhibit the great resistance to decomposition and may be carcinogenic, thus posing a risk to human health. The contamination with oil resulted in altering soil properties. More pronounced change was observed in the soil carbon, including the soil contaminated 100 years ago. Over time after contamination, the soil alkalinity enhanced, whereas soil pH did not change. Our study evidences that oil pollutants continue to be present and the soil properties have not recovered even 100 years after pollution. Reclamation of these areas requires the application of special technologies.

Study on Collapse Resistance of RC Frame under the Corner Column Removal Scenario

The progressive collapse of buildings induces a variety of catastrophic consequences, such as casualties and property loss over the past few decades. The corner column is more prone to abnormal load events compared to the inner column and outer column; thus, it is easier to trigger progressive collapse. By considering the effects of floor slabs and adjacent bays on progressive collapse behavior, the pseudo-static loading method was used to study the progressive collapse test of a 1/3 scaled, one story, 2 × 2-bay cast-in-place reinforced concrete frame substructure under the removal condition of a corner column. The test results show that the flexural deformation principally concentrates upon the components of a directly affected part (DAP), and compressive arch actions are observed in members of the indirectly affected part (IAP). Moreover, the slab adjacent to the removed column and periphery elements contributes great resistance to a progressive collapse.

Genotyping of Escherichia coli Causing Vaginal Infection in Dysplastic Patients with Similar Genetic Backgrounds Between Commensal and Virulent Strains

Background: Escherichia coli in the vagina includes several virulence factors in its genome mobile genetic elements and can facilitate colonization, mainly in immunosuppressed patients. Objectives: This work aimed to demonstrate that E. coli strains of vaginal origin isolated from dysplastic patients possess virulence and resistance genes Methods: This study included one hundred and five E. coli strains isolated from women with cervical dysplasia and vaginal infection. The strains were characterized by antimicrobial susceptibility. The Clermont algorithm performed the phylogenetic assignment. The structure of class 1 integrons was performed by identifying integrase (int1), the variable region, and qacEΔ1-sul1 genes. The variable region was amplified, sequenced, and analyzed. Enterobacterial repetitive intergenic consensus (ERIC) PCR and virus typing typed strains with identical genetic arrangements by detecting virulence genes related to cytotoxicity, adherence, and iron uptake. Results: Escherichia coli strains showed great resistance to β-lactams and quinolones, and phylogenetic assignment showed that the group A/C was highly predominant. Sixteen integrons were identified, with monogenic arrays represented by aadA1, dfrB4dfrA7, dfr2D, and dfrA17 cassettes. The prevalence of the biogenic arrays aadA1/dfrA1 and aadA5/dfrA17 was lower than that of blaOXA-1/aadA1. Concerning virulence genes, fimH, traT, and iutA were the most predominant. Conclusions: The high incidence of virulence and resistance factors in commensal and virulent strains of E. coli revealed potential tools in the pathogenesis of vaginal infection.

Assessing the Biodegradation of Vulcanised Rubber Particles by Fungi Using Genetic, Molecular and Surface Analysis

Millions of tonnes of tyre waste are discarded annually and are considered one of the most difficult solid wastes to recycle. A sustainable alternative for the treatment of vulcanised rubber is the use of microorganisms that can biotransform polymers and aromatic compounds and then assimilate and mineralise some of the degradation products. However, vulcanised rubber materials present great resistance to biodegradation due to the presence of highly hydrophobic cross-linked structures that are provided by the additives they contain and the vulcanisation process itself. In this work, the biodegradation capabilities of 10 fungal strains cultivated in PDA and EM solid medium were studied over a period of 4 weeks. The growth of the strains, the mass loss of the vulcanised rubber particles and the surface structure were analysed after the incubation period. With the white rot fungi Trametes versicolor and Pleurotus ostreatus, biodegradation percentages of 7.5 and 6.1%, respectively, were achieved. The FTIR and SEM-EDS analyses confirmed a modification of the abundance of functional groups and elements arranged on the rubber surface, such as C, O, S, Si, and Zn, due to the biological treatment employed. The availability of genomic sequences of P. ostreatus and T. versicolor in public repositories allowed the analysis of the genetic content, genomic characteristics and specific components of both fungal species, determining some similarities between both species and their relationship with rubber biodegradation. Both fungi presented a higher number of sequences for laccases and manganese peroxidases, two extracellular enzymes responsible for many of the oxidative reactions reported in the literature. This was confirmed by measuring the laccase and peroxidase activity in cultures of T. versicolor and P. ostreatus with rubber particles, reaching between 2.8 and 3.3-times higher enzyme activity than in the absence of rubber. The integrative analysis of the results, supported by genetic and bioinformatics tools, allowed a deeper analysis of the biodegradation processes of vulcanised rubber. It is expected that this type of analysis can be used to find more efficient biotechnological solutions in the future.