scholarly journals Carbohydrate Sources, Within a Higher Protein Breakfast, Differentially Effect Postprandial Appetite Response in Adults with Metabolic Syndrome: A Pilot Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 671-671
Author(s):  
Sam Walker ◽  
Jamie Baum ◽  
Aubree Hawley ◽  
Angela Tacinelli ◽  
Drake Enderlin ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Analogue Scale ◽  
Potato Research ◽  
Carbohydrate Source ◽  
Funding Sources ◽  
Research And Education ◽  
Processed Potatoes ◽  
Desire To Eat ◽  
Potato Meal ◽  
Carbohydrate Meal

Abstract Objectives The objective of this study was to determine the effect of carbohydrate source within a higher protein breakfast on postprandial appetite response in adults with metabolic syndrome. Methods Fourteen adults with metabolic syndrome were randomly assigned to consume one of three iso-caloric, higher protein breakfasts (352 kcal; 26.5 ± 0.3 g Pro; 20.0 ± 0.5 g CHO; 19.8 ± 0.3 g 18.0 ± 0.1 g Fat) containing servings of different carbohydrate sources: white potatoes (n = 5; 5 female; 37.6 ± 8.5 y; 98.0 ± 14.1 kg; 39.5 ± 7.3 BMI); 2) processed potatoes (hash browns) (n = 2; 1 female,1 male; 53.0 ± 15.0 y; 81.4 ± 17.0 kg; 29.6 ± 3.0 BMI); or 3) starchy carbohydrate (white rice; n = 5; 4 female,1 male; 33.6 ± 5.0 y; 95.1 ± 18.2 kg; 35.3 ± 4.7 BMI). All participants reported to the lab following an overnight fast. Participants were served their assigned meal (quiche) and were given 15 minutes to fully consume the entire portion. Appetite was assessed via visual analogue scale (VAS) with opposing anchors (e.g., “extremely hungry” or “not hungry at all”) at time points 0, 15, 30, 60, 90, 120, 180 and 240 min. Data were analyzed using Prism GraphPad version 8.0. Significance was set at P < 0.05. Results Although not significant, participants who consumed the starchy carbohydrate meal reported increased hunger (182%), desire to eat (64%), and decreased fullness (8%) when compared to participants consuming the potato meal. In addition, the starchy carbohydrate meal consumption was a significantly associated with a desire for sweetness (P < 0.05). No significant differences in appetite were observed between participants consuming the potato meal and the processed potato meal. Conclusions Preliminary results indicate the source of carbohydrate as part of a higher protein breakfast influences postprandial appetite response in adults with metabolic syndrome, however further research is needed. Funding Sources Alliance for Potato Research and Education.

The Three Rs in Research and Education: A Long Road Ahead in the United States

1996 ◽  
Vol 24 (2) ◽  
pp. 151-158 ◽  
Author(s):  
F. Barbara Orlans
Keyword(s):  
United States ◽  
Animal Experiments ◽  
The United States ◽  
Education Student ◽  
Funding Sources ◽  
Research And Education ◽  
The Right ◽  
Student Projects ◽  
Institutional Oversight ◽  
The Three Rs

Attitudes toward the Three Rs concept of refinement, reduction and replacement in the United States in research and education are widely divergent. Positive responses have come from several sources, notably from four centres established to disseminate information about alternatives. Funding sources to support work in the Three Rs have proliferated. The activities of institutional oversight committees have resulted in the nationwide implementation of important refinements. In the field of education, student projects involving pain or death for sentient animals have declined, and the right of students to object to participation in animal experiments on ethical grounds has been widely established. However, there is still a long way to go. Resistance to alternatives is deep-seated within several of the scientific disciplines most closely associated with animal research. The response of the National Institutes of Health to potentially important Congressional directives on the Three Rs has been unsatisfactory. The prestigious National Association of Biology Teachers, which at first endorsed the use of alternatives in education, later rescinded this policy, because of opposition to it. An impediment to progress is the extreme polarisation of viewpoints between the biomedical community and the animal protectionists.

scholarly journals Pengaruh Pemberian Diet Isokalori Tinggi Serat terhadap Tingkat Satiety pada Kelompok Usia Dewasa Awal

2021 ◽  
Vol 5 (3) ◽  
pp. 237
Author(s):  
Maura Tirta Nabila ◽  
A. Fahmy Arif Tsani ◽  
Ayu Rahadiyanti ◽  
Fillah Fithra Dieny
Keyword(s):  
Visual Analogue Scale ◽  
Food Consumption ◽  
Analogue Scale ◽  
T Test ◽  
Group Design ◽  
Consecutive Sampling ◽  
Desire To Eat ◽  
Paired T Test

Latar Belakang: Belum banyak penelitian yang membandingkan pengaruh diet tinggi serat larut air dan diet tinggi serat tidak larut air terhadap tingkat satiety.Tujuan:Menganalisis pengaruh pemberian diet isokalori tinggi serat terhadap tingkat satiety pada kelompok usia dewasa awal status gizi normal.Metode: Penelitian eksperimentaldengan rancangan pre-post group design. Subjek penelitian adalah 16 orang dewasa awal usia 20-23 tahun (10 perempuan dan 6 laki-laki) yang diambil secara consecutive sampling. Semua subjek diberikan 2 jenis diet isokalori dengan rasio serat larut air : serat tidak larut air sebesar 3:2 dan 1:3 dengan masing-masing wash out period selama 1 hari. Energi yang diberikan sebesar 20% dari total kebutuhan masing-masing subjek. Variabel yang diukur adalah tingkat satiety yang terdiri dari tingkat desire to eat, hunger, fullness dan prospective food consumption/PFC menggunakan kuesioner Visual Analogue Scale. Analisis statistik menggunakan paired t-test, wilcoxon, mann-whitney dan independent t-test.Hasil: Diet tinggi serat larut air memiliki efek lebih lama 1 jam dalam menekan hunger dan desire to eat dan memiliki efek lebih lama 30 menit dalam menekan PFC dibandingkan diet tinggi serat tidak larut air, namun kedua diet tersebut sama-sama baik dalam meningkatkan fullness hingga 3 jam setelah intervensi.Kesimpulan: Pemberian diet tinggi serat dapat menekan tingkat desire to eat, hunger, PFC dan meningkatkan fullness. Diet tinggi serat larut air mempunyai efek lebih lama terhadap tingkat satiety dibandingkan diet tinggi serat tidak larut air.

scholarly journals Potatoes Incorporated into a Higher Protein Diet for 16-Weeks Do Not Influence Cardiometabolic Health in Adults with Metabolic Syndrome: A Pilot Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1698-1698
Author(s):  
Sam Walker ◽  
Jamie Baum ◽  
Aubree Hawley ◽  
Angela Tacinelli ◽  
Drake Enderlin ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Sleep Quality ◽  
Protein Diet ◽  
Cardiometabolic Health ◽  
Mineral Density ◽  
Waist To Hip Ratio ◽  
Processed Potatoes ◽  
Protein Diets

Abstract Objectives To determine if consuming four servings of white potatoes, processed potato products, or starchy carbohydrates for 16 weeks, as part of a higher protein diet, influence markers of cardiometabolic health in adults with metabolic syndrome. Methods Eleven adults with metabolic syndrome were randomly assigned to one of three higher protein diets incorporating different carbohydrate sources: 1) 4 servings of potatoes/week (P; n = 4; 4 female; 48.3 ± 9.4 y; 92.4 ± 9.6 kg; 36.3 ± 4.3 BMI); 2) processed potatoes (PP; n = 2; 1 female,1 male; 53.0 ± 15.0 y; 81.4 ± 17.0 kg; 29.6 ± 3.0 BMI); or 3) starchy carbohydrate (SC; n = 5; 4 female,1 male; 33.6 ± 5.0 y; 95.1 ± 18.2 kg; 35.3 ± 4.7 BMI). Data was collected at baseline, 4, 8,12, and 16 weeks. Glucose, cholesterol, and triglycerides were analyzed using a Cholestech LDX Analyzer. Height, weight, waist-to-hip ratio, blood pressure, mood, sleep quality, and grit were also measured. Body composition was measured using DEXA. Data were analyzed using Prism GraphPad version 8.0. Significance was set at P < 0.05. Results There were no significant changes in body weight, BMI, waist-to-hip ratio, or body composition within or between each group. However, an increase in bone mineral density was observed within all groups(P < 0.05). There was no effect of diet on plasma glucose and lipid levels. In addition, there was no change in blood pressure within each group. However, diastolic blood pressure decreased (P < 0.05) in all groups. There were no changes in mood and grit. However, sleep quality improved within all groups (P < 0.05). In addition, grip strength improved (P < 0.05) within all groups. Conclusions The preliminary results of this study indicate that incorporating white potatoes, processed potatoes, or starch carbohydrates into a higher protein diet, does not influence markers of cardiometabolic health in adults with metabolic syndrome. Higher protein diets, may improve secondary outcomes such as sleep quality, bone mineral density, and grip strength. However, a larger study population is needed. Funding Sources Alliance for Potato Research and Education.

scholarly journals Intake of 3 Eggs/Day or Equivalent Amount of Choline as Supplement for 4 Weeks Increases Plasma Choline Without Changing Plasma TMAO in Participants with Metabolic Syndrome

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 480-480
Author(s):  
Minu Thomas ◽  
Marissa Dibella ◽  
Olga V Malysheva ◽  
Marie A Caudill ◽  
Christopher Blesso ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Inflammatory Markers ◽  
Liver Enzymes ◽  
Initial Period ◽  
Healthy Population ◽  
Random Allocation ◽  
Additional Information ◽  
Reactive Protein ◽  
Funding Sources ◽  
Egg Period

Abstract Objectives Our previous study in a young healthy population indicated that choline from eggs (phosphatidylcholine) was more bioavailable than choline from a supplement (choline bitartrate) as determined by plasma choline concentrations. The purpose of this study was to compare equivalent amounts of two choline sources on plasma choline and its derivatives including trimethylamine N-oxide (TMAO) and inflammatory markers in men and women aged 32 to 70 years old with metabolic syndrome (MetS). Methods Twenty-three subjects with MetS were included in this randomized, crossover clinical trial. Participants underwent an initial period of 2 weeks without consuming any eggs, which was followed by a random allocation to either 3 eggs/day or a choline-supplement for 4 weeks (both diets had a choline equivalent of 400 mg per day). Following a 3-week washout period, participants were allocated to the alternate diet. We measured plasma choline and plasma TMAO as well as C-reactive protein (CRP), inflammatory markers and liver enzymes. Results Although there was an overall significant increase in plasma choline after egg intake, compared to baseline (P < 0.01), there were no significant differences between egg and supplement at the end of the respective interventions (P > 0.05). Baseline values were 7.9 ± 2.1 nmol/ml compared to 9.9 ± 2.2 and 9.5 ± 2.1 nmol/ml for the egg and supplement, respectively (P < 0.01). In addition, plasma TMAO was not different between baseline, or at the end of the egg and supplement periods (P > 0.1). When we measured inflammatory markers, compared to baseline CRP was lower after the egg period (0.49 ± 0.50 vs. 0.36 ± 0.37 mg/dL, P < 0.01) while no differences in this parameter were observed at the end of the egg or the supplement period. Liver enzymes were not affected by treatment. Conclusions These studies indicate that in contrast to healthy individuals, the plasma choline response appears to be similar in MetS participants, independent of its source or chemical composition. Analyzing the microbiota of these subjects will provide additional information regarding how choline is metabolized in individuals with MetS. Funding Sources The Egg Nutrition Center.

scholarly journals Low Serum Choline Concentrations Are Associated with Worse Cognitive Performance in Subjects with Metabolic Syndrome

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1200-1200
Author(s):  
Oscar Coltell ◽  
Eva M Asensio ◽  
Jose V Sorlí ◽  
Rebeca Fernández-Carrión ◽  
José I Giménez-Alba ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cognitive Performance ◽  
Verbal Fluency ◽  
Multivariate Model ◽  
Neuroprotective Effects ◽  
Funding Sources ◽  
Type 2 Diabetics ◽  
Phonemic Fluency ◽  
Trail Making ◽  
Essential Nutrient

Abstract Objectives Choline is an essential nutrient critical for components of the cell membrane, such as choline-containing phospholipids (phosphatidylcholine and sphingomyelin), and in synthesis of the neurotransmitter acetylcholine. Choline has been shown to exert neuroprotective effects, but the association between serum choline and cognitive performance has been scarcely investigated. Our aims are: 1) To study the association between serum total choline, phosphatidylcholine and sphingomyelin with cognitive performance in subjects with metabolic syndrome; and 2) to analyze genetic variants and dietary intake most associated with cholines in this population. Methods We analyzed 426 subjects (aged 55–75 y) with metabolic syndrome from the PREDIMED Plus-Valencia Study. Serum total choline, phosphatidylcholine and sphingomyelin were determined by NMR spectroscopy. Cognitive tests, including verbal fluency (both semantic and phonemic fluency) and the Trail Making Test (TMT) (parts A and B), were administered. Candidate gene polymorphisms were determined by array genotyping. Diet was analyzed by validated questionnaires. Multivariate regression models were fitted. Results Cholines (total, phosphatidylcholine and sphingomyelin) were strongly associated with sex (higher in women; P < 0.001), age (lower at increasing age; P < 0.05) and diabetes (lower in type-2 diabetics; P < 0.01) in a multivariate model. Although the three tested variables presented statistically significant associations with cognition, serum sphingomyelin was the most associated. Thus, in a multivariate model, serum phosphatidylcholine was directly associated with better verbal fluency (P = 0.040 and P = 0.029 for phonemic and semantic, respectively) and inversely associated (lower score mean better performance) with the TMT-A (P = 0.013) and the TMT-B (P = 0.035). In the genetic analysis, we detected several polymorphisms strongly associated with cholines (rs10991629-SLC44A1 with P < 0.005 and rs8068641-PEMT; P < 0.01, among others). We identified several dietary associations as well as gene-diet modulations. Conclusions Phosphatidylcholines are associated with better cognitive function and their levels are modulated by diet and genetics. Funding Sources Generalitat Valenciana (PROMETEO2017/017) and Spanish Ministry of Science (FPU 18/0,1703).

Strategies for Biomarker Development in Psoriatic Disease: A Report from the GRAPPA 2010 Annual Meeting

2012 ◽  
Vol 39 (2) ◽  
pp. 423-426 ◽  
Author(s):  
CHRISTOPHER T. RITCHLIN
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Psoriatic Arthritis ◽  
Psoriatic Disease ◽  
Funding Sources ◽  
Inflammatory Bowel ◽  
Biomarker Research ◽  
Anxiety Depression ◽  
Collaborative Efforts ◽  
Musculoskeletal Involvement

Psoriatic disease includes psoriasis and associated comorbidities (arthritis, uveitis, inflammatory bowel disease, cardiovascular disease, metabolic syndrome, and anxiety/depression) and is remarkably diverse in disease presentation and course. The marked heterogeneity of musculoskeletal involvement in psoriatic arthritis (PsA) presents major challenges to clinicians regarding diagnosis, risk stratification, and management. Members of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) have begun collaborative efforts to develop biomarkers that can assist in the diagnosis and management of patients with psoriasis and related comorbidities. This brief review provides a rationale for biomarker research in PsA, consideration of types and sources of biomarkers, and examples of important biomarker studies in PsA, followed by a review of trial designs for biomarker research and a discussion of potential funding sources.

scholarly journals Cardiotrophin-1 and components of metabolic syndrome: what is the role in the development of atrial fibrillation?

EP Europace ◽  
2021 ◽  
Vol 23 (Supplement_3) ◽  
Author(s):  
V Ionin ◽  
EL Zaslavskaya ◽  
EI Barashkova ◽  
DS Skuridin ◽  
EI Baranova ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Metabolic Syndrome ◽  
Blood Serum ◽  
Metabolic Disorders ◽  
Type I Collagen ◽  
Public Institution ◽  
Type I ◽  
Funding Sources ◽  
Comparison Groups ◽  
Energy Processes

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): Pavlov University Introduction. The cardiotrophin-1 (CT-1) is a cytokine from the interleukin-6 family associated with pathology of the cardiovascular system, contributing to myocardial remodeling and the development of fibrosis in patients with hypertension. CT-1 is involved in the regulation of energy processes and the metabolism of adipose tissue, as well as in the regulation of lipid and carbohydrate metabolism. Revealed an increase in the deposition of type I collagen in the atrial myocardium against the background of dilatation of the left atrium and an increase in the expression of CT-1. The role of CT-1 in the development of AF is currently being actively studied. Purpose. To determine the concentration of cardiotrophin-1 (CT-1) in patients with metabolic syndrome (MS) and atrial fibrillation (AF) with an assessment of the relationship with the parameters of obesity and metabolic disorders. Methods. In a one-stage case-control study, 352 patients aged 35 to 65 years were included: patients with MS (n = 223), of which 107 patients with AF, and comparison groups consisted of patients with AF without MS (n = 69) and practically healthy examined without cardiovascular diseases and metabolic disorders (n = 60). Results. It was found that the concentration of CT-1 in serum in patients with AF is higher than in patients with MS without AF (766,2 (539,2-1032,3) and 590,2 (480,1-922,3) pg/ml, p = 0,005) and higher than in healthy subjects (780,2 (550,2-1050,3) and 410,1 (290,2-549,2) pg/ml, p < 0,0001). It was found that in patients with AF and MS, the concentration of CT-1 in the blood serum is higher than in patients with AF without MS (851,2 (589,1-1146,3) and 681,1 (480,1-823,2) pg/ml, p = 0,004). CT-1 positively correlates with the concentration of glucose in blood plasma (r = 0,423, p = 0.002) and triglycerides (r = 0,207, p = 0,003), as well as with the waist circumference (r = 0,265, p < 0.001) and the thickness of epicardial fat (r = 0,351, p < 0,001). Using ROC analysis, it was found that with an increase in the concentration of CT-1 in blood serum more than 638,1 pg/ml, the probability of AF increased by 4 times (OR = 4.0, 95%CI 2,31-6,94, p < 0,0001). Conclusion. An increase of serum CT-1 concentration is associated with heart remodeling and obesity in patients with MS and probably has a pathogenetic role in increasing the risk of AF in this cohort of patients.

scholarly journals Association between Dietary Lutein/Zeaxanthin Intake and Metabolic Syndrome Among U.S. Females: An Analysis of National Health and Examination Survey 2015–2018

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 82-82
Author(s):  
Yanqi Zhang ◽  
Linda Knol ◽  
Libo Tan
Keyword(s):  
Metabolic Syndrome ◽  
Intervention Studies ◽  
Smoking Status ◽  
Premenopausal Women ◽  
Beneficial Effects ◽  
Glucose Levels ◽  
Funding Sources ◽  
Separate Model ◽  
The Relationship ◽  
Dose Dependent

Abstract Objectives The prevalence of metabolic syndrome (MetS) is higher among U.S. females than males, mainly due to the higher prevalence of dyslipidemia and elevated fasting glucose levels. Lutein (L) and its isomer zeaxanthin (Z) are carotenoids that can alter the composition of lipoprotein, which may affect components of MetS. They also act as potent antioxidants that benefit metabolic health. Dietary intake of L and Z is inversely associated with MetS in U.S. males, however, this association is unclear in females. The purpose of this study was to investigate the relationship between dietary and supplemental intake of L/Z and MetS prevalence among U.S. females. Methods A sample of premenopausal women aged 20–50 years was drawn from NHANES 2015–2018. The diagnostic criteria of MetS was based on the National Cholesterol Education Program Adult Treatment Panel. Dietary L/Z intake was calculated from two 24-hour recalls. Supplemental L/Z intake was extracted from two 24-hour dietary supplements use files. Both dietary and supplemental L/Z intakes were divided into four quartiles. The association between MetS and quartile of L/Z intake was assessed using logistic regression analyses while adjusting for race, age, smoking status, and total energy intake. A separate model was run with the addition of supplemental L/Z. Results Among the 630 U.S. females included in these analyses, the prevalence of MetS was 22.84%. Mean dietary L/Z intakes by quartiles 1, 2, 3, and 4, respectively, were 0.30 mg/d, 0.64 mg/d, 1.16 mg/d, and 4.60 mg/d. When comparing the highest intake quartile to the lowest, women in the highest quartile had significantly lower risk of MetS after adjusting for covariates (OR: 0.38, 95% CI 0.15–0.97). The means of dietary plus supplemental L/Z intake by quartiles 1, 2, 3, and 4, respectively, were 0.33 mg/d, 0.64 mg/d, 1.21 mg/d, and 4.73 mg/d. No relationship was noted between the sum of dietary and supplemental L/Z intake and the odds of MetS. Conclusions When compared to participants with the lowest intake (quartile) of dietary L/Z, those in the highest quartile had significantly reduced odds of MetS. This relationship was not dose dependent suggesting extreme intakes of greater than 1.7 mg/d were related to a reduced risk. Further intervention studies are warranted to investigate the beneficial effects of dietary L/Z on risk factors of MetS in U.S. females. Funding Sources None.

scholarly journals Role of QRS amplitude, fractionation and duration in predicting clinical response to anti-inflammatory treatment in cardiac sarcoidosis

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
M Arceluz ◽  
D Frankel ◽  
C Tschabrunn ◽  
P Santangeli ◽  
P Bravo ◽  
...  
Keyword(s):  
Ejection Fraction ◽  
Cardiac Sarcoidosis ◽  
Response To Treatment ◽  
Funding Sources ◽  
Strong Trend ◽  
Innovation Fund ◽  
Positron Emission ◽  
Qrs Duration ◽  
Lv Ejection Fraction ◽  
Research And Education

Abstract Background Low QRS amplitude (QRSa), QRS fractionation (QRSf) and longer QRS duration (QRSd) are markers of myocardial fibrosis and inflammation in non-ischemic cardiomyopathy (NICM). Objective To determine if reduction of inflammation with treatment of cardiac sarcoidosis (CS) may reverse these 12 lead ECG parameter changes. Methods 21 patients (pts) with CS and VT ablation with a positive baseline positron emission tomographic (PET 1) scan were studied. All pts received prednisone ≥40 mg for 4 to 8 weeks followed by a taper and maintenance with methotrexate ± low-dose prednisone, <10 mg/day, until clinically stable and resolution of inflammation on PET 2 one year after initial. In addition, pts with low LV ejection fraction (13/21) received guideline directed medical therapy for heart failure. Pts at 1yr with positive PET2 (9) were compared to those with negative PET2 (12). Baseline and 1yr 12-lead ECGs were analyzed for QRSd, ≥2QRSf contiguous leads and QRSa in the limb leads. Results Pts in PET2(+) vs PET2(−) groups has similar gender (men 89% vs 100%, p=0.42), age (57±8 vs 56±10 years, p=0.8) and LV ejection fraction (41±11 vs 46±11, p=0.31). Baseline 12-lead ECGs showed similar QRSd, ≥2QRSf contiguous leads and QRSa for PET2(+) vs PET2(−); P all >0.15 (Table 1). At 1 yr there was a lower prevalence of ≥2QRSf contiguous leads and strong trend for shorter QRS duration and larger QRSa in lead DI if PET2(−) vs PET2(+). 4 pts demonstrated loss of QRSf 2 contiguous leads and/or increase in QRSa in DI by at least 0.15 mV from baseline if PET2(−) and none if PET2(+). Conclusions In pts with CS and VT, reversal of inflammation may result in a greater QRSa and reduction in QRSf. An increase in QRSa in lead 1 by >0.15mV and/or loss of QRSf identifies a clear positive response to treatment and negative PET at 1 year. FUNDunding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Richard T and Angela Clark Innovation Fund in Cardiovascular Medicine, the Mark S Marchlinski EP Research and Education Fund and the Winkelman Family Fund in Cardiovascular Innovation. Table 1

scholarly journals High Prevalence and Its Influencing Factors of Vitamin D Deficiency Among Women of Reproductive Age in Central China (P10-119-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Yuan Zhang ◽  
Xinming Song ◽  
Lifang Jiang ◽  
Jilei Wu ◽  
Gong Chen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Influencing Factors ◽  
Reproductive Age ◽  
Central China ◽  
Women Of Reproductive Age ◽  
Hydroxyvitamin D ◽  
Funding Sources ◽  
Nutrition Research ◽  
Research And Education

Abstract Objectives To examine the prevalence and its influencing factors of vitamin D deficiency. among women of reproductive age in central China. Methods A total of 1151 women of reproductive age were from an established Women's Reproductive Health Cohort Study, and their exposure factors, blood samples were collected between 2009 and 2010 in four counties of Henan Province, China. Pregnancy outcomes were followed up and a nested case control study was performed reproductive to estimate prevalence and its influencing factors of vitamin D deficiency according to serum 25-hydroxyvitamin D [25(OH)D] < 26.0 ng/mL. Results The prevalence of Vitamin D deficiency among women of reproductive age in central China was 61.5%. Significant determinants of serum 25(OH)D deficiency among women of reproductive age in central China were nutrition supplement (aOR 0.53, 95% CI 0.40–0.71), intake frequency of eggs (aOR 1.61, 95%CI 1.11–2.33) and fruits (aOR 2.50, 95% CI 1.43–4.37), Hemoglobin (aOR 2.25, 95% CI 1.38–3.66), gravidity (aOR 1.79,95% CI:1.27–2.51), family annual income (aOR 1.48, 95% CI 1.11–1.98) and passive smoking (aOR 1.56, 95% CI :1.20–2.03). Conclusions Vitamin D deficiency among women of reproductive age in central China should have high degree of concern, we should pay more attention on the nutritional status improvement and health education of women of reproductive age in central China. Funding Sources National Natural Science Foundation of China; Dietary Nutrition Research and Education Fund of Danone Nutrition Center. Supporting Tables, Images and/or Graphs

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