Depression and anxiety (DA) in children within one year of a cancer diagnosis.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 10064-10064
Author(s):  
Patrick Leavey ◽  
Julie N Germann ◽  
David Leonard ◽  
Thomas Stuenzi ◽  
Jane LeVieux ◽  
...  
Keyword(s):  
Trait Anxiety ◽  
Cancer Diagnosis ◽  
Time Course ◽  
American Association ◽  
First Year ◽  
Depression And Anxiety ◽  
Psychiatric Consultation ◽  
Single Institution ◽  
The Mean ◽  
One Year

10064 Background: While 10% of children were treated with anti-depressants within 1 year of a cancer diagnosis in a previous study, neither the prevalence nor time course of DA were studied. The American Association of Pediatrics advocates for the use of screening for DA, yet data are lacking regarding timing, frequency, or predictive success of screening in children concurrently receiving therapy for cancer. Methods: We evaluated 87 prospectively diagnosed children at a single institution for DA at 5 time points during the first year of a cancer diagnosis. 55 children completed all screening, 70 missed at most one visit. Starting within 1 month of cancer diagnosis, patients completed the Childhood Depression Inventory (CDI) and the Speilberger State/Trait Anxiety Inventory (STAI) and again at 3, 6, 9, and 12 months. Those patients who scored ≥ 11 on the CDI or ≥ one standard deviation above the mean for age on the STAI were referred for psychiatric consultation the same day. Results: Overall 33 patients (39%) indicated symptoms suggestive of either depression or anxiety during their first year of cancer therapy; n=29 (35%) depression, n=17 (20%) state and n=10 (12%) trait anxiety. Fifty-six consultations resulted in 33 psychiatry diagnoses confirmed in 21 patients (23 depression, 3 anxiety and 7 other). Half of the patients received a diagnosis of DA at least twice over the course of the study, suggesting persistent, significant symptoms. Conclusions: We conclude that screening for DA is effective in children with cancer and that prevalence for symptoms is high. The highest risk for symptoms of DA is within 1 month of diagnosis but during the 1st year of therapy children continue to suffer symptoms of DA highlighting the importance of continued screening. [Table: see text]

STUDIES ON FOLIC ACID IN INFANCY

PEDIATRICS ◽  
1964 ◽  
Vol 33 (4) ◽  
pp. 507-511
Author(s):  
Yehuda Matoth ◽  
Ariela Pinkas ◽  
Rina Zamir ◽  
Fouad Mooallem ◽  
Nathan Grossowicz
Keyword(s):  
Folic Acid ◽  
Folinic Acid ◽  
Economic Status ◽  
Mean Value ◽  
First Year ◽  
Mean Values ◽  
Healthy Infants ◽  
Initial Drop ◽  
The Mean ◽  
One Year

The level of folic and folinic acid in whole blood was assayed in 373 healthy infants from birth to one year. Folic acid was high at birth and dropped gradually over the first 8 postnatal weeks. The mean value for the remainder of the first year was significantly below the adult mean. Folinic acid was likewise high at birth and dropped parallel with the folic acid. However, following the initial drop, folinic acid mean values remained well above the adult mean. Folic and folinic acid values were higher in breast-fed than in artificially fed infants and lower in infants whose economic status was poor than in babies belonging to families of higher income.

scholarly journals P0217NEUTROPHIL TO LYMPHOCYTE RATIO AT ADMISSION CAN ESTIMATE VASCULITIS ACTIVITY AND POOR PROGNOSIS IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIS: A RETROSPECTIVE STUDY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Inês Duarte ◽  
José Agapito Fonseca ◽  
Joana Gameiro ◽  
Estela Nogueira ◽  
Cristina Outerelo ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Severe Sepsis ◽  
Inflammatory Marker ◽  
Univariate Analysis ◽  
Severe Infection ◽  
First Year ◽  
Lymphocyte Ratio ◽  
The Mean ◽  
One Year ◽  
Clinical Records

Abstract Background and Aims Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a multisystemic disease. Despite the improvement in mortality rate since the introduction of immunosuppression, long-term prognosis is still uncertain not only because of the disease activity but also due to treatment associated adverse effects. The neutrophil-to-lymphocyte ratio (NLR) has been demonstrated as an inflammatory marker in multiple settings. In this study, we aimed to investigate the prognostic ability of the NLR in AAV patients. Method We conducted a retrospective analysis of the clinical records of all adult patients with AVV admitted to the Service of Nephrology and Renal Transplantation of Centro Hospitalar Universitário Lisboa Norte from January 2006 to December 2019. NLR was calculated at admission. The outcomes measured were severe infection at 3 months and one-year mortality. The prognostic ability of the NLR was determined using the receiver operating characteristic (ROC) curve. A cut-off value was defined as that with the highest validity. All variables underwent univariate analysis to determine statistically significant factors that may have outcomes. Only variables which significantly differed were used in the multivariate analysis using the logistic regression method. Results We registered 45 cases of AVV. The mean age at diagnosis was 67.5±12.1 years and 23 patients were male. The mean BVAS at presentation was 26.0±10.4. Twenty-nine patients were ANCA-MPO positive, 7 ANCA-PR3 positive and 9 were considered negative ANCA vasculitis. At admission, mean SCr was 6.7 ± 2.9mg/dL, ESR was 76.9 ± 33.8, hemoglobin was 9.5 ± 1.7g/dL, C-reactive protein was 13.2 ± 5.8mg/dL and NLR was 8.5 ± 6.8. Thirty-five patients were treated with cyclophosphamide, eight patients with rituximab for induction therapy. Twenty patients developed severe infection within the first three months after starting induction immunosuppression. In a multivariate analysis, older age (73.6±10.5 vs 62.6±11.3, p=0.002, adjusted OR 1.08 [95% CI 1.01 – 1.16], p= 0.035) and higher NLR (11.9±7.4 vs 5.9±5.0, p=0.002, adjusted OR 1.14 [95% CI 1.01 – 1.29], p= 0.035) were predictors of severe infection at 3 months. NLR ≥ 4.04 predicted severe infection at 3 months with a sensitivity of 95% and specificity of 52% and the AUROC curve was 0.0794 (95% CI 0.647 – 0.900). Nine patients died within the first year. Severe infection at 3 months was independently associated with mortality within the first year (OR 6.19 [95% CI 1.12 – 34.32], p= 0.037). Conclusion NLR at diagnosis was an independent predictor of severe sepsis within the first 3 months after immunosuppression start, and severe sepsis within the first three months was consequently correlated with one-year mortality. NLR is an easily calculated and low-cost laboratory inflammation biomarker and can prove useful in identifying AAV patients at risk of infection and poorer prognosis.

The impact of a breast cancer diagnosis on women’s work status.

2018 ◽  
Vol 36 (7_suppl) ◽  
pp. 23-23
Author(s):  
Lucinda Barry ◽  
Leanne Storer ◽  
Meron Pitcher
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Financial Stress ◽  
Breast Cancer Diagnosis ◽  
Work Status ◽  
Paid Employment ◽  
The Mean ◽  
Woman's Work ◽  
One Year ◽  
The Impact

23 Background: The diagnosis and treatment of cancer often causes financial stress, partly by impacting on the ability to continue in paid employment. Our aim was to identify changes in work status 12 months after a diagnosis of breast cancer. Methods: An audit of the medical records of women who presented to the Western Health (Victoria, Australia) nurse led breast cancer Survivorship Clinic (SC) between October 2015 and October 2016 was performed to identify employment status at diagnosis and at their review at SC 12 months later. Results: 111 records were reviewed. The mean age was 55 (range 28-82yrs). 84 of these women (76%) were 65 years of younger at the time of diagnosis. 46 of the 84 women ≤65 years were in paid employment at diagnosis (55%), and 38 (83%) were still working in some capacity at review in the SC. Of the 38 still working, 28 were working in the same capacity, 8 were working reduced hours, and 2 were working increased hours. Women who had axillary dissections were most likely to have changed work status. Financial stress was reported by 8/19 of women who stopped working or had changed work hours, including 9 no longer in paid employment and 10 with changed hours. 2/28 women working in the same capacity reported financial stress. 65% of those who reported financial stress (11/17) had chemotherapy as part of their treatment. Conclusions: A breast cancer diagnosis has the ability to influence a woman's work status one year after diagnosis. Health professionals should appreciate the potential work concerns and financial stresses continuing to affect their patients.

scholarly journals COVID Obesity: A One-Year Narrative Review

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2060
Author(s):  
Diana L. Palacios Ovalle ◽  
Susana Rodrigo-Cano ◽  
Aránzazu González ◽  
Carla Soler ◽  
Ana I. Catalá-Gregori ◽  
...  
Keyword(s):  
Scientific Literature ◽  
Narrative Review ◽  
World Health ◽  
First Year ◽  
Anthropometric Parameters ◽  
The West ◽  
Anthropometric Parameter ◽  
The Mean ◽  
One Year ◽  
Health Organization

On 11 March 2020, coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization (WHO). This study focuses on a narrative review about the illness during the first year of the pandemic in relation to obesity. Databases were used to search studies published up to 8 December 2020. In total, 4430 articles and other scientific literature were found, and 24 articles were included in this one-year narrative review. The mean BMI value of severe COVID-19 patients ranged from 24.5 to 33.4 kg/m2, versus <18.5 to 24.3 kg/m2 for non-severe patients. Articles using the terms obesity or overweight without indicating the BMI value in these patients were common, but this is not useful, as the anthropometric parameters, when not defined by this index, are confusing due to the classification being different in the West compared to among Asian and Korean criteria-based adults. We proposed a new term, called COVID obesity, to define the importance of this anthropometric parameter, among others, in relation with this pandemic.

scholarly journals The Success Rate and Complications of Post-radiofrequency Ablation in Patients With Small Saphenous Insufficiency

2021 ◽  
Vol 27 (3) ◽  
pp. 368-383
Author(s):  
Hossein Hemmati ◽  
◽  
Mani Moayeri Far ◽  
Seyyedeh Maral Mousavi ◽  
Ghazaleh Hemmati ◽  
...  
Keyword(s):  
Radiofrequency Ablation ◽  
Adverse Effects ◽  
Success Rate ◽  
First Year ◽  
Skin Burn ◽  
Superficial Thrombophlebitis ◽  
The Mean ◽  
One Year ◽  
Study Participants ◽  
Vein Insufficiency

Aims: This study aimed to determine the success rate and complications occurring after Radiofrequency Ablation (RFA) in patients with small saphenous insufficiency who underwent RFA in Rasht. Methods & Materials: Patients with small saphenous vein insufficiency who underwent RFA were explored respecting success rate and potential complications, such as pain, hematoma, neuropathy, Endothermal Heat-Induced Thrombosis (EHIT), and skin burns. The study subjects were assessed 2 weeks after the procedure. Reconanalysis was followed up in the study participants by ultrasound at 2 weeks, 3-6 months, and the first year after RFA. Findings: This study examined 62 patients. A 100% success rate was reported and no case of reflux was observed in the first control ultrasound 2 weeks after RFA. The mean pain score significantly decreased (P<0.001). Besides, in one year, 3 cases of recanalization, 7 cases of EHIT, 9 cases of neuropathy, and 1 case of superficial thrombophlebitis were reported; no case of skin burn was observed. Conclusion: Considering the 100% success rate and slight adverse effects of this method, such as pain and recanalization, RFA is an acceptable approach. Furthermore, the incidence of EHIT should be considered.

scholarly journals Evaluation of air pollutants (PM10 and SO2) in the first year of the COVID-19: A city sample from Turkey

2021 ◽  
Vol 10 (1) ◽  
pp. 041-047
Author(s):  
Ömer Faruk Tekin
Keyword(s):  
Air Pollutants ◽  
Monitoring Network ◽  
Cross Sectional Study ◽  
First Year ◽  
Air Quality Monitoring ◽  
Sectional Study ◽  
Cross Sectional ◽  
Before And After ◽  
The Mean ◽  
One Year

The aim of this study is to evaluate the change of air pollutants in the province of Van compared to the previous year during the COVID-19 pandemic. The study is a cross-sectional study conducted in Van where is a city in eastern Turkey. PM10 and SO2 values obtained from the National Air Quality Monitoring Network website. The lockdowns imposed in the province of Van within the scope of combating COVID-19 have been recorded by examining the decisions of the Sanitary Board on the Van Governorship's official website. The mean of PM10 measurement values in the period before and after COVID-19 were 40.89±19.6 µg/m3 and 41.3±20.39 µg/m3, respectively. The mean of SO2 measurement values were 17.76±18.48 µg/m3 and 23.49±20.96 µg/m3 before and after COVID-19, respectively. When one year after and before COVID-19 was evaluated, there was no difference in PM10 values in terms of year averages, while SO2 value was found to be increased compared to the previous year. However, when analyzed by months, there were months when PM10 values were found to be increased (March, September and October) and decreased (July, August and November) compared to the previous year.

scholarly journals Functional improvement in patients with idiopathic pulmonary fibrosis undergoing single lung transplantation

2015 ◽  
Vol 41 (4) ◽  
pp. 299-304 ◽  
Author(s):  
Adalberto Sperb Rubin ◽  
Douglas Zaione Nascimento ◽  
Letícia Sanchez ◽  
Guilherme Watte ◽  
Arthur Rodrigo Ronconi Holand ◽  
...  
Keyword(s):  
Lung Function ◽  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Lung Transplantation ◽  
Functional Improvement ◽  
First Year ◽  
Single Lung Transplantation ◽  
The Third ◽  
The Mean ◽  
One Year

AbstractObjective: To evaluate the changes in lung function in the first year after single lung transplantation in patients with idiopathic pulmonary fibrosis (IPF).Methods: We retrospectively evaluated patients with IPF who underwent single lung transplantation between January of 2006 and December of 2012, reviewing the changes in the lung function occurring during the first year after the procedure.Results: Of the 218 patients undergoing lung transplantation during the study period, 79 (36.2%) had IPF. Of those 79 patients, 24 (30%) died, and 11 (14%) did not undergo spirometry at the end of the first year. Of the 44 patients included in the study, 29 (66%) were men. The mean age of the patients was 57 years. Before transplantation, mean FVC, FEV1, and FEV1/FVC ratio were 1.78 L (50% of predicted), 1.48 L (52% of predicted), and 83%, respectively. In the first month after transplantation, there was a mean increase of 12% in FVC (400 mL) and FEV1 (350 mL). In the third month after transplantation, there were additional increases, of 5% (170 mL) in FVC and 1% (50 mL) in FEV1. At the end of the first year, the functional improvement persisted, with a mean gain of 19% (620 mL) in FVC and 16% (430 mL) in FEV1.Conclusions: Single lung transplantation in IPF patients who survive for at least one year provides significant and progressive benefits in lung function during the first year. This procedure is an important therapeutic alternative in the management of IPF.

Long-term experience with onabotulinumtoxinA in the treatment of chronic migraine: What happens after one year?

Cephalalgia ◽  
2014 ◽  
Vol 35 (10) ◽  
pp. 864-868 ◽  
Author(s):  
Eva Cernuda-Morollón ◽  
César Ramón ◽  
Davinia Larrosa ◽  
Rocío Alvarez ◽  
Nuria Riesco ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Adverse Events ◽  
Chronic Migraine ◽  
Muscle Atrophy ◽  
First Year ◽  
Acute Medication ◽  
The Mean ◽  
One Year ◽  
Term Response

Background OnabotulinumtoxinA (onabotA) has shown its efficacy over placebo in chronic migraine (CM), but clinical trials lasted only up to one year. Objective The objective of this article is to analyse our experience with onabotA treatment of CM, paying special attention to what happens after one year. Patients and methods We reviewed the charts of patients with CM on onabotA. Patients were injected quarterly during the first year but the fifth appointment was delayed to the fourth month to explore the need for further injections. Results We treated 132 CM patients (mean age 47 years; 119 women). A total of 108 (81.8%) showed response during the first year. Adverse events, always transient and mild-moderate, were seen in 19 (14.4%) patients during the first year; two showed frontotemporal muscle atrophy after being treated for more than five years. The mean number of treatments was 7.7 (limits 2–29). Among those 108 patients with treatment longer than one year, 49 (45.4%) worsened prior to the next treatment, which obliged us to return to quarterly injections and injections were stopped in 14: in 10 (9.3%) due to a lack of response and in four due to the disappearance of attacks. In responders, after an average of two years of treatment, consumption of any acute medication was reduced by 53% (62.5% in triptan overusers) and emergency visits decreased 61%. Conclusions Our results confirm the long-term response to onabotA in three-quarters of CM patients. After one year, lack of response occurs in about one out of 10 patients and injections can be delayed, but not stopped, to four months in around 40% of patients. Except for local muscle atrophy in two cases treated more than five years, adverse events are comparable to those already described in short-term clinical trials.

scholarly journals Risk factors associated with weight gain after kidney transplantation: A cohort study

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243394
Author(s):  
Cristina Carra Forte ◽  
Elis Forcellini Pedrollo ◽  
Bruna Bellincanta Nicoletto ◽  
Jéssica Blatt Lopes ◽  
Roberto Ceratti Manfro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Kidney Transplantation ◽  
Renal Transplantation ◽  
Weight Gain ◽  
Female Gender ◽  
Normal Weight ◽  
First Year ◽  
The Mean ◽  
One Year

Background Renal transplantation is the best modality of renal replacement therapy for patients with end-stage renal disease. However, it is associated with weight gain and metabolic abnormalities, which adversely impact transplant outcomes. Objective The objective of this study was to identify the risk factors of one-year weight gain after renal transplantation. Methods A retrospective cohort study was conducted with 374 patients that underwent kidney transplantation between January 2006 and July 2013. Clinical and laboratory variables were collected from electronic records, and the outcome of interest was weight gain during the first year after renal transplantation. The data were reported as mean ± standard deviation, median (interquartile range) or number of subjects (%). The association between variables were assessed via chi-square test and ANOVA. For analysis of risk factors related to the outcomes of interest, multivariable logistic regression models were used. Results There were 181 (48.4%) female patients, 334 (89.3%) with white ethnicity and the mean age was 44.4 ± 12.8 years. The mean BMI pre-transplant was 24.7 ± 4.1 kg/m2, and 35 (9.9%) patients were classified as obese; 119 (33.6%) as overweight; 187 (52.8%) as normal weight; and 13 (3.7%) as malnourished. After one year of follow-up, the mean BMI was 26.2 ± 5.0 kg/m2, and 61 (17.3%) patients were classified as obese; 133 (37.8%) as overweight; 148 (42.0%) as normal weight; and 10 (2.8%) as malnourished. Weight gain was observed in 72.7% patients, and the average increase was 7.12 ± 5.9 kg. The female gender, lower pre-transplant body weight, lower number of hospitalizations, and a kidney received from a living donor were associated with weight gain by more than 5% in the first year post-transplant. Conclusion Female gender and lower pre-transplant body weight were independently associated with weight gain by more than 5% in the first year after kidney transplantation; lower rates of hospitalization and donation from living donors were also risk factors for this outcome.

EARLY VARIATIONS OF PLASMA CORTISOL AFTER PULSE INTRAVENOUS INJECTION OF DIBUTYRYL CYCLIC ADENOSINE 3′,5′-MONOPHOSPHATE IN NORMAL SUBJECTS

1973 ◽  
Vol 72 (4) ◽  
pp. 753-761 ◽  
Author(s):  
Alberto Angeli ◽  
Giuseppe Boccuzzi ◽  
Roberto Frajria ◽  
Daniela Bisbocci ◽  
Franco Ceresa
Keyword(s):  
Intravenous Injection ◽  
Plasma Cortisol ◽  
Time Course ◽  
Healthy Adult ◽  
Normal Subjects ◽  
Adult Women ◽  
Healthy Women ◽  
Adrenal Steroidogenesis ◽  
The Mean ◽  
Zero Time

ABSTRACT 10 mg/kg of dibutyryl cyclic adenosine 3′,5′-monophosphate (Db-cAMP) was iv pulse injected into twelve healthy adult women. The plasma cortisol levels were determined as 11-OHCS at zero time and then at 2.5, 5, 7.5, 10, 15, 30, 60 and 180 min after the injection. The data were compared with those obtained at the corresponding times in two groups of eleven and seventeen healthy women after the injection of 250 ng and 250 μg of synthetic β-1-24 corticotrophin performed in the same manner as the injection of the nucleotide. The mean increments in plasma cortisol were significantly lower after Db-cAMP than after ACTH. Differences were noted by analyzing the time course of the responses. In the case of stimulation with Db-cAMP the 11-OHCS levels rose progressively to a maximum at 15–30 min. By contrast, a peak of plasma cortisol was evident in most cases within a few min after the injection of ACTH; after a fall, a later rise was then observed starting from 15 min. The differences in the plasma 11-OHCS responses after the two stimuli may also be of interest clinically for the investigation of some aspects of adrenal steroidogenesis.

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