The Success Rate and Complications of Post-radiofrequency Ablation in Patients With Small Saphenous Insufficiency

Aims: This study aimed to determine the success rate and complications occurring after Radiofrequency Ablation (RFA) in patients with small saphenous insufficiency who underwent RFA in Rasht. Methods & Materials: Patients with small saphenous vein insufficiency who underwent RFA were explored respecting success rate and potential complications, such as pain, hematoma, neuropathy, Endothermal Heat-Induced Thrombosis (EHIT), and skin burns. The study subjects were assessed 2 weeks after the procedure. Reconanalysis was followed up in the study participants by ultrasound at 2 weeks, 3-6 months, and the first year after RFA. Findings: This study examined 62 patients. A 100% success rate was reported and no case of reflux was observed in the first control ultrasound 2 weeks after RFA. The mean pain score significantly decreased (P<0.001). Besides, in one year, 3 cases of recanalization, 7 cases of EHIT, 9 cases of neuropathy, and 1 case of superficial thrombophlebitis were reported; no case of skin burn was observed. Conclusion: Considering the 100% success rate and slight adverse effects of this method, such as pain and recanalization, RFA is an acceptable approach. Furthermore, the incidence of EHIT should be considered.

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Evaluation of Transient Elastography in Prediction Of De novo Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation

QJM ◽

10.1093/qjmed/hcab107.013 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Nadia abdelaty Abdelkader ◽

Moustafa Hamed Abdelaleem ◽

Mohammed El-Gharib Abo El- maaty ◽

Heba Ismail Aly ◽

Sayed Ahmed Sayed

Keyword(s):

Hepatocellular Carcinoma ◽

Radiofrequency Ablation ◽

Transient Elastography ◽

P Value ◽

Hepatic Decompensation ◽

Non Invasive ◽

Prediction Of Mortality ◽

The Mean ◽

One Year

Abstract Background Hepatocellular carcinoma (HCC) is the sixth most common malignancy worldwide and it is also a common cause of death in patients with chronic liver disease. The curative treatment options for HCC that are currently available are surgical resection, liver transplantation and radiofrequency ablation .Despite progressive improvements in the efficacy of RFA, the survival of patients with HCC who undergo RFA remains disappointing, mainly due to frequent intrahepatic recurrence of HCC after RFA. Aim of the work To evaluate the role of transient elastography (as an indirect indicator to degree of liver fibrosis) in prediction of denovo recurrence of hepatocellular carcinoma after radiofrequency ablation in hepatitis C related hepatocellular carcinoma .And to compare between transient elastography and other non invasive fibrosis indices in prediction of denovo recurrence of hepatocellular carcinoma after radiofrequency ablation hepatitis C related hepatocellular carcinoma Patients and methods This prospective cohrt study was conducted on hepatocellular carcinoma patient, who underwent radiofrequency ablation in Tropical Medicine Department in Eldemerdash and Ain Shams Specialized Hospital, HCC clinic Ain Shams University Hospitals, Cairo, Egypt between march, 2017 and May, 2019. Data of the patient, who underwent radiofrequency ablation during the study period, were reviewed and the patients who fulfilled the inclusion criteria were enrolled into this study. The patients who fulfilled the inclusion criteria and underwent radiofrequency ablation were followed up for 12 months. Results TE revealed 28 patients with F4 and only 2 patients with F3, the mean measurement of liver stiffness was (22.45 ± 10.36) KPa. There was a significant negative correlation between LS and denovo recurrence of HCC (mean of LS in patients with complete response was 17.19 ± 3.32 and the mean of LS in patient with denovo recurrence was 36,94 ± 5.93,with the The best cut off value ≥24.65 (p value < 0.001)). There was no significant correlation between CDC, FIB4, API scores and denovo recurrence of HCC. Also it was found that the LS was significantly associated with prediction of manifestation of hepatic decompensation after RFA (means of LS in patient without manifestation decompensation after RFA (p value <0.001) .Regarding prediction of mortality, LS at cut off value > 42 .75 (p value = 0,031) was significantly associated with prediction of mortality after one year of RFA. As regard serum non invasive fibrosis indices our results showed correlation between FIB4 score and hepatic decompensation after one year of intervention (the mean of FIB4 score in patients ascites and jaundice was 6.05 ± 4.71 (p value = 0.05) ).Therewas no statistically significant correlation between CDS and API with hepatic decompensation after RFA .As regard role of serum non invasive fibrosis indices in prediction of mortality after RFA, FIB4 score, CDS and API were statistically non significant. Conclusion Our data suggest that LS measurement is a useful predictor of HCC de novorecurrence overall survival and possibility of hepatic decompensation after RFA

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STUDIES ON FOLIC ACID IN INFANCY

PEDIATRICS ◽

10.1542/peds.33.4.507 ◽

1964 ◽

Vol 33 (4) ◽

pp. 507-511

Author(s):

Yehuda Matoth ◽

Ariela Pinkas ◽

Rina Zamir ◽

Fouad Mooallem ◽

Nathan Grossowicz

Keyword(s):

Folic Acid ◽

Folinic Acid ◽

Economic Status ◽

Mean Value ◽

First Year ◽

Mean Values ◽

Healthy Infants ◽

Initial Drop ◽

The Mean ◽

One Year

The level of folic and folinic acid in whole blood was assayed in 373 healthy infants from birth to one year. Folic acid was high at birth and dropped gradually over the first 8 postnatal weeks. The mean value for the remainder of the first year was significantly below the adult mean. Folinic acid was likewise high at birth and dropped parallel with the folic acid. However, following the initial drop, folinic acid mean values remained well above the adult mean. Folic and folinic acid values were higher in breast-fed than in artificially fed infants and lower in infants whose economic status was poor than in babies belonging to families of higher income.

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P0217NEUTROPHIL TO LYMPHOCYTE RATIO AT ADMISSION CAN ESTIMATE VASCULITIS ACTIVITY AND POOR PROGNOSIS IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIS: A RETROSPECTIVE STUDY

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0217 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Inês Duarte ◽

José Agapito Fonseca ◽

Joana Gameiro ◽

Estela Nogueira ◽

Cristina Outerelo ◽

...

Keyword(s):

Multivariate Analysis ◽

Severe Sepsis ◽

Inflammatory Marker ◽

Univariate Analysis ◽

Severe Infection ◽

First Year ◽

Lymphocyte Ratio ◽

The Mean ◽

One Year ◽

Clinical Records

Abstract Background and Aims Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a multisystemic disease. Despite the improvement in mortality rate since the introduction of immunosuppression, long-term prognosis is still uncertain not only because of the disease activity but also due to treatment associated adverse effects. The neutrophil-to-lymphocyte ratio (NLR) has been demonstrated as an inflammatory marker in multiple settings. In this study, we aimed to investigate the prognostic ability of the NLR in AAV patients. Method We conducted a retrospective analysis of the clinical records of all adult patients with AVV admitted to the Service of Nephrology and Renal Transplantation of Centro Hospitalar Universitário Lisboa Norte from January 2006 to December 2019. NLR was calculated at admission. The outcomes measured were severe infection at 3 months and one-year mortality. The prognostic ability of the NLR was determined using the receiver operating characteristic (ROC) curve. A cut-off value was defined as that with the highest validity. All variables underwent univariate analysis to determine statistically significant factors that may have outcomes. Only variables which significantly differed were used in the multivariate analysis using the logistic regression method. Results We registered 45 cases of AVV. The mean age at diagnosis was 67.5±12.1 years and 23 patients were male. The mean BVAS at presentation was 26.0±10.4. Twenty-nine patients were ANCA-MPO positive, 7 ANCA-PR3 positive and 9 were considered negative ANCA vasculitis. At admission, mean SCr was 6.7 ± 2.9mg/dL, ESR was 76.9 ± 33.8, hemoglobin was 9.5 ± 1.7g/dL, C-reactive protein was 13.2 ± 5.8mg/dL and NLR was 8.5 ± 6.8. Thirty-five patients were treated with cyclophosphamide, eight patients with rituximab for induction therapy. Twenty patients developed severe infection within the first three months after starting induction immunosuppression. In a multivariate analysis, older age (73.6±10.5 vs 62.6±11.3, p=0.002, adjusted OR 1.08 [95% CI 1.01 – 1.16], p= 0.035) and higher NLR (11.9±7.4 vs 5.9±5.0, p=0.002, adjusted OR 1.14 [95% CI 1.01 – 1.29], p= 0.035) were predictors of severe infection at 3 months. NLR ≥ 4.04 predicted severe infection at 3 months with a sensitivity of 95% and specificity of 52% and the AUROC curve was 0.0794 (95% CI 0.647 – 0.900). Nine patients died within the first year. Severe infection at 3 months was independently associated with mortality within the first year (OR 6.19 [95% CI 1.12 – 34.32], p= 0.037). Conclusion NLR at diagnosis was an independent predictor of severe sepsis within the first 3 months after immunosuppression start, and severe sepsis within the first three months was consequently correlated with one-year mortality. NLR is an easily calculated and low-cost laboratory inflammation biomarker and can prove useful in identifying AAV patients at risk of infection and poorer prognosis.

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Radiofrequency ablation for Barrett’s esophagus high-volume center initial results

Acta chirurgica iugoslavica ◽

10.2298/aci1201019s ◽

2012 ◽

Vol 59 (1) ◽

pp. 19-24

Author(s):

Aleksandar Simic ◽

Ognjan Skrobic ◽

Marijan Micev ◽

Mirko Gligorijevic ◽

Dejan Velickovic ◽

...

Keyword(s):

Radiofrequency Ablation ◽

High Volume ◽

Lower Esophageal Sphincter Pressure ◽

Sphincter Pressure ◽

Esophageal Function ◽

Mean Values ◽

Retrosternal Pain ◽

The Mean ◽

One Year ◽

Initial Results

Introduction: Barrett?s esophagus (BE) is a well established precursor of esophageal adenocarcinoma. Both, surveillance and therapeutic strategies have been proposed over the years. Recent development of endoscopic radiofrequency ablation (RFA) brought new perspectives in the treatment of BE, with excellent initial results. Methods: The study of 40 pts with macroscopically visible BE on endoscopy and biopsy proven goblet cells presence, was conducted from January 2010 until March 2012. In all pts a complete symptomatic, endoscopic and manometric evaluation was performed. Initially RFA HALO 90 and 360 were performed in 28 and 12pts respectively. Repeated treatments were conducted in 7 pts. The overall number was 50, while the mean number of RFA procedures per patient was 1.25. Results: The mean circumferential length and maximal extent of BE were 1.61 and 3.29 cm respectively. We did not encounter esophageal perforation or hemorrhage during the procedure. Complications were transient short-term retrosternal pain (23 pts) and dysphagia (11 pts). Three months after the RFA mean values of cumulative symptom and heartburn score dropped significantly (p<0.05). Functional diagnostics did not disclose any statistically significant decrease of lower esophageal sphincter pressure or esophageal body contraction amplitudes. One year follow-up was obtained in 26 pts and revealed a complete macroscopically visible BE eradication. So far, in 19 pts a laparoscopic Nissen fundoplication was performed up to 3 months after complete RFA BE eradication. Conclusion: HALO RFA procedure is safe and very effective in the treatment of pts with BE, does not lead to esophageal function impairment, and produces no long term and serious side effects.

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Cricothyrotomy Is Faster Than Tracheostomy for Emergency Front-of-Neck Airway Access in Dogs

Frontiers in Veterinary Science ◽

10.3389/fvets.2020.593687 ◽

2021 ◽

Vol 7 ◽

Author(s):

Sureiyan Hardjo ◽

Catriona Croton ◽

Solomon Woldeyohannes ◽

Sarah Leonie Purcell ◽

Mark David Haworth

Keyword(s):

Success Rate ◽

Randomised Trial ◽

Technical Difficulty ◽

Estimating Equation ◽

Procedure Time ◽

Veterinary Students ◽

The Mean ◽

Study Participants ◽

Airway Access ◽

Mean Time

Objectives: In novice final year veterinary students, we sought to: (1) compare the procedure time between a novel cricothyrotomy (CTT) technique and an abbreviated tracheostomy (TT) technique in canine cadavers, (2) assess the success rate of each procedure, (3) assess the complication rate of each procedure via a damage score, (4) evaluate the technical difficulty of each procedure and (5) determine the preferred procedure of study participants for emergency front-of-neck access.Materials and Methods: A prospective, cross-over, block randomised trial was performed, where veterinary students completed CTT and TT procedures on cadaver dogs. Eight students were recruited and performed 32 procedures on 16 dogs. A generalised estimating equation approach to modelling the procedure times was used.Results: The procedure time was significantly faster for the CTT than the TT technique, on average (p < 0.001). The mean time taken to complete the CTT technique was 49.6 s (95% CI: 29.5–69.6) faster on average, with a mean CTT time of less than half that of the TT. When taking into account the attempt number, the procedure time for a CTT was 66.4 s (95% CI: 38.9–93.9) faster than TT for the first attempt, and for the second attempt, this was 32.7 s (95% CI: 15.2–50.2) faster, on average. The success rate for both procedures was 100% and there was no difference detected in the damage or difficulty scores (P = 0.13 and 0.08, respectively). Seven of eight participants preferred the CTT.Clinical Significance: CTT warrants consideration as the primary option for emergency front-of-neck airway access for dogs.

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Experience with CAPD in Diabetic Patients in Toronto

Peritoneal Dialysis International ◽

10.1177/089686088100201s02 ◽

1981 ◽

Vol 2 (1_suppl) ◽

pp. 12-14 ◽

Cited By ~ 7

Author(s):

Clair Williams ◽

Dale Belvedere ◽

Daniel Cattran ◽

Sheila Clayton ◽

Edward Cole ◽

...

Keyword(s):

Success Rate ◽

Cause Of Death ◽

Cardiovascular Events ◽

Survival Rates ◽

First Year ◽

Diabetic Patients ◽

Dialysis Modality ◽

Short Term ◽

The Mean

During the first four years of the CAPD programs in Toronto, 409 patients completed CAPD training; of these 64 (15.7%) were diahetics. The mean age of the diabetics was 46.7 and of the non-diabetics 51.4 years. One and two-year survival rates were not significantly different between the two groups (93%-82% for the non-diabetics and 90%-72% for the diabetics}. The main cause of death was cardiovascular events, in both groups. During the first year on CAPD, diabetics were transplanted at a higher rate than non-diabetics (20% vs. 9%). The overall technique success rate, the rate of transfer to an alternative dialysis modality and the incidence of peritonitis were similar in the two groups. At least in the short -term, diabetics do well on CAPD. It is suggested that CAPD may be the dialysis modality of choice in diabetics with ESRD.

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Depression and anxiety (DA) in children within one year of a cancer diagnosis.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.10064 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. 10064-10064

Author(s):

Patrick Leavey ◽

Julie N Germann ◽

David Leonard ◽

Thomas Stuenzi ◽

Jane LeVieux ◽

...

Keyword(s):

Trait Anxiety ◽

Cancer Diagnosis ◽

Time Course ◽

American Association ◽

First Year ◽

Depression And Anxiety ◽

Psychiatric Consultation ◽

Single Institution ◽

The Mean ◽

One Year

10064 Background: While 10% of children were treated with anti-depressants within 1 year of a cancer diagnosis in a previous study, neither the prevalence nor time course of DA were studied. The American Association of Pediatrics advocates for the use of screening for DA, yet data are lacking regarding timing, frequency, or predictive success of screening in children concurrently receiving therapy for cancer. Methods: We evaluated 87 prospectively diagnosed children at a single institution for DA at 5 time points during the first year of a cancer diagnosis. 55 children completed all screening, 70 missed at most one visit. Starting within 1 month of cancer diagnosis, patients completed the Childhood Depression Inventory (CDI) and the Speilberger State/Trait Anxiety Inventory (STAI) and again at 3, 6, 9, and 12 months. Those patients who scored ≥ 11 on the CDI or ≥ one standard deviation above the mean for age on the STAI were referred for psychiatric consultation the same day. Results: Overall 33 patients (39%) indicated symptoms suggestive of either depression or anxiety during their first year of cancer therapy; n=29 (35%) depression, n=17 (20%) state and n=10 (12%) trait anxiety. Fifty-six consultations resulted in 33 psychiatry diagnoses confirmed in 21 patients (23 depression, 3 anxiety and 7 other). Half of the patients received a diagnosis of DA at least twice over the course of the study, suggesting persistent, significant symptoms. Conclusions: We conclude that screening for DA is effective in children with cancer and that prevalence for symptoms is high. The highest risk for symptoms of DA is within 1 month of diagnosis but during the 1st year of therapy children continue to suffer symptoms of DA highlighting the importance of continued screening. [Table: see text]

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One-year outcomes of radiofrequency ablation of incompetent perforator veins using the radiofrequency stylet device: Cohort study from East Asia

Phlebology The Journal of Venous Disease ◽

10.1177/0268355520973488 ◽

2020 ◽

pp. 026835552097348

Author(s):

Chang-Ming Wang ◽

Shi-Lu Zhao ◽

Qi-Chen Feng ◽

Shuo Gai ◽

Xuan Li

Keyword(s):

Cohort Study ◽

Radiofrequency Ablation ◽

Success Rate ◽

Technical Success ◽

Technical Success Rate ◽

Sonographic Evaluation ◽

Primary Endpoints ◽

Secondary Endpoints ◽

One Year

Objectives The present study was designed to assess outcomes of patients undergone radiofrequency ablation (RFA) for their incompetent perforator veins (IPVs) with ClosureFast stylets. Methods Data of 165 IPVs in 138 limbs of 117 consecutive patients between July 2017 to Nov. 2019 were retrospectively reviewed. Primary endpoints (technical success rate, complications) and secondary endpoints (VCSS) were analyzed. Results The immediate technical success rate was 100%. There were no major complications. The rate of ecchymosis and induration was 5.8%. 129/165 IPVs in 79.5% (93/117) patients had achieved sonographic evaluation at 1 year followed-up, in which 3 perforators were recanalized. VCSS scores at pre-operation and 1-year follow-up were 5.77 ± 1.88 and 2.70 ± 1.39, respectively ( t= 29.644, P= .000). Conclusions In conclusion, RFA is safe and effective for the treatment of IPVs. At the 1-year follow-up, the RFA of IPVs showed a low recanalization rate and had a satisfactory improvement on VCSS.

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COVID Obesity: A One-Year Narrative Review

Nutrients ◽

10.3390/nu13062060 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2060

Author(s):

Diana L. Palacios Ovalle ◽

Susana Rodrigo-Cano ◽

Aránzazu González ◽

Carla Soler ◽

Ana I. Catalá-Gregori ◽

...

Keyword(s):

Scientific Literature ◽

Narrative Review ◽

World Health ◽

First Year ◽

Anthropometric Parameters ◽

The West ◽

Anthropometric Parameter ◽

The Mean ◽

One Year ◽

Health Organization

On 11 March 2020, coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization (WHO). This study focuses on a narrative review about the illness during the first year of the pandemic in relation to obesity. Databases were used to search studies published up to 8 December 2020. In total, 4430 articles and other scientific literature were found, and 24 articles were included in this one-year narrative review. The mean BMI value of severe COVID-19 patients ranged from 24.5 to 33.4 kg/m2, versus <18.5 to 24.3 kg/m2 for non-severe patients. Articles using the terms obesity or overweight without indicating the BMI value in these patients were common, but this is not useful, as the anthropometric parameters, when not defined by this index, are confusing due to the classification being different in the West compared to among Asian and Korean criteria-based adults. We proposed a new term, called COVID obesity, to define the importance of this anthropometric parameter, among others, in relation with this pandemic.

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Evaluation of air pollutants (PM10 and SO2) in the first year of the COVID-19: A city sample from Turkey

World Journal of Advanced Research and Reviews ◽

10.30574/wjarr.2021.10.1.0130 ◽

2021 ◽

Vol 10 (1) ◽

pp. 041-047

Author(s):

Ömer Faruk Tekin

Keyword(s):

Air Pollutants ◽

Monitoring Network ◽

Cross Sectional Study ◽

First Year ◽

Air Quality Monitoring ◽

Sectional Study ◽

Cross Sectional ◽

Before And After ◽

The Mean ◽

One Year

The aim of this study is to evaluate the change of air pollutants in the province of Van compared to the previous year during the COVID-19 pandemic. The study is a cross-sectional study conducted in Van where is a city in eastern Turkey. PM10 and SO2 values obtained from the National Air Quality Monitoring Network website. The lockdowns imposed in the province of Van within the scope of combating COVID-19 have been recorded by examining the decisions of the Sanitary Board on the Van Governorship's official website. The mean of PM10 measurement values in the period before and after COVID-19 were 40.89±19.6 µg/m3 and 41.3±20.39 µg/m3, respectively. The mean of SO2 measurement values were 17.76±18.48 µg/m3 and 23.49±20.96 µg/m3 before and after COVID-19, respectively. When one year after and before COVID-19 was evaluated, there was no difference in PM10 values in terms of year averages, while SO2 value was found to be increased compared to the previous year. However, when analyzed by months, there were months when PM10 values were found to be increased (March, September and October) and decreased (July, August and November) compared to the previous year.

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