scholarly journals Pengaruh ekstrak daun binahong (Anredera cordifolia ) terhadap pemulihan siklus estrus mencit (Mus musculus)

2021 ◽  
Vol 10 (2) ◽  
pp. 32
Author(s):  
Diana Novita Sari ◽  
Ramadhan Sumarmin ◽  
Fitri Arsih ◽  
Fitra Arya Dwi Nugraha
Keyword(s):  
Estrous Cycle ◽  
Analysis Of Variance ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Bark Extract ◽  
Vaginal Smear ◽  
Level Of Significance ◽  
Range Test

This study aimed to determine the effect of binahong (Anredera cordifolia) leaf extract on the recovery of the estrous cycle of mice (Mus musculus) which has been induced for the extension of the estrous cycle using angsana (Pterocarpus indicus) bark extract. In this study vaginal smear was performed daily at 10.00 WIB to determine the phase of the estrous cycle for 26 days. Mice were divided into 5 groups, each with 6 replicates. The treatments were T1 (positive control), T2 (negative control), T3 (0.8 mg/head/day), T4 (2.4 mg/head/day) and T5 (4 mg/head/day). The data obtained were processed using Analysis of Variance (ANOVA) and followed by the Duncan's New Multiple Range Test (DNMRT) at a 95% level of significance.  The results showed that the angsana (Pterocarpus indicus) bark extract adminsitration (T2) lengthen (p <0.05) the estrous cycle of mice compared to those of normal mice (T1). The administration of binahong (Anredera cordifolia) leaf extract on T3 and T4 groups mice were followed by shorter (p <0.05) estrous cycle than those of T2, and it were not significantly different (p >0.05) compared to T1 group. However, the higher dose of binahong (Anredera cordifolia) leaf extract (T5) revealed the length of estrous cycle was not significantly different (p >0.05) compared to T2 group. It can be concluded that the administration of binahong leaf extract was able to recover the normal estrous cycle of mice.

scholarly journals Uji Efek Antidiabetik Ekstrak Daun Trembesi (Albizia saman (Jacq.) Merr) Terhadap Mencit (Mus musculus L)

WARTA FARMASI ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 43-52
Author(s):  
Muhammad Azdar Setiawan ◽  
Muhammad Syaiful Saehu ◽  
Kartini Kartini
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose ◽  
Albizia Saman

ABSTRAK Daun trembesi (Albizia saman (Jacq.) Merr) adalah salah satu tanaman berkhasiat menurunkan kadar glukosa darah dimana kandungan kimianya berpotensi menurunkan kadar glukosa darah antara lain flavonoid yang bekerja dengan cara menstimulasi sel- sel beta dari pulau langerhans, sehingga sekresi insulin ditingkatkan.Penelitian ini bertujuan untuk mengetahui efek antidiabetes ekstrak daun trembesi (Albizia saman (Jacq.) Merr) pada mencit (Mus musculus). Metode Penelitian ini merupakan penelitian Eksperimen dimana sebanyak 20 ekor mencit dibuat diabetes dengan menggunakan Streptozotosin 150 mg/kgBB secara Intraperitonial. Kemudian dibagi menjadi 5 kelompok perlakuan, yaitu: Ekstrak dosis 25 mg/kgBB, 50 mg/kgBB, 100  mg/kgBB, sebagai kontrol positif Glibenclamid 5 mg dan kontrol negatif suspensi Na.CMC 0,5%. Data yang diperoleh dianalisis dengan uji ANOVA. Hasil analisa statistik menunjukan pada konsentrasi ekstrak 100 mg/kgBB memberikan efek yang optimum dengan perlakuan kontrol positif Glibenklamid.  Kata Kunci  : Ekstrak Daun Trembesi, Antidiabetik.  ABSTRACT Trembesi leaf (Albizia saman (Jacq.) Merr) is one of the efficacious plants to reduce blood glucose levels where the chemical content has the potential to reduce blood glucose levels, among others, flavonoids that work by stimulating beta cells of the island langerhans, so that insulin secretion is increased. It aims to determine the antidiabetic effect of trembesi leaf extract (Albizia saman (Jacq.) Merr) in mice (Mus musculus). This research method is an experimental study in which as many as 20 mice were made diabetic using Streptozotosin 150 mg / kgBW intraperitonially. Then divided into 5 treatment groups, namely: Extract dose 25 mg / kg body weight, 50 mg / kg body weight, 100 mg / kg body weight, as positive control Glibenclamid 5 mg and negative control suspension Na.CMC 0.5%. The data obtained were analyzed by ANOVA test. The results of statistical analysis showed that the extract concentration of 100 mg / kgBB gave the optimum effect with the positive control of Glibenclamide. Keywords: Trembesi Leaf Extract, Antidiabetic.

scholarly journals UJI EFEK ANALGESIK EKSTRAK KULIT BATANG POHON MATOA (Pometia pinnata) PADA MENCIT (Mus musculus)

2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Rafly F. Lumintang ◽  
Jane Wuisan ◽  
Pemsy M. Wowor
Keyword(s):  
Mus Musculus ◽  
Analgesic Effect ◽  
Negative Control Group ◽  
Treated Group ◽  
Positive Control ◽  
Negative Control ◽  
Bark Extract ◽  
Control Group ◽  
Group Iii ◽  
Group I

Abstract: Pain is an unpleasant sensation that derives from the complex neurochemical processes in the central and peripheral nervous systems. Side effects of drugs inter alia opioids and NSAIDs can cause serious disorders, therefore, it is necessary to find and develop other effective analgesic drugs with low toxicity. In Indonesia, matoa (Pometia pinnata) is known as a typical plant in Papua especially in West Papua. In some countries, parts of matoa plants are used as traditional medicine. This study aimed to determine the analgesic effect of matoa bark extract (Pometia pinnata) on mice Mus musculus. This was an experimental study. Nine male mice weighed 30 g were divided into 3 groups, each consisted of 3 mice. Group I, the negative control group, was given aquadest; group II, the positive control group, was given aspirin solution; and group III, the treated group, was given matoa bark extract. Analgesic effect was determined by counting the mice movements (licking their back legs or jumping) during 1 minute in a beaker with a temperature of 550C. The results showed that after 30 minutes the average number of movements of the treated group decreased from 22 times to 19.3 times, and continued to decrease until 1 movement after 120 minutes. Conclusion: Matoa bark extract showed analgesic effect on mice Mus musculus.Keywords: analgesic effect, matoa bark, miceAbstrak: Nyeri adalah sensasi yang tidak menyenangkan yang berasal dari proses neurokimia kompleks di sistem saraf pusat dan perifer. Opioid dan golongan AINS dapat menimbulkan efek samping yang cukup berat; oleh karena itu, diperlukan obat analgesik yang efektif dengan toksisitas rendah. Di Indonesia, matoa (Pometia pinnata) dikenal sebagai tanaman khas Papua terutama Papua Barat. Di beberapa negara, bagian-bagian dari tanaman matoa telah digunakan sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui efek analgesik ekstrak kulit batang pohon matoa (Pometia pinnata) pada mencit Mus musculus. Penelitian ini menggunakan metode eksperimental. Sembilan ekor mencit jantan dengan berat rata-rata 30 g dibagi atas 3 kelompok hewan uji yang masing-masing terdiri dari 3 ekor mencit. Kelompok I yaitu kelompok kontrol negatif diberikan akuades; kelompok II yaitu kelompok kontrol positif diberikan larutan aspirin; dan kelompok III yaitu kelompok perlakuan diberikan ekstrak kulit batang matoa. Efek analgesik berupa jumlah gerakan mencit selama 1 menit saat diletakan di dalam beker dengan suhu tetap 550C. Gerakan yang dihitung berupa gerakan menjilat kaki belakang atau meloncat. Hasil penelitian menunjukkan bahwa pada menit ke-30 terjadi penurunan rerata jumlah respon gerakan mencit dari 22 kali menjadi 19,3 kali yang terus berkurang hingga menit ke-120 dimana hanya terdapat 1 gerakan. Simpulan: Ekstrak kulit batang pohon matoa memiliki efek analgesik pada mencit Mus musculus.Kata kunci: efek analgesik, kulit batang matoa, mencit

scholarly journals AKTIVITAS SENYAWA ANTIBAKTERI EKSTRAK PAREPAT (Sonneratia alba) TERHADAP PERTUMBUHAN Ralstonia solanacearum DAN Streptococcus sobrinus

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Saat Egra ◽  
Mardhiana Mardhiana ◽  
Ningrum Indah Rahayu ◽  
Nurjannah Nurjannah ◽  
Sudirman Sirait ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Stem Bark ◽  
Positive Control ◽  
Negative Control ◽  
Bark Extract ◽  
Streptococcus Sobrinus ◽  
Mangrove Plant ◽  
Natural Medicine ◽  
Antibacterial Assay ◽  
Sonneratia Alba

AbstractParepat/pidada putih (Sonneratia alba) is a type of mangrove plant that is used by the traditional tribe for natural medicine. This study uses leaves and stem bark extracted with ethanol. Antibacterial assay uses Ralstonia Solanaceaerum and Streptococcus sobrinus by diffusion agar method. The concentrations used were 5000ppm, 10000ppm, 20000ppm with positive control (Chloramphenicol), and negative control (Ethanol 40%). The results of this study obtain the moisture factor of S. alba leaves has a humidity of 0.31 and stem bark of 0.49. The yield showed that the amount of S. alba leaf extract was 23.86% and the bark was 7.31%. S. alba leaf extract was able to inhibit the bacteria R. solanacearum at concentrations of 5000ppm, 10000ppm and 20000ppm with inhibitory values of 27.46%, 34.34% and 37.78%, respectively. While bark extract can inhibit R. solanacearum at concentrations of 5000 ppm, 10000 ppm and 20000 ppm with inhibitory values of 35.38%, 38.47% and 41.92%, respectively. S. alba leaf extract is able to inhibit S. sobrinus bacteria only at concentrations of 10000 ppm and 20000 ppm with inhibitory values of 28.07% and 48.51%. Whereas S. alba bark extract was able to inhibit S. sobrinus at a concentration of 5000 ppm, 10000 ppm and 20000 ppm with inhibitory values of 16.18%, 49.02% and 61.27%. Keywords: Antibacterial, Leave, Stem bark, Mangrove, S. alba AbstrakParepat/pidada putih (Sonneratia alba) merupakan salah satu jenis tumbuhan mangrove yang dimanfaatkan oleh masyarakat sebagai obat tradisional. Penelitian ini menggunakan daun dan kulit batang yang diekstraksi dengan etanol. Pengujian antibakteri menggunakan Ralstonia Solanaceaerum dan Streptococcus sobrinus dengan metode difusi agar sumuran. Kosentrasi yang digunakan yaitu 5000 ppm, 10000 ppm, 20000 ppm dengan kontrol positif (Chloramphenicol), dan kontrol negatif (Etanol 40%). Hasil penelitian ini menunjukkan faktor kelembaban daun S. alba memiliki kelembaban yaitu 0,31 dan kulit batang yaitu 0,49. Rendemen menunjukkan bahwa jumlah ekstrak daun S. alba yaitu 23,86% dan kulit batang 7,31%. Ekstrak daun S. alba mampu menghambat bakteri R. solanacearum pada konsentrasi 5000ppm, 10000ppm dan 20000ppm dengan nilai persentase hambat yaitu masing-masing 27,46%, 34,34% dan 37,78%. Sedangkan ekstrak kulit batang mampu menghambat R. solanacearum pada konsentrasi 5000 ppm, 10000 ppm dan 20000 ppm dengan nilai persentase hambat secara berturut 35,38%, 38,47% dan 41,92%. Ekstrak daun S. alba mampu menghambat bakteri S. sobrinus hanya pada konsentrasi 10000 ppm dan 20000 ppm dengan nilai persentase hambat yaitu 28,07% dan 48,51%. Sedangkan ekstrak kulit batang S. alba mampu menghambat S. sobrinus pada konsentrasi 5000 ppm, 10000 ppm dan 20000 ppm dengan nilai persentase hambat yaitu 16,18%, 49,02% dan 61,27%. Kata kunci: Antibakteri, Daun, Kulit bantang, Mangrove, S. alba.

PENGARUH EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) TERHADAP GLUKOSA DARAH MENCIT (Mus musculus L.) JANTAN YANG DIINDUKSI SUKROSA

BioScience ◽  
2018 ◽  
Vol 2 (1) ◽  
pp. 61
Author(s):  
Elsa Yuniarti
Keyword(s):  
Blood Glucose ◽  
Mus Musculus ◽  
Leaf Extract ◽  
Negative Control ◽  
State University ◽  
Betel Leaf ◽  
Randomized Design ◽  
The Subject ◽  
Effective Drugs ◽  
Zoology Department

Patients withdiabetes mellitus (DM) continues to grow because prosperity and people's lifestyles.Treatment of diabetes often usei njections of insulin and oral antidiabetic drugs. Thetreatment has no side effects. Therefore, it is necessary to find effective drugs using plants thatred betel leaf (Piper crocatum Ruiz & Pav.). Red betel leaf contains flavonoids which are antioxidants. This study aims to determine the effect and dose of extract of red betel leaf (Piper crocatum Ruiz & Pav.) The most effective agains blood glucose in mice(Mus musculusL.) male induced sucrose.This study was an experimental study. The research was conducted in October 2015 in the Division of Laboratory Animal and Zoology Department of Biology, State University of Padang. The subject of research in the form of mice (Mus musculus L.) males totaled 24 tails. The design used was completely randomized design (CRD) with 6 treatments and 4 repetitions. The treatment is given as follows: treatment I: the diabetes control without any treatment given, treatment II: as a negative control (sucrose 3 g/kg bw), treatment III: sucrose+suspension of red betel leaf extract (dosage 0,7 g/kg bw), treatment IV: sucrose+suspension of red betel leaf extract (dosage 1,4 g/kg bw), treatment V: sucrose+suspension of red betel leaf extract (dosage of 2,1 g/kg bw) and treatment VI: sucrose+suspension extracts red betel leaf (dosage 2,8 g/kg bw).The results showed that the extract of red betel leaf (Piper crocatum Ruiz & Pav.) at a dose of 0,8 g/kg bw 1,4 g/kg bw 2,1 g/kg bw and 2,8 g/kg bw can lowers blood glucose in mice. However, the most appropriate dose in lowering blood glucose in mice (Mus musculus L.) at 2,8 g/kg bw in mice.

UJI IMUNOMODULATOR DARI EKSTRAK ETANOL DAUN WARU (HIBISCUS TILIACEUS) DENGAN METODE HIPERSENSITIVITAS TIPE LAMBAT

2019 ◽  
Vol 1 (2) ◽  
pp. 11-16
Author(s):  
Yanna Rotua Sihombing ◽  
Debi Dinha Sitepu
Keyword(s):  
Treatment Group ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Delayed Type Hypersensitivity ◽  
Hypersensitivity Response ◽  
Delayed Type Hypersensitivity Response

Immunomodulator is a compound that can increaase the imuno system. One of the plants that have immunomodulator’s activity is Waru Leaf (Hibiscus tiliaceus). the purpose of this research was to test the effect of immunomodulator by extract of Waru Leaf ethanol on rat male. The activity of immunomodulator was determined by using digital pletysmometer by measuring the differences between the last leg swelling’s volume and the first leg swelling’s volume. The treatment group were divided into 5 groups. Each group consistof 5 rats CMC-Na 0,5% (negative control), Stimuno®  32,5 mg/kgBW (positive control), dose of EEDW 50, 100 and 200 mg/kgBW, and bacteria E.coli as antigen. The results slowed that distribution of EEDW dose 200 mg/kgBW can give the effect of immunostimulant by swelling enthancement compared by CMC-Na 0,5 %. EEDW 200 mg/kgBW that have activity comparable with Stimuno®  32,5 mg/kgBW. Thus, it is concluded that of Waru Leaf extract has immunomodulator effects on delayed-type hypersensitivity response of rat male.

Potential Antiseptic of Rhodomyrtus tomentosa leaves extract on Healing wound in Male Wistar rats

2021 ◽  
pp. 3143-3149
Author(s):  
Endang Sri Purwanti Ningsih ◽  
Noorlaila Noorlaila ◽  
Ikhwan Rizki Muhammad ◽  
Windy Yuliana Budianto
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Wound Care ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Rhodomyrtus Tomentosa

Background: The process of wound healing is influenced by various factors such as age, hormones, and wound care. Wound care is done to accelerate wound healing which can be done by various methods, one of them is traditional care. Traditional wound care can use medicinal plants. Rhodomyrtus tomentosa is a medicinal plant that has an antioxidant, anti-inflammatory, antitumor and antibacterial content. Thus this study aims to evaluate the effectiveness of the antiseptic solution of the Rodhomyrtus tomentosa leaf extract on wound healing in male Wistar rats. Method: this research is pure experimental research with post test only control group design. Thirty male white rats were divided into five groups, namely negative control, positive control, Rhodomyrtus tomentosa leaf extract 15%, 30%, and 60%. Rhodomyrtus tomentosa leaf extraction was carried out by maceration method with 70% ethano solvent. The extraction results are divided into 3 concentrations (15%, 30% and 60%). The wound healing process was evaluated by measuring the length of the wound manually from 0 to 10 days in each group. Meanwhile, the number of fibroblast cells was calculated through hematoxylin eosin (HE) staining and observed using an Olympus CX41 microscope with a 10x magnification and objective lens magnification in 3 fields. Result: There was a significant difference in the reduction in wound length (p =< 0,000) between the five experimental groups (Rhodomyrtus tomentosa leaf extract solution 15%, 30% and 60%, negative control and positive control. Solution of rhodomyrtus tomentosa leaf extract accelerated the increase in the number of fibroblasts compared to the negative control group (p = 0.003), but did not make a difference (p = 0.403) with the positive control group. Rhodomyrtus tomentosa leaf extraction solution had the same microscopic effect on the number of fibroblasts with a positive control group given 0.9% NaCl solution. Conclusion: There was a significant difference in the number of fibroblasts between all groups, but no difference in wound healing length.

scholarly journals PENGGUNAAN KRIM EKSTRAK BATANG DAN DAUN SURUHAN (Peperomia pellucida L.H.B.K) DALAM PROSES PENYEMBUHAN LUKA BAKAR PADA TIKUS PUTIH (Rattus norvegicus)

2015 ◽  
Vol 1 (2) ◽  
pp. 198-208
Author(s):  
Nur Fitri
Keyword(s):  
Treatment Group ◽  
Rattus Norvegicus ◽  
Leaf Extract ◽  
Healing Process ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Herbaceous Plant

Background: Peperomia pellucida L'HBK or known as messengers in the Indonesian plant is a herbaceous plant that belongs to the family Piperaceae. This study aimed to determine the effect of the stem and leaf extract cream messengers to the healing process of burns in rats (Rattus norvegicus. Methods: This was an experimental study using a completely randomized design. Test animals were divided into three groups, each - each group consisted of 3 rats. The first group is the negative control group (distilled water), the second group is a positive control group (Bioplacenton®), the third group is the group treated stem and leaf extract cream errand. The diameter of the wound and fibroblasts observed histopathology and is used as an indicator of the healing process of burns. The burns were treated and observed the healing effect for 20 days. Data were analyzed statistically wound diameter using ANOVA followed by LSD test. Results: The results showed the cream extracts of stems and leaves telling effect on the healing process of burns on rats. Conclusion: The results also showed that the treatment group and the leaf stem extract cream messengers and control groups positively influence the healing process of burns significantly when compared to the negative control group. Meanwhile, the treatment group stem and leaf extract cream messengers have no preformance difference influence the healing process of burns a significant positive control group

scholarly journals Uji daya hambat ekstrak daun awar-awar (ficus septica burm.f) terhadap pertumbuhan bakteri staphylococcus aureus dan eschericia coli

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Ismiranti D.A. Tuna ◽  
Pemsi M. Wowor ◽  
Henoch Awaloei
Keyword(s):  
Staphylococcus Aureus ◽  
Bacterial Infection ◽  
Natural Science ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
University Faculty ◽  
Microbiology Laboratory ◽  
Causal Organism ◽  
Empiric Data

Abstract: Awar-awar (Ficus septica Burm.F) is one of the plants that used by comunities. Based from the empiric data, this plant is believed have efficacy as a drug and could treat diseases. Staphylococcus aureus dan Eschericia coli are the most frequent causal organism in human bacterial infection. This study aimed to determine whether there is inhibition of leaf extract awar-awar against Staphylococcus aureus and Eschericia coli. This was a laboratory experimental with Kirby-Bauer pitting modification at Phytochemistry and Microbiology Laboratory of Sam Ratulangi University Faculty of Mathematics and natural Science. Awar-awar leaf extract was obtained from maceration process with 96% ethanol. Consentration of thick extract that was used were 100 mg/ml, 50 mg/ml, 25 mg/ml, 12,5 mg/ml. ciprofloxacin was used as positive control,and aquades was used as negative control. The result showed that the average of inhibition diemeters by awar-awar leaves were 100 mg/ml, 50 mg/ml, 25 mg/ml, 12,5 mg/ml respectively are 27,5 mm, 24,3 mm, 22,3 mm, 21,8 in Staphylococcus aureus, whereas in Eschericia coli were 24,8 mm, 21 mm, 18,3 mm, 17 mm. Conclusion: Awar-awar leaf extract has a potential inhibion effect on the growth of Staphylococcus aureus and Eschericia coli.Keywords: awar-awar leaves extract, staphylococcus aureus, eschericia coli, inhibition test. Abstrak: Tanaman awar-awar merupakan salah satu tanaman yang digunakan masyarakat untuk pengobatan. Berdasarkan data empiris, tanaman ini dipercaya memiliki khasiat sebagai obat dan bisa mengobati penyakit. Bakteri Staphylococcus aureus dan Eschericia coli merupakan penyebab infeksi utama pada manusia. Penelitian ini bertujuan untuk mengetahui ada tidaknya daya hambat ekstrak daun awar-awar terhadap bakteri Staphylococcus aureus dan Eschericia coli. Jenis penelitian ini ialah eksperimental laboratorium dengan modifikasi Kirby-Bauer sumuran di Laboratorium Fitokimia dan Mikrobiologi Fakultas MIPA Universitas sam Ratulangi. Ekstrak daun awar-awar diperoleh dari proses maserasi dengan etanol 96%. Konsentrasi ekstrak kental yang digunakan dalam penelitian ini ialah 100 mg/ml, 50 mg/ml, 25 mg/ml, 12,5 mg/ml. Siprofloksasin sebagai kontrol positif, dan akuades sebagai kontrol negatif. Hasil penelitian mendapatkan rata-rata diameter zona hambat ekstrak daun awar-awar konsentrasi 100 mg/ml, 50 mg/ml, 25 mg/ml, 12,5 mg/ml berturut-turut ialah 27,5 mm, 24,3 mm, 22,3 mm, 21,8 mm pada bakteri Staphylococcus aureus, sedangkan pada bakteri Eschericia coli ialah 24,8 mm, 21 mm, 18,3 mm, 17 mm. Simpulan: Ekstrak daun awar-awar berpotensi memiliki daya hambat terhadap pertumbuhan bakteri Staphylococcus aureus dan Eschericia coli. Kata kunci: ekstrak daun awar-awar, staphylococcus aureus, eschericia coli, uji daya hambat.

scholarly journals UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ECENG GONDOK (Eichhornia crassipes (Mart.)Solms) DAN DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 44-53
Author(s):  
Andri Priyoherianto ◽  
◽  
Panji Ratih Suci ◽  
Putri Rizki Cahya Fatimah ◽  
Atik Nur Wijayanti
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Water Hyacinth ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Normal Limits ◽  
Blood Glucose Levels ◽  
Sugar Levels

Diabetes mellitus is a chronic metabolic disorder that occurs due to destruction of pancreatic ? cells characterized by blood glucose levels that exceed normal limits. The purpose of this study was to determine the therapeutic effect of the combination of water hyacinth leaf extract and Sintrong leaf in reducing blood glucose levels in alloxan-induced experimental animals. Water hyacinth leaf powder and Sintrong leaves were extracted using the maceration method with 70% ethanol as a solvent. A total of 25 mice were divided into 5 groups, namely negative control CMC-Na 0.5%, positive control glibenclamide 0.00065 mg / g BW, water hyacinth leaf extract 17.5 mg / kg BW, Sintrong leaf extract 10.5 mg/ kg BW and a combination of water hyacinth leaf extract 17.5 mg / kg BW and sintrong leaf 10.5 mg / kg BW. The results showed that a single extract of water hyacinth and Sintrong leaves was able to reduce blood sugar levels for 7 days. The combination dose was effective in reducing blood sugar levels with a combination dose of 17.5 mg/ kg water hyacinth leaf extract in combination for 7 days.

scholarly journals PENGARUH TRITERPEN TOTAL PEGAGAN (Centella asiatica (L) Urban) TERHADAP FUNGSI KOGNITIF BELAJAR DAN MENGINGAT PADA MENCIT JANTAN ALBINO (Mus musculus) YANG DIHAMBAT DENGAN SKOPOLAMIN

Molekul ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. 89
Author(s):  
Herlina Herlina
Keyword(s):  
Cognitive Function ◽  
Learning And Memory ◽  
Mus Musculus ◽  
Memory Performance ◽  
Centella Asiatica ◽  
Positive Control ◽  
Negative Control ◽  
Learning Ability ◽  
Control Group ◽  
Albino Mice

Pegagan (Centella asiatica (L) Urban) has been described to posses CNS effects such as improving cognitive function, learning and memory. The aim of the research was to evaluate the effects of total triterpen’s pegagan extract on cognitive functions as the learning and memory performance in male albino mice (Mus musculus) inhibited by scopolamine. The research design was Complete Randomized Design (RAL) – factorial on thirty six mice divided into 4 groups. One control group received only aquabidest (negative control). Three treatment groups received total triterpen 16 mg/kg BW, 32 mg/kg BW orally and piracetam 500 mg/kg BW by intra peritoneally (positive control) for 21 days. Data indicating learning and memory process of all subjects were obtained from one-trial passive avoidance test. Data were analyzed by two way ANOVA and BNT (p<0,05). Result showed that total triterpen 32 mg/kg BW had significantly prolonged the retention time compared to control group indicating improvement in cognitive function (505,03 second vs -18,53 second) (p<0,05) and it was not significantly different to piracetam 500 mg/kg BW group (505,03 second vs 522,48 second) (p>0,05). In conclusion, total triterpen from pegagan (Centella asiatica (L) Urban) improved learning ability and memory of male albino mice (Mus musculus) even though, it was inhibited by scopolamine.

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