A clinical study of effect of peri-tonsillar infiltration of ropivacaine on tonsillectomy haemorrhage

<p><strong>Background:</strong> The aim of this study to determine the relationship between the peritonsillar infiltration of ropivacaine hydrochloride and haemorrhage in patients undergoing tonsillectomy.</p><p><strong>Methods </strong>This prospective study was conducted in the department of otorhinolaryngology and head and neck surgery, Adichunchanagiri institute of medical sciences, B. G. Nagara, Mandya district. A sample size of 30 patients which satisfied the inclusion criteria were included in the study. <strong></strong></p><p>Ropivacaine (0.75%)<strong> </strong>was locally infiltrated on the right side (R-side) in the peri-tonsillar region before the surgery. The left side was considered as the control side. Intra-operative blood loss was estimated separately for both the sides. The data from the study will be analysed using chi square test and Student t test technique.</p><p><strong>Results:</strong> The 17 (56.7%) females and 13 (43.3%) males participated in the study. Majority of the cases belonged to &lt;10 years of age group. By analysing the data, blood loss was found to be higher on the left side (control side) compared to the right side on which peri-tonsillar infiltration of ropivacaine was given. The association between the blood loss on the right side and the left side (control side) was found to be significant (p&lt;0.0001).<strong></strong></p><p><strong>Conclusions: </strong>Based on the result of our study it can be derived that the peri-tonsillar infiltration of Ropivacaine (0.75%) is very effective in reducing intra-operative bleeding and at the same time providing a better bloodless field during surgery. Hence, we recommend the use of peri-tonsillar infiltration of Ropivacaine (0.75%) in view of better management of intra-operative blood lossissn.2454-5929.ijohns20220041</p>

Contact Heat Evoked Potentials in China: Normal Values and Reproducibility

Background: Contact heat evoked potentials (CHEPs) is used to diagnose small fiber neuropathy (SFN). We established the normal values of CHEPs parameters in Chinese adults, optimized the test technique, and determined its reproducibility.Methods: We recruited 151 healthy adults (80 men; mean age, 37 ± 14 years). CHEPs was performed on the right forearm to determine the optimal number of stimuli, and then conducted at different sites to establish normal values, determine the effects of demographic characteristics and baseline temperature, and assess the short- (30 min) and long-term (1 year) reproducibility. N2 latency/height varied with age and sex, while P2 latency/height and N2–P2 amplitude varied with age. The optimal number of stimuli was three.Results: N2 latency/height (t = 5.45, P &lt; 0.001) and P2 latency/height (χ2 = −4.06, P &lt; 0.001) decreased and N2–P2 amplitude (t = −5.01, P &lt; 0.001) and visual analog scale score (χ2 = −5.84, P &lt; 0.001) increased with increased baseline temperature (35 vs. 32°C). CHEPs parameters did not differ with time (baseline vs. 30 min vs. 1 year).Conclusion: We established normal CHEPs values in Chinese adults. We found that CHEPs parameters changed with baseline temperature and that the short- and long-term test reproducibility were satisfactory.

THE INFLUENCE OF KINESTHETIC PERCEPTION, HAND-EYE COORDINATION, AND SELF-CONFIDENCE ON STROKE DRIVE SKILLS IN BADMINTON GAME

This study aims to reveal the direct and indirect effects, as well as the simultaneous effect of exogenous variables on endogenous variables. The sample in this study were 30 beginner athletes of Gold Badminton Club and Sarwendah Badminton Club Jakarta. The research approach used in this study is an associative quantitative approach, a survey method with a test technique. The data analysis technique used a path analysis approach (path analysis). Data were analyzed by path analysis through structural model testing at = 0.05. The results showed that: 1) there was a direct kinesthetic effect on the badminton game's ball drive skills of 0.438, 2) there was a direct effect of eye-hand coordination on the badminton game's ball drive skills of 0.208, 3) there was a direct influence of self-confidence on the ball drive skills badminton game is 0.336, 4) there is a direct kinesthetic effect on self-confidence which is 0.237, 5) there is a direct effect of eye-hand coordination on self-confidence which is 0.199. From the analysis of the direct and indirect effects, it can be concluded that the biggest influence is the direct effect of kinesthetic coordination on the badminton game's repulsive drive skills of 0.438.

Strengthening Islamic Financial Literacy Education for Millennial Generation

Indonesia is one of the countries with the largest Muslim population in the world. In this era of disruption, millennials are the generation that plays an essential role in contributing to government programs. One of the programs launched is the development of national Islamic finance. Financial literacy is a basic need for everyone, including the millennial generation, to avoid financial problems. The financial sector has been effective in encouraging economic development, both in terms of the ability and accuracy of spending, business financing, and the accuracy of savings and investment choices. This study aims to determine the impact of Strengthening Islamic Financial Literacy Education on the Millennial Generation. This study uses a quantitative approach with the Wilcoxon test technique. The population in this study were students majoring in management at UPN Veteran University, with a sample of 88 respondents using the purposive sampling technique. The results showed differences in students representing the millennial generation after the Islamic financial literacy education training was carried out; this was indicated by a sign of 0.037 or less than 0.05. In the implementation of literacy, there has also been a change between before and after the provision of Islamic financial literacy training to students. This study also revealed that universities play an essential role in providing education to students in understanding Islamic financial literacy.

Footprints of Climate Change, Global Warming, Government Economic Policies on Crops Production: Adaptation Strategies

Climate change has become one of the most imperative snags of this century. Climate change is a grave global threat, and Pakistan has been ranked eighth on the list of countries most vulnerable to climate change by the German watch Global Climate Risk Index. The increasing amount of carbon dioxide (CO2), the foremost contributor to global warming, seems to provoke this problem. Agriculture-based economies have always been dependent on the vagaries of nature and climate. This study in your hand underscores climate change, global warming and government economic policies footprint on four major crop production (Wheat, Rice, Sugarcane, and Cotton) in Pakistan with the help of time-series data acquired from 1977 to 2016. The ARDL bounds espouse test technique relied on ADF test results. The study concluded that climate change and government economic policies have a positive influence on crops produced in the long as well as short-run except global warming and input index, which have a negative influence in the short run. Policymakers and researchers must drive attention to adopt advanced cultivation processes through farming practice through international research institutions' assistance.

Perbedaan Prestasi Belajar Mahasiswa Prodi PJKR-FIK Universitas Negeri Malang Angkatan 2017 Antara Semester Genap 2018/2019 Dengan Semester Genap 2019/2020

The Covid-19 pandemic, which has attacked in all countries, especially in Indonesia in 2020, has changed the learning methods at education levels of education in Indonesia, especially learning for elementary school (SD) to college or University levels. This study examines the value of learning achievement of students of the PJKR FIK study program, State University of Malang. The purpose of this study was to determine and assess whether there was a significant difference in the learning achievement scores of the 2017 Off A class of student theory and practice between the 2018/2019 and even 2019/2020 semesters in the PJKR FIK study program, State University of Malang. This research is included in the ex post facto study using a causal comparative design. The sample of this study was 37 students of the PJKR offering A class of 2017. Data analysis in this study used the Kolmogorov-Smirnov normality test technique, the homogeneity test (Ftest), and the difference test in the form of an unrelated sample t test. Based on the data analysis, the result obtained by the coefficient Tcount greater than or equal to Ttable at a significant level of 0,05, meaning that H₀ is rejected and H₁ is accepted. This means that there is a significant difference in the learning achievement values of the theory and practice subject in the 2018/2019 and even 2019/2020 semesters in the 2017 A class Offering students of the PJKR FIK study Program, State University of Malang. Abstrak: Pandemi Covid-19 yang menyerang di semua negara khususnya di negara Indonesia pada tahun 2020 ini, merubah metode pembelajaran pada jenjang pendidikan yang ada di Indonesia khususnya pembelajaran dari jenjang Sekolah Dasar (SD) sampai ke jenjang Perguruan Tinggi atau Universitas. Penelitian ini mengkaji nilai prestasi belajar mahasiswa program studi PJKR FIK Universitas Negeri Malang. Tujuan dari penelitian ini adalah untuk mengetahui dan mengkaji ada tidaknya perbedaan yang signifikan nilai prestasi belajar mata kuliah teori dan praktek mahasiswa angkatan 2017 Off A antara semester genap 2018/2019 dan genap 2019/2020 pada prodi PJKR FIK Universitas Negeri Malang. Penelitian ini termasuk dalam penelitian expost facto dengan menggunakan rancangan causal comparative. Sampel penelitian ini berjumlah 37 mahasiswa Prodi PJKR offering A angkatan tahun 2017. Analisis data pada penelitian ini menggunakan teknik uji normalitas Kolmogorov-smirnov, uji homogenitas (uji F), dan uji beda dalam bentuk uji t sampel berhubungan. Berdasarkan analisis data diperoleh hasil koefisien Thitung lebih besar sama dengan Ttabel pada taraf signifikan 0,05, artinya bahwa H₀ ditolak dan H₁ diterima. Artinya, ada perbedaan yang signifikan hasil prestasi belajar antara semester genap 2018/2019 (sebelum pandemi Covid-19) dengan semester genap 2019/2020 (sebelum dan saat pandemi Covid-19) pada mahasiswa offering A angkatan 2017 program studi PJKR FIK Universitas Negeri Malang.

Attitude towards the disease and quality of life of patients with multiple sclerosis as a target of personalized psychotherapy for PTSD

Attitude towards the disease and quality of life of patients with multiple sclerosis as a target of personalized psychotherapy for PTSDA chronic, progressive, potentially disabling disease with a poor prognosis can trigger the development of post-traumatic stress disorder (PTSD). The article presents the results of a survey of 127 patients with multiple sclerosis (MS), of which 61 patients had PTSD symptoms that developed in connection with the underlying disease were verified. The control group included 67 patients with MS who were resistant to stress. To fulfill the objectives of the study, all patients underwent a thorough collection of anamnestic information. To study the structure of the internal picture of the disease, we used a test technique aimed at diagnosing the type of attitude toward the disease (TOBOL). The study of QOL indicators was carried out using the SF-36 questionnaire.To assess the cognitive, emotional and behavioral aspects of anxiety about progression, the following questionnaires were used: “A short questionnaire for assessing the fear of disease progression” A. Mehnert, P. Herschbach, P. Berg (2006), adapted by N.А. Sirota, D.V. Moskovchenko (2014) and “Questionnaire of cognitive ideas about the disease” A. Evers, F. Kraaimaat (1998), adapted by N.A. Sirota, D.V. Moskovchenko (2014). As a result of the study, it was revealed that the patients of the main group have significantly lower scores of both physical and mental functioning when assessing the quality of life. At the same time, patients with PTSD are characterized by a higher intensity of anxiety about progression, negative thinking, and emotional reactions associated with the disease. An inadequate internal picture of the disease, characterized by the presence of mental maladjustment due to the disease, prevails in the group of patients with PTSD. All of these factors can be predictors of the development of PTSD. It is necessary to conduct further studies of the psychological characteristics of this group of patients in order to identify the targets of psychotherapeutic influence.

Enhancing Students Learning Outcomes and Creative Thinking Skills in Computer Numeric Control Subject Using Project-Based Learning Model

This study aimed to determine the effect of project-based learning on student learning outcomes and creative thinking skills in computer numeric control subjects at SMK KAL-1 Surabaya. This study used a quasi-experimental factorial research design with a 2-way ANOVA test technique. In this study, 66 students from class XI of the Mechanical Engineering Expertise Program were divided into experimental groups (n= 33) and a control group (n= 33). The instrument used in this research is in the form of test sheets and observations to measure the level of students creative thinking and their learning outcomes. This study found that student learning outcomes using project-based learning are significantly higher than students who taught using direct learning models in computer numeric control subjects. Furthermore, the learning outcomes of students who have a high level of creative thinking are significantly higher than those of students who have a low level of creative thinking. Moreover, there is an interaction between using learning models and creative thinking on three domains of learning outcomes (cognitive, affective, and psychomotor) in computer numeric control subjects.

Preparation and Analysis of New 1,3,5-Trisubstituted-2-Pyrazolines Derivative for Their Analgesic Potential

The goal of the study was to develop, synthesise, and characterise a novel 1,3,5-trisubstituted-2-pyrazolines derivative, as well as to assess its analgesic potential. The reaction of chalcone derivatives with 4-hydrazinylbenzene sulfonamide hydrochloride and phenyl hydrazine hydrochloride yielded 1,3,5-tri-substituted-2-pyrazolines derivatives. The IR, 1HNMR, and mass spectrum analyses were used to characterise a total of sixteen substances. Analgesic activity of the proposed substances has been tested. The analgesic effect of the produced compounds was tested using two methods: the hot plate test technique and acetic acid induced writhing in mice. To compare the effectiveness, pentazocine and acetyl acetic acid were utilised as reference drugs. The hot plate test technique and acetic acid induced writhing in mice were used to assess the analgesic effect of the 16 produced chemical series A1-A8, and B1-B8. The evaluation's outcomes were viewed using Pentazocine and acetyl acetic acid as the standard drugs. In a 90-minute hot plate test, compounds A2 (10.30 s), A4 (9.45 s), A7 (11.65 s), and A8 (11.26 s) showed a delay in paw withdrawal latency time. Compounds B2 (9.10 s) and B7 (10.42 s) prolong the paw withdrawal latency time after 90 minutes in series B1-B8, reduce the pain feeling, and inhibit pain induced by heat methods. Compounds A2, A5, A6, A7, and A8 from Series A1-A8 showed 83.00, 76.01, 80.34, 86.99, 88.15 percent inhibition, substantially (p0.05 and p0.001, respectively), and decreased the number of wriths caused by 0.6 percent acetic acid at a dosage of 10 mg/kg. Acetylsalicylic acid (10 mg/kg) appears to be more successful in lowering the number of wriths, with a 99.0% reduction in the number of wriths (p0.001). B1, B3, and B4 have the least amount of active activity. These all finding suggest that these synthesized compounds have the potential as analgesic agent.

Qualitative and Quantitative Determination of Secondary Metabolites and Antioxidant Potential of Plumbago indica Root Extracts

Due to their well-known attribute of having minimal side effects as compared to medicines, natural items with medical potential are progressively gaining prominence in clinical research. The roots of Plumbago indica (P. indica, Plumbaginaceae) are commercially significant since they are the primary source of plumbagin and its derivatives. Plumbagin is well-known for its many pharmacological properties. P. indica roots yielded three naphthoquinones: plumbagin, 3, 30-biplumbagin, and elliptinone, which were employed as standard markers for quantitative HPLC analysis. The goal of this research was to screen phytochemicals, assess alkaloids, phenolic and flavonoid content, and measure the antioxidant potential of P. indica roots. The well-known test methodology was used to determine qualitative analysis of several phytochemical ingredients as well as quantitative analysis of total alkaloids, phenol, and flavonoids. The antioxidant activity of an ethanolic extract of P. indica roots was investigated in vitro using the 1,1-diphenyl, 2-picrylhydrazyl (DPPH) test technique. Alkaloids, glycosides, flavonoids, saponins, phenolics, proteins, and glucose were found in the ethanol and aqueous extracts, according to phytochemical study. P. indica roots ethanolic extract had 5.55, 0.930, and 3.940 mg of total phenolic, flavonoids, and alkaloids respectively. For comparative purposes, ascorbic acid was employed as a benchmark. In the investigated models, the extract showed dose-dependent free radical scavenging properties. For the DPPH technique, P. indica roots extract had an IC50 value of 23.02 µg/ml, which was equivalent to that of ascorbic acid (IC50=17.68 µg/ml). These researches contributed to the accurate identification of this plant material. The plant's broad variety of phytochemicals implies that it has medicinal potential, which might be investigated in the pharmaceutical sector as well as in traditional medicine.