scholarly journals Results of the TCM Method of Pulmonary Tuberculosis Examination on Lung TB Suspects

2021 ◽  
Vol 3 (1) ◽  
pp. 50-55
Author(s):  
Muhajir Muhajir
Keyword(s):  
Infectious Disease ◽  
Early Adulthood ◽  
Secondary Data ◽  
Research Data ◽  
Test Method ◽  
Drug Resistant ◽  
Molecular Test ◽  
Pulmonary Tb ◽  
Negative Results ◽  
Gender And Age

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB). Determinants of pulmonary TB disease include gender, and age. The Rapid Molecular Test Method (TCM) is a breakthrough TB program for Drug Resistant TB patients. The TCM method takes two hours to get the patient's diagnosis. TCM method for diagnosing TB and resistance to rifampin quickly and accurately. Tidar Magelang Hospital is one of the referral places for TCM examinations from various health facilities. The purpose of this study was to describe the results of the TCM method of pulmonary TB examination on pulmonary TB suspects at Tidar Magelang Hospital. This type of research is descriptive. The research data is secondary data obtained from Tidar Hospital Magelang. Based on age, namely early adolescence, late adolescence, early adulthood, late adulthood, early elderly, late elderly, and seniors, the results were sensitive rif 0.76%, 11.45%, 9, 54%, 7.25%, 5.73%, 8.78% and 3.82%. Negative results 1.15%, 1.91%, 6.87%, 7.25%, 7.63%, 14.89% and 12.98%. The rif results were sensitive to 27.1% males and 20.23% females. Negative results in 31.3% men and 21.37% women. The most sensitive rif results are in Magelang, followed by Magelang City, then East Jakarta Municipality, Banjarnegara and Purworejo. Negative results were found in Magelang, followed by Magelang City, then Wonosobo and East Waringin City.

scholarly journals Hasil diagnostik Mycobacterium tuberculosis dari sputum penderita batuk ≥ 2 minggu dengan pewarnaan Ziehl-Neelsen di Puskesmas Minanga Malalayang Dua, Puskesmas Bahu, dan Puskesmas Teling Atas Manado

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Raden MS. Ramadhan ◽  
John Porotu'o ◽  
Olivia A. Waworuntu
Keyword(s):  
Infectious Disease ◽  
Health Care ◽  
Mycobacterium Tuberculosis ◽  
Specific Therapy ◽  
Cross Sectional ◽  
Pulmonary Tb ◽  
Negative Results ◽  
Primary Health ◽  
Cross Sectional Design ◽  
Mycobaterium Tuberculosis

Abstract: Tuberculosis (TB) is an infectious disease which still commonly found at puskesmas (primary health care) in Manado. WHO has proclaimed “The End TB Strategy” program to reduce the incidence of TB. The TB germ can be identified with the Ziehl-Neelsen staining. This study was aimed to identify Mycobacterium tuberculosis in the sputum of patients that were suffered from cough for ≥2 weeks and had not received specific therapy and of relapsed pulmonary TB patients at Puskesmas Minanga Malalayang Dua, Puskesmas Bahu, and Puskesmas Teling Atas Manado by using Ziehl-Neelsen staining. This was a descriptive prospective study with a cross-sectional design. The results showed that of 30 samples of patients, the highest percentages were as follows: at Puskesmas Teling Atas, males (60%), ages 35-59 years old (60%), M. tuberculosis (-) (90%); at Puskesmas Bahu, females (60%), ages 15-34 years old (60%), M. tuberculosis (-) (100%); at Puskesmas Minanga Malalayang Dua, males (60%), ages 15-34 years old (70%), M. tuberculosis (-) (100%). Conclusion: Most patients had sputum with negative results of Mycobaterium tuberculosis which met the The End TB Strategy of WHO. Keywords: Mycobaterium tuberculosis, Ziehl-Neelsen staining, tuberculosis Abstrak: Tuberkulosis (TB) adalah penyakit menular yang masih sering ditemukan di puskesmas Kota Manado. WHO telah mencanangkan “The End TB Strategy” program to reduce the incidence of TB. Kuman TB dapat diidentifikasi dengan pemeriksaan Ziehl-Neelsen. Penelitian ini bertujuan untuk mengidentifikasi Mycobacterium tuberculosis pada sputum penderita batuk ≥2 minggu yang belum mendapatkan terapi spesifik atau penderita TB paru relaps di Puskesmas Teling Atas, Puskemas Bahu, dan Puskesmas Minanga Malalayang Dua Manado dengan pewarnaan Ziehl-Neelsen. Jenis penelitian ialah deskriptif prospektif dengan desain potong-lintang. Pada hasil penilitian didapatkan 30 sampel penderita batuk ≥2 minggu yang belum mendapatkan terapi spesifik atau penderita TB Paru relaps. Distribusi persentase tertinggi di Puskesmas Teling Atas ialah: laki-laki (60%), usia 35-59 tahun (60%), dan basil tahan asam/BTA (-) (90%). Persentase tertinggi di Puskemas Bahu ialah: perempuan (60%), usia 15-34 tahun (60%), dan BTA (-) (100%) sedangkan di Puskesmas Minanga Malalayang Dua ialah: laki-laki (60%), usia 15-34 tahun (70%), dan BTA(-) (100%). Simpulan: Pada ketiga puskemas tersebut, hampir seluruh pasien mempunyai sputum BTA (-) yang memenuhi The End TB Strategy dari WHO.Kata kunci: Mycobaterium tuberculosis, pewarnaan Ziehl-Neelsen, tuberkulosis

scholarly journals Insidensi Tuberkulosis Paru pada Pasien Diabetes Melitus Tipe 2 di Ruang Rawat Inap Penyakit Dalam RSUP Dr. M. Djamil Padang

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Dina Fitri Fauzia ◽  
Masrul Basyar ◽  
Asman Manaf
Keyword(s):  
Internal Medicine ◽  
Pulmonary Tuberculosis ◽  
Medical Records ◽  
Secondary Data ◽  
Internal Medicine Ward ◽  
Pulmonary Tb ◽  
Negative Results ◽  
Type 2 Dm ◽  
Diabetes Melitus

AbstrakDiabetes melitus (DM) merupakan suatu penyakit metabolik dengan karakteristik hiperglikemia akibat kelainan sekresi dan/atau gangguan kerja insulin. Sekitar 80% dari seluruh kasus DM merupakan DM tipe 2. Salah satu komplikasi DM adalah tuberkulosis (TB) paru. Tujuan penelitian ini adalah mengevaluasi insidensi TB paru pada pasien DM tipe 2 di Ruang Rawat Inap Penyakit Dalam RSUP Dr. M. Djamil Padang. Instrumen penelitian yang digunakan adalah data sekunder dari Instalasi Rekam Medis RSUP Dr. M. Djamil Padang berupa data pasien DM tipe 2 dan rekam medik pasien DM tipe 2 dengan TB paru yang dirawat di Ruang Rawat Inap Penyakit Dalam RSUP Dr. M. Djamil Padang sejak 1 Januari 2011 – 31 Desember 2011. Hasil penelitian ini menunjukkan bahwa terdapat 29 kasus TB paru dari 748 orang pasien DM tipe 2 (3,88%). Kasus DM tipe 2 dengan TB paru terbanyak ditemukan pada kelompok jenis kelamin laki-laki (58,62%), usia < 60 tahun (72,41%; mean: 54,66 ± 12,77 tahun), dan normoweight (51,72%). Sebagian besar pasien menunjukkan hasil pemeriksaan BTA sputum negatif (65,52%). Insidensi pada penelitian ini sedikit lebih rendah daripada hasil penelitian sebelumnya.Kata kunci: insidensi, tuberkulosis paru, diabetes melitus tipe 2 AbstractDiabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. Type 2 DM makes up about 80% of all cases of DM. One of the DM’s complications is pulmonary tuberculosis (TB). The objective of this study was to evaluate the incidence of pulmonary TB among type 2 DM patients in Internal Medicine Ward RSUP Dr. M. Djamil Padang. The instruments used in this research were the secondary data derived from the Medical Record Departement RSUP Dr. M. Djamil Padang in the form of type 2 DM patients’ data and medical records of type 2 DM patients with pulmonary TB who were treated in Internal Medicine Ward RSUP Dr. M. Djamil Padang since January 1st 2011 – December 31st 2011. The results of this research showed that there were 29 cases of pulmonary TB among 748 type 2 DM patients (3,88%). Most of type 2 DM with pulmonary TB cases were found in males (58,62%), < 60 years old (72,41%; mean: 54,66 ± 12,77 years old), and normoweight group (51,72%). Most of these patients showed negative results on the sputum AFB examination (65,52%). The incidence in this research is lower than the previous studies.Keywords: incidence, pulmonary tuberculosis, type 2 diabetes mellitus

scholarly journals PEMANFAATAN TES CEPAT MOLEKULER (TCM) GENEXPERT SEBAGAI ALAT DIAGNOSTIK TB PARU DI RSUD WANGAYA KOTA DENPASAR

2020 ◽  
Vol 18 (3) ◽  
pp. 135-148
Author(s):  
Novianti Novianti ◽  
Oster Suriani Simarmata ◽  
Dina Bisara Lolong
Keyword(s):  
Public Health Problem ◽  
Multidrug Resistant ◽  
Rapid Diagnosis ◽  
Case Finding ◽  
Major Public Health Problem ◽  
Drug Resistant ◽  
Pulmonary Tb ◽  
Negative Results ◽  
The City ◽  
Positive Results

ABSTRACT Tuberculosis remains a major public health problem, with an estimated 9 million TB incidence cases, 300,000 of which are drug resistant TB cases and resulted in 1.5 million deaths worldwide in 2013. However, only 58% of new cases, TB cases were confirmed bacteriologically using WHO recommended test including the Xpert® MTB/RIF Rapid Diagnosis. The use of GeneXpert in Indonesia has existed since 2014 and has never been evaluated in its utilization, including in the city of Denpasar, namely in Wangaya Hospital as one of the recipients of the GeneXpert pulmonary TB diagnostic aid. The results of this study showed that the results of GeneXpert examination were much higher in the percentage of Positive TB Case Findings compared to microscopic examination so that there is an increase in the number of positive TB cases by 14.3%. The GeneXpert examination succeeded in giving positive results compared to the microscopic results showing negative results, which were sensitive Rifampicin (14.6%) and resistant Rifampicin (2.4%). However, the utilization of TB suspect examination with GeneXpert has not been maximized in increasing the number of TB patients suspected of having TB, in fact, the percentage of positive TB case finding compared to TB suspicion is increasing. Keywords:GeneXpert, rapid diagnosis of tuberculosis, pulmonary tuberculosis   ABSTRAK Tuberkulosis (TB) tetap menjadi masalah kesehatan masyarakat yang utama, diperkirakan telah terjadi 9 juta kasus insiden TB, 300.000 di antaranya adalah kasus TB multidrug resistant (TB MDR) dan mengakibatkan 1,5 juta kematian di seluruh dunia pada tahun 2013. Namun, baru 58% dari kasus baru, kasus TB dikonfirmasi secara bakteriologis menggunakan tes yang direkomendasikan oleh WHO termasuk Tes Cepat Molekuler (TCM) GeneXpert® MTB/RIF (Xpert). Pemanfaatan TCM GeneXpert di Indonesia ada sejak 2014 dan belum pernah dilakukan evaluasi dalam pemanfaatannya termasuk di Kota Denpasar yaitu di RSUD Wangaya sebagai salah satu penerima bantuan alat diagnostik TB Paru TCM GeneXpert. Hasil studi menunjukkan bahwa hasil pemeriksaan dengan TCM GeneXpert jauh lebih tinggi persentase penemuan kasus positif TBC dibanding dengan pemeriksaan mikroskopis sehingga terdapat peningkatan jumlah kasus positif TBC sebesar 14,3% di RSUD Wangaya pada tahun 2018.  Pemeriksaan TCM GeneXpert berhasil memberikan hasil yang positif di saat hasil pemeriksaan mikroskopis menunjukkan hasil negatif yaitu Rifampisin sensitif (14,6%) dan Rifampisin resisten (2,4%). Pemanfaatan pemeriksaan terduga TB dengan TCM GeneXpert belum maksimal dalam meningkatkan jumlah pemeriksaan pasien terduga TB Paru, walaupun persentase penemuan kasus positif TB dibanding terduga TB meningkat. Kata kunci: Tes cepat molekuler, geneXpert, tuberkulosis paru

Anti-tubercular activity of some six membered heterocycle compounds

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Infectious Disease ◽  
Cell Wall ◽  
Latent Tuberculosis ◽  
Drug Resistant ◽  
Significant Development ◽  
Tb Treatment ◽  
Modern Drug ◽  
Mycobacterial Cell Wall ◽  
Membered Heterocycle ◽  
New Chemical Entity

The effectiveness in TB treatment is difficult because the structural composition of the mycobacterial cell wall is very complicated, which makes many drugs ineffective. Tuberculosis is still one of the most imperative infectious disease worldwide becouse its important reason is drug resistant, persistent or latent tuberculosis and synergism with HIV. Furthermore no any new chemical entity has come. The recently application of modern drug design promise to bring significant development in the fight against TB. In present review we discussed brief introduction of tuberculosis.

COVID-19: how nuclear medicine can provide a differential diagnosis in very dubious case

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Maria Silvia De Feo ◽  
Viviana Frantellizzi ◽  
Giuseppe De Vincentis
Keyword(s):  
Infectious Disease ◽  
Differential Diagnosis ◽  
Ct Scan ◽  
Imaging Technique ◽  
False Negative ◽  
Clinical Signs ◽  
Negative Results ◽  
Infectious Disease Department ◽  
False Negative Results ◽  
99Mtc Hmpao

Background: We present the case of a 55-year-old woman, admitted to the Infectious Disease Department of Policlinico Umberto I, Rome, in mid-March 2020, with suspicion of COVID-19 infection. Objective: The rRT-PCR was negative and the following CT scan, performed to exclude false-negative results and help diagnosis, was inconclusive. Methods: It was decided to submit the patient to 99mTc-HMPAO-labelled leukocyte scan. Results: This exam led to the diagnosis of infective endocarditis. Conclusion: In the present pandemic scenario, 99mTc-HMPAO-labelled leukocyte scan represents a reliable imaging technique for differential diagnosis with COVID-19 in patients with confusing clinical signs, possible false-negative rRT-PCR results and inconclusive CT scan.

scholarly journals Antimicrobial Activity of Ceftazidime-Avibactam Tested against Multidrug-Resistant Enterobacteriaceae and Pseudomonas aeruginosa Isolates from U.S. Medical Centers, 2013 to 2016

2017 ◽  
Vol 61 (11) ◽  
Author(s):  
Helio S. Sader ◽  
Mariana Castanheira ◽  
Dee Shortridge ◽  
Rodrigo E. Mendes ◽  
Robert K. Flamm
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Multidrug Resistant ◽  
Drug Resistant ◽  
Large Collection ◽  
Content Type ◽  
Negative Results ◽  
Medical Centers ◽  
Extensively Drug Resistant ◽  
Genes Encoding

ABSTRACT The in vitro activity of ceftazidime-avibactam and many comparator agents was determined against various resistant subsets of organisms selected among 36,380 Enterobacteriaceae and 7,868 Pseudomonas aeruginosa isolates. The isolates were consecutively collected from 94 U.S. hospitals, and all isolates were tested for susceptibility by reference broth microdilution methods in a central monitoring laboratory (JMI Laboratories). Enterobacteriaceae isolates resistant to carbapenems (CRE) and/or ceftazidime-avibactam (MIC ≥ 16 μg/ml) were evaluated for the presence of genes encoding extended-spectrum β-lactamases and carbapenemases. Ceftazidime-avibactam inhibited >99.9% of all Enterobacteriaceae at the susceptible breakpoint of ≤8 μg/ml and was active against multidrug-resistant (MDR; n = 2,953; MIC50/90, 0.25/1 μg/ml; 99.2% susceptible), extensively drug-resistant (XDR; n = 448; MIC50/90, 0.5/2 μg/ml; 97.8% susceptible), and CRE (n = 513; MIC50/90, 0.5/2 μg/ml; 97.5% susceptible) isolates. Only 82.2% of MDR Enterobacteriaceae (n = 2,953) and 64.2% of ceftriaxone-nonsusceptible Klebsiella pneumoniae (n = 1,063) isolates were meropenem susceptible. Among Enterobacter cloacae (22.2% ceftazidime nonsusceptible), 99.8% of the isolates, including 99.3% of the ceftazidime-nonsusceptible isolates, were ceftazidime-avibactam susceptible. Only 23 of 36,380 Enterobacteriaceae (0.06%) isolates were ceftazidime-avibactam nonsusceptible, including 9 metallo-β-lactamase producers and 2 KPC-producing strains with porin alteration; the remaining 12 strains showed negative results for all β-lactamases tested. Ceftazidime-avibactam showed potent activity against P. aeruginosa (MIC50/90, 2/4 μg/ml; 97.1% susceptible), including MDR (MIC50/90, 4/16 μg/ml; 86.5% susceptible) isolates, and inhibited 71.8% of isolates nonsusceptible to meropenem, piperacillin-tazobactam, and ceftazidime (n = 628). In summary, ceftazidime-avibactam demonstrated potent activity against a large collection (n = 44,248) of contemporary Gram-negative bacilli isolated from U.S. patients, including organisms resistant to most currently available agents, such as CRE and meropenem-nonsusceptible P. aeruginosa.

scholarly journals PERSEPSI GENERASI MUDA TERHADAP KEGIATAN PERTANIAN DI KELURAHAN BUHA KECAMATAN MAPANGET KOTA MANADO

2018 ◽  
Vol 14 (3) ◽  
pp. 123 ◽  
Author(s):  
Carolina Sofya Werembinan ◽  
Caroline B. D. Pakasi ◽  
Lyndon R. J. Pangemanan
Keyword(s):  
Agricultural Sector ◽  
Agricultural Land ◽  
Descriptive Analysis ◽  
Secondary Data ◽  
Primary Data ◽  
Young Generation ◽  
Agricultural Activities ◽  
Gender And Age ◽  
Younger Generation ◽  
Parental Work

This study aims to determine the perceptions of the younger generation of agricultural activities in the Buha Sub-District of Mapanget District. This research was carried out from August 2017 to May 2018. Primary data was collected through interviews of 15 generations of young people with the help of filling out questionnaires. Secondary data was obtained from the Buha Village Office, Mapanget District. This analysis uses descriptive analysis. The results of this study indicate that the perception of the younger generation of agricultural activities in the Buha Sub-District is overall negative for agricultural activities. Viewed from internal factors include education, employment, gender and age. The higher the level of education, the wider the insight of the younger generation so that the lack of interest in the younger generation in agricultural activities is getting bigger. The younger generation who already have permanent jobs in the non-agricultural sector look down on agricultural activities because they assume that agricultural activities have a low social level. Women have a low interest in agricultural activities because they assume that agricultural activities are not suitable for women because it will damage their appearance. Respondents aged 21-30 years have a low interest in agricultural activities, in addition to reduced agricultural land. External factors include socialization, parental work status and land ownership status. The younger generation with a low level of socialization results in a lack of interest in the younger generation in agricultural activities. Parents of respondents who work in agriculture or non-agriculture do not want their children to make agricultural activities the main job. The young generation whose parents still own agricultural land is still doing agricultural activities to help their parents work on their farms.

scholarly journals ANALISIS MATRIKS BCG (BOSTON CONSULTING GROUP) DALAM STRATEGI MEMPERTAHANKAN PANGSA PASAR PADA SMARTPHONE MEREK SAMSUNG (STUDI KASUS PADA PT. SAMSUNG ELEKTRONIK INDONESIA TAHUN 2019)

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Kiki Maristia
Keyword(s):  
Data Collection ◽  
Product Development ◽  
Market Share ◽  
Calculation Result ◽  
Secondary Data ◽  
Research Data ◽  
Market Growth ◽  
Group Matrix ◽  
Bcg Matrix ◽  
Data Collection Technique

The purpose of this research itself is to determine the market position PT Samsung Elektronik Indonesia in the BCG matrix (Boston Consulting Group) and formulating strategies to maintain market share. This type of research used in this research is to use descriptive methods. While this research data collection technique uses secondary data based on written documents in the form of sales results and market share PT Samsung Elektronik Indonesia. The calculation result of BCG Matrix owned by PT Samsung Elektronik Indonesia shows that the company is in the position of Cash Cows where the position has a medium market growth with high market share. Thus the company can formulate strategies in the form of product development and diversification. Keywords: BCG (Boston Consulting Group Matrix), Implementation of Strategies, Market Share Defense

scholarly journals ANALISIS KAJIAN SOSIAL EKONOMI PEMBANGUNAN DAN PERLUASAN TOSERBA “ X ”

2018 ◽  
Vol 2 (2) ◽  
pp. 66-89
Author(s):  
Desfitriady Desfitriady ◽  
Tatang Kusmayadi
Keyword(s):  
Random Sampling ◽  
Research Method ◽  
Sampling Method ◽  
Secondary Data ◽  
Simple Random Sampling ◽  
Research Data ◽  
Qualitative And Quantitative ◽  
The Government ◽  
The Village ◽  
Descriptive Method

The purpose of this study is to know and understand the community in the Village Sayati Margahayu District Bandung regency with the development and extension of department store (Convenience Store) "X". The research method is descriptive method using qualitative and quantitative approach as the basis of analysis and interpretation. Sample determination technique used is cluster with simple random sampling method and purposive sampling, which means that the sample used in accordance with the purpose of research. Data which is primary and secondary data. The results showed that people responded positively and variedly about the decision to the extension of the "X" Stores, and only a small portion would be used, but it was only up to the government.

scholarly journals Pembatasan Jangka Waktu Penundaan Kewajiban Pembayaran Utang terhadap Debitor dalam Kepailitan

2017 ◽  
Vol 2 (2) ◽  
pp. 123
Author(s):  
Novitasari Novitasari
Keyword(s):  
Legal Protection ◽  
Secondary Data ◽  
Research Data ◽  
Term Limits ◽  
Short Term ◽  
Research Results ◽  
Master Thesis ◽  
The Postponement ◽  
Debt Payment

The aims of the research is to analyze reasons for short term restriction onthe Postponement of Debt Payment Obligation (PDPO), the existence of time limitprovisions resulting the failure of the debtors’ debt efforts with creditors, and thePKPU’s term limits on legal protection for the interests of debtors to prevent bankruptcy.This research is a normative juridical research. Data used in this researchwere secondary data obtained from official documents, books related to the objectof research, research results in the form of reports, bachelor thesis, master thesis,dissertation and regulations. This research was also supported with primary databy conducting an interview with Advocates as resource persons to support the research.Data were analyzed qualitatively. The results of the research indicated that:(1) the term restriction given by Law no. 37 of 2004 concerning Bankruptcy andPostponement of Debt Payment Obligation has an objective of making debtors ableto offer amicable resolution to creditors related to debt payments so that debtors cancontinue their business. (2) The term is not a determinant of the failure of amicableresolution effort in the Postponement of Debt Payment Obligation, but affect theprocess of achieving the Postponement of Debt Payment Obligation, (3) Law No.37 of 2004 concerning Bankruptcy and Postponement of Debt Payment Obligationprovides security guarantee such as giving the debtors an opportunity to reorganizebusiness or company management or to restructure their debts within the period ofPostponement of Debt Payment Obligation, and the debtor does not lose their rightsto take care of the company and assets, so that the debtors still have the authorityto manage the company. It can be concluded from the research that (1) Law no.37 of 2004 concerning Bankruptcy and Postponement of Debt Payment Obligationprovides a short term for the debtors so that the debtors are really able to makeamicable resolution to the creditor in relation to the payment of debts. (2). The termis not a determinant of the failure of amicable resolution effort in the Postponementof Debt Payment Obligation, but affect the process of achieving the Postponementof Debt Payment Obligation. (3). Law no. 37 of 2004 concerning Bankruptcy and Postponement of Debt Payment Obligation has provided a guarantee of legal protection in the form of certainty to the debtor to prevent bankruptcy. 

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