Microbiological participants in the etiopathogenesis of otitis in dogs and cats

2020 ◽  
Vol 1 (12) ◽  
pp. 71-77
Author(s):  
N. V. Pimenov ◽  
◽  
E. A. Pustovit ◽  
Keyword(s):  
Biofilm Formation ◽  
Inflammatory Diseases ◽  
Scientific Information ◽  
Scientific Research ◽  
Domestic Animals ◽  
Scientific Data ◽  
Antibacterial Treatment ◽  
Therapeutic Approaches ◽  
Antimicrobial Drugs ◽  
Colonization Ability

The problem of otitis in small pets is widespread and requires improvement of therapeutic approaches based on modern scientific data and research achievements. This article presents an overview of current sources of primary scientific information on the field of microbiology in inflammatory diseases of the ear in small domestic animals – dogs and cats. Information about microbiom (involved in the pathogenesis of otitis), ability of microorganisms to biofilm formation and resistance to antimicrobial drugs is presented. The associativity of the bacterial component, its colonization ability and these characteristics actualize the problem of improving antibacterial treatment, prevention tactics and scientific research in this matter.

Clinical and hematological features of the manifestation of Bordetelle infection in decorative rabbits and the biological properties of the pathogen Bordetella bronchiseptica

2021 ◽  
Vol 1 (11) ◽  
pp. 35-41
Author(s):  
Nikolay V. Pimenov ◽  
◽  
Olga A. Serezhechkina ◽  
Regina F. Ivannikova ◽  
◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Causative Agent ◽  
Biological Properties ◽  
Scientific Data ◽  
Antibacterial Treatment ◽  
The Body ◽  
Bordetella Bronchiseptica ◽  
Therapeutic Approaches ◽  
Antimicrobial Drugs

The problem of bordetella bronchiseptica infection in small pets is widespread and requires improvement of therapeutic approaches based on modern scientific data and research achievements. The article provides data on the causative agent of bordetellosis, information on its resistance to antimicrobial drugs and a description of the semiotics and course of infection in a private rabbit farm. Antibiotic resistance of bacteria, its ability to long-term carriage in the body and these properties actualize the problem of improving antibacterial treatment, prevention tactics and scientific research in this matter.

scholarly journals A Review of the Pathogenesis of Osteoarthritis and the Use of Intra-articular Platelet Therapy for Joint Disease in Animals and Humans

2014 ◽  
Vol 5 ◽  
pp. BTRI.S14578 ◽  
Author(s):  
Girolamo A. Ortolano ◽  
Barry Wenz
Keyword(s):  
Health Care ◽  
Stem Cells ◽  
Surgical Intervention ◽  
Domestic Animals ◽  
Medical Intervention ◽  
Joint Disease ◽  
Therapeutic Approaches ◽  
Disease Modifying ◽  
Care Costs ◽  
Clinical Problems

Osteoarthritis (OA) is the most prevalent musculoskeletal disease in humans and domestic animals. It causes significant clinical problems and substantial health care costs. In the absence of disease-modifying medical intervention, therapy is currently restricted to palliative measures prior to surgical intervention. We review the pathogenesis, as well as conservative and emerging restorative therapeutic approaches, including cytokines, stem cells, and platelets. The various methods of platelet concentrate preparations and their reported outcomes are discussed. Data collected from the use of intra-articular platelet therapy (IAPT) in dogs are reviewed, which suggest that this approach may delay or in some cases even obviate the need for surgical intervention.

Antibacterial treatment and hirudotherapy in hormono— dependent and inflammatory diseases of female genital organs

1998 ◽  
Vol 79 (4) ◽  
pp. 280-281
Author(s):  
R. I. Zhivoglyad
Keyword(s):  
Antibacterial Therapy ◽  
Inflammatory Diseases ◽  
Hirudo Medicinalis ◽  
Antibacterial Treatment ◽  
Pathologic Process ◽  
Combined Use ◽  
Biochemical Indices ◽  
Positive Effect ◽  
Female Genital

The results of the influence of the Hirudo medicinalis leeches and antibacterial therapy on homeostasis indices in patients with hormono dependent and inflammatory diseases of genital organs are analyzed. The positive effect of hirudotherapy courses on general and biochemical indices of blood changed as a result of the pathologic process progression is shown. The combined use of hirudotherapy and antibacterial treatment is recommended.

Medicinal importance, pharmacological activities and analytical aspects of canadine in the medicine: An important phytochemical of Hydrastis canadensis

2021 ◽  
Vol 01 ◽  
Author(s):  
Dinesh Kumar Patel
Keyword(s):  
Natural Products ◽  
Data Analysis ◽  
Human Health ◽  
Scientific Information ◽  
Modern Medicine ◽  
Scientific Data ◽  
Pharmacological Activities ◽  
Hydrastis Canadensis ◽  
Biological Importance ◽  
Human Disorders

Background: Natural products and their derived phytochemicals have been used in the medicine and gaining importance in the modern medicine due to their therapeutic potential and health beneficial effect on human disorders. Plenty of herbal drug based products are available in the market and playing an important role in the human health care system due to their health beneficial properties in human being. In the modern age we can find many herbal based products in the market mainly prepared from the natural products and used for the prevention and treatment of various human disorders. Benzylisoquinoline alkaloids are the important class of alkaloidal compounds and the better example are morphine, codeine, sanguinarine, berberine and canadine which are mainly known for their medicinal value in the medicine. Methods: Hydrastis canadensis is the important medicinal plant found to contain a significant amount of canadine, hydrastine and berberine. In the present investigation, numerous scientific databases such as Google, Pubmed, Science direct etc. have been searched to collect the important scientific information of canadine and analyzed to know the health beneficial aspect of canadine in the medicine. All the collected scientific information data’s were analyzed and have been categorized into mainly pharmacological and analytical aspects. Results: From the analysis of the collected scientific information, it was found that Hydrastis canadensis contain significant amount of canadine with many more phytochemical including canadaline, hydrastidine, isohydrastidine etc. Pharmacological activity data analysis revealed the biological importance of Hydrastis canadensis in the medicine for their traditional uses against gastritis, colitis, duodenal ulcers, loss of appetite, liver disease, bile secretion disorder, snake bites and vaginitis in the medicine. However, scientific data analysis of canadine revealed their effectiveness for their acetylcholinesterase inhibitory activity, anti-cancer, anti-microbial, anti-allergic activity and anti-oxidant activity. Different modern analytical tools have been used in the modern medicine for the isolation and quantification of canadine in the Hydrastis canadensis. Conclusion: Present investigation revealed the medicinal importance and pharmacological activities of a canadine in the medicine for the treatment of numerous human health complications. These scientific data will be helpful to the scientist to know the biological importance of canadine in the medicine against various forms of human complications.

scholarly journals Epigenetic Regulations of Inflammatory Cyclooxygenase-Derived Prostanoids: Molecular Basis and Pathophysiological Consequences

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Hedi Harizi
Keyword(s):  
Target Genes ◽  
Inflammatory Diseases ◽  
Epigenetic Alterations ◽  
Therapeutic Approaches ◽  
Immunological Disorders ◽  
Tissue Microenvironment ◽  
Individual Variations ◽  
Fine Regulation ◽  
Additional Level ◽  
The Impact

The potential relevance of prostanoid signaling in immunity and immunological disorders, or disease susceptibility and individual variations in drug responses, is an important area for investigation. The deregulation of Cyclooxygenase- (COX-) derived prostanoids has been reported in several immunoinflammatory disorders such as asthma, rheumatoid arthritis, cancer, and autoimmune diseases. In addition to the environmental factors and the genetic background to diseases, epigenetic mechanisms involved in the fine regulation of prostanoid biosynthesis and/or receptor signaling appeared to be an additional level of complexity in the understanding of prostanoid biology and crucial in controlling the different components of the COX pathways. Epigenetic alterations targeting inflammatory components of prostanoid biosynthesis and signaling pathways may be important in the process of neoplasia, depending on the tissue microenvironment and target genes. Here, we focused on the epigenetic modifications of inflammatory prostanoids in physiological immune response and immunological disorders. We described how major prostanoids and their receptors can be functionally regulated epigenetically and consequently the impact of these processes in the pathogenesis inflammatory diseases and the development of therapeutic approaches that may have important clinical applications.

scholarly journals Mediating Corporeality: Re-Interpretations at the Art/Science Interface

Somatechnics ◽  
2012 ◽  
Vol 2 (2) ◽  
pp. 284-304
Author(s):  
Patricia Adams
Keyword(s):  
Digital Imaging ◽  
Scientific Research ◽  
Digital Technologies ◽  
Adult Stem Cell ◽  
Image Data ◽  
Scientific Data ◽  
Research Data ◽  
The Self ◽  
First Century ◽  
Individual Perspective

Contemporary scientific discoveries are rapidly modifying established concepts of embodiment and corporeality. For example, developing techniques in adult stem cell research can actively remodel the human body; whilst neuroscientists are shedding increasing light on the functioning of our brains. My research at the art/science nexus draws upon recent media theories to investigate the ways twenty-first century constructs of ‘humanness’ and the ‘self’ are affected by both historical and contemporary scientific research and developments in digital imaging technologies. In this article, examples from my artworks: “machina carnis” and “HOST” illustrate how my use of innovative digital technologies and collaborative methodologies has enabled me to immerse myself in the scientific experience at first hand. I demonstrate how my reinterpretations of what is commonly termed ‘hard’ scientific research data does not seek to emulate ‘objective’ readings of the experimental digital image data but rather recontextualises it in the context of my artworks. These artworks acknowledge the personal and visceral content in the scientific data and enable viewer/participants to reflect upon the issues raised from an emotive and individual perspective.

scholarly journals Choosing between different AI approaches? The scientific benefits of the confrontation, and the new collaborative era between humans and machines

1970 ◽  
Vol 4 (2) ◽  
pp. 209-216
Author(s):  
Jordi Vallverdú
Keyword(s):  
Distributed Computing ◽  
In Silico ◽  
Extended Mind ◽  
Scientific Research ◽  
Scientific Data ◽  
Human Cognition ◽  
Scientific Practices ◽  
Huge Amount ◽  
Key Points ◽  
Aim Of Science

AI is a multidisciplinary activity that involves specialists from several fields, and we can say that the aim of science, and AI science, is solving problems. AI and computer sciences are been creating a new kind of making science, that we can call in silico science. Both models top-eown and bottomup are useful for e-scientific research. There is no a real controversy between them. Besides, the extended mind model of human cognition, involves human-machine interactions. Huge amount of data requires new ways to make and organize scientific practices: supercomputers, grids, distributed computing, specific software and middleware and, basically, more efficient and visual ways to interact with information. This is one of the key points to understand contemporary relationships between humans and machines: usability of scientific data.

scholarly journals Mesenchymal Stromal Cell Secretome for the Treatment of Immune-Mediated Inflammatory Diseases: Latest Trends in Isolation, Content Optimization and Delivery Avenues

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1802
Author(s):  
Elena Munoz-Perez ◽  
Ainhoa Gonzalez-Pujana ◽  
Manoli Igartua ◽  
Edorta Santos-Vizcaino ◽  
Rosa Maria Hernandez
Keyword(s):  
Stromal Cells ◽  
State Of The Art ◽  
Inflammatory Diseases ◽  
Therapeutic Approaches ◽  
Pharmacological Management ◽  
Beneficial Effects ◽  
New Therapeutic Approaches ◽  
Immune Mediated ◽  
High Prevalence ◽  
Inflammatory Processes

Considering the high prevalence and the complex pharmacological management of immune-mediated inflammatory diseases (IMIDs), the search for new therapeutic approaches for their treatment is vital. Although the immunomodulatory and anti-inflammatory effects of mesenchymal stromal cells (MSCs) have been extensively studied as a potential therapy in this field, direct MSC implantation presents some limitations that could slow down the clinical translation. Since the beneficial effects of MSCs have been mainly attributed to their ability to secrete a plethora of bioactive factors, their secretome has been proposed as a new and promising pathway for the treatment of IMIDs. Formed from soluble factors and extracellular vesicles (EVs), the MSC-derived secretome has been proven to elicit immunomodulatory effects that control the inflammatory processes that occur in IMIDs. This article aims to review the available knowledge on the MSC secretome, evaluating the advances in this field in terms of its composition, production and application, as well as analyzing the pending challenges in the field. Moreover, the latest research involving secretome administration in IMIDs is discussed to provide an updated state-of-the-art for this field. Finally, novel secretome delivery alternatives are reviewed, paying special attention to hydrogel encapsulation as one of the most convenient and promising strategies.

scholarly journals Antimicrobial Synergy of Silver-Platinum Nanohybrids With Antibiotics

2021 ◽  
Vol 11 ◽  
Author(s):  
Bansi Ranpariya ◽  
Gayatri Salunke ◽  
Srikanta Karmakar ◽  
Kaushik Babiya ◽  
Santosh Sutar ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Bacterial Infections ◽  
Bacterial Biofilm ◽  
Antimicrobial Drugs ◽  
Mortality And Morbidity ◽  
Green Route ◽  
Antimicrobial Synergy ◽  
First Time ◽  
Tuber Extract ◽  
Powerful Strategy

Various bacterial pathogens are responsible for nosocomial infections resulting in critical pathophysiological conditions, mortality, and morbidity. Most of the bacterial infections are associated with biofilm formation, which is resistant to the available antimicrobial drugs. As a result, novel bactericidal agents need to be fabricated, which can effectively combat the biofilm-associated bacterial infections. Herein, for the first time we report the antimicrobial and antibiofilm properties of silver-platinum nanohybrids (AgPtNHs), silver nanoparticles (AgNPs), and platinum nanoparticles (PtNPs) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The AgPtNHs were synthesized by a green route using Dioscorea bulbifera tuber extract at 100°C for 5 h. The AgPtNHs ranged in size from 20 to 80 nm, with an average of ∼59 nm. AgNPs, PtNPs, and AgPtNHs showed a zeta potential of −14.46, −1.09, and −11.39 mV, respectively. High antimicrobial activity was observed against P. aeruginosa and S. aureus and AgPtNHs exhibited potent antimicrobial synergy in combination with antibiotics such as streptomycin, rifampicin, chloramphenicol, novobiocin, and ampicillin up to variable degrees. Interestingly, AgPtNHs could inhibit bacterial biofilm formation significantly. Hence, co-administration of AgPtNHs and antibiotics may serve as a powerful strategy to treat bacterial infections.

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