scholarly journals Innovation Of The Utilization Of Musa Acuminata Leather Waste To Be Cocupi (Coockies Banana Leather) As A Health Promotion In Prevention Of Diabetes Mellitus

2020 ◽  
Vol 14 (3) ◽  
pp. 187-200
Author(s):  
Mukhlisah Mukhlisah
Keyword(s):  
Diabetes Mellitus ◽  
Health Promotion ◽  
Human Life ◽  
Positive Control ◽  
Negative Control ◽  
Musa Acuminata ◽  
Banana Peel ◽  
Nutritional Content ◽  
Sugar Levels ◽  
Prevention Of Diabetes

Health is the most important thing in human life. Lifestyles and diets that are not suitable for the increase in the prevalence of regenerative diseases such as diabetes mellitus. Diabetes mellitus is a chronic disease characterized by a lack of the hormone insulin produced by the pancreas to regulate the amount of sugar levels in the blood. People do not realize that banana peels (Musa acuminata) can be used to prevent diabetes. Banana peel (Musa acuminata) has abundant nutritional content, including carbohydrates, protein, potassium. Based on other research articles, banana peels also contain a number of active compounds to prevent diabetes, namely pectin (10-21%), lignin (6-12%), cellulose (7.6% -9.6%), and hemicellulose (6). , 4-9.4%). Therefore, researchers have innovated to process banana peel waste (Musa acuminata) into COKUPI (Banana Skin Cookies) as a health promotion in preventing diabetes mellitus. The purpose of this study was to determine the potential of banana peel waste (Musa acuminata) as a prevention of diabetes mellitus. The benefit of this research is as a community guide in the utilization of banana peel waste (Musa acuminata). The material used in this study included banana peel cookies, alloxan, and mice. This study used an experimental method, namely by using the same 25 mice were given alloxan and measured blood sugar levels. After being measured, the white mice (Mus musculus) did fast for 18 hours. COKUPI was given with different treatments, namely negative control, positive control, doses of 100g, 200g, and 300g for 15 days. The results of this study were Kepok banana peels (Musa acuminata) which were processed into effective cookies as an alternative to prevent diabetes mellitus.

scholarly journals Increased Plasma GLP-1 Levels after Resistant Starch Type 3 From Cassava Starch (Manihot Esculanta Crantz) Diet on Diabetic Rat

2018 ◽  
Vol 4 (2) ◽  
pp. 116
Author(s):  
Elly Nurus Sakinah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Resistant Starch ◽  
Nutritional Therapy ◽  
Positive Control ◽  
Cassava Starch ◽  
Negative Control ◽  
Diabetic Rat ◽  
Sugar Levels ◽  
Type 3

Diabetes mellitus (DM) occur when human body is unable to produce enough insulin and/or unable to use insulin effectively, resulting in an increase of blood sugar levels (hyperglycemia). Indonesia  has  ranks  fourth  after  United  States,  China  and  India  in  the  prevalence  of  DM. Controling blood sugar and insulin levels can be done through the stimulation effect of Glucagon- like peptide-1 (GLP-1). The goal of this study was to determine the effects of resistant starch type 3 (RS3) from cassava starch in increasing plasma GLP-1 levels. This reasearch use male mouse (Ratttus novergicus) as a diabetic model by providing a high-fat diet (HFD) for one mounth than combine with intraoperitonel injection of low dose streptozotocin (STZ). The mouse then grouped into 4 groups randomly (1) normal or negative control, (2) cassava starch diet, (3) RS3 diet, (4) positive control. Blood sugar levels were measured before and after STZ injection to determine the diabetic conditions (blood sugar > 200 mg /dL). After 4 weeks of dietary administration blood sugar  and  plasma  GLP-1  levels  were  examined  using  ELISA.  Statistical  analysis  showed decreased in blood sugar levels and increased in plasma GLP-1 levels after one mounth of RS3 diet. This research shows that RS3 from cassava starch has a potential role as a nutritional therapy on diabetes mellitus condition. Keywords: Resistant starch type 3, cassava starch, GLP-1, Blood Sugar, Diabetes Mellitus

Improved cellular immunity and increased insulin in streptozotosin-induced mice using ethanol coriander (Coriandrum sativum) extract

2021 ◽  
pp. 3689-3694
Author(s):  
Dahliatul Qosimah ◽  
Sri Widyarti ◽  
MAG Beltran ◽  
Muhaimin Rifa’i
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Gastric Tube ◽  
Fat Metabolism ◽  
Relative Number ◽  
Positive Control ◽  
Negative Control ◽  
Coriandrum Sativum ◽  
Treatment Groups ◽  
Sugar Levels

An increase in blood sugar levels is an indication of diabetes mellitus (DM). DM is a metabolic disease characterized by disorders of carbohydrate and fat metabolism due to impaired activity, insulin secretion or both. Alternatively, the body's inability to secrete insulin. The purpose of this study was to determine the effect of coriander extract (Coriandrum sativum) on mice induced by streptozotocin (STZ) on the relative number of CD11b and insulin-IL6 cells. The study used Balb-C strain mice, aged 2.5-3 months, with five (5) treatment groups which were given STZ at a dose of 145mg/kg BW on the 8th day IP (Intraperitoneal) after adaptation for seven days, then add coriander extract with successive doses of 25 (T1), 50 (T2), and 100mg/kg BW (T3), negative control (healthy) (T4) and positive control (STZ) (T5) through the administration of intraperitoneal gastric tube. Blood Glucose is measured on the 13th day. Herbs are given on days 14-28. On the 29th day, the mice. An increase in blood sugar levels is an indication of diabetes mellitus (DM). DM is a metabolic disease characterized by disorders of carbohydrate and fat metabolism due to impaired activity, insulin secretion or both Alternatively, the body's inability to secrete insulin. The purpose of this study was to determine the effect of coriander extract (Coriandrum sativum) on mice induced by streptozotocin (STZ) on the relative number of CD11b and insulin-IL6 cells. The study used Balb-C strain mice, aged 2.5-3 months, with five (5) treatment groups which were given STZ at a dose of 145mg/kg BW on the 8th day IP (Intraperitoneal) after adaptation for seven days, then add coriander extract with successive doses of 25 (T1), 50 (T2), and 100mg/kg BW (T3), negative control (healthy) (T4) and positive control (STZ) (T5) through the administration of intraperitoneal gastric tube. Blood Glucose is measured on the 13th day. Herbs are given on days 14-28. On the 29th day, the mice were sacrificed Furthermore, the pancreas was taken for insulin examination, and the spleen was checked with the relative number of CD11b-IL6 and T CD4 cells using a flow cytometer. Data were quantitatively analyzed using the One Way ANOVA test (p≤0.05). The results showed that doses of coriander in T1 treatment causes an increase in insulin levels, decreased blood sugar levels, weight gain, proliferation and activation of CD4+ T cells, and decrease inflammation (CD11b cell-IL6) on the tissue. This research concludes that extracts of coriander can reduce Hyperglycemia in mice by modulation of cellular immunity and increased levels of insulin

scholarly journals UJI AKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK ETANOL DAUN ECENG GONDOK (Eichhornia crassipes (Mart.)Solms) DAN DAUN SINTRONG (Crassocephalum crepidioides (Benth.) S. Moore) PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 44-53
Author(s):  
Andri Priyoherianto ◽  
◽  
Panji Ratih Suci ◽  
Putri Rizki Cahya Fatimah ◽  
Atik Nur Wijayanti
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Water Hyacinth ◽  
Leaf Extract ◽  
Positive Control ◽  
Negative Control ◽  
Glucose Levels ◽  
Normal Limits ◽  
Blood Glucose Levels ◽  
Sugar Levels

Diabetes mellitus is a chronic metabolic disorder that occurs due to destruction of pancreatic ? cells characterized by blood glucose levels that exceed normal limits. The purpose of this study was to determine the therapeutic effect of the combination of water hyacinth leaf extract and Sintrong leaf in reducing blood glucose levels in alloxan-induced experimental animals. Water hyacinth leaf powder and Sintrong leaves were extracted using the maceration method with 70% ethanol as a solvent. A total of 25 mice were divided into 5 groups, namely negative control CMC-Na 0.5%, positive control glibenclamide 0.00065 mg / g BW, water hyacinth leaf extract 17.5 mg / kg BW, Sintrong leaf extract 10.5 mg/ kg BW and a combination of water hyacinth leaf extract 17.5 mg / kg BW and sintrong leaf 10.5 mg / kg BW. The results showed that a single extract of water hyacinth and Sintrong leaves was able to reduce blood sugar levels for 7 days. The combination dose was effective in reducing blood sugar levels with a combination dose of 17.5 mg/ kg water hyacinth leaf extract in combination for 7 days.

scholarly journals Efektivitas Ekstrak Buah Merah (Pandanus conoideus De Vriese) Asal Kabupaten Poso Sebagai Alternatif Penurun Kadar Gula Darah

2017 ◽  
Vol 5 (4) ◽  
pp. 185
Author(s):  
Anang Wahid M. D. Diah ◽  
Ni Kadek Ana Diani ◽  
Minarni Rama Jura
Keyword(s):  
Free Radicals ◽  
Blood Sugar ◽  
Positive Control ◽  
Negative Control ◽  
Effective Concentration ◽  
Fruit Extract ◽  
Control Data ◽  
Significance Level ◽  
The Third ◽  
Sugar Levels

Bioactive compounds contained in red fruit (pandanus conoideus De Vriese) among others are flavonoids and tannins. The compounds are classified as very powerful antioxidants and can inhibit free radicals. This study aimed to determine the effective concentration of the red fruit extract from Poso as an alternative for lowering blood sugar levels. The separatin method used was boiling. The animals test were 15 male of mice (Mmus musculus) induced by ethylene diamine tetra acetic (EDTA). The mice were divided randomly into 5 groups with different treatments. The first, the second, and the third treatments were given red fruit extract each with a concentration of 10%, 20% and 30%. The fourth treatment was given glibenclamide suspension as a positive control, and the fifth treatments was given Na-CMC as a negative control. Data were analyzed using a statistical analysis of variance (Anova) test followed by Duncan test. The results showed that the preclinical test of red fruit extract reduced blood sugar levels of mice, and the most effective concentration was 20% as much as 68% (w/v) with significance level a = 0.05.

scholarly journals Effect of Streptozotocin on Liver Histology Damage in Rats Model of Gestational Diabetes Mellitus

2021 ◽  
Vol 8 (9) ◽  
pp. 18-22
Author(s):  
Liganda Endo Mahata ◽  
Hirowati Ali ◽  
Arina Widya Murni
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Ethical Issues ◽  
Positive Control ◽  
Negative Control ◽  
Liver Histology ◽  
Pregnant Rats ◽  
Healthy Group ◽  
Streptozotocin Induced Diabetes

Background: Gestational Diabetes Mellitus (GDM) is a disorder of carbohydrate metabolism that causes hyperglycemia, insulin resistance and failure of organs especially the liver. There is great interest in understanding the pathophysiology and treatment of GDM. Due to ethical issues involving human studies, it is necessary to use animal models to understand pathophysiology and potential treatment for GDM. Streptozotocin-induced diabetes mellitus in pregnant rats was commonly used by several author. Aims: The aim of this study is to investigate the effect of streptozotocin (STZ) on liver histology in pregnant rats. Methods: Pregnant rats were divided into two groups; 1) Negative control, 2) Positive control. Positive control were pregnant rats induced with a single intraperitoneal injection of streptozotocin 40 mg/Kg b.w. Fourteen days after induction, rats were sacrificed to evaluate the histopathological effect of STZ on the liver using hematoxylin Eosin staining and calculate the presentation of degraded cell and sinusoidal area with ImageJ 1.49v software, National Institute of Health, Bethesda, MD, USA. Data were processed statistically using SPSS with T-Test. Results: Microscopic examination of the liver of STZ-induced rats showed histologic changes in the form of an increase in the number of degenerated cells and a significant expansion of the sinusoidal area (p < 0.000). The percentage of degenerated cells in the healthy group was 9.3%, increased to 70% in the STZ-induced group. In addition, the percentage of the sinusoidal area, which was 19.98% in the healthy group, increased to 49.5%. Conclusions: Streptozotocin induces liver damage in the pregnant rats model. Keywords: Gestational Diabetes Mellitus, Streptozotocin, Liver, Histology

scholarly journals Effects of Extracts of Plathymenia Reticulata Benth and Azadirachta Indica (Neem) in Glycated Hemoglobin in Diabetic Rats

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A438-A439
Author(s):  
Ezio De Martino Neto ◽  
Joyce Satil Chaves da Silva ◽  
Eliane Cristina Lourenço ◽  
Arthur Cesário de Castro Neto ◽  
Isabella Cecilio Resende Ferreira ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Azadirachta Indica ◽  
Insulin Treatment ◽  
Glycated Hemoglobin ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Male Adult ◽  
Significant Difference

Abstract Introduction: The Plathymenia reticulata benth is a herbal medicine that has properties of pancreatic islet hyperplasia and glycemic control in diabetic rats. Neem (Azadirachta indica A. Juss, Meliaceae) is a tree native to India that has several medicinal effects. Goal: To verify the effect of glycated hemoglobin levels in rats with type 1 and non-diabetic diabetes mellitus, in treatment with Plathymenia Reticulata Benth, Neem and the association between them. compared to insulin. Methodology: Diabetes was induced by intraperitoneal streptozotocin (65mg/kg) administration after a 24-hour fast. The diagnosis was made using a blood glucose value above 200mg/dl. The study was conducted in 60 male adult Wistar rats, weighing between 180 and 220 grams, divided into 9 groups, between diabetics (DM) and non-diabetic controls (NdM), and treated with Neem (300 mg/kg), cold aqueous extract of Plathymenia (100 mg/kg), water (negative control) and insulin (3 IU/day) - positive control; and association between plants. The treatment was performed by orogastric gavage for a period of 28 consecutive days, and weekly weight and daily feed intake were performed. Data were analyzed using ANOVA and Tukey-Kramer’s pos-hoc test, with a significance level of 5% using the SPSS25.0 software. The results are expressed on average ± EPM. Results: There was a significant difference in glycated hemoglobin levels in rats submitted to insulin treatment (6.18 ± 0.36) compared to those submitted to treatment with Neem (10.12 ± 1.29, p=0.047), Plathymenia+Neem (12.09 ± 0.38, p=0.006) and water (10.86 ± 1.26, p=0.015). However, no significant difference was observed between the reduction in glycated hemoglobin levels in the groups submitted to insulin treatment compared to the group treated with Plathymenia (7.30 ± 0.68, p=0.911). Conclusion: The results allow us to evaluate a non-inferiority condition in relation to the use of the Plathymenia when compared to treatment with insulin therapy, positive control in the treatment of type 1 diabetes mellitus. The Plathymeniamay present as a herbal option in the treatment of the disease and prevention of complications. Further studies are necessary to evaluate the effect of the extract on other aspects related to the pathology.

scholarly journals THE IMPACT OF METFORMIN AND ROSUVASTATIN ON THE MARKERS OF OXIDATIVE STRESS, GLYCEMIC CONTROL, AND LIPID PROFILE IN RATS WITH STREPTOZOTOCIN-NICOTINAMIDE-INDUCED DIABETES AFTER ACUTE INTRACEREBRAL HEMORRHAGE

2021 ◽  
Vol 78 (4) ◽  
pp. 87-93
Author(s):  
Volodymyr Zhyliuk ◽  
Anton Lievykh ◽  
Alla Shevtsova ◽  
Vitaliy Mamchur ◽  
Viktoriia Tkachenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Glycemic Control ◽  
Intracerebral Hemorrhage ◽  
Lipid Profile ◽  
Positive Control ◽  
Negative Control ◽  
Oxidative Modification ◽  
Markers Of Oxidative Stress ◽  
The Impact

Hyperproduction of highly active carbonyl compounds and reactive oxygen species initiates the development of oxidative stress in various pathological conditions and protein carbonylation is considered to be one of the key factors in the progression of diabetes mellitus and associated complications. This comparative research aimed to study the effect of metformin and rosuvastatin on the levels of biochemical markers of oxidative stress, glycemic control, and lipid profile in rats with type 2 diabetes mellitus (T2DM) complicated by a brain hemorrhage.T2DM was simulated with a single intraperitoneal injection of nicotinamide and streptozotocin (NA/STZ) to male Wistar rats (n=38). Intracerebral hemorrhage (ICH) was induced by microinjection of 1 μL of bacterial collagenase 0.2 IU/μL into the striatum. Animals were randomized into 5 groups: negative control, intact rats; positive control 1, NA/STZ; positive control 2, NA/STZ+ICH; metformin, 250 mg/kg +NA/STZ+ICH; rosuvastatin, 15 mg/kg+NA/STZ+ICH. Drug effects were assessed by the area under the glycemic curve (AUC), the content of glucose, glycated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), homocysteine (Hcy), advanced glycation end products (AGEs), and the markers of oxidative modification of proteins – aldehyde- and ketonephenylhydrazones (APH/KPH) in blood serum.It was found that brain hemorrhage in rats with T2DM can intensify the manifestations of oxidative modification of molecules and worsen glycemic control and lipid profile. Under these conditions, rosuvastatin improved lipid metabolism and reduced the levels of AGEs by 35.1% but did not affect glycemia and content of APH/KPH. Metformin reduced oxidative stress (AGEs by 35.4%, KPH by 21.2%) as well as improved both glycemic status and lipid profile (TG level by 20.2%, TG/HDL ratio by 31.9%). Both drugs did not produce any effect on Hcy level.Thus, metformin in conditions of T2DM complicated by acute ICH has advantages over rosuvastatin in relation to the markers of oxidative modification and glycemic control.

scholarly journals EFFECT OF Aloe vera GEL ON SUPEROXIDE DISMUTASE (SOD) LEVEL IN STREPTOZOTOCIN (STZ)-INDUCED DIABETIC WISTAR Rattus novergicus LIVER

2015 ◽  
Vol 2 (1) ◽  
pp. 51
Author(s):  
Nia Lukita Ariani ◽  
Abdul Gofur ◽  
Dwi Listyorini ◽  
Hendra Susanto ◽  
Yuda Handaya
Keyword(s):  
Diabetes Mellitus ◽  
Superoxide Dismutase ◽  
Aloe Vera ◽  
Wistar Rat ◽  
Positive Control ◽  
Negative Control ◽  
Diabetic Rats ◽  
Wistar Strain ◽  
Aloe Vera Gel ◽  
One Way Anova

Diabetes mellitus is a metabolic disorder characterized by the increasing levels of blood glucose as a result of either impaired of insulin secretion, insulin action, or both. Persistent hyperglycemia causes oxidative stress. Aloe vera is known of having an antioxidant activity. One of intrinsic antioxidant enzyme is superoxide dismutase (SOD) which eliminates superoxide radical. This research aims to determine the effect of Aloe vera gel on SOD level in STZ-induced diabetic Wistar rat liver. Wistar strain of Rattus novergicus used in this research were grouped into eight groups, consist of negative control (K-), non diabetic groups (NDM) consist of NDM 1 (dose of 30 mg/day), NDM 2 (dose of 60 mg/day), NDM 3 (dose of 120 mg/day), positive control (DM), and the DM group consists of DM 1 (dose of 30 mg/day), DM 2 (dose of 60 mg/day), and DM 3 (dose of 120 mg/day), with three replications each. Diabetic rats were induced using an intra-peritoneal injection of 60 mg/kg BW STZ. Three milliliters of Aloe vera gel were given intragastrointestinally for 14 days started from three days after injection of STZ. The level of liver SOD was measured with spectrophotometer.The results of One-Way Anova showed that Aloe vera gel has a significant effect on SOD levels (p< 0.05). Further analysis using LSD showed that only the treatment of NDM with 60 mg/day of Aloe vera gel giving a significant decreasing of SOD level compared to (K-). The conclusion is that Aloe vera has potency as a natural antioxidant. Keywords: Aloe vera, diabetes mellitus, superoxide dismutase (SOD), liver, streptozotocin (STZ) 

scholarly journals Effect of Kepok Banana Peel Extract (Musa spp.) on the Number of Pituitary Basophil Cells in Rats (Rattus norvegicus) with High-Fat Diet

2020 ◽  
Vol 151 ◽  
pp. 01063
Author(s):  
Nora Usrina ◽  
Muslim Akmal ◽  
Rinidar Rinidar ◽  
Mustafa Sabri ◽  
Gholib Gholib
Keyword(s):  
Rattus Norvegicus ◽  
High Fat Diet ◽  
Household Consumption ◽  
Positive Control ◽  
Negative Control ◽  
Male Rats ◽  
Banana Peel ◽  
High Fat ◽  
Group 3 ◽  
Peel Extract

Banana peels are the outer envelopes of banana fruits as the by-product of household consumption and banana processing. Kepok banana peel contains bioactive compounds that function as antioxidants which reduce the effects of free radicals. This research was conducted to determine the effect of giving Kepok banana peel extract on the number of basophilic cells in rats with a high-fat diet. The study used 25 male rats aged 2.5-3 months old, which alloted into 5 groups with 5 rats each. The first group was fed on standard feed (K1, positive control), while the second group given high-fat diet (K2, negative control). The rats in group 3, 4, and 5 were given high-fat diet + vitamin C (K3), high-fat diet + 100 mg/kg BW banana peel extract (K4), and high-fat diet + 200 mg/ kg BW banana peel extract (K5), respectively. A sample of the pituitary gland was collected after 60 days of the treatment. The data were analyzed using one way analysis of variance (ANOVA) followed by the Duncan test. The results of this study indicated that the administration of Kepok banana peel extract at a dose of 100 mg/kg BW can maintain the number of basophilic cells, whereas at dose of 200 mg/kg BB has the potential to reduce the number of basophilic cells in rats fed high-fat feed.

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