scholarly journals Study the Protective Effect of Ginger against the Toxicity of Dimethoate on Hormones in Rabbits

2021 ◽  
pp. 24-33
Author(s):  
Sara M. Elgazwi ◽  
Fayrouz A. Khaled ◽  
Manal F. Alsanous
Keyword(s):  
Body Weight ◽  
Medicinal Plant ◽  
Protective Effect ◽  
Relative Weight ◽  
Zingiber Officinale ◽  
High Toxicity ◽  
Organophosphorus Insecticides ◽  
Treatment Groups ◽  
Toxicity Effect ◽  
Anti Inflammation

Organophosphorus insecticides have been widely classified as a health dangerous and high toxicity compounds due to their widespread use and release into the environment. Ginger (Zingiber officinale) has been used as a medicinal plant since antiquity and is known to play diverse biological roles including anti oxidation, anti-inflammation, hyperlipidemia, anti-carcinogenesis, anti-nausea, anti-thrombosis, and antibacterial process. The purpose of these experiments was to study decreasing the toxicity effect of Dimethoate by ginger. All animals in this study were assigned to one of four treatment groups: 0 mg ginger and 0 mg dimethoate /kg BW (control); 100 mg ginger/kg BW; 43.2 mg dimethoate /kg BW; and 43.2 mg dimethoate plus 100 mg ginger/kg BW. Rabbits were orally managed the particular measurements each other day for 12 weeks. Results indicated that treatment with ginger alone caused significant (P<0.05) increase in body weight (BW) and relative weight of testes compared to control animals. Whereas the rabbits treated with dimethoate showed significant (P<0.05) decrease in BW and relative weight of testes compared with control. Results showed that treatment with DM caused significant (P<0.05) decrease activity of testosterone, T3 and T4. While, increase the levels of FSH and LH in plasma. Ginger caused significant (P<0.05) increase in the activity of testosterone, T3 and T4 in plasma compared to control. While, decrease the levels of FSH and LH in plasma. The presence of ginger with DM caused significant (P<0.05) decrease in the reduction of T3 and T4, while caused an improvement in the levels of testosterone as compared to control and the presence of ginger with DM caused increase in the levels of FSH and LH as compared to control, and this means that ginger counteracted the toxic effects of DM.

Some Indian herbs have protective effects against deleterious effects of ochratoxin A in broiler chicks

2021 ◽  
pp. 1-14
Author(s):  
S.D. Stoev ◽  
K. Dimitrov ◽  
I. Zarkov ◽  
T. Mircheva ◽  
D. Zapryanova ◽  
...  
Keyword(s):  
Body Weight ◽  
Protective Effect ◽  
Ochratoxin A ◽  
Relative Weight ◽  
Fine Powder ◽  
Inhibitory Effect ◽  
Feed Additives ◽  
Tinospora Cordifolia ◽  
Broiler Chicks ◽  
Protective Effects

A protective effect of two herbs, Glycyrrhiza glabra and Tinospora cordifolia, given as feed additives was observed against the growth inhibitory effect of ochratoxin A (OTA) and associated immunosuppression and biochemical or pathomorphological changes. The feed levels of 3 mg/kg OTA and fine powder of one of both herbs were given during a period of 32 days to female broiler chicks divided into 3 experimental and 1 control groups (14 chicks per group). The observed pathological and biochemical changes, the changes in relative organs’ weight and body weight, and the decrease of antibody titer against Newcastle disease were more pronounced in the OTA-treated chicks without herbal supplementation, and less pronounced in the chicks treated additionally with G. glabra or T. cordifolia as was shown by the better feed performance and the higher body weight in the chicks treated with the herbs. The higher relative weight of lymphoid organs of the chicks supplemented with both herbs revealed their beneficial effects on the immune system. The hepatoprotective effect of both herbs was evident, being stronger in the chicks additionally supplemented with G. glabra shown by the pathomorphological findings and by the lower levels of aspartate transaminase (131.1 U/l) compared to chicks given only OTA (156.0 U/l). A protective effect of T. cordifolia on the bone marrow and kidneys was found as was shown by the lower levels of uric acid (382.9 μmol/l) compared to chicks given only OTA (466.9 μmol/l).

scholarly journals A study of the Effect of Adding the Water of the Anise Seeds PimpinellaAnisuml to the Drinking Water on the Characteristics of the Body Weight and Some Carcass Characteristics of the Birds of Quail at the Age of Four and Six Weeks.

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Ali Hussein Khalil al-Hilali ◽  
Zahra Muhammad Najm al-Badri
Keyword(s):  
Drinking Water ◽  
Body Weight ◽  
Agricultural Research ◽  
Relative Weight ◽  
Carcass Characteristics ◽  
The Body ◽  
College Of Agriculture ◽  
Treatment Groups ◽  
Carcass Cuts

This experiment has been conducted in agricultural research and experiences of the college of Agriculture / University of Al-Muthanna station for the period 07/22/2014 - 11/22/2015 in order to study the effect of adding the aquase dressing of anise seed to the drinking water on the body weight dressing percentages, relative weight of carcass cuts (Breast,thigh,hack ,wing and neck) in which 3males and 3females have been slaughterin all treatment . A total of 256 of one day old quails chicks were randomly allocated into four treatment groups. The Results show that the addition of aqueous extract of anise seeds with a significant effect (P <0.05) in vivo weight and carcass weight and percentages for weights Qtaiat carcass (chest, thighs, back, wings, neck) at the age of (6.4 weeks) . The results also show that gender has a significant effect on the studied traits

scholarly journals Protective effect of zingiber officinale on mobile phone induced rat brain injury.

2021 ◽  
Vol 28 (12) ◽  
pp. 1797-1803
Author(s):  
Syed Alamdar Raza Zaidi ◽  
Mohammad Fawad Saeeduddin ◽  
Aisha Qamar ◽  
Shabnam Khan ◽  
Rozina Khan ◽  
...  
Keyword(s):  
Body Weight ◽  
Protective Effect ◽  
Mobile Phone ◽  
Rat Brain ◽  
Zingiber Officinale ◽  
Control Group ◽  
Final Body Weight ◽  
Group B ◽  
3G Mobile Phone ◽  
Group D

Objective: To observe the protective effect of zingiber officinale against radio frequency (RF) radiation-induced oxidative stress on rat brain due to 3G mobile phone. Study Design: Prospective Experimental study. Setting: Department of Anatomy, BMSI, JPMC, Karachi. Period: January to March 2018. Material & Methods: Twenty four healthy, adult, Albino rats, 3-4 months of age, weighing 150-300 gm were acquired. They were sorted into four groups. Group A was marked as control, Group B was exposed to 3G mobile phone 2100MHz radiation 24 hours daily, Group C was exposed to same dose of radiation as group B along with zingiber officinale 250mg/kg/day orally, and Group D was given same dose of zingiber officinale as in group C. The rats were euthanized at end of study period after recording their final weight. Brain of rats was removed and weighed. It was processed for haematoxylin and eosin stain to observe general morphology of cerebellum. Results: The data displayed an insignificant increase in final body weight and absolute brain weight in group B animals as compared to control, whereas an insignificant increase and insignificant decrease was observed in body weight and absolute weight of brain when group C was compared with group B respectively. Microscopic examination of cerebellum in H & E stained sections revealed distortion of cellular architecture in group B as compared to control. Tissue sections from group C demonstrated significant restoration of cerebellar architecture. Results of group D were similar to control. Conclusion: Cell phones emit radiation causing damage to brain, especially cerebellum, however, concurrent use of ginger significantly ameliorates this damaging effect.

Evaluation of unconventional poultry feed in broilers

2019 ◽  
Vol 17 (1) ◽  
Keyword(s):  
Body Weight ◽  
Treatment Group ◽  
Blood Meal ◽  
Feed Consumption ◽  
Trial Period ◽  
Feed Ingredients ◽  
Treatment Groups ◽  
Broiler Production ◽  
Group I ◽  
Unconventional Feed

Background: Commercial broiler is a rapidly growing sector in Bangladesh. The broilers are supplied with the balanced ration prepared from a number of ingredients which are not available uniformly throughout the years. On the other hands, manufactured feeds are costly and inconvenient for the rural farmers. This study is undertaken to use unconventional feed ingredients aiming to decrease the broiler production cost. Method: A total of ninety-nine day- old broiler chicks (Hubbard) of either sex were used in this study in 3 treatment groups to assess processed unconventional feed item (shoti, blood meal, poultry dropping and molasses) on growth and profitability upon rearing for 60 days. Broilers were reared in dip litter system and were fed ad libitum on conventional and unconventional diet dividing into 3 treatment diets namely, treatment diet 1 (T1: Conventional as control), treatment diet 2 (T2: unconventional with blood meal and shoti), and treatment diet 3 (T3: unconventional with blood meal, shoti, poultry droppings and molasses) throughout the trial period. Treatment group 1 (T1) was used as control. Results: Broilers fed on control diet (conventional feed) achieved higher (P<0.01) body weight, while the broilers offered diets with the highest amount of unconventional feed had the lowest body weight. Increased (P<0.01) feed intake was observed during 21days and 49 days of age when broilers fed diets with the supplementation, but no significant differences were found among the groups in terms of feed consumption during 33 day of age. FCR differed significantly (P<.01) throughout the trial period with the broilers fed diets without supplementation of unconventional feed item had the superior FCR than the others. Mortality rate was 6.06%,9.09%, and 9.09% in treatment group I, treatment group II, and treatment group III respectively while live weights, feed conversion and feed consumption was unaffected by all the dietary groups with/without incorporation of unconventional feed item up to day 60 days of age. Statistically significant (P<0.01) decreased live weight was observed among the treatment groups in 60-day-old birds. Productivity and cost-benefit analysis were performed. Conclusion: Use of unconventional feed ingredients in broiler production greatly reduces the feed cost with little hampering the growth rate and hence, it is profitable for the farmers.

scholarly journals Dietary sophorolipid accelerates growth by modulation of gut microbiota population and intestinal environments in broiler chickens

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Min-Jin Kwak ◽  
Min-Young Park ◽  
Yong-Soon Choi ◽  
Junghwan Cho ◽  
Duleepa Pathiraja ◽  
...  
Keyword(s):  
Body Weight ◽  
Barrier Function ◽  
Broiler Chickens ◽  
Pathogenic Bacteria ◽  
Inflammatory Cytokine ◽  
Intestinal Inflammation ◽  
Defense System ◽  
Villus Height ◽  
Treatment Groups ◽  
Gut Barrier Function

Abstract Background Gut is a crucial organ for the host’s defense system due to its filtering action of the intestinal membrane from hazardous foreign substances. One strategy to strengthen the gut epithelial barrier function is to upregulate beneficial microflora populations and their metabolites. Sophorolipid (SPL), which is a glycolipid bio-surfactant, could increase beneficial microflora and decrease pathogenic bacteria in the gastrointestinal tract. Therefore, herein, we conducted an experiment with broiler chickens to investigate the fortifying effects of SPL on the host’s gut defense system by modulating the microbiota population. Methods A total of 540 1-day-old chicks (Ross 308) were used, and they were immediately allotted into three treatment groups (6 replications with 30 chicks/pen) according to their initial body weight. The dietary treatments consisted of CON (basal diet), BAM (10 mg/kg bambermycin), and SPL (10 mg/kg SPL). During the experiment, birds freely accessed feed and water, and body weight and feed intake were measured at the end of each phase. On d 35, birds (one bird/pen) were sacrificed to collect jejunum and cecum samples. Results Dietary SPL and BAM supplementation significantly accelerated birds’ growth and also significantly improved feed efficiency compared to CON. Intestinal microbial community was significantly separated by dietary SPL supplementation from that of CON, and dietary SPL supplementation significantly increased Lactobacillus spp. and Akkermansia muciniphila. Moreover, birds fed with dietary SPL also showed the highest concentration of cecal butyrate among all treatment groups. Gut morphological analysis showed that dietary SPL significantly increased villus height, ratio of villus height to crypt depth, goblet cell numbers, and the gene expression levels of claudin-1 and mucin 2. Additionally, dietary SPL significantly decreased the mRNA expression level of pro-inflammatory cytokine, interleukin-6, and increased that of anti-inflammatory cytokine, interleukin-10, compared to other treatments. Conclusions Dietary SPL increases the beneficial bacterial population and butyrate concentration, which leads to a strengthened gut barrier function. In addition, the intestinal inflammation was also downregulated by dietary SPL supplementation.

scholarly journals Nucleotide Supplementation to Whole Milk Has Beneficial Effects on Post-Weaning Holstein Calf Performance

Animals ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 218
Author(s):  
Yousef Abbaslou ◽  
Davood Zahmatkesh ◽  
Ehsan Mahjoubi ◽  
Mehdi Hossein Yazdi ◽  
Hamed Beiranvand ◽  
...  
Keyword(s):  
Body Weight ◽  
Average Daily Gain ◽  
Free Access ◽  
Treatment Groups ◽  
Beneficial Effects ◽  
Positive Effects ◽  
Whole Milk ◽  
Calf Performance ◽  
Daily Gain ◽  
Fecal Score

The positive effects of nucleotide (NU) supplementation in milk replacer have been elucidated in infants and in dairy calves; however, NU addition to whole milk has not been evaluated previously. This study aimed to assess NU supplementation in the whole milk on calf growth and health. Thirty Holstein calves (body weight: 39.1 ± 1.0 kg; 3 d after birth) were randomly assigned to the following treatments: whole milk without any supplementation (NU0), whole milk + 0.5 g/d added a NU-containing supplement to whole milk (NUCS0.5), and whole milk + 1 g/d added a NU-containing supplement to whole milk (NUCS1). Calves were weaned at d 55 and stayed on study until d 75. Calves had free access to feed and water throughout the study. Dry matter intakes (DMI) were similar among treatments (p > 0.05) during the pre-weaning period; however, increasing NU resulted in a linear (p < 0.05) increase in DMI during the post weaning period (2158, 2432, and 2518 g/d for NU0, NUCS0.5, and NUCS1, respectively). Treatments did not affect body weight (BW) at the first and second month of study, but final BW linearly increased as NU was added (87.1, 90.6, and 95.4 kg for NU0, NUCS0.5, and NUCS1, respectively). Neither pre-weaning average daily gain nor post-weaning average daily gain was affected by treatments; accordingly, feed efficiency was similar among treatment groups. Days with loose fecal score were linearly decreased as NU was added to whole milk during the first month of life, while the fecal score did not differ among treatments until the end of the study. No difference was observed in the skeletal growth of calves in the current study. Therefore, it can be concluded that NU supplementation in the whole milk has some beneficial effects on calf performance in terms of final BW, post-weaning DMI, and less days with loose feces.

scholarly journals Dental pulp stem cells overexpressing hepatocyte growth factor facilitate the repair of DSS-induced ulcerative colitis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ning Li ◽  
Yichi Zhang ◽  
Narayan Nepal ◽  
Guoqing Li ◽  
Ningning Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ulcerative Colitis ◽  
Body Weight ◽  
Stem Cell ◽  
Dental Pulp ◽  
The Other ◽  
Therapeutic Effects ◽  
Colon Injury ◽  
Treatment Groups ◽  
Hepatocyte Growth

Abstract Background Ulcerative colitis (UC) is a chronic and recurrent disease without satisfactory treatment strategies. Dental pulp stem cell (DPSC) transplantation has been proposed as a potential therapy for UC. This study aimed to investigate the therapeutic effects of the rat hepatocyte growth factor (HGF) gene transduced into DPSCs for UC. Methods The therapeutic effects of HGF-DPSCs transplanted intravenously into a rat model of UC induced by 5% dextran sulphate sodium (DSS) were compared with the other treatment groups (LV-HGF group, DPSCs group and GFP-DPSCs group). Immunofluorescence and immunohistochemistry were used to observe the localization and proliferation of HGF-DPSCs at the site of colon injury. The expression levels of inflammatory factors were detected by real-time quantitative PCR (RT-PCR) and western blotting. The oxidative stress markers were detected by ELISA. DAI scores and body weight changes were used to macroscopically evaluate the treatment of rats in each group. Results Immunofluorescence and immunohistochemistry assays showed that HGF-DPSCs homed to colon injury sites and colocalized with intestinal stem cell (ISC) markers (Bmi1, Musashi1 and Sox9) and significantly promoted protein expression (Bmi1, Musashi1, Sox9 and PCNA). Anti-inflammatory cytokine (TGF-β and IL-10) expression was the highest in the HGF-DPSCs group compared with the other treatment groups, while the expression of pro-inflammatory cytokines (TNF-α and INF-γ) was the lowest. Additionally, the oxidative stress response results showed that malondialdehyde (MDA) and myeloperoxidase (MPO) expression decreased while superoxide dismutase (SOD) expression increased, especially in the HGF-DPSCs group. The DAI scores showed a downward trend with time in the five treatment groups, whereas body weight increased, and the changes were most prominent in the HGF-DPSCs group. Conclusions The study indicated that HGF-DPSCs can alleviate injuries to the intestinal mucosa by transdifferentiating into ISC-like cells, promoting ISC-like cell proliferation, suppressing inflammatory responses and reducing oxidative stress damage, which provides new ideas for the clinical treatment of UC.

scholarly journals Effect of Carica papaya L. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin

2020 ◽  
Vol 151 ◽  
pp. 01011
Author(s):  
Safrida Safrida ◽  
Mustafa Sabri
Keyword(s):  
Body Weight ◽  
Carica Papaya ◽  
Stem Bark ◽  
Negative Control ◽  
Diabetic Rats ◽  
Cholesterol Concentration ◽  
Bark Extract ◽  
Treatment Groups ◽  
Randomized Design ◽  
Stem Bark Extract

This study was designed to determine the effect of Carica papaya L. stem bark extracts on cholesterol concentration in rats induced with glibenclamide. A completely randomized design was used for the experiment which consisted of 6 treatment groups, each group consisted of four rats, as follows:1) KN (negative control, non-diabetic rats); KP, diabetic rats given glibenclamide 10 mg/kg body weight; EP 1, diabetic rats given 0 mg/kg body weight/day extract; EP2, diabetic rats given 100 mg/kg body weight/day extract; and EP3, diabetic rats given 200 mg/kg body weight/day extract, EP4, diabetic rats given 300 mg/kg body weight/day extract for 28 day. The results showed that C. papaya L. stem bark extract decreased (P<0.05) cholesterol levels in diabetic rats. It was concluded that C. papaya L. stem bark extract had potential as anti-hypercholesterolemic in diabetic rats.

Sign in / Sign up

Export Citation Format

Share Document