scholarly journals Influence of the “Active Mix” supplement with separate administration of antagonistic components on the structure of the mice internal organs

2021 ◽  
Vol 36 ◽  
pp. 05013
Author(s):  
D.S. Berestov ◽  
Yu.G. Vasiliev ◽  
A.N. Kulikov ◽  
N.V. Isupova

The question of the need for separate administration of feed additives’ components that are antagonistic from the point of view of their chemical properties and physiological effects has long been debated among researchers. The authors have proposed a new supplement based on chelate compounds, which components’ effect on the organism of laboratory animals has been partially considered earlier. However, the assessment of the components’ effects on the morphology of the excretory and reproductive systems’ organs has not been studied. In this regard, the work considered the effect of feed additive components with separate introduction of chemically and physiologically antagonistic components on the pathoanatomical picture, as well as the microstructure of the kidneys and testes of laboratory mice to assess potentially negative effects on the excretory and reproductive systems. The supplement was administered orally at various dosages. The organ structure was assessed after 1, 2 weeks and 1 month. The microstructure of the kidneys and testes was histologically studied in the experiment and control. The negative influence absence of the supplement components in the entire range of applied dosages is shown. The absence of visible deviations of the pathoanatomical picture during autopsy of experimental animals was noted.

Author(s):  
G. I. Pavlenko ◽  
◽  
N. S. Pavlova ◽  
D. A. Drozdov ◽  
N. A. Brichko ◽  
...  

The search for drugs to reduce the negative effects of ecotoxicants on the body of laboratory animals was conducted. Hemovit-meyan, solvimine selenium, ecostimul-2, miksovit A and elvestin have been tested. The use of these drugs reduced the negative effect of ecotoxicants, normalized some indicators, but did not give complete detoxification of the animal body. On the basis of the obtained results, it is concluded that it is reasonable to use a complex of preparations and feed additives with different mechanisms of protective action.


Author(s):  
N. M. Baluh

Established that the largest distribution combined with feed additives which include a number of biologically active substances. As an alternative to antibiotics, the use of which recently banned their production and significantly reduced feeding system is used four groups of drugs, enzymes, probiotics, prebiotics and аcidifiers. The largest number of feed additives used in poultry feed. Therefore, to improve the consumption and use of feed efficiency, obtaining maximum animal performance ensured a high level of balanced nutrition using the same enzyme–probiotic supplements. It is to include such feed additives «Proenzym» which consists of live bacteria genus Bacillus subtilis and an enzyme tsellyulaza. What prevents gastrointestinal diseases, improves digestion and absorption of essential nutrients intake. Therefore, the aim was to study the effect of feeding different doses feed additive «Proenzym» in the quail Full–feed and its impact on productivity and internal organs. For the experiment selected 200 day old Estonian quail breed. Of these, the principle of analogues formed four groups of 50 goals each. The duration of the experiment – 56 days. The first (control) group during the entire experiment received a basic diet, and quail research groups in addition to the basic diet fed different doses of feed additives. For the effects of various doses feed additive had a positive effect on live weight quails in 42 and 49–day age. Yes, most live weight at the end of the experiment were females and males second experimental group 10.8% and 8.3%, which in addition to full–feed introduced minimum dose «Proenzym» The introduction of the new maximum amount of feed factor had a significant impact on the weight of internal organs, quails second group for the actions of study drug increased the mass of the lungs and liver, respectively, 0.6 g and 3.4 g, and gallbladder in 4 experimental group 0.16 g. Therefore, we can conclude that the diets of quails best was the maximum amount of feed additive.


2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 156-157
Author(s):  
Shelby M Ramirez ◽  
Janaka Wickramasinghe ◽  
Nadiia Stepanchenko ◽  
Maria Oconitrillo ◽  
Jayamuni Silva ◽  
...  

Abstract Phytogenic feed additives that contain anti-inflammatory and antioxidant properties may have potential to reduce inflammation and oxidation observed during bouts of heat stress. The trial objective was to determine the effects of a phytogenic feed additive on markers of stress in heifers subjected to diurnal heat stress (dHS). Eighteen Holstein and four Jersey heifers (5–6 months of age; d1 BW=205±9 kg) were assigned to two dietary treatments (n = 11) based on breed and age; 1) a basal TMR diet (CTL), 2) CTL supplemented with 0.25 g/head/d of a proprietary blend of phytogenics (PFA; BIOMIN America, Inc., Overland Park, KS). Heifers were housed individually and fed their respective treatments for 14d prior to dHS (d-14-1), subjected dHS (d1-7), and followed through a recovery period (d8-11). Weights were collected at d1 (baseline), d7 (end of dHS), and d11 (end of recovery). The temperature set point was assigned at 33°C from 0900 to 2100 h and allowed to equilibrate with outside temperature during night (24°C) for a total of 7d dHS. Total DMI (tDMI) and DMI from 0900 to 2100 h (hsDMI) were recorded daily. Serum was collected at d1, 2, 7 and 11 to determine effect of treatment on markers of oxidation, inflammation, and stress. Treatment effects were analyzed using PROC MIXED in SAS with treatment and time as fixed effects and heifer as a random effect. Temperature humidity index during dHS was greater during the day (84.5) versus night (73.3). There were no treatment differences (P>0.05) in d 0–11 on ADG, ADFI, or GF between treatments. However, PFA numerically increased hsDMI, reduced (P< 0.05) haptoglobin and tended to reduce (P< 0.10) lipopolysaccharide binding protein compared with CTL. Overall, dietary PFA may be a potential strategy to mitigate the stresses that heifers experience during dHS.


Energies ◽  
2020 ◽  
Vol 13 (18) ◽  
pp. 4751
Author(s):  
Nikki Sjulander ◽  
Timo Kikas

Bioethanol production from lignocellulosic biomass is still struggling with many obstacles. One of them is lignocellulosic inhibitors. The aim of this review is to discuss the most known inhibitors. Additionally, the review addresses different detoxification methods to degrade or to remove inhibitors from lignocellulosic hydrolysates. Inhibitors are formed during the pretreatment of biomass. They derive from the structural polymers-cellulose, hemicellulose and lignin. The formation of inhibitors depends on the pretreatment conditions. Inhibitors can have a negative influence on both the enzymatic hydrolysis and fermentation of lignocellulosic hydrolysates. The inhibition mechanisms can be, for example, deactivation of enzymes or impairment of vital cell structures. The toxicity of each inhibitor depends on its chemical and physical properties. To decrease the negative effects of inhibitors, different detoxification methods have been researched. Those methods focus on the chemical modification of inhibitors into less toxic forms or on the separation of inhibitors from lignocellulosic hydrolysates. Each detoxification method has its limitations on the removal of certain inhibitors. To choose a suitable detoxification method, a deep molecular understanding of the inhibition mechanism and the inhibitor formation is necessary.


2021 ◽  
Vol 13 (2) ◽  
pp. 10921
Author(s):  
Ayoub ALLAM ◽  
Amine H. BORSALI ◽  
Abdelkrim KEFIFA ◽  
Mohamed ZOUIDI ◽  
Anne M. FARNET DA SILVA ◽  
...  

The research work was conducted on eroded soil in the Keroua forest of Saida, Algeria, whose objective is to know the changes in the physicochemical and biological properties of forest soils subjected to the effect of water erosion. The samples were taken to a depth between 0-10 cm in each zone (eroded zone and control zone). Our results show that the biological properties are the most affected by water erosion where there was a significant decrease in basal respiration and microbial biomass, which had a negative influence on the metabolic quotient (higher values in the eroded area). For chemical properties, there was an increase in organic matter and total limestone, while the pHWater decreased in the eroded zone. For the physical properties. We raised a slight difference between the two areas, but which was not statistically significant.


2022 ◽  
Vol 951 (1) ◽  
pp. 012079
Author(s):  
Samadi ◽  
S Wajizah ◽  
A Tarman ◽  
Ilham ◽  
I Wahyudi

Abstract Phytogenies have been widely used as alternative feed additives to replace antibiotics in animal production. The present study aims to evaluate inclusion of S. cumini extract as feed additives on performance and haematological parameters of commercial broiler chickens. A total of 100-day-old commercial chickens (mixed sex) were randomly allocated to four treatments with five replicates. Each treatment was administrated different level of S. cumini extract in the drinking water (P0=control, P1=0.25 g/l drinking water, P2=0.50 g/l drinking water and P3=1.0 g/l drinking water). Commercial diet was provided during experiment based on nutrition requirement for starter and grower. Water and feed were given ad libitum. Data were collected to measure broiler performances and haematological parameters. One way ANOVA was applied in this study and significantly different among treatments were stated (P≥0.05). The results indicated that inclusion of S.cumini extract as feed additives in drinking water did not significantly affected (P>0.05) on animal performances and haematological parameters of commercial broiler chickens. Therefore, it concluded that S.cumini extract can be applied as alternative feed additive due to no negative effects of the S.cumini iextract on performances and haematological parameters.


Author(s):  
M. I. Zhyla ◽  
G. M. Mykhalus ◽  
O. A. Maksymovych ◽  
O. V. Lapin ◽  
O. V. Mykhalyuk ◽  
...  

Poultry farming using modern technologies requires the employment of veterinary preparation for the prevention of infectious diseases and also feed additives for the improvement of metabolic functions and correction of body resistance. The article presents the results of clinical trials of feed additives in the form of an ionic solution concentrate of the biologically active nanosilicon "Arsil". The clinical study was performed on healthy ten-day-old broiler chicken, cross "Cobb-500", organized into three groups of 20 heads each: Group I received a feed additive at a dose of 0.5 ml per 1 liter of water, group II – at a dose of 1.0 ml per 1 liter of water and group III was the control group (on a regular diet, without feed additives). The use of the studied feed additive was carried out by watering with water for 30 days. Poultry of all groups were fed with identical feeds in accordance with regulatory requirements taking into account the age of the bird. The clinical condition of the bird was monitored daily, control weightings were performed once a week and blood samples were taken for laboratory tests on days 15 and 35 of the experiment. At the end of the experiment, a diagnostic slaughter of birds of all groups and a complete pathological autopsy with selection of material for histological examination were performed. Studies have shown that the use of the feed additive "Arsil" contributed to weight gain and average daily gain, improved the feed conversion and the tendency for the growth of the concentration of hemoglobin, hematocrit and erythrocytes in broiler chicken from the experimental groups compared with the control group at the end of fattening. The structure of the internal organs of birds of all studied groups is preserved, macroscopic changes in organs and tissues are not detected. An increase in the coefficients of mass of immune-competent organs in broiler chicken fed the feed additive "Arsil" compared with the control group was found.


2020 ◽  
Vol 1 (8) ◽  
pp. 38-44
Author(s):  
T. N. Lenkova ◽  
◽  
I. N. Nikonov ◽  
M. V. Selina ◽  
◽  
...  

This article presents the results of a study on testing a promising feed supplement based on a strain of Lactobacillus plantarum, with a high antagonistic activity for campylobacter. Probiotics now refers to live microbial feed additives that improve the health and productivity of farm animals. Probiotics can improve the growth rate of broiler chickens and control or prevent intestinal diseases, including salmonellosis, necrotic enteritis, and coccidiosis Scientific and industrial experience was carried out on broilers of the Cobb XNUMX cross country from daily to XNUMX days of age. As a result of research conducted by the scientific group, it was shown that feeding broiler chickens with a probiotic feed additive based on Lactobacillus plantarum helps to increase their productivity during the entire growing cycle and have a beneficial effect on the health status of farm birds.


2021 ◽  
Author(s):  
Ipsheta Bose ◽  
T. Sujatha ◽  
Rahul Singh ◽  
Jai Sunder ◽  
Gayatri Samaddar

Abstract Seaweed (known as the marine algae) has a tradition of being part of the animal feed in the coastal areas, from ancient times. Seaweed, are mixed with animal feed, because when consumed alone can have some negative effects on the animal. Seaweed are very rich in useful metabolite (pigments, carotenoids, phlorotannin, polyunsaturated fatty acids, agar, alginate and carrageenan) and minerals (iodine, zinc sodium calcium, magnesium, iron, selenium), being considered as a natural source of additives that can substitute the antibiotic usage in various animals. Inclusion of naturally available material in poultry feed additive can have a positive influence on the poultry performance and enrich the quality of their by product. As an easily available and renewable biomass rich in biologically active compounds, seaweeds can meet this demand. Different forms of seaweed powder from naturally occurring biomass, cultivated or waste biomass, extracted compounds, post extraction residues or liquid extracts may be used in poultry feeding. This study describes the nutritional values of seaweeds and their effects in poultry feed additive, and to what extent their unique properties can serve as an alternative to antibody growth promoter.


2007 ◽  
Vol 23 (5-6-2) ◽  
pp. 67-75
Author(s):  
A. Zachwieja ◽  
T. Szulc ◽  
A. Potkański ◽  
R. Mikuła ◽  
W. Kruszyński ◽  
...  

The results of certain studies indicate that a relation exists between the quality of colostrum and milk and the correct balancing of energy and protein in the diet for cows in particular during the last three weeks before parturition. The aim of this study was to determine the effect of fat additives offered to cows during the dry period on the composition and physico-chemical properties of colostrum and the pre-colostrum secretion. 24 cows were assigned to one of three groups. Group I - control, received no feed additives; II - received feed supplemented by a mixture of fish and rapeseed oil in a 1:1 ratio, III - received feed supplemented by protected fat (Brgafat). In both cases the addition of fat amounted to 360g, i.e. 2% DM. All animals received a PMR concentrate in quantities calculated according to the INRA system. From all the cows samples were taken about 48 hours before parturition of the pre-colostrum secretion and directly after calving of colostrum from the first, complete milking. The samples taken were analyzed for basic composition, for the overall number of microorganisms (ONM), somatic cell count (SSC), content of urea, coagulation time after adding rennet, thermo stability as well as potential (oSH) and active (pH) acidity. The results of the studies conducted indicate that the composition and physico-chemical properties of colostrum and pre-colostrum is differentiated. Offering protected fat as a feed additive for cows during the last three weeks of the dry period had a significant effect on the share of dry matter and crude protein in the colostrum produced. The addition of a mixture of fish and rapeseed oil did not have a similar effect.


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