scholarly journals Anticancer Activities of Ginsenosides, the Main Active Components of Ginseng

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Heeok Hong ◽  
Delgerzul Baatar ◽  
Seong Gu Hwang
Keyword(s):  
Therapeutic Potential ◽  
Alternative Therapy ◽  
Modern Medicine ◽  
Cancer Therapies ◽  
Active Components ◽  
Anticancer Activities ◽  
Complementary And Alternative Therapy ◽  
Invasion And Migration ◽  
And Migration ◽  
The Many

Cancer incidence rate has been increasing drastically in recent years. One of the many cancer treatment methods is chemotherapy. Traditional medicine, in the form of complementary and alternative therapy, is actively used to treat cancer, and many herbs and active ingredients of such therapies are being intensely studied to integrate them into modern medicine. Ginseng is traditionally used as a nourishing tonic and for treating various diseases in Asian countries. The therapeutic potential of ginseng in modern medicine has been studied extensively; the main bioactive component of ginseng is ginsenosides, which have gathered attention, particularly for their prospects in the treatment of fatal diseases such as cancer. Ginsenosides displayed their anticancer and antimetastatic properties not only via restricting cancer cell proliferation, viability, invasion, and migration but also by promoting apoptosis, cell cycle arrest, and autophagy in several cancers, such as breast, brain, liver, gastric, and lung cancer. Additionally, ginsenosides can work synergistically with already existing cancer therapies. Thus, ginsenosides may be used alone or in combination with other pharmaceutical agents in new therapeutic strategies for cancer. To date however, there is little systematic summary available for the anticancer effects and therapeutic potential of ginsenosides. Therefore, we have reviewed and discussed all available literature in order to facilitate further research of ginsenosides in this manuscript.

scholarly journals Natural Compounds as Regulators of the Cancer Cell Metabolism

2013 ◽  
Vol 2013 ◽  
pp. 1-16 ◽  
Author(s):  
Claudia Cerella ◽  
Flavia Radogna ◽  
Mario Dicato ◽  
Marc Diederich
Keyword(s):  
Cancer Cell ◽  
Therapeutic Potential ◽  
Cell Metabolism ◽  
Physiological Mechanism ◽  
Natural Compounds ◽  
Bioactive Molecules ◽  
Anticancer Activities ◽  
Cancer Cell Metabolism ◽  
Altered Metabolism ◽  
And Migration

Even though altered metabolism is an “old” physiological mechanism, only recently its targeting became a therapeutically interesting strategy and by now it is considered an emerging hallmark of cancer. Nevertheless, a very poor number of compounds are under investigation as potential modulators of cell metabolism. Candidate agents should display selectivity of action towards cancer cells without side effects. This ideal favorable profile would perfectly overlap the requisites of new anticancer therapies and chemopreventive strategies as well. Nature represents a still largely unexplored source of bioactive molecules with a therapeutic potential. Many of these compounds have already been characterized for their multiple anticancer activities. Many of them are absorbed with the diet and therefore possess a known profile in terms of tolerability and bioavailability compared to newly synthetized chemical compounds. The discovery of important cross-talks between mediators of the most therapeutically targeted aberrancies in cancer (i.e., cell proliferation, survival, and migration) and the metabolic machinery allows to predict the possibility that many anticancer activities ascribed to a number of natural compounds may be due, in part, to their ability of modulating metabolic pathways. In this review, we attempt an overview of what is currently known about the potential of natural compounds as modulators of cancer cell metabolism.

scholarly journals Aromatherapy and Yagya Therapy for Mental Health

2021 ◽  
Vol 3 (2) ◽  
pp. 29-41
Author(s):  
Devangkumar Trivedi
Keyword(s):  
Mental Health ◽  
Spiritual Development ◽  
Therapeutic Potential ◽  
Alternative Therapy ◽  
Medicinal Herbs ◽  
Psychological Problems ◽  
Tablet Form ◽  
Complementary And Alternative Therapy ◽  
Therapeutic Benefits ◽  
Different Cultures

Aromatherapy is a well-known complementary and alternative therapy around the world. It has always existed in different cultures with its own unique imprint. Aromatherapy, as the name itself suggests depends on the fragrance or aroma of essential oils extracted from the leaves or root of medicinal herbs. This was incorporated in humans for health benefits in various forms such as pulmonary inhalation, massage, at times, in powder or tablet form. Studies have shown the therapeutics potential of aromatherapy widely observed on human (clinical trials), and also on animal models to treat various physiological as well as psychological problems including mental health suggesting its potential. One of ancient vedic method, Yagya involved inhalation of herbal vapors similar to more recent aromatherapy. In India, the process of Yagya is an ancient technique used for personal and spiritual development. In Yagya various medicinal herbs are used in mixtures that have therapeutic potential to treat psychological problems. In this review we have covered all the therapeutic benefits of medicinal herbs used in Aromatherapy and in Yagya along with herbal components used in Yagya to shed light on the Yagya in fortifying mental health.

scholarly journals Effects and Components of Herb Pair Huanglian-Banxia on Diabetic Gastroparesis by Network Pharmacology

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Guoqiang Liang ◽  
Lurong Zhang ◽  
Guorong Jiang ◽  
Xuanyi Chen ◽  
Yang Zong ◽  
...  
Keyword(s):  
Alternative Therapy ◽  
Diabetic Gastroparesis ◽  
Network Pharmacology ◽  
Active Components ◽  
Complementary And Alternative Therapy ◽  
Pharmacological Approach ◽  
Target Network ◽  
Heavy Burden ◽  
Bioactive Ingredients ◽  
Coptidis Rhizoma

Diabetic gastroparesis (DGP) is a serious and chronic complication of long-standing diabetes mellitus, which brings a heavy burden to individuals and society. Traditional Chinese medicine (TCM) is considered a complementary and alternative therapy for DGP patients. Huanglian (Coptidis Rhizoma, HL) and Banxia (Pinelliae Rhizoma, BX) combined as herb pair have been frequently used in TCM prescriptions, which can effectively treat DGP in China. In this article, a practical application of TCM network pharmacological approach was used for the research on herb pair HL-BX in the treatment of DGP. Firstly, twenty-seven potential active components of HL-BX were screened from the TCMSP database, and their potential targets were also retrieved. Then, the compound-target network and PPI network were constructed from predicted common targets, and several key targets were found based on the degree of the network. Next, GO and KEGG enrichment analyses were conducted to obtain several significantly enriched terms. Finally, the experimental verification was made. The results demonstrated that network pharmacological approach was a powerful means for identifying bioactive ingredients and mechanisms of action for TCM. Network pharmacology provided an effective strategy for TCM modern research.

scholarly journals Quinonoids: Therapeutic Potential for Lung Cancer Treatment

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Hua-Zhong Ying ◽  
Chen-Huan Yu ◽  
Hao-Kun Chen ◽  
Huan-Huan Zhang ◽  
Jie Fang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Products ◽  
Anticancer Drugs ◽  
Therapeutic Potential ◽  
Invasion And Migration ◽  
Anticancer Effects ◽  
Incidence And Mortality ◽  
High Incidence ◽  
Underlying Mechanisms ◽  
And Migration

Lung cancer is the leading cause of cancer-related deaths worldwide. Owing to its high incidence and mortality, the development and discovery of novel anticancer drugs is of great importance. In recent years, many breakthroughs have been achieved in the search for effective anticancer substances from natural products. Many anticancer drugs used clinically and proven to be effective are derived from natural products. Quinonoids, including naphthoquinones, phenanthrenequinones, benzoquinones, and anthraquinones, constitute a large group of natural bioactive compounds that widely exist in higher and lower plant species. Given that most of these compounds possess anticancer effects, they are applied in many cancer studies, especially in lung cancer research. They can promote apoptosis, induce autophagy, and inhibit proliferation, angiogenesis, and cell invasion and migration. Some drugs can enhance anticancer effects when combined with other drugs. Thus, quinonoids have broad application prospects in the treatment of lung cancer. Here, we summarize the previous studies on the antilung cancer activities of quinonoids together with their underlying mechanisms and analyze the common research targets with different effects so as to provide references for the discovery of quinonoids against lung cancer.

scholarly journals Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiangchan Hou ◽  
Le Tang ◽  
Xiayu Li ◽  
Fang Xiong ◽  
Yongzhen Mo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Potassium Channel ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cancer Therapies ◽  
Migration Ability ◽  
Invasion And Migration ◽  
Therapy Targets ◽  
Novel Strategy ◽  
And Migration

Breast cancer is the most common malignant tumor in women, and its incidence is increasing each year. To effectively treat breast cancer, it is important to identify genes involved in its occurrence and development and to exploit them as potential drug therapy targets. Here, we found that potassium channel subfamily K member 6 (KCNK6) is significantly overexpressed in breast cancer, however, its function in tumors has not been reported. We further verified that KCNK6 expression is upregulated in breast cancer biopsies. Moreover, overexpressed KCNK6 was found to enhance the proliferation, invasion, and migration ability of breast cancer cells. These effects may occur by weakening cell adhesion and reducing cell hardness, thus affecting the malignant phenotype of breast cancer cells. Our study confirmed, for the first time, that increased KCNK6 expression in breast cancer cells may promote their proliferation, invasion, and migration. Moreover, considering that ion channels serve as therapeutic targets for many small molecular drugs in clinical treatment, targeting KCNK6 may represent a novel strategy for breast cancer therapies. Hence, the results of this study provide a theoretical basis for KCNK6 to become a potential molecular target for breast cancer treatment in the future.

scholarly journals The Use of Acupuncture as an Alternative Treatment Method for Ovarian Dysfunction: A Narrative Review

2021 ◽  
Vol 6 (4) ◽  
Author(s):  
Xu J ◽  
Fan Y ◽  
Geng J ◽  
Zhang Y ◽  
Xia T
Keyword(s):  
Assisted Reproduction ◽  
Ovarian Function ◽  
Elderly Women ◽  
Hot Spot ◽  
Alternative Therapy ◽  
Treatment Method ◽  
Modern Medicine ◽  
Reproductive Age ◽  
Future Application ◽  
Complementary And Alternative Therapy

It is well known that diminished ovarian reserve is one of the main causes of infertility in older women. Also, due to the delayed reproductive age of women, there is a gradual increase in the number of elderly women using assisted reproduction techniques to assist pregnancy. However, due to the decrease in ovarian function, the sensitivity of ovaries to gonadotropin (Gn) is reduced and follicles fail to develop and mature to ovulation, which is one of the important reasons for cancelling cycles during the application of assisted reproduction for ovulation. Therefore, improving ovarian function is an important factor in improving pregnancy rates in advanced women during assisted conception. Modern medicine has no clear drugs to restore ovarian function in women, while acupuncture, as an effective and simple complementary and alternative therapy, has gradually become a hot spot for application in patients with reduced ovarian function in recent years. Therefore, this paper aims to investigate the mechanism, clinical efficacy and future application prospects of acupuncture in improving ovarian function in women.

scholarly journals N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Fenghua Tan ◽  
Mengyao Zhao ◽  
Fang Xiong ◽  
Yumin Wang ◽  
Shanshan Zhang ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Rna Splicing ◽  
Epigenetic Modification ◽  
Metabolic Reprogramming ◽  
Signal Transduction Pathways ◽  
Cancer Therapies ◽  
Biological Processes ◽  
Rna Molecules ◽  
Invasion And Migration ◽  
And Migration

AbstractThe N6-methyladenosine (m6A) modification is a dynamic and reversible epigenetic modification, which is co-transcriptionally deposited by a methyltransferase complex, removed by a demethylase, and recognized by reader proteins. Mechanistically, m6A modification regulates the expression levels of mRNA and nocoding RNA by modulating the fate of modified RNA molecules, such as RNA splicing, nuclear transport, translation, and stability. Several studies have shown that m6A modification is dysregulated in the progression of multiple diseases, especially human tumors. We emphasized that the dysregulation of m6A modification affects different signal transduction pathways and involves in the biological processes underlying tumor cell proliferation, apoptosis, invasion and migration, and metabolic reprogramming, and discuss the effects on different cancer treatment.

scholarly journals Panax Notoginseng Saponins Exert Anti-osteosarcoma Effect by Inhibiting G0 / G1 Phase and Affecting p53-mediated Autophagy and Mitochondrial Apoptosis

2021 ◽  
Author(s):  
Guangtao Han ◽  
Ting Liu
Keyword(s):  
Cell Cycle ◽  
Panax Notoginseng ◽  
Osteosarcoma Cell ◽  
Osteosarcoma Cells ◽  
Panax Notoginseng Saponins ◽  
Active Components ◽  
Invasion And Migration ◽  
And Migration

Abstract BackgroundOsteosarcoma is the most common primary bone malignancy. Chemotherapy for osteosarcoma often induces severe complications to the patients. Thus, the identification of new effective antineoplastic agents with fewer side effects remain a necessity. Panax notoginseng saponins (PNS) were therapeutic active components of panax notoginseng and were reported taking the capability to inhibit the growth of several tumors in vitro and in vivo. However, its effect on osteosarcoma has not been studied. This study first investigated the effect of PNS on osteosarcoma cells.MethodsCCK-8 essay used to determine the appropriate working concentration of PNS on osteosarcoma,annixV-FITC/PI experiment used to measure the apoptosis of PNS on osteosarcoma, wound healing assay was used to detect the migration of PNS on osteosarcoma, cell invasiveness was measured by transwell essay,cell cycle was measured by PI,the expression of relative protein was shown by western blot.ResultsOur result indicated that PNS inhibited osteosarcoma cells’ proliferation, invasion and migration, promoted their apoptosis. Besides, PNS also increased mitochondrial membrane potential and the level of reactive oxygen species. Cell cycle of osteosarcoma was arrested in G0 / G1 phase after treatment with PNS. The expression of p53, and mitochondrial related apoptosis proteins were promoted; however, decreased autophagy in osteosarcoma cells with PNS treatment were observed.ConclusionTaking the above effect of PNS on osteosarcoma, PNS were of the potential therapeutic value for treatment of osteosarcoma.

LncRNA MIR4435-2HG is a potential early diagnostic marker for ovarian carcinoma

2019 ◽  
Vol 51 (9) ◽  
pp. 953-959 ◽  
Author(s):  
Jianming Gong ◽  
Xiaoyang Xu ◽  
Xuanli Zhang ◽  
Yingqiao Zhou
Keyword(s):  
Ovarian Carcinoma ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Early Stage ◽  
Cancer Therapies ◽  
Migration Assay ◽  
Invasion And Migration ◽  
And Migration ◽  
Tgf Β1

Abstract LncRNA MIR4435-2HG is characterized as an oncogene in lung cancer. However, its role in ovarian carcinoma (OC) is unclear. In this study, we aimed to investigate the role of MIR4435-2HG in OC. We found that both MIR4435-2HG and transforming growth factor beta 1 (TGF-β1) were upregulated in OC. MIR4435-2HG is associated with tumor metastasis but not with tumor size. Upregulation of MIR4435-2HG distinguished early stage (Stage I and II) OC patients from healthy controls. Correlation analysis showed that plasma levels of MIR4435-2HG and TGF-β1 were positively correlated only in OC patients. qPCR and western blot analysis results showed that MIR4435-2HG overexpression led to upregulation of TGF-β1 in OC cells, while TGF-β1 treatment did not significantly affect MIR4435-2HG expression. Transwell invasion and migration assays showed that MIR4435-2HG and TGF-β1 promoted the invasion and migration of OC cells while TGF-β inhibitor suppressed the invasion and migration of these cells. Further analysis of the Transwell invasion and migration assay results showed that TGF-β inhibitor reduced the effects of MIR4435-2HG overexpression. Therefore, our results suggested that lncRNA MIR4435-2HG may promote OC by upregulating TGF-β1. Further characterization of the functions of MIR4435-2HG in OC may provide novel targets for cancer therapies.

scholarly journals The Wonderful Activities of the Genus Mentha: Not Only Antioxidant Properties

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1118
Author(s):  
Majid Tafrihi ◽  
Muhammad Imran ◽  
Tabussam Tufail ◽  
Tanweer Aslam Gondal ◽  
Gianluca Caruso ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Essential Oils ◽  
Antioxidant Properties ◽  
Antibacterial Activities ◽  
Anticancer Activities ◽  
Invasion And Migration ◽  
Cycle Arrest ◽  
Migration Potential ◽  
Considerable Impact ◽  
And Migration

Medicinal plants and their derived compounds have drawn the attention of researchers due to their considerable impact on human health. Among medicinal plants, mint (Mentha species) exhibits multiple health beneficial properties, such as prevention from cancer development and anti-obesity, antimicrobial, anti-inflammatory, anti-diabetic, and cardioprotective effects, as a result of its antioxidant potential, combined with low toxicity and high efficacy. Mentha species are widely used in savory dishes, food, beverages, and confectionary products. Phytochemicals derived from mint also showed anticancer activity against different types of human cancers such as cervix, lung, breast and many others. Mint essential oils show a great cytotoxicity potential, by modulating MAPK and PI3k/Akt pathways; they also induce apoptosis, suppress invasion and migration potential of cancer cells lines along with cell cycle arrest, upregulation of Bax and p53 genes, modulation of TNF, IL-6, IFN-γ, IL-8, and induction of senescence phenotype. Essential oils from mint have also been found to exert antibacterial activities against Bacillus subtilis, Streptococcus aureus, Pseudomonas aeruginosa, and many others. The current review highlights the antimicrobial role of mint-derived compounds and essential oils with a special emphasis on anticancer activities, clinical data and adverse effects displayed by such versatile plants.

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