scholarly journals COMPONENT COMPOSITION AND BIOLOGICAL ACTIVITY OF GENUS VIOLA (VIOLACEAE) OF RUSSIAN FLO-RA

2020 ◽  
pp. 19-45
Author(s):  
Natal'ya Valeriyevna Petrova ◽  
Nina Anatol'yevna Medvedeva
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Component Composition ◽  
The Past ◽  
Aerial Parts ◽  
Different Types ◽  
The Subject ◽  
The Russian Federation ◽  
Chemical Formulas

The subject of the review is the component composition and biological activity of species of genus Viola L. (Violaceae) from the flora of the Russian Federation according publications appeared over the past few decades. Chemical constituents and biological activities have been reported for 24 species of the 100 Viola species occurring in Russian. Components of various structures: flavonoids, cyclotides, anthocyanidins, phenylpropanoic acids, coumarins, alkaloids, fatty acids and its derivatives and ect. were found in the roots, aerial parts, flowers and leaves. Composition of 137 flavonoids, alkaloids, coumarins etc. was expanded with references to their chemical formulas and literature sources. Data of the essential oils isolated from the leaves of V. tricolor L., V. arvensis Murray, V. yedoensis Makino и V. odorata L. is systematized. It was demonstrated that extracts, their fractions, and some components showed different types of biological activity, including anti-inflammatory, cytotoxic and antiviral ones. The revealed range of biological activity partially confirmed expediency of using species of genus Viola in folk and standard practice medicine.

Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity

2020 ◽  
Vol 20 (19) ◽  
pp. 2019-2035
Author(s):  
Esmaeil Sheikh Ahmadi ◽  
Amir Tajbakhsh ◽  
Milad Iranshahy ◽  
Javad Asili ◽  
Nadine Kretschmer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Biological Activity ◽  
Small Molecules ◽  
Anticancer Activity ◽  
Clinical Significance ◽  
Phase Ii ◽  
Biological Activities ◽  
Phase Ii Clinical Trials ◽  
Naturally Occurring ◽  
The Subject

Naturally occurring naphthoquinones (NQs) comprising highly reactive small molecules are the subject of increasing attention due to their promising biological activities such as antioxidant, antimicrobial, apoptosis-inducing activities, and especially anticancer activity. Lapachol, lapachone, and napabucasin belong to the NQs and are in phase II clinical trials for the treatment of many cancers. This review aims to provide a comprehensive and updated overview on the biological activities of several new NQs isolated from different species of plants reported from January 2013 to January 2020, their potential therapeutic applications and their clinical significance.

scholarly journals Traditional Uses, Phytochemistry, and Pharmacology of Elegia Species: A Review

2021 ◽  
Vol 90 (1) ◽  
pp. 4
Author(s):  
Panagiotis Lymperis ◽  
Ekaterina-Michaela Tomou ◽  
Marco Nuno De Canha ◽  
Namrita Lall ◽  
Helen Skaltsa
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Traditional Uses ◽  
Comprehensive Search ◽  
Extensive Information ◽  
The Subject ◽  
Phytochemical Profile ◽  
Ecological Dominance ◽  
New Research

In South Africa, plants belonging to the Restionaceae family possess an ecological dominance. As a result, they have been the subject of numerous morphological, anatomical, and evolutionary studies. However, few studies have focused on their phytochemical profile and their potential pharmacological activities. The genus Elegia L. is the second largest of this family comprising 52 species, which are mainly used as materials for thatching. Limited studies on the chemical constituents of Elegia species and their importance as medicinal plants have been undertaken. This review provides constructive and extensive information about the botanical characterization, distribution, traditional uses, phytochemistry and pharmacology of the genus Elegia. A comprehensive search of previously published literature was performed for studies on this genus, using databases with different key search words. This survey documented 52 Elegia species summarizing their previous taxonomic classification. In addition, 14 species were found to be studied for their phytochemical profile, revealing 14 chemical compounds. Concerning their biological activities, only one species (E. tectorum (L.f.) Moline and H.P.Linder) is reported for its anti-wrinkle activity. Moreover, two species are locally used for thatching and as materials for brooms. The present review highlights the Elegia genus as an important source of bioactive phytochemicals with flavonol glycosides being the main metabolites and reveals the uncharted territory of this genus for new research studies.

scholarly journals Phytochemical Constituents Identified from the Aerial Parts of Lespedeza cuneata and Their Effects on Lipid Metabolism during Adipocyte Maturation

Separations ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 203
Author(s):  
Heesun Kang ◽  
Minjeong Yoo ◽  
Sangah Yi ◽  
Taewan Kim ◽  
Jiwon Ha ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Lespedeza Cuneata ◽  
Gene Expressions ◽  
Aerial Parts ◽  
Phytochemical Investigation ◽  
Phytochemical Constituents ◽  
Regulate Lipid Metabolism

Lespedeza cuneata, belonging to Fabaceae, is well-known as Chinese bushclover, and it has been used in traditional folk medicines for the treatment of disorders, such as diabetes, hematuria, and insomnia. As part of continuing research projects to discover interesting natural compounds with biological activities from Korean medicinal plants, the phytochemical investigation of L. cuneata resulted in the isolation of five chemical constituents: α-tocopherol (1), 7a-methoxy-α-tocopherol (2), 13(R)-hydroxy-octadeca-(9Z,11E,15Z)-trien-oic acid (3), α-dimorphecolic acid (4), and lupeol (5). The structural determination of the isolated compounds was elucidated from data gathered through nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography–mass spectrometry (LC/MS). Until now, this study is the first to report these five compounds from the plant L. cuneata. Moreover, these isolated compounds (1–5) were evaluated for their anti-adipogenesis effects and their role in lipid metabolism during adipocyte maturation. As a result, the upregulation of mRNA expression levels of Fabp4 from 3T3-L1 pre-adipocytes treated with compounds 3 and 4 demonstrated that these compounds efficiently induced adipocyte differentiation. Furthermore, compounds 3 and 4 were found to regulate lipid metabolism by the induction of lipolytic and of lipogenic gene expressions. Therefore, experimental data from these findings supported that the compounds 3 and 4 induce the adipogenesis of 3T3-L1 pre-adipocytes and regulate lipid metabolism.

scholarly journals Synthesis of Multi-Substituted Pyrrole Derivatives Through [3+2] Cycloaddition with Tosylmethyl Isocyanides (TosMICs) and Electron-Deficient Compounds

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2666 ◽  
Author(s):  
Zhengning Ma ◽  
Zicheng Ma ◽  
Dawei Zhang
Keyword(s):  
Natural Product ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Cycloaddition Reaction ◽  
Synthesis Methods ◽  
Pyrrole Derivatives ◽  
The Past ◽  
Different Types ◽  
Product Structures ◽  
Core Framework

Pyrrole and its polysubstituted derivatives are important five-membered heterocyclic compounds, which exist alone or as a core framework in many pharmaceutical and natural product structures, some of which have good biological activities. The Van Leusen [3+2] cycloaddition reaction based on tosylmethyl isocyanides (TosMICs) and electron-deficient compounds as a substrate, which has been continuously developed due to its advantages such as operationally simple, easily available starting materials, and broadly range of substrates, is one of the most convenient methods to synthetize pyrrole heterocycles. In this review, we discuss the different types of two carbon synthons in the Van Leusen pyrrole reaction and give a summary of the progress of these synthesis methods in the past two decades.

MECHANISM FOR COMMITTING CORRUPTION-RELATED CRIMES BY DELIVERING PROHIBITED ITEMS TO THE TERRITORY OF INSTITUTIONS THAT PROVIDE ISOLATION FROM SOCIETY

2020 ◽  
pp. 27-34
Author(s):  
Надежда Викторовна Грязева
Keyword(s):  
Criminal Activity ◽  
Relevant Information ◽  
Penal System ◽  
Correctional Institutions ◽  
Criminal Cases ◽  
Close Attention ◽  
The Past ◽  
The Subject ◽  
The Russian Federation ◽  
Special Environment

В работе представлен механизм совершения коррупционных преступлений посредством доставки запрещенных предметов на территорию исправительных учреждений лицами из числа сотрудников органов и учреждений УИС, который изложен в виде последовательного (поэтапного) ряда процессов взаимодействия участников события прошлого, результатом которых являются следы-отображения, содержащие криминалистически значимую информацию о самом преступлении и участвующих в нем лицах. Пристальное внимание уделено преступной деятельности субъектов - должностных лиц органов и учреждений УИС - как системообразующему элементу рассматриваемой криминалистической категории. Субъектам расследования - следователям Следственного комитета РФ - для полноты, всесторонности и объективности установления обстоятельств по уголовным делам необходимо изучение закономерностей преступной деятельности должностных лиц, совершающих коррупционные преступления, проявляющихся в окружающей обстановке в виде материальных и идеальных следов, а также специфики деятельности учреждений УИС, образующей особую обстановку, элементы которой используют участники преступного события. В статье обозначены основные элементы механизма преступлений рассматриваемой группы: преступная деятельность субъекта; поведение и деятельность иных участников события; обстановка совершения преступления; отдельные элементы обстановки, используемые участниками события; орудия, средства преступления и иные предметы, используемые для достижения цели преступления; обстоятельства, положительно или отрицательно влияющие на достижение планируемого результата. На основе общего представления о механизме преступления и практических материалов в работе представлены основные этапы совершения коррупционных преступлений сотрудниками учреждений, обеспечивающих изоляцию от общества. The article presents the mechanism of committing corruption-related crimes by the delivery of prohibited items to the territory of correctional institutions by officers and employers of bodies and institutions of the penal system, which is set out in a sequential (phased) of a number of processes of interaction of participants of events of the past, resulting in traces of the display that contains forensically relevant information about the crime and involved persons. Close attention is paid to the criminal activity of subjects-officials of bodies and institutions of the penal system, as a system-forming element of the considered criminalistic category. The subjects of the investigation - the investigators of the Investigative Committee of the Russian Federation for completeness, comprehensiveness and objectivity of establishing the circumstances in criminal cases it is necessary to study patterns of criminal activity of officials committing crimes of corruption, manifested in the environment in the form of material and ideal traces, and also specificity of activity of establishments the FPS forming a special environment whose elements are using members of the criminal event. The article outlines the main elements of the mechanism of crimes groups: criminal activities of the subject; the behavior and activity of other participants of the event; the scene of the crime; individual elements of the scene used by the participants of the event; implements, tools of crime and other items used to achieve the goal of the crime; the circumstances positively or negatively influence the achievement of the planned result. Based on a general understanding of the mechanism of crime and practical materials, the paper presents the main stages of committing corruption crimes by employees of institutions that provide isolation from society.

scholarly journals Stagnation of Social Partnership in Russia

2020 ◽  
Vol 16 (1) ◽  
pp. 70-74
Author(s):  
Oleg V. Neterebskiy
Keyword(s):  
Russian Federation ◽  
Social Partnership ◽  
The Past ◽  
Social Risks ◽  
Social Standards ◽  
Role Of The State ◽  
The Social ◽  
The Subject ◽  
The Russian Federation

The Object of the Study. The system of social partnership in the Russian Federation. The Subject of the Study. Agreements of the social partnership system of the Russian Federation at various levels (federal, territorial, sectoral). The Purpose of the Study. Identification of trends and main causes of changes in the agreements of the social partnership system in the Russian Federation at various levels and their impact on basic social standards. The Main Provisions of the Article. The author analyzes the agreements of the federal, sectoral and territorial levels of the social partnership system of the Rossiyskaya Federatsiya in chronological dynamics and examines the causes and trends of stagnation of social partnership The analysis of specific obligations of the parties to the agreements, shows a departure from the positive practices developed in the past shows the declarativity of social partnership agreements of the last period and the increasing role of the state while reducing the influence of civil society institutions and related social risks.

scholarly journals PRESERVING THE MEMORY OF THE GREAT PATRIOTIC WAR IN THE RUSSIAN ONOMASTIC SPACE

2020 ◽  
Vol 23 (4) ◽  
pp. 89-98
Author(s):  
Sergei A. Popov ◽  
◽  
Ksenia M. Gerasimova ◽  
Keyword(s):  
Significant Contribution ◽  
Historical Memory ◽  
Main Attention ◽  
The Past ◽  
Sports Events ◽  
The People ◽  
Great Patriotic War ◽  
History Of ◽  
The Subject ◽  
The Russian Federation

The subject of analysis in this article is the ranks of proper names that have entered the onomastic space of Russia over the past 75 years, in which the memory of the heroes and events of the Great Patriotic War of 1941–1945 has been preserved. The purpose of the work is to identify the specificity of onomastic units associated with the specified period in the history of our country. The authors of the article suggest calling them heroic toponyms, ergonyms, carabonyms, etc. According to the authors, the onomastic space of the Russian Federation is currently one of the most reliable types of historical memory of the people, since the names, surnames, and occupations of people who have made a significant contribution to the history of a particular settlement, region or country in overall, as well as the names of historical events. The process of this onomastic nomination is presented as part of the state policy of memory. The article examines in the aspect of commemoration toponyms, microtoponyms, oikonyms, urbanonyms, oronyms, carabonyms, astronyms, cosmonyms, ergonyms, as well as modern memorial sports events dedicated to the events and heroes of the Great Patriotic War of 1941-1945. The main attention is paid to heroic toponymy, in particular, the specificity of the commemorative nomination in the settlements on the territory of which during the war years hostilities took place (hero cities, cities of military glory, settlements of military valor) are highlighted. The authors come to the conclusion that reliable information about one of the most difficult periods of Russian history will be reliably transmitted from generation to generation through the onomastic space of Russia.

scholarly journals Item in dependability: definition and content of the concept

Dependability ◽  
2019 ◽  
Vol 19 (4) ◽  
pp. 3-7 ◽  
Author(s):  
V. A. Netes
Keyword(s):  
Comparative Analysis ◽  
International Standards ◽  
The Past ◽  
Different Types ◽  
The Subject ◽  
Federal Laws ◽  
Basic Concepts ◽  
Definition Of ◽  
Correct Understanding ◽  
The Relationship

Aim. The paper continues the series of publications that investigate and discuss the essence and definitions of the basic concepts of the dependability theory. It analyzes the basic concept, which is the subject of consideration in dependability, for which the term “item” is usually used. The concept of “dependability” is defined for it, and in general all the terminology of dependability applies to it. The following issues are considered: how to name and define this subject of consideration, what it can be, what can be its constituents. In particular, the relationship between the concepts of “item” and “product” is discussed.Methods. The evolution of definitions of this concept in the Russian and international terminological standards in dependability over the past 30 years is traced. A comparative analysis of other standards and federal laws relating to items of different types is carried out. The viability of two main ways of getting an idea of a concept is considered: illustrative (based on examples) and definitional (by means of sequential definition of some concepts through others).Findings and conclusions. The definition and correct understanding of the concept of “item” is of great importance, as it affects the scope of dependability standards. It is explained why it is necessary to accept that the definitions of the basic concepts cannot be rigorously formalized and are in fact only explanations. It is shown that the definitions of the item in the existing Russian and international standards (GOST 27.002–2015 and IEC 60050-192:2015) have inaccuracies. To eliminate them, improved notes to the definition of an item are proposed. The first note lists the possible types of items: products (parts, assembly units, complexes) and their components; buildings and structures; systems consisting of jointly functioning products and structures and their subsystems. The second note indicates the relationship between the main constituents of the item: hardware, software and people (personnel), and their possible combinations. The paper provides reasons for considering virtual items that play an important role in today’s information and telecommunication technologies and are logically isolated subsystems within the systems that they are part of. Besides that, it points out the deficiencies in the definitions of various items in GOST 18322–2016.

Termination of the contract on the service in the criminal executive system of the Russian Federation: analysis of legislation and judicial practice

2020 ◽  
pp. 155-161
Author(s):  
Юлия Александровна Борзенко
Keyword(s):  
Russian Federation ◽  
Penal System ◽  
The Past ◽  
Judicial Practice ◽  
Personal Opinion ◽  
The Subject ◽  
The Russian Federation ◽  
Executive System ◽  
The Law ◽  
Correction System

1 августа 2020 г. будет ровно два года, как действует долгожданный сотрудниками уголовно-исполнительной системы Федеральный закон от 19.07.2018 № 197-ФЗ «О службе в уголовно-исполнительной системе Российской Федерации и о внесении изменений в Закон Российской Федерации “Об учреждениях и органах, исполняющих уголовные наказания в виде лишения свободы”» (далее - Закон «О службе в УИС»). Прошедший срок уже позволяет сделать выводы об эффективности его положений, коллизиях и пробелах в нормах с позиции правоприменителя и сложившейся судебной практики. К сожалению, отсутствие доктринальных трудов по рассматриваемому вопросу исключает возможность дискуссии в рамках статьи. Безусловно, все положения Закона «О службе в УИС» заслуживают детального внимания, но, по нашему мнению, особую социальную значимость и озабоченность для сотрудников, проходящих службу, вызывают нормы главы 12 Закона «О службе в УИС», регламентирующей основания и порядок прекращения и расторжения контракта о службе в УИС. В статье проведен анализ отдельных норм Закона «О службе в УИС», касающихся расторжения контракта и увольнения сотрудников УИС, выбор анализируемых положений обуславливается сложившейся судебной практикой и личным мнением автора о последовательном изучении ст. 84 рассматриваемого нормативного акта. Не исключено, что в последующем автор вернется к рассматриваемой теме и продолжит исследование не изученных в настоящей статье положений главы 12 Закона «О службе в УИС». On August 1, 2020, there will be exactly two years since the long-awaited Federal Penitentiary System Act of July 19, 2018 N 197-ФЗ On Serving in the Penitentiary System of the Russian Federation and on Amending the Law of the Russian Federation On Institutions and Bodies performing criminal sentences of imprisonment ”(hereinafter - the Law “On Service in the Penal Correction System”). The past term already allows us to draw conclusions about the effectiveness of its provisions, the gaps in the norms, not only on the basis of doctrinal analysis, but also from the perspective of the law enforcer, the prevailing judicial practice. Of course, all the provisions of the Law “On Service in the Penal Administration” deserve detailed attention, but, in our opinion, the norms of chapter 12 of the Law “On Service in the Penal Administration”, which regulates the grounds and procedure for terminating and termination of the service contract in the penal correction system. The article analyzes certain provisions of the Law “On Service in the Penal Correction System” regarding termination of the contract and dismissal of the penal system; the choice of the analyzed provisions is determined by the prevailing judicial practice and the author’s personal opinion on the consistent study of Art. 84 of the considered normative act. It is possible that in the future, the author will return to the subject under consideration and continue the study of the provisions of chapter 12 of the Law “On Service in the Penal Correction System” that are not studied in this article.

scholarly journals The correlation between the phenolic composition and biological activities of two varieties of Brazilian propolis (G6 and G12)

2012 ◽  
Vol 48 (3) ◽  
pp. 557-564 ◽  
Author(s):  
Ingridy Simone Ribeiro Cabral ◽  
Tatiane Luiza Cadorin Oldoni ◽  
Severino Matias de Alencar ◽  
Pedro Luiz Rosalen ◽  
Masaharu Ikegaki
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Cytotoxic Activities ◽  
Phenolic Composition ◽  
Flavonoid Content ◽  
Biological Assays ◽  
Different Types ◽  
Brazilian Propolis ◽  
Strong Antimicrobial Activity

Biological assays that have been performed on different types of Brazilian propolis have shown that type 6 propolis (G6) has a strong antimicrobial activity and a low flavonoid content. This study aimed to evaluate the correlation between the phenolic composition and the biological activities displayed by propolis G6 from the state of Bahia and green propolis, also known as type 12 (G12). The values of the flavonoids and the total phenolics in propolis G6 were different than those in propolis G12. Although the G12 variety presented greater antioxidant activity, propolis G6 proved to have greater antimicrobial and cytotoxic activities. The results showed that the phenolic compounds may not be the only compounds responsible for the biological activity. More detailed studies of the chemical composition and an assessment of the biological activity are required to establish the quality of propolis.

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