Formulasi Sediaan Krim Ekstrak Etanol Daun Puding Hitam (Graptophyllum Pictum (L.) Griff)

2018 ◽  
Vol 3 (1) ◽  
pp. 43
Author(s):  
Elmitra Elmitra ◽  
Setya Enti Rikomah
Keyword(s):  
Physical Properties ◽  
Ethanol Extract ◽  
Ash Content ◽  
Test Results ◽  
Extract Concentration ◽  
The People ◽  
The Us ◽  
Anti Inflammatory ◽  
Dispersive Power

Daun puding hitam <em>(Graftophyllum pictum</em> (L.) Griff<em>)</em> oleh masyarakat dimanfaatkan untuk pengobatan antiinflamasi, obat luka dan bisul. Penggunaan daun puding hitam sebagai obat luar masih sangat sederhana dengan cara menghaluskan daun puding hitam dengan air secukupnya kemudian dioleskan sehingga memerlukan waktu untuk membuatnya. Penelitian ini bertujuan untuk membuat ekstrak etanol daun puding hitam dalam bentuk krim sehingga memudahkan dalam penggunaannya. Pembuatan ekstrak dilakukan dengan metode maserasi menggunakan etanol 70%. Ekstrak etanol daun puding hitam dilakukan evaluasi ekstrak meliputi organoleptis, pH, Kelarutan, kadar abu dan uji flavonoid. Ekstrak kemudian diformulasi menjadi krim dengan konsentrasi 10%, 15% dan 20% dan dievaluasi selama 3 minggu meliputi sifat fisiknya meliputi warna, bau, konsistensi, pH, homogenitas dan daya sebar. Data yang diperoleh dari uji pH dan daya sebar dianalisis secara statistik dengan ANOVA <em>One way</em>. Hasil uji pH didapat nilai sig 0.000 (&lt;0.05) yang menunjukkan bahwa konsentrasi ekstrak mempengaruhi pH sediaan krim. pH pada penyimpanan stabil dengan nilai sig 0.994 (&gt;0.05). Konsentrasi ekstrak tidak mempengaruhi daya sebar dengan nilai sig 0.910 (&gt;0.05), tetapi mempengaruhi warna. Semakin tinggi konsentrasi ekstrak semakin pekat warna krim. Krim bersifat homogen, pH 5-6 dan tidak mengiritasi kulit pada 10 orang panelis, tetapi tidak memenuhi syarat daya sebar yang baik.<p><em>Leaves of puding hitam (Graftophyllum pictum (L.) Griff) is used by the people as anti-inflammatory treatment, cure wounds and ulcers. The us of leaves puding hitam as external medicine is very simply by mixed puding hitam leaves with water then it can be applied but it takes a time to make it. This reseach objective make ethanol extract of puding hitam as a cream so it more easy in using. Making extraction is done by maceration method us ethanol 70%. The ethanol extract of leaves puding hitam is evaluatid includes extracts organoleptic, pH, solubility, ash content and flavonoid test. Then it’s formulated into a cream with 10%, 15% and 20% concentration. The evaluated is done in three weeks include physical properties color, odor, consistency, pH, homogeneity and dispersive power. This data is obtained from the scatter pH test and statistically analyzed by ANOVA One way. The pH test results obtained sig 0.000 (&lt; 0.05), indicating that the concentration of the extract affects the pH of the cream preparations. pH stable on storage with sig 0.994 (&gt; 0.05). The extract concentration did not affect the scatter with sig 0.910 (&gt;0.05), but it can more affects of the color. The higher concentration of extract will be more dark to cream color. Cream is homogeneous, pH 5-6 and does not irritate the skin at the 10 panelists, but did not qualify good dispersive power.</em></p>

scholarly journals FORMULASI SEDIAAN KRIM A/M DENGAN VARIASI KONSENTRASI EKSTRAK ETANOL DAGING BUAH PEPAYA (Carica Papaya) MENGGUNAKAN EMULGATOR TWEEN 80 DAN SPAN 80

Media Farmasi ◽  
2020 ◽  
Vol 16 (1) ◽  
pp. 33
Author(s):  
Gita Puspita ◽  
Nining Sugihartini ◽  
Iis Wahyuningsih
Keyword(s):  
Phase Separation ◽  
Physical Properties ◽  
Carica Papaya ◽  
Physical Stability ◽  
Ethanol Extract ◽  
Tween 80 ◽  
Test Results ◽  
Fruit Extract ◽  
Extract Concentration ◽  
Span 80

Papaya (Carica papaya) contains flavonoid and phenolic compounds proven to have sunscreen and antithyrosinase activity. For this reason, there is a need to formulate them in the form of cream preparations. This study analyzes the effect of the ethanol extract concentration of papaya flesh in the form of A / M cream preparations on their physical properties. The extracts were obtained using the maceration method with 70% ethanol solvent in A / M cream preparations and concentrations of 1%, 3%, and 5% through Tween 80 and Span 80 emulgators. Creams were evaluated for physical properties, including pH, adhesion, dispersion, viscosity, and physical stability. The test results showed that an increase in the concentration of ethanol extract led to a decrease in pH (p <0.05), viscosity (p <0.05), adhesion (p <0.05), and an increase in dispersion (p <0.05). Additionally, phase separation occurs at a concentration of 5% papaya fruit extract cream. These results show that variations in the ethanol extract concentration of papaya fruit influence the physical properties of A / M cream.Keywords: Carica papaya; A / M cream; Physical Properties.Pepaya (Carica papaya) mengandung senyawa flavonoid dan fenolik  yang terbukti memiliki aktivitas sebagai tabir surya dan antitirosinase sehingga perlu diformulasikan dalam bentuk sediaan krim. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh konsentrasi ekstrak etanol daging buah papaya dalam bentuk sediaan krim A/M terhadap sifat fisik sediaan. Ekstraksi buah papaya diperoleh dengan metode maserasi dengan pelarut etanol 70% dalam sediaan krim A/M dengan konsentrasi 1% (FI), 3% (F2) Dan 5% (F3). Krim dievaluasi sifat fisik meliputi pH, daya lekat, dan daya sebar, viskositas dan stabilitas fisik. Hasil uji menunjukkan bahwa peningkatan konsentrasi ekstrak etanol buah papaya menyebabkan penurunan pH (p<0.05), viskositas (p<0.05), daya lekat (p<0.05), peningkatan daya sebar (p<0.05). Terjadi pemisahan fase pada konsentrasi 5% krim ekstrak buah papaya. Berdasarkan hasil dapat disimpulkan bahwa variasi konsentrasi ekstrak etanol daging buah papaya memiliki pengaruh terhadap sifat fisik krim A/MKata kunci : Carica papaya; krim A/M; Sifat Fisik

scholarly journals Anti-Inflammatory Potential of Takokak (Solanum Torvum) Ethanol Extract in Rats Exposed to 7,12-Dimethylbenz[A]Anthracene (Dmba)

2015 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
Nur Rahman ◽  
Sri Anna Marliyati ◽  
Muhammad Rizal Martua Damanik ◽  
Faisal Anwar
Keyword(s):  
Body Weight ◽  
Study Design ◽  
Concentration Factor ◽  
Ethanol Extract ◽  
Solanum Torvum ◽  
Extract Concentration ◽  
Tnf Α ◽  
Anti Cancer ◽  
Administration Time ◽  
Anti Inflammatory

Background: Takokak fruit (Solanum torvum) is a type of eggplant containing solasodin, solamargin, solasonin and other phytochemicals components with anti-inflammatory and anti-cancer properties. The purpose of this study was to examine the effects of takokak ethanol extract on TNF-α, IL6, and SOD levels.Methods: Experimental factorial study design, with the effect of takokak extract concentration factor (0, 400 and 800 mg/kgBW), takokak extract administration time factor including preventive (weeks 1-7) and curative (weeks 6-12) administration, and necropsy factor (necropsy in weeks 12 and 16). The data obtained included rats body weight, TNF-α, IL-6 and SOD levels.Results: The result showed that the interaction between takokak concentration and handling has significant effect on the increase of TNF-α levels (p=0.003) and the decrease of IL-6 levels (p=0.000). Interaction between takokak concentration, handling and necropsy has significant effect on the increase of SOD levels (p=0.010).Conclusion: Takokak ethanol extract has significant effect on the increase of TNF-α, and SOD levels, and the decrease of IL-6 levels.

scholarly journals PERBANDINGAN EKSTRAK LAMUR Aquilaria malaccensis DENGAN METODE MASERASI DAN REFLUKS

2020 ◽  
Vol 2 (2) ◽  
pp. 97-104
Author(s):  
Eka Siswanto Syamsul ◽  
Nadhila Ajrina Amanda ◽  
Dwi Lestari
Keyword(s):  
Data Analysis ◽  
Ethanol Extract ◽  
Extraction Process ◽  
Test Method ◽  
Test Results ◽  
Phytochemical Screening ◽  
The People ◽  
Aquilaria Malaccensis ◽  
Stomach Pain ◽  
Significant Difference

Gaharu (Aquilaria malaccensis Lamk) is a plant of the thymelaeaceae family that is widely used by the people of West Kutai Regency as a medicinal plant for skin wounds, diabetes, asthma, stomach pain and sleep disorders, aromatherapy and used as ingredients for perfume because it has a distinctive aroma. The extraction process will determine how much yield is produced. This study aims to determine the percent (%) yield of agarwood leaf ethanol extract using maceration and reflux methods. The research stage includes plant determination, sample processing, extraction using maceration and reflux methods with 70% ethanol solvent, determination of the yield and phytochemical screening. Data analysis in the form of descriptive data analysis and presented in tabular form. The results showed that the reflux method produced a higher average yield of 30.70% and maceration method of 29.97%. Statistical test results using the Independent Sample T-Test method showed that there was no significant difference in the yield produced from the maceration and reflux method because (p> 0.05). Phytochemical screening test results showed that agarwood leaf extract contains flavonoids, tannins, saponins and steroids

scholarly journals STANDARISASI NON SPESIFIK EKSTRAK ETANOL DAUN KECAPI (Sandoricum koetjape Merr.) DAN EKSTRAK ETANOL DAUN KELUWIH (Artocarpus communis)

2020 ◽  
Vol 16 (02) ◽  
pp. 105
Author(s):  
Maria Ulfah ◽  
Dhia Salsabilla ◽  
Evi Sukawati
Keyword(s):  
Heavy Metal ◽  
Water Content ◽  
Metal Contamination ◽  
Heavy Metal Contamination ◽  
Ethanol Extract ◽  
Ash Content ◽  
Contamination Level ◽  
Test Results ◽  
Standard Parameter ◽  
Sandoricum Koetjape

ABSTRACT The chemicals contained in an extract must be maintained its quality. The aim of this study is to prove both that the ethanol extract of kecapi (Sandoricum koetjape, Merr.) and keluwih (Artocarpus communis) leaves meet the non-specific parameters on the standardization of the extract. The ethanol extract of kecapi and keluwih leaves were extracted using the ultrasonic method. The extract was tested with non-specific parameters including water content, total ash content and metal contamination level. The test results are compared with standard parameter references. Ethanol extract of kecapi leaf have water content of 27.75% ± 1.708, total ash content of 4.856% ± 0.040 and levels of As metal contamination < 0.030 mg/Kg, Hg < 0.002 mg/Kg, Pb < 0.400 mg/Kg, while ethanol extract of keluwih leaf have water content of 23.206 ± 0.091%, total ash content of 9,678 ± 0.306% and levels of heavy metal contamination of As < 0.03 mg/Kg, Hg < 0.006 mg/Kg, Pb < 0.02 mg/Kg. The both extract meet the standard parameters of water content, total ash content and levels heavy metal contamination. Key words: kecapi leaves (Sandoricum koetjape, Merr.), keluwih leaves (Artocarpus communis), non-specific standardization

UJI AKTIVITAS EKSTRAK ETANOL GAMBIR (Uncaria gambir Roxb.) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KULIT PUNGGUNG MENCIT PUTIH JANTAN (Mus musculus)

2017 ◽  
Vol 1 (2) ◽  
pp. 133
Author(s):  
Fitri Handayani ◽  
Eka Siswanto ◽  
Lintang Ayu Trisna Pangesti
Keyword(s):  
Treatment Group ◽  
Healing Process ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Test Results ◽  
Anova Analysis ◽  
The People

Gambir (Uncaria gambir Roxb.) contains flavonoids, tannins, saponins and alkaloids that can help in the healing process of burns on the back skin of mice. Gambir has been used for the treatment because it has the effect of antimicrobial and anti-inflammatory. Gambir is used by the people as a traditional medicine to treat burns.This research is experimental research. The object studied is the potential of gambir extract on healing burns of mice back skin. The number of mice used are 15 which divided into 5 groups: the positive control group (branded ointment), negative control group (vaseline flavum), group of gambir ethanol extract and vaseline flavum concentration of 25%, 35%, and 45%. Each group consisted of 3 mice.Backs of the mice induced using a heated solder which tip contained stainlees plate measuring 1x1 cm and placed for 2 seconds on the back skin of mice. The percentage of burns healing is obtained by calculating the surface area of the wound. The data were analyzed using ANOVA analysis followed by LSD test. The results showed that ethanol extract of gambir concentration of 25% with the healing burns percentage of (72.00%), the concentration of 35% (85.00%), and the concentration of 45% (88.67%) have activity on healing burns of back skin of mice. The results of data analysis using ANOVA showed that the data has significant differences with a significance value <0.05 is 0.000. LSD test results stated that each treatment group have significant differences with a significance value <0.05. It can be seen that with increasing dose will be followed by duration of burns healing

scholarly journals STANDARISASI NON SPESIFIK EKSTRAK ETANOL DAUN KECAPI (Sandoricum koetjape Merr.) DAN EKSTRAK ETANOL DAUN KELUWIH (Artocarpus communis)

2019 ◽  
Vol 16 (02) ◽  
pp. 20
Author(s):  
Maria Ulfah ◽  
Dhia Salsabilla ◽  
Evi Sukawati
Keyword(s):  
Heavy Metal ◽  
Water Content ◽  
Metal Contamination ◽  
Heavy Metal Contamination ◽  
Ethanol Extract ◽  
Ash Content ◽  
Contamination Level ◽  
Test Results ◽  
Standard Parameter ◽  
Sandoricum Koetjape

ABSTRACT The chemicals contained in an extract must be maintained its quality. The aim of this study is to prove both that the ethanol extract of kecapi (Sandoricum koetjape, Merr.) and keluwih (Artocarpus communis) leaves meet the non-specific parameters on the standardization of the extract. The ethanol extract of kecapi and keluwih leaves were extracted using the ultrasonic method. The extract was tested with non-specific parameters including water content, total ash content and metal contamination level. The test results are compared with standard parameter references. Ethanol extract of kecapi leaf have water content of 27.75% ± 1.708, total ash content of 4.856% ± 0.040 and levels of As metal contamination < 0.030 mg/Kg, Hg < 0.002 mg/Kg, Pb < 0.400 mg/Kg, while ethanol extract of keluwih leaf have water content of 23.206 ± 0.091%, total ash content of 9,678 ± 0.306% and levels of heavy metal contamination of As < 0.03 mg/Kg, Hg < 0.006 mg/Kg, Pb < 0.02 mg/Kg. The both extract meet the standard parameters of water content, total ash content and levels heavy metal contamination. Key words: kecapi leaves (Sandoricum koetjape, Merr.), keluwih leaves (Artocarpus communis), non-specific standardization

scholarly journals Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp

2019 ◽  
Vol 2 (1) ◽  
pp. 1-9
Author(s):  
Wa Ode Sitti Zubaydah ◽  
Wahyuni Wahyuni ◽  
Sahidin Sahidin ◽  
Tian Amalia Halik ◽  
Rina Andriani ◽  
...  
Keyword(s):  
Diclofenac Sodium ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Negative Control ◽  
Test Method ◽  
Inflammatory Activity ◽  
Extract Concentration ◽  
Dispersion Test ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The aim of this study was to determine the characteristics of the gel formula based on it�s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% ?-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren�gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.

scholarly journals Optimization Carbopol And Glycerol As Basis Of Hand Gel Antiseptics Extract Ethanol Ceremai Leaf (Phyllantus Acidus (L.) Skeels) With Simplex Lattice Design

2017 ◽  
Vol 2 (01) ◽  
pp. 35 ◽  
Author(s):  
Dwi Saryanti ◽  
Izzatun Ni'mah Zulfa
Keyword(s):  
Physical Properties ◽  
Ethanol Extract ◽  
Gelling Agent ◽  
Test Results ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Carbopol 940 ◽  
Phyllanthus Acidus ◽  
Simplex Lattice ◽  
The One

Ceremai leaf (<em>Phyllanthus acidus </em>(L.) Skeels) is the one of the potential plant which contain flavonoid that had antibacterial activity. Carbopol is a gelling agent that is easily dispersible in water and provide consistency to the gel, while the glycerin is a humectant that can improve the softness of the gel. Carbopol can provide viscosity / hardness in the gel it is necessary to combine with glycerin to soften the gel and the increase of the spread The aims of this research to know the optimum composition from carbopol and gliserol in antiseptic gel formulation of ceremai leaf ethanol extract by Simplex Lattice Design (SLD). The method of extraction used maseration method with ethanol 70 % solvent. extract made of gel with components carbopol 940(0-100%) and glycerin(0-100%) with respond criteria physical properties such as pH, spreadability, sticking and protection power. The optimum formulated based on Simplex Lattice Design<em> </em>was the combination of carbopol 50 % : glycerol 50 %. Optimum results are obtained gel has a good physical properties. The test results showed that the effectiveness of antiseptic hand gels have generated a good antiseptic. Acceptability test results showed that the gel can be accepted by society.

scholarly journals Formulation and physical properties of lotion Kalakai root ethanol extract (Stenochlaena palustris Bedd)

2021 ◽  
pp. 235-240
Author(s):  
Rabiatul Adawiyah ◽  
Riska Apriliyanti ◽  
Agustinawati Umaternate
Keyword(s):  
Physical Properties ◽  
Ph Value ◽  
Ethanol Extract ◽  
Quality Parameters ◽  
Root Extract ◽  
Adhesion Properties ◽  
Extract Concentration

Aim: To determine the physical (organoleptic, homogeneity, pH, dispersibility and adhesion) properties of the ethanol extract of Kalakai root lotion with a concentration of 1%, 2% and 3%. Methods: This study used the maceration method that was carried out by testing the physical properties of the lotion preparation with three concentrations, namely 1%, 2% and 3% using one type, namely the M/A type. Results: It was found that at a concentration of 3% it was a formula for the ethanol extract of Kalakai root that met the quality parameters of the good physical properties of the lotion. Conclusion: Kalakai root extract concentration influenced the physical properties of the lotion preparation tested. The higher the kalakai root extract concentration, to a concentration of 3%, did not affect the pH value or homogeneity, but the kalakai root extract lotion preparation had higher results for the spreadability and adhesion.

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