scholarly journals Handling deviating control values in concentration-response curves

2020 ◽  
Vol 94 (11) ◽  
pp. 3787-3798
Author(s):  
Franziska Kappenberg ◽  
Tim Brecklinghaus ◽  
Wiebke Albrecht ◽  
Jonathan Blum ◽  
Carola van der Wurp ◽  
...  
Keyword(s):  
Cell Biology ◽  
Negative Control ◽  
Problem Solution ◽  
Literature Study ◽  
Response Curves ◽  
Solvent Control ◽  
Real Concentration ◽  
Replicate Measurements ◽  
The Relationship ◽  
Biased Estimates

Abstract In cell biology, pharmacology and toxicology dose-response and concentration-response curves are frequently fitted to data with statistical methods. Such fits are used to derive quantitative measures (e.g. EC$$_{20}$$ 20 values) describing the relationship between the concentration of a compound or the strength of an intervention applied to cells and its effect on viability or function of these cells. Often, a reference, called negative control (or solvent control), is used to normalize the data. The negative control data sometimes deviate from the values measured for low (ineffective) test compound concentrations. In such cases, normalization of the data with respect to control values leads to biased estimates of the parameters of the concentration-response curve. Low quality estimates of effective concentrations can be the consequence. In a literature study, we found that this problem occurs in a large percentage of toxicological publications. We propose different strategies to tackle the problem, including complete omission of the controls. Data from a controlled simulation study indicate the best-suited problem solution for different data structure scenarios. This was further exemplified by a real concentration-response study. We provide the following recommendations how to handle deviating controls: (1) The log-logistic 4pLL model is a good default option. (2) When there are at least two concentrations in the no-effect range, low variances of the replicate measurements, and deviating controls, control values should be omitted before fitting the model. (3) When data are missing in the no-effect range, the Brain-Cousens model sometimes leads to better results than the default model.

Sifat-sifat Submodul Prima dan Submodul Prima Lemah

2020 ◽  
Vol 2 (2) ◽  
pp. 183
Author(s):  
Hisyam Ihsan ◽  
Muhammad Abdy ◽  
Samsu Alam B
Keyword(s):  
Prime Ideal ◽  
Literature Study ◽  
Prime Submodules ◽  
Unitary Module ◽  
Prime Submodule ◽  
Definition Of ◽  
The Relationship

Penelitian ini merupakan penelitian kajian pustaka yang bertujuan untuk mengkaji sifat-sifat submodul prima dan submodul prima lemah serta hubungan antara keduanya. Kajian dimulai dari definisi submodul prima dan submodul prima lemah, selanjutnya dikaji mengenai sifat-sifat dari keduanya. Pada penelitian ini, semua ring yang diberikan adalah ring komutatif dengan unsur kesatuan dan modul yang diberikan adalah modul uniter. Sebagai hasil dari penelitian ini diperoleh beberapa pernyataan yang ekuivalen, misalkan  suatu -modul ,  submodul sejati di  dan ideal di , maka ketiga pernyataan berikut ekuivalen, (1)  merupakan submodul prima, (2) Setiap submodul tak nol dari   -modul memiliki annihilator yang sama, (3) Untuk setiap submodul  di , subring  di , jika berlaku  maka  atau . Di lain hal, pada submodul prima lemah jika diberikan  suatu -modul,  submodul sejati di , maka pernyataan berikut ekuivalen, yaitu (1) Submodul  merupakan submodul prima lemah, (2) Untuk setiap , jika  maka . Selain itu, didapatkan pula hubungan antara keduanya, yaitu setiap submodul prima merupakan submodul prima lemah.Kata Kunci: Submodul Prima, Submodul Prima Lemah, Ideal Prima. This research is literature study that aims to examine the properties of prime submodules and weakly prime submodules and the relationship between  both of them. The study starts from the definition of prime submodules and weakly prime submodules, then reviewed about the properties both of them. Throughout this paper all rings are commutative with identity and all modules are unitary. As the result of this research, obtained several equivalent statements, let  be a -module,  be a proper submodule of  and  ideal of , then the following three statetments are equivalent, (1)  is a prime submodule, (2) Every nonzero submodule of   -module has the same annihilator, (3) For any submodule  of , subring  of , if  then  or . In other case, for weakly prime submodules, if given  is a unitary -module,  be a proper submodule of , then the following statements are equivalent, (1)  is a weakly prime submodule, (2) For any , if  then . In addition, also found the relationship between both of them, i.e. any prime submodule is weakly prime submodule.Keywords: Prime Submodules, Weakly Prime Submdules, Prime Ideal.

Learning from intelligent conversation

IMP Journal ◽  
2016 ◽  
Vol 10 (3) ◽  
pp. 512-539 ◽  
Author(s):  
Luitzen De Boer ◽  
Poul Houman Andersen
Keyword(s):  
System Theory ◽  
Design Methodology ◽  
Historical Analysis ◽  
Research Field ◽  
Literature Study ◽  
Content Type ◽  
Narrative Literature ◽  
The Relationship ◽  
Conceptual Research

Purpose The purpose of the paper is to contribute to further advancing of IMP as a research field by setting up and starting a theoretical conversation between system theory and the IMP. Design/methodology/approach The approach is based on a narrative literature study and conceptual research. Findings The authors find that system theory and cybernetics can be regarded as important sources of inspiration for early IMP research. The authors identify three specific theoretical “puzzles” in system theory that may serve as useful topics for discussion between system theorists and IMP researchers. Originality/value Only a handful of papers have touched upon the relationship between system theory and IMP before. This paper combines a narrative, historical analysis of this relationship with developing specific suggestions for using system theory as a vehicle for further advancement of IMP research.

scholarly journals THE ANTHELMINTIC EFFECTS OF ETHANOL EXTRACT OF CURANGA FEL-TERRAE LEAVES ON ASCARIDIA GALLI

2017 ◽  
Vol 10 (3) ◽  
pp. 117 ◽  
Author(s):  
Popi Patilaya ◽  
Dadang Irfan Husori ◽  
Imam Bagus Sumantri
Keyword(s):  
Sodium Chloride ◽  
Plant Extract ◽  
Room Temperature ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Ascaridia Galli ◽  
Plant Leaves ◽  
Sodium Carboxymethylcellulose ◽  
Solvent Control

ABSTRACTObjective: This study was to investigate the anthelmintic effects of ethanol extract of Curanga fel-terrae leaves on Ascaridia galli.Methods: Extract of C. fel-terrae was prepared by percolating the dried powder of the plant leaves. To observe anthelmintic effects, A. galli wasexposed to the plant extract solutions in different concentrations at room temperature for 72 hrs. Sodium chloride 0.9%, sodium carboxymethylcellulose 0.5%, and albendazole 0.1% were served as negative control, solvent control, and positive control, respectively. The anthelmintic effectswere determined by observing the time taken for paralysis and the time taken for death of A. galli during experiment.Results: The results demonstrated that there were no different effects between negative and solvent controls. However, the ethanol extract ofC. fel-terrae leaves exhibited significantly paralysis and death effects toward A. galli. The plant extracts at the concentration of 100 mg/ml showedsimilar anthelmintic effects with albendazole 0.1%. This study also indicated that the paralysis and death effects of plant extract were shorter whenthe worms exposed with the concentration above of 100 mg/ml.Conclusion: This study indicated that the ethanol extract of C. fel-terrae leaves has potential anthelmintic effects on A. galli.Keywords: Curanga fel-terrae, Ascaridia galli, Anthelmintic, Helminthiasis, Ascariasis. 

scholarly journals The Impact of Gadget Use on the Aspects of Early Childhood Language Development during Covid-19

2021 ◽  
Vol 3 (1) ◽  
pp. 01-07
Author(s):  
Vebionita Megi Putri ◽  
Delfi Eliza
Keyword(s):  
Early Childhood ◽  
Language Development ◽  
Literature Study ◽  
Men And Women ◽  
Use Of Technology ◽  
Entire World ◽  
Learning At Home ◽  
The Government ◽  
The Impact ◽  
The Relationship

Children are generations or descendants as a result of the relationship between men and women, whether in marriage or not. Early childhood is an individual who is experiencing a period of very rapid growth, even though now the entire world is experiencing the Covid-19 pandemic, it is not an obstacle to children's development and growth. With the pandemic, the government is implementing learning at home, the use of technology media is the main key in online learning. This study aims to describe the impact of using gadgets in early childhood in the aspects of language development. This research was conducted using the literature study method in which journals, books and other sources reinforce this research.

scholarly journals RELASI AGAMA DAN NEGARA

2017 ◽  
Vol 10 (2) ◽  
pp. 1-21
Author(s):  
Edi Gunawan
Keyword(s):  
Human Rights ◽  
Religious Freedom ◽  
Human Beings ◽  
Literature Study ◽  
Islamic Thought ◽  
Religion And State ◽  
The Right ◽  
State Relations ◽  
The Relationship ◽  
Descriptive Method

This paper examines religious and state relations of Islamic thought perspective. This study aims to describe how the relationship between religion and state in the view of Islam. The method used in obtaining data is descriptive method through literature study. The results of the study show that among Muslim figures or thinkers such as Nurcholish Madjid and Abdur Rahman Wahid agree that there is a constructive relationship between state and religion which by revivalists separates it. Some of the indicators are: (1) Islam gives the principles of the formation of a state with the concept of khalīfah ,dawlah, or hukūmah, (2) Islam emphasizes the democratic values of truth and justice, and (3) Islam upholds Human Rights by stating that the basic rights that human beings bring ever since they are born are the right of religious freedom. Therefore, Islam essentially emphasizes the importance of human rights to be upheld in a state, because human rights are rights that should not be disturbed and deprived from the person who has the right.

scholarly journals Makna Kekerabatan Dalam Budaya Lonto Leok Pada Proses Pilkada Di Manggarai Barat

2021 ◽  
Vol 9 (1) ◽  
pp. 9-19
Author(s):  
Benedictus Simangunsong ◽  
Felisianus N. Rahmat
Keyword(s):  
Political Process ◽  
Secondary Data ◽  
Primary Data ◽  
Literature Study ◽  
Election Process ◽  
The Everyday ◽  
Kinship Ties ◽  
The Relationship ◽  
Depth Interviews

                                                                        Abstrak Budaya memainkan peran yang sangat penting dalam politik karena menjadi cerminan masyarakat dalam menentukan sikap dan pilihan politik atau membentuk karakteristik masyarakat dalam berpolitik. Contoh dari hubungan antara budaya dan politik bisa tergambarkan pada isu kekerabatan  pada pilkada Manggarai Barat 2020 yang dibahas dalam penelitian ini. Fenomena kekerabatan yang dimaksud adalah adanya kecenderungan dari masyarakat Manggarai Barat pada umumnya untuk memilih pemimpin yang seasal atau karena faktor kekerabatan dan kekeluargaan atau dikenal sebagai budaya lonto leok yang masih kuat mempengaruhi kehidupan masyarakat termasuk politik. Penelitian ini menggunakan paradigma interpretif dengan metode penelitian Fenomenologi. Adapun pengumpulan data penelitian dilakukan dengan data primer yaitu melakukan wawancara mendalam dan dokumentasi serta data sekunder berupa studi kepustakaan. Wawancara dilakukan kepada para informan yang melakukan lonto leok menjelang Pilkada Mabar Tahun 2020 dan juga pada pilkada-pilkada sebelumnya. Hasil penelitian menunjukkan bahwa makna kekerabatan dalam budaya lonto leok pada proses pilkada di Manggarai Barat adalah kebersamaan dan ketergantungan. Sementara peran budaya lonto leok dalam proses politik adalah pada saat pengambilan keputusan dan menumbuhkan ikatan kekerabatan.   Kata kunci: Budaya, Politik, Kekerabatan, Lonto Leok, fenomenologi, makna kekerabatan                                                                   Abstract   Culture plays a very important role in politics because it reflects the everyday life of society in determining political attitudes and choices or shaping the characteristics of society in politics. One of them many examples about the relationship between culture and politics can be illustrated in the issue of kinship in the 2020 West Manggarai regional election discussed in this study. The kinship phenomenon in question is the tendency of the West Manggarai community in general to choose leaders who are in the same kinship and it is known as the lonto leok culture which still strongly influences people's life, including politics. This study uses an interpretive paradigm with phenomenological research methods. The research data collection was carried out with primary data, namely conducting in-depth interviews and documentation and secondary data in the form of literature study. Interviews were conducted with informants who conducted lonto leok ahead of the 2020 Mabar Pilkada and also in the previous pilkada. The results showed that the meaning of kinship in the lonto leok culture in the election process in West Manggarai was togetherness and dependence. Meanwhile, the role of lonto leok culture in the political process is at the time of making decisions and fostering kinship ties.   Keywords: Culture, Politics, Kinship, Lonto Leok, phenomenology, meaning of kinship  

Features of using technology of project training to increase the interest of students studying biology

2020 ◽  
Vol 44 (3) ◽  
pp. 172-181
Author(s):  
G. Baitasheva ◽  
◽  
А. Musina ◽  
A. Issayeva ◽  
Zh. Myrzabaeva ◽  
...  
Keyword(s):  
Group Work ◽  
Cell Biology ◽  
Use Of Technology ◽  
Teachers And Students ◽  
Asking Questions ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship ◽  
Further Development

On the basis of the updated educational program were discussed issues of application of design technologies, in biology lessons in the section «Cell Biology» on the method of spiral training. Communication between parents, teachers and students is provided for in project technology. The point is that interest in the topic will increase by asking questions to parents. I was asked to voice my question, share my ideas through group work. The analysis of the works of these scientists is carried out and some stages of application are noted. In order to increase the interest of students studying the subject of biology, the specifics of the use of technology in project training are determined. In the field of biology are defined stages of work aimed at further development and consolidation of data on the topic «Cell Biology». The role of the teacher was shown. Highlighted the relationship of parents with children and friendship, communication in the classroom.

scholarly journals Multiscale mechanics of mucociliary clearance in the lung

2019 ◽  
Vol 375 (1792) ◽  
pp. 20190160 ◽  
Author(s):  
Janna C. Nawroth ◽  
Anne M. van der Does ◽  
Amy Ryan (Firth) ◽  
Eva Kanso
Keyword(s):  
Cell Biology ◽  
Mucociliary Clearance ◽  
Treatment Options ◽  
Diagnostic Tools ◽  
Regional Variability ◽  
Multiscale Mechanics ◽  
Airway Diseases ◽  
Open Questions ◽  
Human Lungs ◽  
The Relationship

Mucociliary clearance (MCC) is one of the most important defence mechanisms of the human respiratory system. Its failure is implicated in many chronic and debilitating airway diseases. However, due to the complexity of lung organization, we currently lack full understanding on the relationship between these regional differences in anatomy and biology and MCC functioning. For example, it is unknown whether the regional variability of airway geometry, cell biology and ciliary mechanics play a functional role in MCC. It therefore remains unclear whether the regional preference seen in some airway diseases could originate from local MCC dysfunction. Though great insights have been gained into the genetic basis of cilia ultrastructural defects in airway ciliopathies, the scaling to regional MCC function and subsequent clinical phenotype remains unpredictable. Understanding the multiscale mechanics of MCC would help elucidate genotype–phenotype relationships and enable better diagnostic tools and treatment options. Here, we review the hierarchical and variable organization of ciliated airway epithelium in human lungs and discuss how this organization relates to MCC function. We then discuss the relevancy of these structure–function relationships to current topics in lung disease research. Finally, we examine how state-of-the-art computational approaches can help address existing open questions. This article is part of the Theo Murphy meeting issue ‘Unity and diversity of cilia in locomotion and transport’.

scholarly journals Relasi Antara Investor Pariwisata Dengan Masyarakat Lokal Di Desa Pakraman Laplapan Desa Petulu Kecamatan Ubud

2018 ◽  
Vol 5 (1) ◽  
pp. 51
Author(s):  
I Ketut Agus Gita Suprapta ◽  
I Gusti Agung Oka Mahagangga
Keyword(s):  
Social Conflict ◽  
Outer Zone ◽  
Limited Resources ◽  
Middle Zone ◽  
Literature Study ◽  
Tourist Destination ◽  
Economic Resource ◽  
Good Relationship ◽  
The Relationship

The research titled is "relationship between tourism investors and lokal communities in Desa Pakraman Laplapan Petulu Village (Case Study Social Conflict)", purpose to understand the relationship undertaken by tourism investors with lokal communities that happened in the Ubud tourist destination. Data were collected through observation, interview and literature study. Infoman taken by purposive, which determine the informan with a certain considerations that are considered able to provide data to the maximum in accordance with the criteria of the research objectives. The collected data were analyzed descriptively qualitative. An important concept in the study include the concept of Typology Relations Styling in 3 Zone which consists of the outer zone, the middle zone and center zone. The results of this study indicate that, Desa Pakraman Laplapan as a region lies in the outer zone. Relationships that lived between tourism investors and lokal communities in Desa Pakraman Laplapan patterned conflictual. This pattern is shown by the regulation provided by the lokal community to tourism investors who are less rational. As for the view of the conflict is a way to snatch for limited resources. And one of them is the economic resource owned by the investor. Styling tourism investor relations with the lokal community in Desa Pakraman Laplapan has been sticking to the surface of the endless conflict. In this case, the farmer must make good relationship with tourism investors because it would help to farmers.   Keywords: Relationship, Investors, Lokal Communities, Conflict

Continuous Tonic Spike Activity in Spider Warm Cells in the Absence of Sensory Input

2006 ◽  
Vol 96 (3) ◽  
pp. 989-997 ◽  
Author(s):  
E. Gingl ◽  
H. Tichy
Keyword(s):  
Electrical Stimulation ◽  
Sensory Input ◽  
Discharge Rate ◽  
Rate Of Change ◽  
Intrinsic Properties ◽  
Response Curves ◽  
Temperature Changes ◽  
Different Temperatures ◽  
Low Amplitude ◽  
The Relationship

The warm cells of the spider tarsal organ respond very sensitively to low-amplitude changes in temperature and discharge continuously as the rate of change in temperature reaches zero. To test whether the continuous tonic discharge remains without sensory input, we blocked the warm cell's receptive region by Epoxy glue. The activity continued in this situation, but its dependence on temperature changes was strongly reduced. We interpret this to mean that the warm cells exhibit specific intrinsic properties that underlie the generation of the tonic discharge. Experiments with electrical stimulation confirmed the observation that the warm cells persist in activity without an external drive. In warm cells with blocked receptive region, the response curves describing the relationship between the tonic discharge and the level of depolarization is the same for different temperatures. In warm cells with intact receptive region, the curves are shifted upward with rising temperature, as if the injected current is simply added to the receptor current. This indicates a modulating effect of the receptor current on the tonic discharge. Stimulation causes a change in the tonic discharge rate and thereby enables individual warm cells to signal the direction in addition to the magnitude of temperature changes.

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