scholarly journals Hemodialysis biocompatibility mathematical models to predict the inflammatory biomarkers released in dialysis patients based on hemodialysis membrane characteristics and clinical practices

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Amira Abdelrasoul ◽  
Heloisa Westphalen ◽  
Shaghayegh Saadati ◽  
Ahmed Shoker
Keyword(s):  
Molecular Docking ◽  
Clinical Data ◽  
Flow Rate ◽  
Treatment Time ◽  
Morphological Characteristics ◽  
Operating Conditions ◽  
Inflammatory Biomarkers ◽  
Membrane Properties ◽  
Clinical Practices ◽  
Membrane Materials

AbstractChronic kidney disease affects millions of people around the globe and many patients rely on hemodialysis (HD) to survive. HD is associated with undesired life-threatening side effects that are linked to membrane biocompatibility and clinical operating conditions. The present study develops a mathematical model to predict the inflammatory biomarkers released in HD patients based on membrane morphology, chemistry, and interaction affinity. Based on the morphological characteristics of two clinical-grade HD membrane modules (CTA and PAES-PVP) commonly used in Canadian hospitals, a molecular docking study, and the release of inflammatory cytokines during HD and in vitro incubation experiments, we develop five sets of equations that describe the concentration of eight biomarkers (serpin/antithrombin-III, properdin, C5a, 1L-1α, 1L-1β, C5b-9, IL6, vWF). The equations developed are functions of membrane properties (pore size, roughness, chemical composition, affinity to fibrinogen, and surface charge) and HD operating conditions (blood flow rate, Qb, and treatment time, t). We expand our model based on available clinical data and increase its range of applicability in terms of flow rate and treatment time. We also modify the original equations to expand their range of applicability in terms of membrane materials, allowing the prediction and validation of the inflammatory response of several clinical and synthesized membrane materials. Our affinity-based model solely relies on theoretical values of molecular docking, which can significantly reduce the experimental load related to the development of more biocompatible materials. Our model predictions agree with experimental clinical data and can guide the development of novel materials and support evidence-based membrane synthesis of HD membranes, reducing the need for trial-and-error approaches.

scholarly journals Case studies of clinical hemodialysis membranes: influences of membrane morphology and biocompatibility on uremic blood-membrane interactions and inflammatory biomarkers

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Heloisa Westphalen ◽  
Shaghayegh Saadati ◽  
Ubong Eduok ◽  
Amira Abdelrasoul ◽  
Ahmed Shoker ◽  
...  
Keyword(s):  
Membrane Surface ◽  
Cascade Reactions ◽  
Operating Conditions ◽  
Inflammatory Biomarkers ◽  
Membrane Properties ◽  
Dialysis Session ◽  
Blood Samples ◽  
Membrane Materials ◽  
The Impact

Abstract End stage renal disease (ESRD) patients depend on hemodialysis (HD) as a life-sustaining treatment, but HD membrane properties play a critical role in blood activation during HD and can lead to severe patient outcomes. This study reports on a series of investigations on the common clinical HD membranes available in Canadian hospitals to explore the key reasons behind their susceptibility to blood activation and unstable cytokine. Clinical HD membranes composed of cellulose triacetate (CTA) and polyvinylpyrrolidone: polyarylethersulfone (PAES: PVP) were thoroughly characterized in terms of morphology and chemical composition. Membrane-surface interactions with uremic blood samples after HD treatment were probed using Fourier Transform Infra-Red (FTIR) and Raman spectroscopic techniques in order to understand changes in chemistry on membrane fibers. In addition, as part of this innovative study, we utilized Molecular Modeling Docking to examine the interactions of human blood proteins and membrane models to gain an in-depth understanding of functional group types responsible for perceived interactions. In-vitro adsorption of fibrinogen on different clinical HD membranes was compared at similar clinical operating conditions. Samples were collected from dialysis patients to ascertain the extent of inflammatory biomarkers released, before, during (30 and 90 min) and after dialysis (4 h). Collected blood samples were analyzed using Luminex assays for the inflammatory biomarkers of Serpin/Antithrombin-III, Properdin, C5a, 1L-1α, 1L-1β, TNF-α, IL6, and vWF. We have likewise incubated uremic blood in vitro with the two membrane materials to determine the impact that membrane materials pose in favor of activation away from the hydrodynamics influences. The results of our morphological, chemical, spectroscopic, and in vitro incubation analyses indicate that CTA membranes have a smoother surface and higher biocompatibility than PAES: PVP membranes, however, it has smaller pore size distribution, which results in poor clearance of a broad spectrum of uremic toxins. However, the rougher surface and greater hydrophilicity of PAES: PVP membranes increases red blood cell rupture at the membrane surface, which promotes protein adsorption and biochemical cascade reactions. Molecular docking studies indicate sulfone functional groups play an important role in the adsorption of proteins and receptors. PAES: PVP membranes result in slower but greater adsorption of fibrinogen, but are more likely to experience reversible and irreversible fouling as well as backfiltration. Our major finding is that a single dialysis session, even with a more biocompatible membrane such as CTA, increases the levels of complement and inflammation factors, but to a milder extent than dialysis with a PAES membrane.

scholarly journals Selective Extraction of ω-3 Fatty Acids from Nannochloropsis sp. Using Supercritical CO2 Extraction

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2406 ◽  
Author(s):  
Gian Paolo Leone ◽  
Roberto Balducchi ◽  
Sanjeet Mehariya ◽  
Maria Martino ◽  
Vincenzo Larocca ◽  
...  
Keyword(s):  
Flow Rate ◽  
Treatment Time ◽  
Selective Extraction ◽  
Extraction Yield ◽  
Operating Conditions ◽  
Treatment Conditions ◽  
Pre Treatment ◽  
Co2 Flow ◽  
Supercritical Fluid Carbon Dioxide ◽  
Treatment Step

In this article, microalgae Nannochloropsis sp. was used for fatty acid (FA) extraction, using a supercritical fluid-carbon dioxide (SF-CO2) extraction method. This study investigated the influence of different pre-treatment conditions by varying the grinding speed (200–600 rpm), pre-treatment time (2.5–10 min), and mixing ratio of diatomaceous earth (DE) and Nannochloropsis sp. biomass (0.5–2.0 DE/biomass) on FAs extraction. In addition, the effect of different operating conditions, such as pressure (100–550 bar), temperature (50–75 °C), and CO2 flow rate (7.24 and 14.48 g/min) on eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) recovery, was analyzed. Experimental data evidenced that, keeping constant the extraction conditions, the pre-treatment step enhanced the FAs extraction yield up to 3.4 fold, thereby the maximum extracted amount of FAs (61.19 mg/g) was attained with the pre-treatment with a ratio of DE/biomass of 1 at 600 rpm for 5 min. Moreover, by increasing both SF-CO2 pressure and temperature, the selectivity towards EPA was enhanced, while intermediate pressure and lower pressure promoted DHA recovery. The highest amount of extracted EPA, i.e., 5.69 mg/g, corresponding to 15.59%, was obtained at 75 °C and 550 bar with a CO2 flow rate of 14.48 g/min, while the maximum amount of extracted DHA, i.e., ~0.12 mg/g, equal to 79.63%, was registered at 50 °C and 400 bar with a CO2 flow rate of 14.48 g/min. Moreover, the increased CO2 flow rate from 7.24 to 14.48 g/min enhanced both EPA and DHA recovery.

Stabilization of the Speed of the Hydraulic Motor Through Throttle Compensation for Volume Losses

2020 ◽  
Vol 26 (3) ◽  
pp. 126-130
Author(s):  
Krasimir Kalev
Keyword(s):  
Flow Rate ◽  
Hydraulic Drive ◽  
Pressure Change ◽  
Operating Conditions ◽  
Drive System ◽  
Inlet Pressure ◽  
Schematic Diagram ◽  
Hydraulic Characteristics ◽  
Hydraulic Motor ◽  
Flow Through

AbstractA schematic diagram of a hydraulic drive system is provided to stabilize the speed of the working body by compensating for volumetric losses in the hydraulic motor. The diagram shows the inclusion of an originally developed self-adjusting choke whose flow rate in the inlet pressure change range tends to reverse - with increasing pressure the flow through it decreases. Dependent on the hydraulic characteristics of the hydraulic motor and the specific operating conditions.

scholarly journals Chemical–Electrochemical Process Concept for Lead Recovery from Waste Cathode Ray Tube Glass

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1546
Author(s):  
Árpád Imre-Lucaci ◽  
Melinda Fogarasi ◽  
Florica Imre-Lucaci ◽  
Szabolcs Fogarasi
Keyword(s):  
Flow Rate ◽  
Current Density ◽  
Complete Recovery ◽  
Electrochemical Process ◽  
Operating Conditions ◽  
General Effect ◽  
Optimal Operating ◽  
Recirculation Flow ◽  
Lead Recovery ◽  
Cathode Ray Tube

This paper presents a novel approach for the recovery of lead from waste cathode-ray tube (CRT) glass by applying a combined chemical-electrochemical process which allows the simultaneous recovery of Pb from waste CRT glass and electrochemical regeneration of the leaching agent. The optimal operating conditions were identified based on the influence of leaching agent concentration, recirculation flow rate and current density on the main technical performance indicators. The experimental results demonstrate that the process is the most efficient at 0.6 M acetic acid concentration, flow rate of 45 mL/min and current density of 4 mA/cm2. The mass balance data corresponding to the recycling of 10 kg/h waste CRT glass in the identified optimal operating conditions was used for the environmental assessment of the process. The General Effect Indices (GEIs), obtained through the Biwer Heinzle method for the input and output streams of the process, indicate that the developed recovery process not only achieve a complete recovery of lead but it is eco-friendly as well.

Photo-degradation of butyl parahydroxybenzoate by using TiO2-supported catalyst

2013 ◽  
Vol 67 (10) ◽  
pp. 2141-2147 ◽  
Author(s):  
Patrick Atheba ◽  
Patrick Drogui ◽  
Brahima Seyhi ◽  
Didier Robert
Keyword(s):  
Flow Rate ◽  
Photocatalytic Oxidation ◽  
Supported Catalyst ◽  
Operating Conditions ◽  
Treatment Efficiency ◽  
Optimal Operating ◽  
Photo Degradation ◽  
Photochemical Process ◽  
Recirculation Flow ◽  
High Treatment

The present work evaluates the potential of the photocatalysis (PC) process for the degradation of butylparaben (BPB). Relatively high treatment efficiency was achieved by comparison to photochemical process. Prior to photocatalytic degradation, adsorption (AD) of BPB occurred on the titanium dioxide (TiO2)-supported catalyst. AD was described by Langmuir isotherm (KL = 0.085 L g−1, qm = 4.77 mg g−1). The influence of angle of inclination of the reactor, pH, recirculation flow rate and initial concentration of BPB were investigated. The PC process applied under optimal operating conditions (recirculation flow rate of 0.15 L min−1, angle of inclination of 15°, pH = 7 and 5 mg L−1 of BPB) is able to oxidize 84.9–96.6% of BPB and to ensure around 38.7% of mineralization. The Langmuir–Hinshelwood kinetic model described well the photocatalytic oxidation of BPB (k = 7.02 mg L−1 h−1, K = 0.364 L mg−1).

Flow Features Analysis of Throttle Notches of Proportional Direct Valve

2011 ◽  
Vol 189-193 ◽  
pp. 2285-2288
Author(s):  
Wen Hua Jia ◽  
Chen Bo Yin ◽  
Guo Jin Jiang
Keyword(s):  
Fluid Flow ◽  
Dynamic Behavior ◽  
Flow Rate ◽  
Discharge Coefficient ◽  
3D Models ◽  
Operating Conditions ◽  
Flow Models ◽  
Flow Features ◽  
Rate Discharge ◽  
Spool Valve

Flow features, specially, flow rate, discharge coefficient and efflux angle under different operating conditions are numerically simulated, and the effects of shapes and the number of notches on them are analyzed. To simulate flow features, 3D models are developed as commercially available fluid flow models. Most construction machineries in different conditions require different actions. Thus, in order to be capable of different actions and exhibit good dynamic behavior, flow features should be achieved in designing an optimized proportional directional spool valve.

scholarly journals Experimental Investigation and Modeling of Inertance Tubes

2005 ◽  
Vol 127 (5) ◽  
pp. 1029-1037 ◽  
Author(s):  
L. O. Schunk ◽  
G. F. Nellis ◽  
J. M. Pfotenhauer
Keyword(s):  
Mass Flow Rate ◽  
Mass Flow ◽  
Flow Rate ◽  
Acoustic Power ◽  
Operating Conditions ◽  
Thermodynamic Efficiency ◽  
Pulse Tube ◽  
Design Charts ◽  
Wide Range ◽  
Pulse Tube Refrigerators

Growing interest in larger scale pulse tubes has focused attention on optimizing their thermodynamic efficiency. For Stirling-type pulse tubes, the performance is governed by the phase difference between the pressure and mass flow, a characteristic that can be conveniently adjusted through the use of inertance tubes. In this paper we present a model in which the inertance tube is divided into a large number of increments; each increment is represented by a resistance, compliance, and inertance. This model can include local variations along the inertance tube and is capable of predicting pressure, mass flow rate, and the phase between these quantities at any location in the inertance tube as well as in the attached reservoir. The model is verified through careful comparison with those quantities that can be easily and reliably measured; these include the pressure variations along the length of the inertance tube and the mass flow rate into the reservoir. These experimental quantities are shown to be in good agreement with the model’s predictions over a wide range of operating conditions. Design charts are subsequently generated using the model and are presented for various operating conditions in order to facilitate the design of inertance tubes for pulse tube refrigerators. These design charts enable the pulse tube designer to select an inertance tube geometry that achieves a desired phase shift for a given level of acoustic power.

scholarly journals Preparation and characterization of different geometrical shapes of multi-bore hollow fiber membranes and application in vacuum membrane distillation

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Elham M. El-Zanati ◽  
Eman Farg ◽  
Esraa Taha ◽  
Ayman El-Guindi ◽  
Heba Abdallah
Keyword(s):  
Mechanical Properties ◽  
Flow Rate ◽  
Hollow Fiber ◽  
Amorphous Structure ◽  
Membrane Distillation ◽  
Operating Conditions ◽  
Hollow Fiber Membranes ◽  
Preparation Conditions ◽  
Geometrical Shapes ◽  
Fiber Membranes

Abstract Multi-bore hollow fiber membranes were prepared through phase inversion spinning process using new locally designed spinnerets of various geometrical shapes. The spun cylindrical-like, rectangular or ribbon-like, and triangular-like are prepared, dried, and characterized by scanning electronic microscope. Fibers of circular (seven, five, and four bores) shape, rectangular of five bores, and triangular of three bores were chosen to study the effect of both geometrical configuration and the number of bores on the amorphous structure and the mechanical properties of the membranes. Membrane geometry, surface amorphous, and bore arrangements are very sensitive to the operating conditions, especially the extrusion and drawing rates. Three polymeric blends of different compositions are used to prepare multi-bore hollow fiber membranes. This study revealed that the blend composition of PES 16%, PVP 2%, PEG 2%, diethylene glycol 2%, and NMP 78% gives excellent mechanical properties. Optimization of the preparation conditions also developed, where the dope flow rate, the bore flow rate, and the air gap were 1.14 cm3 s−1, 1.1 cm3 s−1, and 0 cm, respectively. Furthermore, this study proved that the circular arrangement has high mechanical strength. The prepared seven-MBHF membranes were applied in the membrane distillation process, a solution of 35 g/l NaCl was used to test the membrane performance, and the achieved flux and rejection were 28.32 L/m2 h and 98.9%, respectively. This performance demonstrated that the prepared membrane in this way is suitable to compete with conventional reverse osmosis technology that uses single track hollow fibers.

scholarly journals Heterogeneous Bonding of PMMA and Double-Sided Polished Silicon Wafers through H2O Plasma Treatment for Microfluidic Devices

Coatings ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 580
Author(s):  
Chao-Ching Chiang ◽  
Philip Nathaniel Immanuel ◽  
Yi-Hsiung Chiu ◽  
Song-Jeng Huang
Keyword(s):  
Plasma Treatment ◽  
Flow Rate ◽  
Gas Flow ◽  
Treatment Time ◽  
Optical Emission ◽  
Microfluidic Devices ◽  
Oh Radicals ◽  
Gas Flow Rate ◽  
Oh Groups ◽  
Plasma Treatment Time

In this work we report on a rapid, easy-to-operate, lossless, room temperature heterogeneous H2O plasma treatment process for the bonding of poly(methyl methacrylate) (PMMA) and double-sided polished (DSP) silicon substrates by for utilization in sandwich structured microfluidic devices. The heterogeneous bonding of the sandwich structure produced by the H2O plasma is analyzed, and the effect of heterogeneous bonding of free radicals and high charge electrons (e−) in the formed plasma which causes a passivation phenomenon during the bonding process investigated. The PMMA and silicon surface treatments were performed at a constant radio frequency (RF) power and H2O flow rate. Changing plasma treatment time and powers for both processes were investigated during the experiments. The gas flow rate was controlled to cause ionization of plasma and the dissociation of water vapor from hydrogen (H) atoms and hydroxyl (OH) bonds, as confirmed by optical emission spectroscopy (OES). The OES results show the relative intensity peaks emitted by the OH radicals, H and oxygen (O). The free energy is proportional to the plasma treatment power and gas flow rate with H bonds forming between the adsorbed H2O and OH groups. The gas density generated saturated bonds at the interface, and the discharge energy that strengthened the OH-e− bonds. This method provides an ideal heterogeneous bonding technique which can be used to manufacture new types of microfluidic devices.

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