Abstract P266: The Association Of Recent Age-specific Growth Of The
            >
            65 Years Population With Heart Disease Mortality In The United States, 2005-2017

Introduction: In 2011, the number of deaths with an underlying cause of heart disease (HD) reached its lowest level in 56 years. However, there has subsequently been a steady increase in the annual number of total HD deaths, owing to a rapid increase (23%) in the size of the population ≥65 years of age in the U.S. To understand these trends, we sought to characterize differences between 2005-2011 and 2011-2017 in population and mortality by age subgroups among those ≥65 years. Methods: We determined age-specific population size, HD mortality rate, and absolute number of HD deaths in the ≥65 age group for the time periods 2005-2011 and 2011-2017, as well as for the <65 years age group, using the CDC WONDER online data set. Results: Age-specific population growth was greatest among those 65-74 years between 2005-2011 and 2011-2017, representing 76% of the total population growth among those ≥65 years old in both time periods (Table) and 51% of the growth for the entire population from 2011-2017. From 2005-2011, decreases in the mortality rate of 20% or greater in each of the age subgroups (65-74, 75-84, 85+) resulted in a decline in the number of total HD deaths in each of the age groups in spite of substantial population increases in the 65-74 and 85+ age groups. However, subsequent changes in the age-specific mortality rate among those ≥65 years were lower than population increases from 2011-2017, resulting in an increased number of total HD deaths in all > 65 years age subgroups. This was most notable among those age 65-74 years in whom the 32% population increase with a 1.5% decline in the mortality rate resulted in a 30% increase in the number of HD deaths, representing 61.3% of the increase in number of HD deaths in the 65+ years age group and 53% of the increase of HD deaths in all age groups from 2011-2017. Conclusions: The rapid growth of the 65-74 years age group (baby boomers) accounts for most of the population growth in the ≥65 years age group and more than half the increase in both total population growth and the total number of HD deaths from 2011-2017.

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Comparison of Prevalence of Periodontitis with Different Indices in Population of District Ghaziabad

Dental Journal of Advance Studies ◽

10.1055/s-0038-1672041 ◽

2016 ◽

Vol 04 (01) ◽

pp. 023-030

Author(s):

Vimal Kumar ◽

Pallak Arora ◽

Manish Khatri ◽

Shivani Sharma ◽

Sumit Malhotra ◽

...

Keyword(s):

Periodontal Disease ◽

Total Population ◽

Age Groups ◽

Cross Sectional Study ◽

Sample Population ◽

Age Group ◽

Cross Sectional ◽

Multi Stage ◽

Younger Age ◽

Study Population

Abstract Objective: To estimate the prevalence of periodontal disease with different indices. Methods & materials: The study population consisted of multistage stratified random sample of 1300 subjects from total population of district Ghaziabad. A cross-sectional study was conducted with multi stage stratified random sampling techniques to select the sample population. The subjects were divided into different age groups and the periodontal assessment was made on the basis of CPITN index and ESI Index. Results: The CPITN has shown to estimate incorrect periodontal disease prevalence because of its underestimation of the disease severity. A huge difference was noticed in the prevalence rate of periodontitis when subjects were examined with ESI index. Conclusion Periodontal disease was found to be highly prevalent in the study population and severity of disease increased with age. More number of subjects in younger age group were found to be healthy.

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Abstract 257: Urban Teaching and Non-Teaching Hospitals Outcomes: Myocardial Infarction

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.10.suppl_3.257 ◽

2017 ◽

Vol 10 (suppl_3) ◽

Author(s):

Priscilla O Okunji ◽

Johnnie Daniel

Keyword(s):

Myocardial Infarction ◽

Mortality Rate ◽

Income Group ◽

The United States ◽

Teaching Hospitals ◽

Age Difference ◽

Age Group ◽

Urban Teaching ◽

Significant Difference ◽

The Impact

Background: Patients with myocardial infarction reportedly have different outcomes on discharge according to hospital characteristics. In the present study, we evaluated the differences between urban teaching hospitals (UTH) and non-teaching hospitals (NTH), discharged in 2012. We also investigated on the outcomes. Methods: Sample of 117,808 subjects diagnosed with myocardial infarction were extracted from a nationwide inpatient stay dataset using the International Classification Data, ICD 9 code 41000 in the United States, according to hospital location, size, and teaching status. Results: The analysis of the data showed that more whites were admitted to both teaching and non teaching hospitals with more males (~24%) admitted than their female counterparts. However, blacks were admitted more (~15%) in urban teaching hospitals than medium urban non teaching hospitals. Age difference was noted as well, while age group (60-79 years) were admitted more in UTH, inversely urban non-teaching hospitals admitted more older (80 years or older) age group. A significant difference (~28%) was observed in both hospital categories with UTH admitting more patients of $1.00 - $38,999.00 income group than other income categories. In addition, it was observed that patients with MI stayed more (~5%) for 14 or more days, and charged more especially for income group of $80,000 or above in UTH than NTH. No significant difference was found in the mortality rate for both hospital categories. Conclusion: The overall outcomes showed that the mortality rate between urban teaching and non-teaching hospitals were non significant, though the inpatients MI stayed longer and were charged more in UTH than NTH. The authors call for the study to be replicated with a higher level of statistical measures to ascertain the impact of the variables on the outcomes for a more validated result.

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Treatment of cyanotic heart diseases in children

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh04s1009j ◽

2004 ◽

Vol 132 (suppl. 1) ◽

pp. 9-13

Author(s):

Ida Jovanovic ◽

Vojislav Parezanovic ◽

Slobodan Ilic ◽

Djordje Hercog ◽

Milan Vucicevic ◽

...

Keyword(s):

Heart Disease ◽

Mortality Rate ◽

Surgical Procedures ◽

Heart Surgery ◽

Heart Diseases ◽

Arterial Switch Operation ◽

Open Heart Surgery ◽

Age Groups ◽

Mortality Rates ◽

Cyanotic Heart Disease

Cyanotic heart diseases are relatively rare, but they are severe and heterogeneous congenital heart diseases, which require complex surgery. Development of different advanced surgical procedures, such as arterial switch operation (ASO), Fontan and its modifications, Norwood etc. operations, as well as better perioperative care significantly improved survival rate and quality of life of these children. The study group included 308 children treated for cyanotic heart disease in Yugoslavia, in the period January 2000 to July 2004. Some of them (239, 77.6%) were treated at the University Children?s Hospital in Belgrade, and others (69, 22.4%) in different institutions abroad. The age of the operated patients varied between 1 day and 19 years (median 12 months). The patients (pts) were divided into four groups, according to the disease and type of the operation. In the whole group of 308 patients treated due to cyanotic heart disease, there were 232 (75.3%) cases with open heart surgery and 76 (24.7%) with closed procedures. The mortality rate was significantly different between disease/operation groups, and age groups. Average mortality rates differed from 11.8% for palliative procedures to 12.5% for complete corrections. Mortality rate and achieved surgical results in treatment of chil?dren with cyanotic heart diseases were significantly worse than those published by leading cardiac surgery centers in the world. However, there is a clear tendency in introducing new surgical procedures, lowering the age at which the operation is done and decreasing the mortality rates.

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Population Structure and Life Table of Dog Conch (Strombus turturella) in Bangka Belitung Islands, Indonesia [Struktur Populasi dan Tabel Hidup Siput Gonggong (Strombus turturella) di Kepulauan Bangka Belitung, Indonesia]

Jurnal Ilmiah Perikanan dan Kelautan ◽

10.20473/jipk.v11i2.13112 ◽

2019 ◽

Vol 11 (2) ◽

pp. 72

Author(s):

Okto Supratman ◽

Tati Suryati Syamsudin

Keyword(s):

Mortality Rate ◽

Life Table ◽

High Mortality ◽

Economic Value ◽

Age Groups ◽

Time Estimation ◽

First Year ◽

Age Group ◽

Growth Coefficient ◽

Recruitment Time

AbstractDog Conch (Strombus turturella) has an essential economic value in Bangka Belitung Islands. Allegedly, the population of Dog Conch is decreasing due to overexploitation. The purpose of this study is to provide information related to the distribution of long frequency, growth pattern, age group, recruitment time estimation and life table of Dog Conch. This research took place on the coast of Tukak Village and Anak Air Island, Bangka Belitung Islands. Samples of Dog Conch were taken using 3x3 m2 square. The shell length of Dog Conch found ranged between 18.18 to 77.49 mm, consisting of three age groups. Asymptotic length value (L∞), growth coefficient (K) and theoretical age on zero-length (t0) were 83.94 mm, 0.79/year and -0.152 sequentially. In the first year, Dog Conch grows to 50.18 mm and slows down when it grows older until it is 13 years old. The proportion of high mortality rate was at 1 to 2 years old and 3 to 4 years old or in adult individuals, while the highest life expectancy rate was in the age group of 0-1-year old or young individuals. It indicated that the high mortality rate was in the group in which people use to consume or sell in the marketsAbstrakSiput gonggong (Strombus turturella) memiliki nilai ekonomis penting di Kepulauan Bangka Belitung. Diduga populasi siput gonggong semakin menurun akibat dari eksploitasi berlebihan. Tujuan penelitian ini adalah untuk memberikan informasi terkait distribusi frekuensi panjang, pola pertumbuhan, kelompok umur, estimasi waktu rekruitmen dan tabel hidup siput gonggong. Lokasi penelitian berada di Pesisir Desa Tukak dan Pulau Anak Air, Kepulauan Bangka Belitung.Pengambilan sampel siput gonggong dilakukan dengan menggunakan kuadrat 3x3 m2. Panjang cangkang siput gonggong yang ditemukan berkisar antara 18.18 s.d 77.49 mm yang terdiri atas 3 kelompok umur. Nilai panjang asymptotic (L∞), koefisien pertumbuhan (K) dan umur teoritis ketika panjang sama dengan nol (t0) adalah 83.94 mm, 0.79/tahun dan -0.152 secara berurutan. Pada tahun pertama siput gonggong mengalami pertumbuhan, mencapai 50.18 mm dan melambat ketika umur semakin tua hingga umur 13 tahun. Proporsi laju kematian tinggi terdapat pada umur 1 s.d 2 tahun dan 3 s.d 4 tahun atau pada individu dewasa, sedangkan nilai harapan hidup tertinggi terdapat pada kelompok umur 0-1 tahun atau individu muda. Hal ini menunjukkan bahwa kematian tertinggi terdapat pada kelompok umur yang telah diambil oleh masyarakat untuk dikonsumsi dan dijual ke pasaran.

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Sex differences in non-communicable disease prevalence in China: a cross-sectional analysis of the China Health and Retirement Longitudinal Study in 2011

BMJ Open ◽

10.1136/bmjopen-2017-017450 ◽

2017 ◽

Vol 7 (12) ◽

pp. e017450 ◽

Cited By ~ 4

Author(s):

Yan Liu ◽

Guofeng Liu ◽

Hongjiang Wu ◽

Weiyan Jian ◽

Sarah H Wild ◽

...

Keyword(s):

Sex Differences ◽

Heart Disease ◽

Longitudinal Study ◽

Lung Disease ◽

Chronic Lung Disease ◽

Communicable Disease ◽

Age Groups ◽

Sociodemographic Factors ◽

Age Group ◽

Cross Sectional

ObjectivesTo describe the sex differences in the prevalence of non-communicable diseases (NCDs) in adults aged 45 years or older in China.DesignCross-sectional study.SettingNationally representative sample of the Chinese population 2011.Participants8401 men and 8928 women over 45 years of age who participated in the first wave of the China Health and Retirement Longitudinal Study (CHARLS).Outcome measuresSelf-reported data on overall health and diagnosis of hypertension, dyslipidaemia, diabetes, heart disease, stroke, chronic lung disease, cancer or arthritis. Sex differences in NCDs were described using logistic regression to generate odds ratios (OR) with adjustment for sociodemographic factors and health-related behaviours. All analyses were stratified by age group for 45–64-year-old and ≥65-year-old participants.ResultsIn both age groups, men reported better overall health than women. The crude prevalence of heart disease, cancer and arthritis was higher while that of stroke and chronic lung disease was lower in women than in men. After adjustment, ORs (95% CI) for the 45–64 and ≥65 year age groups were 0.70 (0.58 to 0.84) and 0.66 (0.54 to 0.80), respectively, for arthritis for men compared with women. In contrast, ORs were 1.66 (1.09 to 2.52) and 2.12 (1.36 to 3.30) for stroke and 1.51 (1.21 to 1.89) and 1.43 (1.09 to 1.88) for chronic lung disease for men compared with women. ORs for heart disease (0.65 (0.52 to 0.80)) were lower in men than in women only in the 45–64 year age group.ConclusionsOdds of arthritis were lower while those of stroke and chronic lung disease were higher in men than in women in both age groups. However, odds of heart disease were lower in men than in women, but only in the group of individuals aged 45–64 years.

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Age and Sex: Factors in Defining the Term “Handicap”

Psychological Reports ◽

10.2466/pr0.1975.37.1.103 ◽

1975 ◽

Vol 37 (1) ◽

pp. 103-106 ◽

Cited By ~ 2

Author(s):

Larry J. Coet ◽

Larry W. Thornton

Keyword(s):

Mental Illness ◽

Mental Retardation ◽

Heart Disease ◽

Random Sample ◽

Age Groups ◽

Economic Conditions ◽

Age Group ◽

Sex Factors ◽

Aged Group ◽

Age And Sex

A random sample of 67 males and 74 females was divided into three age groups: 12 to 25, 26 to 45, and 46 to 82 yr. old. Subjects were given a questionnaire asking them to rank five groups or classes of people they felt should be labeled “handicapped.” An analysis of variance indicated that over-all, definitions of the term “handicap” differed significantly according to age and sex. Males emphasized “social” and “intellectual” conditions, while females stressed the more visible (unattractive) conditions. The youngest age group listed “race,” “speech,” and “socio-economic” conditions more frequently, while the middle-aged group was more concerned with “physical incapacitation,” “blindness,” and “heart disease.” The oldest age group stressed “mental illness” and “mental retardation” most frequently.

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Age Related Outcomes for Multiple Myeloma Patients Following Autologous Transplantation

Blood ◽

10.1182/blood.v124.21.3968.3968 ◽

2014 ◽

Vol 124 (21) ◽

pp. 3968-3968 ◽

Cited By ~ 1

Author(s):

Justin LaPorte ◽

Stacey Brown ◽

Xu Zhang ◽

Asad Bashey ◽

Lawrence E. Morris ◽

...

Keyword(s):

Multiple Myeloma ◽

Stem Cell ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Age Groups ◽

Disease Status ◽

The United States ◽

Disease Stage ◽

Age Group ◽

Post Transplant

Abstract Multiple myeloma is the second most common hematological malignancy in the United States. The risk of developing multiple myeloma increases with age; with approximately 85% of patients are over age 55 and 62% over age 65. Through improved supportive care, increased access to hematopoietic stem cell transplantation, and introduction of new biologic agents, survival has increased over the past 20 years. Currently, autologous stem cell transplantation (ASCT) is the standard of care after primary therapy for eligible patients. Research has suggested a greater survival benefit after ASCT for patients < 60 years, but the role of ASCT in older individuals remains less clear. In order to better understand the impact of age on the outcome of myeloma patients receiving ASCT, we analyzed the presenting features and outcomes of 256 consecutive patients at our institution that received a first ASCT between January 2004 and December 2013. Patient characteristics were: median age 61 (range 32-76), Sex: M=55% F=45%, Immunochemical subtype: IgG=59%, IgA =21%, Light chain=16%, Other=4%, Durie-Salmon System (DSS) stage at diagnosis: Stage I=9%, Stage II=20%, Stage III=68%, Unknown=4%, Disease status at transplant: CR/sCRsp=18%, VgPR=27%, PR=49%, Stable=6%, Melphalan preparative dose: 200mg/m2=93%, 140mg/m2=7%. Second ASCT was eventually performed in 60 (23%) of patients, with 39 (15%) of these being planned tandem ASCT. Patient survival and disease status were collected prospectively as part of our comprehensive database. For purposes of analysis, patients were divided by age into three groups: age<55 (n=80), age 55-64 (n=90), age ≥ 65 (n=86). Groups were similar in regards to disease subtype, stage, status at the time of transplant, comorbidity index, and year of transplant; differences included more second transplants and tandem transplants in the youngest age group and more reduced dose melphalan in the oldest age group. At day +100 post-transplant, disease response was CR, VGPR, PR, and <PR in 35%, 24%, 39%, and 2%, respectively and did not differ statistically by age group. Non-relapse mortality at one-year post-transplant was 1%, and did not differ among the <55, 55-64, and ≥ 65 age-groups (0%, 3%, and 0%, respectively). With a median follow-up of 39 months, the estimated 4-year OS, DFS, and relapse incidence (RI) was 73%, 43%, and 48%, respectively. Survival and RI were significantly better in the younger age group (4-yr OS 84%, 70%, 64%; DFS 58%, 35%, 39%; RI 34%, 53%, 53%, respectively in the <55, 55-64, and ≥ 65 age-groups; see figure). Outcomes were extremely favorable in patients <55 years of age transplanted in CR or VGPR with a 4-yr OS, DFS, and RI of 96%, 75%, and 21%, respectively. Even in the older age groups, median overall survival had not been reached by 5 years, suggesting that all age groups benefit from ASCT. There were no statistically significant differences in measured outcomes between patients age 55-64 years and those age ≥ 65 years, confirming that age ≥ 65 years should not be used to determine transplant eligibility. In multivariate analysis, variables predictive of OS included age, disease stage, and year of transplant; whereas for DFS, predictive variables also included disease status at transplant and planned tandem ASCT (see table). This analysis builds on a growing body of evidence suggesting improved outcomes in patients with multiple myeloma. Patients regardless of age appear to benefit from ASCT, with median survival now exceeding 5 years in all age groups. Patients less than 55 years of age and particularly those achieving at least a VGPR prior to ASCT seem to represent a patient population with an extremely favorable prognosis post-transplant. Figure 1 Figure 1. Figure 2 Figure 2. Disclosures No relevant conflicts of interest to declare.

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Contact surveys reveal heterogeneities in age-group contributions to SARS-CoV-2 dynamics in the United States

10.1101/2021.09.25.21264082 ◽

2021 ◽

Author(s):

Taylor Chin ◽

Dennis M. Feehan ◽

Caroline O. Buckee ◽

Ayesha S. Mahmud

Keyword(s):

United States ◽

Age Groups ◽

The United States ◽

Contact Rate ◽

Age Group ◽

Contact Rates ◽

Contact Patterns ◽

Age Structured ◽

The Impact ◽

Over Time

SARS-CoV-2 is spread primarily through person-to-person contacts. Quantifying population contact rates is important for understanding the impact of physical distancing policies and for modeling COVID-19, but contact patterns have changed substantially over time due to shifting policies and behaviors. There are surprisingly few empirical estimates of age-structured contact rates in the United States both before and throughout the COVID-19 pandemic that capture these changes. Here, we use data from six waves of the Berkeley Interpersonal Contact Survey (BICS), which collected detailed contact data between March 22, 2020 and February 15, 2021 across six metropolitan designated market areas (DMA) in the United States. Contact rates were low across all six DMAs at the start of the pandemic. We find steady increases in the mean and median number of contacts across these localities over time, as well as a greater proportion of respondents reporting a high number of contacts. We also find that young adults between ages 18 and 34 reported more contacts on average compared to other age groups. The 65 and older age group consistently reported low levels of contact throughout the study period. To understand the impact of these changing contact patterns, we simulate COVID-19 dynamics in each DMA using an age-structured mechanistic model. We compare results from models that use BICS contact rate estimates versus commonly used alternative contact rate sources. We find that simulations parameterized with BICS estimates give insight into time-varying changes in relative incidence by age group that are not captured in the absence of these frequently updated estimates. We also find that simulation results based on BICS estimates closely match observed data on the age distribution of cases, and changes in these distributions over time. Together these findings highlight the role of different age groups in driving and sustaining SARS-CoV-2 transmission in the U.S. We also show the utility of repeated contact surveys in revealing heterogeneities in the epidemiology of COVID-19 across localities in the United States.

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Sex differences in campylobacteriosis incidence rates at different ages - a seven country, multi-year, meta-analysis. A potential mechanism for the infection.

10.21203/rs.2.19298/v4 ◽

2020 ◽

Author(s):

Manfred S Green ◽

Naama Schwartz ◽

Victoria Peer

Keyword(s):

Sex Differences ◽

Vaccine Development ◽

Meta Analysis ◽

Age Groups ◽

Incidence Rates ◽

Age Group ◽

Male Predominance ◽

Time Period ◽

Meta Regression ◽

Time Periods

Abstract Background . There is evidence that males have higher incidence rates (IR) of campylobacteriosis than femlaes. The objectives of this study were to determine whether the sex differences differ between age groups and are consistent over different countries and over different time periods. Methods. We obtained data on incidence rates of campylobacteriosis by sex and age group over a period of 11-26 years from seven countries. Male to female incidence rate ratios (IRR) were computed by age group, country and time period. For each age group, we used meta-analytic methods to combine the IRRs. Sensitivity analysis was used to test whether the results are robust to differences between countries and time periods. Meta-regression was conducted to estimate the different effects of age, country, and time period on the IRR. Results . In the age groups <1, 1-4, 5-9, 10-14, 15-44, 45-64 and 65+ years old, the pooled IRRs (with 95% CI) were 1.31 (1.26-1.37), 1.34 (1.31-1.37), 1.35 (1.32-1.38), 1.73 (1.68-1.79), 1.10 (1.08-1.12), 1.19(1.17-1.21) and 1.27 (1.24-1.30), respectively. For each age group, the excess campylobacteriosis incidence rates in males differed at different age groups. However, despite some quantitative differences between countries, the excess was consistently present over long time-periods. In meta-regression analysis, age group was responsible for almost all the variation in the IRRs. Conclusions . The male predominance in campylobacteriosis incidence rates starts in infancy. This suggests that this is due, at least in part, to physiological or genetic differences and not just behavioural factors. These findings can provide clues to the mechanisms of the infection and could lead to more targeted treatments and vaccine development.

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Decreasing Incidence of Estrogen Receptor-Negative Breast Cancer in the United States: Trends by Race and Region

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/djab186 ◽

2021 ◽

Author(s):

Brittny C Davis Lynn ◽

Pavel Chernyavskiy ◽

Gretchen L Gierach ◽

Philip S Rosenberg

Keyword(s):

Breast Cancer ◽

United States ◽

Estrogen Receptor ◽

African American Women ◽

Breast Cancer Incidence ◽

Age Groups ◽

The United States ◽

Age Group ◽

Annual Percent Change ◽

Hispanic White

Abstract Background Incidence of estrogen receptor (ER)-negative breast cancer, an aggressive subtype, is highest in United States (US) African American women and in southern residents but has decreased overall since 1992. We assessed whether ER-negative breast cancer is decreasing in all age groups and cancer registries among non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic White (HW) women. Methods We analyzed 17 Surveillance, Epidemiology, and End-Results Program registries (twelve for 1992-2016; five for 2000-2016) to assess NHW, NHB, and HW trends by ER status and age group (30-39, 40-49, 50-69, 70-84 years). We used hierarchical age-period-cohort models that account for sparse data, which improve estimates to quantify between-registry heterogeneity in mean incidence rates and age-adjusted trends versus SEER overall. Results Overall, ER-negative incidence was highest in NHB, then NHW and HW women, and decreased from 1992-2016 in each age group and racial/ethnic group. The greatest decrease was for HW women ages 40-49 years with an annual percent change of –3.5%/year (95% credible interval = −4.4%, −2.7%), averaged over registries. The trend heterogeneity was statistically significant in every race/ethnic and age group. Furthermore, the incidence relative risks by race/ethnicity compared to the race-specific SEER average were also statistically significantly heterogeneous across the majority of registries and age groups (62 of 68 strata). The greatest heterogeneity was seen in HW women, followed by NHB women, and the least in NHW women. Conclusion Decreasing ER-negative breast cancer incidence differs meaningfully by US region and age among NHB and HW women. Analytical studies including minority women from higher and lower incidence areas may provide insights into breast cancer racial disparities.

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